Standard name
Human Ortholog
Description (SGD) Mitochondrial protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0 – – 0 0 0 0 0 0
Bud 0 0 0.05 0.07 0 0 – 0.07 0.06 0 0.07 0.06 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Cytoplasm 0.7 0.68 0.74 0.67 0.43 0.45 – 0.43 0.45 0.46 0.48 0.45 0.73 0.67 0.69 0.82 – – 0.1 0.09 0.09 0.09 0.06 0.06
Endoplasmic Reticulum 0.07 0.06 0 0 0 0 – 0 0.05 0.06 0 0 0.13 0.14 0.12 0 – – 0.08 0.08 0.07 0 0.07 0.08
Endosome 0 0.05 0 0.08 0.31 0.17 – 0.23 0 0.1 0.06 0.07 0 0.07 0 0.06 – – 0 0.07 0 0.05 0.09 0.08
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Mitochondria 0 0 0.22 0.35 0.11 0.25 – 0.2 0.36 0.28 0.4 0.4 0.06 0 0 0 – – 0.08 0.09 0.16 0.16 0.21 0.19
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Vac/Vac Membrane 0.25 0.28 0.13 0 0.25 0.18 – 0.23 0.2 0.18 0.13 0.13 0.11 0.11 0.08 0.35 – – 0.65 0.62 0.59 0.58 0.47 0.5
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 8 5 1 2 4 2 – 8 4 4 7 2 3 15 9 0 – – 4 4 2 1 2 4
Bud 1 3 7 11 13 7 – 24 13 9 16 20 2 3 4 0 – – 3 4 0 3 4 7
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 – – 4 4 1 0 2 0
Bud Site 0 1 1 0 0 0 – 0 0 3 1 3 0 0 0 0 – – – – – – – –
Cell Periphery 3 3 1 2 0 1 – 2 1 2 3 4 2 1 5 0 – – 0 0 0 0 0 0
Cytoplasm 363 299 95 107 130 84 – 139 101 125 104 163 75 182 175 14 – – 63 46 14 12 16 20
Endoplasmic Reticulum 34 28 3 0 8 7 – 2 11 16 7 8 13 38 31 0 – – 50 44 11 5 20 31
Endosome 8 20 0 12 93 32 – 75 9 28 12 26 0 18 9 1 – – 24 34 6 6 25 28
Golgi 0 0 0 0 0 0 – 0 0 2 0 0 0 2 3 0 – – 3 5 0 1 11 14
Mitochondria 14 7 29 55 33 47 – 64 80 76 87 146 6 3 7 0 – – 49 47 24 21 58 71
Nucleus 3 2 1 0 0 0 – 2 0 0 0 1 0 0 0 1 – – 2 0 1 0 0 0
Nuclear Periphery 0 3 0 0 0 1 – 0 2 0 1 2 0 0 0 0 – – 2 3 0 2 1 0
Nucleolus 0 0 0 0 0 2 – 5 4 3 3 3 0 0 0 0 – – 0 0 0 0 1 1
Peroxisomes 0 0 0 0 2 0 – 5 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 1
SpindlePole 0 1 1 0 1 0 – 6 0 5 3 4 0 0 0 0 – – 1 0 0 0 2 1
Vac/Vac Membrane 132 122 17 7 76 33 – 75 44 49 28 48 11 31 21 6 – – 395 329 92 79 132 184
Unique Cell Count 519 441 129 159 300 188 325 222 272 218 363 103 271 252 17 611 531 158 137 283 373
Labelled Cell Count 566 494 156 196 360 216 407 269 322 272 430 112 293 264 22 611 531 158 137 283 373


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.8 6.9 4.5 5.1 6.7 6.0 – 6.4 5.8 6.1 5.8 5.7 6.5 7.3 7.4 9.4 – – 6.8 6.8 7.2
Std Deviation (1e-4) 0.9 1.0 1.1 1.7 1.4 1.3 – 1.3 1.9 1.5 1.6 1.5 1.3 1.4 1.5 2.9 – – 2.7 2.1 2.9
Intensity Change (Log2) – – – 0.17 0.57 0.41 – 0.51 0.36 0.43 0.35 0.34 0.53 0.69 0.71 1.05 – – 0.59 0.59 0.67


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 2.3 0 0 – –
Bud 0.5 -0.5 -0.7 – 0.7 0.2 -1.0 0.7 0 0 0 0 0 – –
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Cytoplasm -1.2 -5.8 -5.1 – -5.9 -5.1 -5.2 -4.7 -5.6 -0.1 -1.3 -0.9 0.8 – –
Endoplasmic Reticulum 0 0 0 – 0 1.2 1.6 0 0 3.1 3.6 3.2 0 – –
Endosome 3.2 7.1 4.9 – 6.0 0 3.8 0 3.1 0 3.0 0 0 – –
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Mitochondria 2.2 -3.1 0.5 – -0.7 2.6 1.2 3.3 3.6 -3.5 -7.4 -6.2 0 – –
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 – –
Vacuole -2.7 2.8 1.0 – 2.4 1.6 1.2 -0.1 0 -0.6 -0.5 -1.5 0 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.4615 3.6157 2.8754 2.3876 1.9518 2.9299 1.8382 2.5656 2.3798 2.0739 1.6471 2.4266 3.292 4.1321 3.7235 3.565 3.3074 4.0062
Actin 0.0092 0.0013 0.0018 0.0004 0.0047 0.0012 0.008 0.0024 0.0061 0.0008 0.0044 0.0024 0.0236 0.0016 0.0057 0.0018 0.0017 0.0092
Bud 0.0008 0.0031 0.0017 0.0016 0.0006 0.001 0.0016 0.0019 0.0022 0.0059 0.0016 0.001 0.0012 0.0021 0.0027 0.0056 0.0029 0.0019
Bud Neck 0.0007 0.0006 0.0028 0.0013 0.0008 0.0017 0.0012 0.0006 0.0043 0.0082 0.0015 0.0021 0.0018 0.0014 0.0027 0.0042 0.0012 0.0088
Bud Periphery 0.0014 0.0048 0.002 0.0021 0.0006 0.0014 0.0026 0.0021 0.0033 0.0133 0.0026 0.0023 0.0022 0.0016 0.0027 0.0072 0.0042 0.0066
Bud Site 0.0026 0.0099 0.0037 0.0011 0.0008 0.0008 0.0048 0.0084 0.0025 0.0147 0.0023 0.0011 0.0044 0.0162 0.0121 0.002 0.002 0.0009
Cell Periphery 0.001 0.0011 0.0005 0.0006 0.001 0.0005 0.0011 0.0008 0.0009 0.0014 0.0005 0.0005 0.0012 0.0008 0.0008 0.0012 0.0004 0.0008
Cytoplasm 0.1508 0.3227 0.2218 0.1604 0.1565 0.2104 0.1469 0.3081 0.1854 0.1809 0.1621 0.1839 0.1933 0.3356 0.2676 0.2686 0.3482 0.2615
Cytoplasmic Foci 0.0444 0.0428 0.0525 0.0489 0.042 0.052 0.0544 0.0619 0.0506 0.0516 0.0784 0.0493 0.0549 0.0834 0.0584 0.0469 0.0625 0.0419
Eisosomes 0.0001 0.0001 0 0 0.0002 0 0.0001 0 0.0001 0 0.0001 0 0.0005 0 0.0001 0.0001 0 0.0002
Endoplasmic Reticulum 0.117 0.0877 0.0518 0.059 0.0972 0.0867 0.0714 0.0419 0.0536 0.0232 0.0151 0.0468 0.1244 0.0753 0.0673 0.0392 0.0159 0.0706
Endosome 0.3646 0.2571 0.3497 0.4844 0.4933 0.377 0.4079 0.3418 0.3591 0.3735 0.4428 0.4089 0.3624 0.2861 0.3498 0.3111 0.3407 0.2911
Golgi 0.0341 0.0272 0.0484 0.0499 0.0474 0.0489 0.0666 0.0426 0.0551 0.0393 0.0432 0.0341 0.0469 0.0471 0.0562 0.0263 0.0325 0.0377
Lipid Particles 0.0096 0.0035 0.0029 0.0036 0.0018 0.0038 0.0092 0.002 0.0094 0.0022 0.0354 0.007 0.0121 0.0045 0.0035 0.0032 0.0029 0.0032
Mitochondria 0.0659 0.0507 0.0879 0.0226 0.0668 0.0709 0.0865 0.0513 0.1267 0.0556 0.0295 0.0744 0.0453 0.0315 0.0715 0.0753 0.0287 0.0958
None 0.0105 0.0483 0.0044 0.0017 0.0094 0.01 0.0083 0.0071 0.0168 0.0025 0.0206 0.0092 0.0381 0.0085 0.0105 0.0111 0.0022 0.0106
Nuclear Periphery 0.0377 0.011 0.0141 0.007 0.0053 0.0142 0.0147 0.0065 0.0095 0.0072 0.0112 0.0122 0.02 0.0122 0.0119 0.0084 0.01 0.0147
Nucleolus 0.0004 0.0003 0.0002 0.0002 0.0002 0.0002 0.0005 0.0002 0.0004 0.0015 0.001 0.0004 0.0018 0.0002 0.0002 0.0002 0.001 0.0002
Nucleus 0.0049 0.0035 0.003 0.0017 0.0015 0.003 0.0031 0.0021 0.0031 0.0028 0.0052 0.0029 0.0082 0.0039 0.0033 0.0026 0.0046 0.0033
Peroxisomes 0.0018 0.0007 0.001 0.0007 0.0005 0.001 0.0026 0.0007 0.0025 0.003 0.0071 0.0054 0.0024 0.0026 0.0011 0.0235 0.0026 0.0019
Punctate Nuclear 0.0008 0.0005 0.0004 0.0004 0.0003 0.0006 0.0016 0.0003 0.0007 0.0005 0.0056 0.0014 0.004 0.0008 0.0008 0.0009 0.002 0.0005
Vacuole 0.1025 0.099 0.1066 0.1104 0.0485 0.0802 0.0837 0.0875 0.0768 0.1554 0.0883 0.107 0.0379 0.0699 0.0534 0.1233 0.1092 0.1056
Vacuole Periphery 0.0392 0.0243 0.0426 0.0422 0.0207 0.0347 0.0233 0.0299 0.0308 0.0564 0.0415 0.0476 0.0135 0.0146 0.0179 0.0371 0.0247 0.033

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 74.6012 111.6652 121.9889 112.6915 112.4695 93.6334 103.4959 141.8222 128.7239 119.1697
Translational Efficiency 3.0536 1.6954 1.4022 1.8751 1.6579 2.9123 2.047 1.5522 1.8556 1.9645

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘


Micrographs

Cell Count

Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
275 475 2122 1222 1674 1962 1994 1762 1949 2437 4116 2984

Protein Abundance

Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 734.33 870.51 1054.41 1328.22 732.94 850.26 1035.22 1345.46 733.14 854.21 1045.11 1338.40
Standard Deviation 80.99 120.41 134.30 242.31 97.03 113.00 152.33 236.15 94.93 114.76 143.64 238.84
Intensity Change Log 2 — 0.245432 0.521936 0.854994 — 0.214209 0.498170 0.876332 — 0.229920 0.510113 0.865692

Localization Score (DeepLoc)

Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001622 0.002792 0.000685 0.023136 0.001558 0.001043 0.003843 0.023900 0.001567 0.001384 0.002215 0.023587
Bud Neck 0.050181 0.015242 0.006239 0.006549 0.023414 0.018764 0.005907 0.005864 0.027191 0.018078 0.006078 0.006145
Bud Site 0.036538 0.061945 0.019629 0.164463* 0.034725 0.035414 0.062185 0.131377* 0.034981 0.040585 0.040245 0.144926*
Cell Periphery 0.001648 0.000960 0.000177 0.006370 0.000807 0.000460 0.000566 0.006950 0.000926 0.000558 0.000365 0.006712
Cytoplasm 0.115733* 0.060742 0.234451* 0.060615 0.088675 0.051710 0.140127* 0.087522 0.092493 0.053471 0.188756* 0.076503
Cytoplasmic Foci 0.245096* 0.214539* 0.151001 0.130381 0.243478* 0.162660 0.183371* 0.155718 0.243706* 0.172772 0.166683 0.145342
Eisosomes 0.000825 0.000216 0.000036 0.000279 0.000319 0.000216 0.000108 0.000484 0.000390 0.000216 0.000071 0.000400
Endoplasmic Reticulum 0.013975 0.014318 0.089154 0.152423* 0.009863 0.010198 0.137998* 0.173298* 0.010443 0.011001 0.112816* 0.164749*
Endosome 0.207590* 0.191453 0.070168 0.091022 0.201194* 0.227760* 0.104884 0.084296 0.202096* 0.220683* 0.086986 0.087051
Golgi 0.047616 0.102003 0.011388 0.157730* 0.059118 0.071851 0.053541 0.143501* 0.057495 0.077728 0.031809 0.149328*
Lipid Particles 0.032686 0.007160 0.017698 0.037374 0.019391 0.009996 0.017165 0.041352 0.021267 0.009444 0.017440 0.039723
Mitochondria 0.056885 0.070012 0.004133 0.008560 0.090199 0.116411* 0.013658 0.020331 0.085499 0.107367* 0.008748 0.015511
Mitotic Spindle 0.001416 0.004577 0.009363 0.007971 0.003118 0.003238 0.006523 0.004303 0.002878 0.003499 0.007988 0.005805
None 0.000165 0.000494 0.000320 0.000174 0.000752 0.000251 0.000243 0.000345 0.000669 0.000298 0.000283 0.000275
Nuclear Periphery 0.000818 0.000309 0.004887 0.000329 0.001034 0.000345 0.001058 0.000161 0.001003 0.000338 0.003032 0.000230
Nuclear Periphery Foci 0.000829 0.000544 0.015721 0.007075 0.000757 0.000496 0.008202 0.004542 0.000767 0.000505 0.012079 0.005579
Nucleolus 0.000516 0.000912 0.000660 0.000051 0.001033 0.000945 0.000246 0.000147 0.000960 0.000938 0.000460 0.000107
Nucleus 0.006323 0.004235 0.021152 0.000723 0.007020 0.003442 0.004117 0.001033 0.006922 0.003597 0.012900 0.000906
Peroxisomes 0.027720 0.013503 0.001755 0.003344 0.014841 0.009358 0.002765 0.004233 0.016658 0.010166 0.002244 0.003869
Vacuole 0.118167 0.175512 0.324267* 0.112722 0.157099 0.207272* 0.217830* 0.080999 0.151606 0.201081* 0.272704* 0.093990
Vacuole Periphery 0.033650 0.058534 0.017116 0.028708 0.041606 0.068169 0.035663 0.029641 0.040483 0.066291 0.026101 0.029259

Localization Changes (T-score)

Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.21 1.91 -10.34 -9.26 -11.08 1.48 -4.24 -11.50 -11.85 -10.18 0.53 -1.88 -15.41 -15.62 -15.03
Bud Neck 5.40 7.18 7.14 3.81 -0.43 2.41 11.63 11.62 9.91 -0.00 4.84 13.48 13.46 10.55 -0.13
Bud Site -3.61 4.07 -17.81 -12.37 -23.80* -0.26 -8.01 -20.11 -20.72 -13.79 -2.14 -2.07 -27.34 -26.36 -27.39*
Cell Periphery 1.31 3.13 -6.80 -9.69 -12.27 0.89 0.63 -9.05 -11.59 -11.42 1.08 1.67 -11.21 -15.64 -16.29
Cytoplasm 5.06 -11.32 5.28 -0.34 27.99 8.86 -9.53 0.03 -8.98 9.65 9.98 -20.51 3.53 -7.58 26.42
Cytoplasmic Foci 2.26 8.40 10.07 9.49 3.95 14.51 10.61 15.49 1.63 5.15 13.70 16.39 20.41 6.83 5.64
Eisosomes 3.80 4.98 3.45 -1.98 -14.04 3.35 8.13 -3.85 -6.98 -10.89 5.02 10.14 -0.18 -7.00 -15.25
Endoplasmic Reticulum -0.07 -13.18 -16.48 -17.31 -8.02 -0.25 -24.40 -24.82 -24.74 -4.31 -0.40 -30.40 -30.95 -30.82 -9.19
Endosome 1.18 11.96 9.97 12.60 -7.03 -4.32 18.96 23.64 30.42 6.20 -3.34 26.05 25.73 32.96 -0.46
Golgi -6.08 7.27 -14.41 -5.78 -25.82* -3.39 1.91 -16.41 -13.43 -18.21* -5.76 10.38 -21.83 -15.92 -31.93*
Lipid Particles 4.62 2.69 -0.89 -10.36 -7.11 6.39 1.44 -8.39 -12.59 -9.62 8.02 2.57 -8.61 -15.96 -11.97
Mitochondria -1.32 6.73 6.12 9.99 -3.75 -4.82 19.81 17.44 22.38 -3.56 -4.54 22.40 19.84 25.47 -5.81
Mitotic Spindle -1.66 -7.05 -5.71 -1.75 1.37 -0.15 -3.58 -1.43 -1.17 2.24 -0.73 -6.51 -3.90 -2.73 2.91
None -1.30 -2.77 -0.29 1.27 3.24 3.38 3.38 2.44 -1.02 -1.08 2.74 3.04 2.93 0.32 0.07
Nuclear Periphery 2.15 -8.84 2.07 -0.31 11.06 2.55 -0.14 3.28 4.20 6.63 2.84 -6.41 3.32 2.24 12.56
Nuclear Periphery Foci 1.23 -17.44 -10.52 -11.33 8.31 1.77 -11.26 -8.48 -9.37 4.65 2.01 -20.65 -13.32 -14.60 10.00
Nucleolus -0.68 -1.14 3.88 1.52 9.11 -0.02 3.47 3.73 3.39 1.30 -0.17 2.51 4.27 3.85 6.26
Nucleus 1.03 -10.15 4.66 2.09 21.36 4.17 3.67 8.07 4.95 10.25 4.12 -7.61 9.20 5.36 22.49
Peroxisomes 3.04 6.29 5.90 4.51 -3.78 4.33 11.42 9.86 6.88 -4.40 5.02 13.36 11.71 8.51 -6.28
Vacuole -4.11 -18.85 0.22 5.30 29.05 -7.23 -9.31 13.04 20.44 23.38 -7.92 -21.86 10.86 19.45 38.38*
Vacuole Periphery -4.28 4.44 1.26 6.46 -6.83 -10.37 3.07 5.89 16.13 3.05 -11.01 9.02 6.40 17.79 -2.81
Standard name
Human Ortholog
Description (SGD) Mitochondrial protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages mitochondrion (18%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Tmh11

Tmh11


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)