Standard name
Human Ortholog
Description (SGD) Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.99 0.91 0.52 0.57 0.38 – 0.38 0.46 0.3 0.43 0.98 0.87 0.63 0.98 0.98 0.98 0.96 0.95 0.93 0.92 0.93 0.91
Endoplasmic Reticulum 0 0 0 0 0.06 0.09 0.06 – 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0.09 – 0.05 0.09 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0.06 0.1 0 0.06 – 0 0 0 0 0 0.07 0.26 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.08 – 0.43 0.19 0.4 0.42 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0.09 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.29 0.28 0.38 – 0.18 0.24 0.26 0.16 0 0.06 0.18 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 7 4 6 – 16 10 6 5 0 2 0 0 0 1 0 0 0 0 1 0
Bud 0 1 2 1 1 0 2 – 6 4 6 7 0 1 0 0 1 0 0 4 2 8 9 10
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 4 10 2 1 9 10 – 10 9 8 5 5 2 2 5 7 1 1 0 0 0 0 0
Cytoplasm 290 251 283 182 107 108 85 – 104 114 79 105 414 457 347 612 391 435 274 242 262 391 451 525
Endoplasmic Reticulum 1 5 3 6 12 16 13 – 10 10 9 8 14 11 16 28 12 26 1 1 9 9 6 21
Endosome 0 0 0 0 6 4 21 – 14 22 12 10 0 0 2 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 12 21 4 13 – 5 9 4 2 0 36 142 2 1 3 0 0 0 0 0 0
Mitochondria 0 1 0 0 3 4 18 – 117 48 105 101 0 0 0 9 4 1 0 0 0 0 0 1
Nucleus 1 1 0 0 4 4 4 – 8 3 13 7 0 2 0 1 1 1 2 1 0 3 1 1
Nuclear Periphery 0 0 0 0 0 0 0 – 3 0 1 1 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 0 1 19 2 2 – 3 1 2 1 0 12 18 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 1 – 0 3 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 4 0 1 3 59 52 84 – 49 60 69 39 1 30 99 2 3 9 1 1 1 8 5 5
Unique Cell Count 295 256 287 201 207 188 223 274 248 261 243 422 526 553 622 400 445 285 255 282 427 483 578
Labelled Cell Count 297 263 299 207 240 207 259 345 293 314 292 434 553 626 659 420 477 285 255 282 427 483 578


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 70.1 73.9 65.2 56.0 19.5 14.5 11.7 – 8.6 9.3 8.2 7.9 69.9 57.9 38.8 54.9 70.5 69.8 72.8 75.4 73.3
Std Deviation (1e-4) 15.5 19.2 14.4 13.0 7.4 5.5 5.1 – 3.8 4.0 3.9 3.5 16.2 16.5 12.7 16.5 22.3 21.5 19.4 20.6 21.2
Intensity Change (Log2) – – – -0.22 -1.74 -2.17 -2.48 – -2.93 -2.8 -3.0 -3.04 0.1 -0.17 -0.75 -0.25 0.11 0.1 0.16 0.21 0.17


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 4.2 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0.7 0.6 – 0.1 0.1 -0.3 -1.0 -2.1 0 0 0 -1.4 0
Cytoplasm -4.1 -12.6 -11.5 -15.1 – -15.5 -13.9 -16.9 -14.3 -0.5 -5.6 -11.4 -0.2 -0.8 -0.8
Endoplasmic Reticulum 0 3.0 4.1 3.1 – 2.0 2.2 1.9 1.8 1.9 0 1.7 2.7 1.7 3.2
Endosome 0 0 0 5.3 – 3.9 5.2 3.7 0 0 0 0 0 0 0
Golgi 0 5.5 0 4.1 – 0 0 0 0 0 4.5 9.4 0 0 0
Mitochondria 0 0 0 4.9 – 12.4 7.8 12.0 12.1 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 3.8 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 5.2 0 0 – 0 0 0 0 0 0 3.1 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 9.5 9.2 11.2 – 7.3 8.7 9.1 6.8 0 3.8 7.5 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 83.1767 103.9116 100.6364 81.4999 88.3763 96.9048 61.6279 97.9071 91.47 102.7991 94.5159 80.3967 76.1314 100.3008 88.7164 82.4886 71.1963 91.0876
Actin 0.0169 0.0002 0.0125 0.0004 0.0344 0.0012 0.0079 0.0014 0.0017 0.0327 0.0001 0.0279 0.0353 0.0006 0.0281 0.0296 0.0208 0.0016
Bud 0.0021 0.0004 0.0011 0.0011 0.0007 0.0011 0.0027 0.0009 0.002 0.0134 0.0005 0.0076 0.0018 0.001 0.0028 0.0027 0.0042 0.0024
Bud Neck 0.0008 0.0005 0.0009 0.0005 0.0007 0.0016 0.0012 0.0005 0.0006 0.0016 0.0002 0.0015 0.0009 0.0005 0.001 0.0021 0.0017 0.002
Bud Periphery 0.0022 0.0002 0.0011 0.0006 0.0004 0.0004 0.0048 0.0013 0.0015 0.0053 0 0.0065 0.0025 0.0003 0.002 0.0029 0.0034 0.0013
Bud Site 0.0046 0.0003 0.0005 0.0002 0.0005 0.0001 0.0019 0.0006 0.001 0.0145 0 0.0028 0.0065 0.0015 0.006 0.0189 0.0016 0.0004
Cell Periphery 0.0131 0.0025 0.004 0.003 0.0009 0.0009 0.0184 0.0024 0.0052 0.0078 0.0001 0.0008 0.0075 0.0019 0.0157 0.0042 0.0018 0.0048
Cytoplasm 0.6016 0.9329 0.8085 0.6732 0.683 0.8663 0.5406 0.9455 0.9071 0.7472 0.9631 0.8521 0.6656 0.9325 0.7558 0.6865 0.6789 0.837
Cytoplasmic Foci 0.0134 0.0008 0.0055 0.0013 0.0101 0.005 0.0032 0.0012 0.0025 0.0115 0.0011 0.0048 0.0019 0.0019 0.0037 0.0059 0.0077 0.0064
Eisosomes 0.0009 0 0.0001 0 0.0003 0 0.0004 0.0004 0 0.0006 0 0 0.0003 0 0.0002 0.0006 0.0002 0
Endoplasmic Reticulum 0.0579 0.0143 0.0196 0.003 0.0408 0.0505 0.0669 0.0083 0.022 0.0012 0.0006 0.007 0.0399 0.0023 0.0062 0.005 0.0401 0.0098
Endosome 0.0175 0.0025 0.0069 0.0069 0.0395 0.0209 0.0288 0.0015 0.0045 0.0065 0.0027 0.0153 0.0143 0.0014 0.0215 0.0143 0.0599 0.02
Golgi 0.0055 0.0003 0.0038 0.0007 0.0222 0.0032 0.0059 0.0003 0.0009 0.0038 0.0001 0.0066 0.0023 0.0001 0.0074 0.0124 0.0079 0.0038
Lipid Particles 0.0086 0.0002 0.0041 0.0002 0.0272 0.0001 0.0075 0.0001 0.0004 0.0032 0 0.0004 0.0007 0.0002 0.0013 0.0044 0.0024 0.0004
Mitochondria 0.0179 0.0014 0.0047 0.0015 0.0089 0.0028 0.0174 0.0122 0.0032 0.0114 0.0001 0.0094 0.0036 0.0004 0.0221 0.0435 0.0206 0.0048
None 0.0072 0.0001 0.0006 0.0003 0.0017 0.0003 0.0046 0.0002 0.0005 0.0019 0.0001 0.0005 0.0108 0.0007 0.0009 0.0035 0.0024 0.0004
Nuclear Periphery 0.0281 0.0026 0.0079 0.0133 0.0508 0.0055 0.0791 0.0019 0.0062 0.0051 0.0021 0.0062 0.0454 0.0122 0.0112 0.0082 0.0503 0.0085
Nucleolus 0.0019 0 0.0004 0.0009 0.0003 0 0.0035 0.0001 0.0004 0.0021 0 0.0001 0.0005 0.0001 0.0008 0.004 0.0014 0.0001
Nucleus 0.0108 0.0013 0.0029 0.0427 0.0038 0.0018 0.0353 0.0015 0.0026 0.006 0.002 0.003 0.0156 0.0036 0.0077 0.0071 0.0201 0.0047
Peroxisomes 0.0066 0 0.0018 0.0001 0.0051 0.0001 0.0007 0.0001 0.0001 0.0018 0 0.0004 0.0003 0 0.0006 0.0015 0.0005 0.0001
Punctate Nuclear 0.002 0 0.0012 0.0002 0.0049 0 0.001 0 0.0001 0.0002 0 0.0001 0.0011 0.0001 0.0004 0.0009 0.0017 0.0002
Vacuole 0.1293 0.0335 0.0874 0.1973 0.0478 0.0283 0.1313 0.017 0.0306 0.0872 0.0209 0.0322 0.1194 0.0333 0.0903 0.1179 0.0487 0.0754
Vacuole Periphery 0.051 0.0059 0.0247 0.0526 0.0163 0.01 0.0367 0.0025 0.007 0.035 0.0062 0.0148 0.0239 0.0054 0.0143 0.0239 0.0237 0.0157

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 2118.9152 2272.5333 2805.7458 1893.575 2500.0648 2416.4154 1807.6496 1663.0183 2076.7656 1563.3264
Translational Efficiency 1.2953 1.3745 1.182 1.7147 1.3852 1.132 1.3852 1.5807 1.1807 1.6188

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘


Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
21 1611 1966 869 1880 1954 2311 986 1901 3565 4277 1855

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2670.35 4768.21 6844.85 5063.88 3904.38 4769.60 5774.56 6189.24 3890.75 4768.97 6266.54 5662.05
Standard Deviation 978.39 1107.77 1311.48 1450.58 937.54 1191.63 1314.10 1625.52 946.83 1154.49 1417.12 1644.86
Intensity Change Log 2 — 0.836419 1.357990 0.923214 — 0.288775 0.564618 0.664669 — 0.536726 0.940641 0.775321

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001673 0.000050 0.000056 0.000167 0.000080 0.000056 0.000064 0.000129 0.000097 0.000053 0.000060 0.000147
Bud Neck 0.001659 0.000291 0.000263 0.002472 0.000454 0.000596 0.000603 0.000976 0.000468 0.000458 0.000447 0.001677
Bud Site 0.028189 0.001823 0.002079 0.006825 0.003052 0.003142 0.003732 0.006353 0.003329 0.002546 0.002972 0.006574
Cell Periphery 0.027305 0.008916 0.017746 0.019531 0.006931 0.002670 0.009388 0.026879 0.007156 0.005492 0.013230 0.023436
Cytoplasm 0.165899* 0.804449* 0.737757* 0.589254* 0.749204* 0.809903* 0.725778* 0.680900* 0.742761* 0.807439* 0.731284* 0.637967*
Cytoplasmic Foci 0.061883 0.006596 0.005139 0.010270 0.013684 0.007566 0.005873 0.010107 0.014216 0.007128 0.005536 0.010183
Eisosomes 0.000030 0.000001 0.000001 0.000004 0.000001 0.000001 0.000001 0.000003 0.000001 0.000001 0.000001 0.000003
Endoplasmic Reticulum 0.004616 0.000660 0.001654 0.000364 0.001610 0.000483 0.000580 0.000629 0.001644 0.000563 0.001074 0.000505
Endosome 0.014785 0.000492 0.000436 0.001039 0.001106 0.000934 0.000520 0.000668 0.001257 0.000734 0.000482 0.000842
Golgi 0.223877* 0.044666 0.028210 0.038179 0.064864 0.023514 0.025365 0.054199 0.066621 0.033072 0.026673 0.046694
Lipid Particles 0.050822 0.008201 0.012813 0.014600 0.006395 0.002608 0.007818 0.017861 0.006886 0.005135 0.010114 0.016334
Mitochondria 0.022324 0.000166 0.000241 0.000212 0.000490 0.000254 0.000286 0.000231 0.000731 0.000214 0.000265 0.000222
Mitotic Spindle 0.003720 0.000546 0.000433 0.002681 0.001451 0.001943 0.000605 0.001579 0.001476 0.001312 0.000526 0.002095
None 0.017225 0.002765 0.000958 0.001388 0.003741 0.003354 0.001350 0.002458 0.003890 0.003088 0.001170 0.001957
Nuclear Periphery 0.000537 0.000418 0.000445 0.000896 0.000435 0.000262 0.000327 0.000676 0.000436 0.000332 0.000381 0.000779
Nuclear Periphery Foci 0.014278 0.011266 0.007299 0.011852 0.014319 0.006560 0.006108 0.011301 0.014318 0.008686 0.006655 0.011559
Nucleolus 0.009975 0.000103 0.000067 0.000233 0.000131 0.000134 0.000122 0.000096 0.000239 0.000120 0.000097 0.000160
Nucleus 0.019884 0.007101 0.003951 0.028571 0.004657 0.019107 0.008285 0.013010 0.004825 0.013681 0.006293 0.020300
Peroxisomes 0.004721 0.000031 0.000051 0.000044 0.000018 0.000026 0.000038 0.000047 0.000070 0.000028 0.000044 0.000045
Vacuole 0.190445 0.051911 0.114236 0.207948* 0.048089 0.074742 0.142508 0.116702 0.049662 0.064425 0.129512 0.159447
Vacuole Periphery 0.136153* 0.049550 0.066162 0.063471 0.079289 0.042146 0.060648 0.055195 0.079918 0.045492 0.063182 0.059072

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.58 1.57 1.43 -6.62 -6.04 1.26 -0.04 -2.46 -5.73 -3.38 2.08 1.16 -2.63 -8.69 -6.77
Bud Neck 2.64 2.61 -3.43 -7.49 -7.45 -1.14 -2.38 -3.27 -2.89 -0.90 0.05 -0.89 -6.91 -7.92 -7.12
Bud Site 1.97 1.93 1.54 -6.66 -6.16 -0.63 -1.61 -3.66 -3.52 -2.94 1.07 0.22 -4.56 -6.75 -6.03
Cell Periphery 1.79 0.92 1.01 -5.31 0.59 6.73 -2.87 -9.76 -12.25 -8.61 2.54 -7.65 -11.16 -13.16 -6.58
Cytoplasm -13.84 -12.35 -8.59 17.05 12.10 -5.91 3.35 5.60 10.39 3.15 -7.18 2.03 10.67 19.21 10.51
Cytoplasmic Foci 2.80 2.87 2.46 -5.21 -6.30 6.29 7.75 1.50 -3.63 -4.78 7.81 9.33 1.53 -6.24 -7.84
Eisosomes 1.61 1.58 1.41 -7.36 -6.48 1.73 -1.45 -5.33 -6.59 -4.52 2.25 0.29 -5.91 -9.83 -7.87
Endoplasmic Reticulum 2.68 1.97 2.92 3.25 3.67 6.28 5.69 5.00 -0.95 -0.32 6.16 2.51 6.56 1.04 3.23
Endosome 3.72 3.73 3.54 -4.24 -4.66 1.29 7.30 5.13 2.80 -2.22 4.97 8.44 3.09 -1.62 -5.13
Golgi 4.72 5.17 5.03 3.93 -2.11 14.61 14.62 3.37 -9.67 -9.45 11.90 15.03 7.48 -4.94 -8.88
Lipid Particles 1.77 1.57 1.52 -4.45 -0.93 6.82 -2.33 -8.35 -11.34 -7.13 2.64 -4.89 -9.11 -11.56 -5.99
Mitochondria 1.19 1.18 1.18 -3.51 -1.26 2.28 1.87 2.03 0.25 0.71 2.27 2.02 2.05 -0.94 0.27
Mitotic Spindle 2.80 2.89 -0.10 -2.92 -3.02 -1.10 2.54 -0.93 -0.11 -1.92 0.20 3.37 -2.10 -2.16 -3.56
None 0.86 0.96 0.93 5.04 -5.42 0.55 3.35 1.39 1.00 -1.44 1.13 3.88 2.44 2.20 -2.10
Nuclear Periphery 0.41 0.26 -1.78 -6.50 -6.21 3.57 2.12 -4.82 -7.43 -6.78 2.49 0.93 -7.53 -9.61 -8.86
Nuclear Periphery Foci 0.56 1.31 0.49 -0.30 -3.95 7.63 8.88 2.80 -4.80 -5.84 5.91 8.68 2.82 -3.46 -6.83
Nucleolus 1.00 1.00 0.98 -3.03 -4.43 0.16 0.26 0.68 2.80 1.63 1.01 1.18 0.39 -2.30 -3.44
Nucleus 0.75 0.93 -1.66 -10.82 -11.72 -11.32 -6.33 -7.22 2.90 -2.57 -9.73 -3.90 -12.74 -7.56 -11.36
Peroxisomes 1.26 1.25 1.25 -1.41 -0.09 -1.81 -3.67 -2.12 -1.37 -0.75 0.97 0.64 0.49 -1.98 -0.68
Vacuole 3.24 1.76 -0.58 -18.08 -10.68 -7.10 -20.06 -12.22 -6.21 4.42 -5.06 -21.84 -20.61 -17.50 -5.23
Vacuole Periphery 2.93 2.37 2.76 -1.07 2.72 9.98 5.41 5.94 -3.32 1.34 9.81 5.05 6.65 -3.12 2.85
Standard name
Human Ortholog
Description (SGD) Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24B has a paralog, RPS24A, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Rps24b

Rps24b


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)