Standard name
Human Ortholog
Description DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.15 0.22 0.36 0.33 0.38 0.32 0.32 0.37 0.29 0.33 0.21 0.27 0.5 0.54 0.58 0.12 0.1 0.08 0.09 0.29 0.12 0.26 0.31 0.37
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.51 0.33 0.14 0.33 0.34 0.58 0.7 0.57 0.72 0.74 0.82 0.76 0 0 0 0.05 0 0.06 0.05 0 0.08 0 0 0
Nucleus 0.55 0.54 0.43 0.41 0.31 0.27 0.21 0.22 0.21 0.17 0.18 0.19 0.42 0.35 0.29 0.75 0.69 0.67 0.57 0.49 0.41 0.39 0.31 0.24
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Vac/Vac Membrane 0.1 0.13 0.1 0.13 0.08 0.09 0.07 0.07 0.05 0.06 0.06 0.06 0.09 0.15 0.11 0.16 0.22 0.23 0.2 0.18 0.27 0.19 0.24 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 0 0 1 1 0 5 6 5 4 8 6 11 0 0 0 0 0 0 2 1 5 2 1 5
Bud Neck 0 0 3 0 1 2 0 2 0 0 0 0 1 1 1 0 0 1 0 0 1 0 3 2
Bud Site 0 0 0 0 0 2 5 4 2 3 5 9 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 18 15 80 87 136 144 187 226 131 179 84 127 77 137 153 33 26 13 12 27 32 22 74 108
Endoplasmic Reticulum 0 1 1 0 1 0 0 0 0 1 0 0 1 1 0 8 10 7 0 0 1 0 1 1
Endosome 0 0 9 2 16 4 1 3 1 0 0 0 1 4 12 5 13 3 1 0 4 0 3 2
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 1 0 0 0
Mitochondria 63 22 31 86 121 260 413 347 323 398 327 357 1 0 2 13 5 10 7 0 23 0 3 11
Nucleus 68 36 96 107 111 119 124 134 92 92 73 88 65 89 77 206 179 112 75 47 116 35 73 71
Nuclear Periphery 0 0 1 1 0 1 2 1 5 2 2 4 0 0 0 0 2 1 0 0 0 0 0 0
Nucleolus 0 0 1 1 1 0 3 0 1 1 1 0 0 0 0 1 2 0 1 0 0 0 1 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 2 1 2 1 6 3 4 2 5 0 1 0 2 0 1 2 0 10 3 9 15
Vac/Vac Membrane 12 9 22 34 29 38 41 40 21 32 22 30 14 39 30 43 56 38 27 17 75 17 55 63
Unique Cell Count 123 67 221 264 357 445 586 611 448 539 400 467 153 256 263 276 260 167 133 97 284 89 237 293
Labelled Cell Count 161 83 247 321 418 577 783 768 583 720 522 633 160 272 275 312 294 187 133 97 284 89 237 293


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.5 4.1 4.3 4.1 4.2 3.5 3.2 3.3 3.1 3.0 2.8 2.8 5.7 5.6 5.4 6.3 6.5 6.3 4.9 5.7 6.0
Std Deviation (1e-4) 0.5 0.6 2.1 1.8 1.8 1.5 1.1 1.2 1.0 1.2 1.2 0.9 1.3 1.2 1.2 1.4 1.4 1.3 0.6 1.4 1.7
Intensity Change (Log2) – – – -0.06 -0.04 -0.33 -0.44 -0.37 -0.48 -0.53 -0.65 -0.61 0.39 0.36 0.31 0.55 0.58 0.54 0.16 0.39 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 1.8 3.4 3.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.577 0.0317 -0.0657 -0.2686 -0.4536 -0.2407 -0.0706 0.0722 -0.2493 -0.4524 -0.3464 -0.108 -1.7474 -1.0339 -1.21 -0.9514 -1.5504 -1.1061
Actin 0.0033 0.0003 0.0003 0 0.0002 0.0003 0.0355 0.0001 0.0155 0.0142 0.0024 0.0024 0.0262 0.0001 0.0053 0.0083 0.0087 0.0041
Bud 0.0016 0.0006 0.0001 0 0.0001 0.0003 0.0015 0.0002 0.0005 0.0005 0.0005 0.0007 0.0003 0.0001 0.0002 0.0001 0.0001 0.0003
Bud Neck 0.0005 0.0009 0.0004 0.0003 0.001 0.0073 0.0144 0.0002 0.0048 0.0006 0.0004 0.0049 0.0018 0.0003 0.0008 0.0006 0.0013 0.0055
Bud Periphery 0.0015 0.0003 0.0001 0 0.0001 0.0003 0.0025 0.0001 0.0007 0.0011 0.0007 0.0012 0.0005 0.0001 0.0002 0.0001 0.0001 0.0003
Bud Site 0.0004 0.0023 0.0002 0.0001 0.0002 0.0002 0.0063 0.0004 0.0014 0.001 0.0011 0.0003 0.0017 0.0004 0.0007 0.0005 0.0003 0.0004
Cell Periphery 0.0001 0.0001 0 0 0 0 0.0005 0 0.0001 0.0001 0.0001 0.0001 0.0002 0 0.0001 0 0.0001 0.0001
Cytoplasm 0.0428 0.0683 0.0476 0.0254 0.0576 0.0604 0.0906 0.12 0.096 0.1516 0.192 0.135 0.0824 0.0969 0.052 0.0663 0.0546 0.0739
Cytoplasmic Foci 0.0037 0.0016 0.0013 0.0007 0.0018 0.0046 0.0275 0.0034 0.022 0.0095 0.0165 0.0051 0.0343 0.0047 0.0086 0.0061 0.0104 0.0133
Eisosomes 0.0001 0 0 0 0 0 0.0004 0 0.0001 0.0003 0.0001 0 0.0004 0 0.0001 0.0001 0.0006 0.0001
Endoplasmic Reticulum 0.0018 0.0035 0.0021 0.0002 0.0006 0.001 0.0077 0.0018 0.0034 0.0037 0.0046 0.0023 0.0093 0.003 0.0017 0.0051 0.0024 0.0038
Endosome 0.0038 0.0019 0.0019 0.0004 0.0009 0.0036 0.0547 0.0016 0.0201 0.0165 0.0431 0.0063 0.007 0.0021 0.0028 0.015 0.0066 0.0058
Golgi 0.0004 0 0 0 0 0.0003 0.0163 0 0.0063 0.0035 0.0116 0.0015 0.0023 0.0001 0.0007 0.0017 0.001 0.0016
Lipid Particles 0.0007 0.0002 0.0002 0.0001 0.0002 0.0003 0.0298 0.0002 0.0071 0.0064 0.0522 0.0005 0.0051 0.0004 0.0021 0.0022 0.0033 0.0045
Mitochondria 0.0006 0.0005 0.0004 0.0004 0.0004 0.0006 0.0131 0.0003 0.0058 0.0077 0.0314 0.007 0.0021 0.0003 0.0006 0.0017 0.0005 0.0011
None 0.1845 0.1497 0.1945 0.2199 0.2212 0.1199 0.1334 0.1344 0.1549 0.2286 0.1765 0.1149 0.1796 0.1808 0.1112 0.1694 0.332 0.0801
Nuclear Periphery 0.0158 0.0184 0.0103 0.0017 0.0074 0.0077 0.0321 0.013 0.0289 0.011 0.0364 0.0167 0.0142 0.0143 0.012 0.0421 0.0121 0.0086
Nucleolus 0.0038 0.0054 0.0085 0.0023 0.0073 0.0127 0.0068 0.0025 0.0038 0.0021 0.0041 0.0075 0.0038 0.0035 0.0038 0.0025 0.0053 0.0062
Nucleus 0.7154 0.7218 0.7185 0.7401 0.6654 0.7341 0.4602 0.7059 0.5896 0.522 0.3857 0.66 0.5909 0.676 0.7781 0.6492 0.5346 0.7559
Peroxisomes 0.0003 0.0001 0 0 0.0001 0.0004 0.0183 0.0001 0.0107 0.0029 0.0124 0.0002 0.0018 0.0001 0.002 0.0006 0.0006 0.0015
Punctate Nuclear 0.0165 0.0222 0.0121 0.0076 0.0349 0.0445 0.0342 0.0139 0.0227 0.0109 0.0189 0.0314 0.0327 0.0153 0.0149 0.0262 0.0237 0.0313
Vacuole 0.0021 0.0017 0.0012 0.0004 0.0005 0.0012 0.0097 0.0016 0.0039 0.0043 0.0055 0.0015 0.0026 0.0013 0.0017 0.001 0.0011 0.0013
Vacuole Periphery 0.0005 0.0004 0.0003 0.0001 0.0001 0.0003 0.0046 0.0003 0.0019 0.0014 0.0037 0.0005 0.0009 0.0003 0.0004 0.0009 0.0005 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 13.3328 12.3297 10.979 10.4088 7.7491 13.7849 14.5443 11.4992 14.9331 11.4392
Translational Efficiency 0.785 0.8777 0.821 0.827 0.8915 0.9097 0.9626 1.1657 0.7882 0.7393

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
839 114 2318 1018 1210 1982 103 986 2049 2096 2421 2004

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 663.67 764.91 832.64 737.53 692.23 738.21 892.24 826.49 680.54 739.66 835.18 781.30
Standard Deviation 83.23 121.72 104.06 141.17 93.73 94.65 88.13 106.99 90.67 96.51 104.13 133.17
Intensity Change Log 2 — 0.204824 0.327227 0.152236 — 0.092780 0.366180 0.255746 — 0.148709 0.347245 0.206008

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000076 0.000361 0.000170 0.001217 0.000062 0.000462 0.000331 0.002006 0.000068 0.000456 0.000177 0.001605
Bud Neck 0.003623 0.005738 0.007830 0.008839 0.001820 0.011278 0.003146 0.008076 0.002558 0.010977 0.007631 0.008463
Bud Site 0.000702 0.001477 0.003052 0.018690 0.002737 0.005255 0.005389 0.024603 0.001903 0.005050 0.003151 0.021599
Cell Periphery 0.000174 0.000133 0.000102 0.000258 0.000184 0.000205 0.000140 0.000215 0.000180 0.000201 0.000104 0.000237
Cytoplasm 0.180695 0.084731 0.115707 0.311145 0.327151 0.159695 0.077342 0.266854 0.267182 0.155618 0.114075 0.289353
Cytoplasmic Foci 0.052742 0.034065 0.001377 0.021253 0.024780 0.032116 0.007102 0.012494 0.036230 0.032222 0.001620 0.016943
Eisosomes 0.000057 0.000056 0.000015 0.000064 0.000031 0.000044 0.000061 0.000058 0.000041 0.000045 0.000017 0.000061
Endoplasmic Reticulum 0.001001 0.004448 0.002755 0.007279 0.000855 0.001749 0.004997 0.003766 0.000915 0.001896 0.002850 0.005551
Endosome 0.001627 0.001375 0.000766 0.005043 0.000860 0.002855 0.001635 0.005415 0.001174 0.002774 0.000803 0.005226
Golgi 0.000364 0.000921 0.000562 0.003283 0.000275 0.000812 0.000200 0.002042 0.000312 0.000818 0.000547 0.002672
Lipid Particles 0.004705 0.005724 0.000324 0.002668 0.001258 0.003922 0.001709 0.001388 0.002669 0.004020 0.000382 0.002038
Mitochondria 0.002517 0.003742 0.001079 0.009069 0.000517 0.007550 0.000785 0.002065 0.001336 0.007343 0.001067 0.005623
Mitotic Spindle 0.001603 0.000448 0.004249 0.019522 0.000268 0.008914 0.003781 0.023006 0.000815 0.008454 0.004229 0.021236
None 0.009527 0.010107 0.004347 0.008725 0.017007 0.006895 0.002805 0.006988 0.013945 0.007070 0.004281 0.007871
Nuclear Periphery 0.000926 0.001110 0.001864 0.002676 0.000408 0.001451 0.001413 0.001738 0.000620 0.001432 0.001845 0.002215
Nuclear Periphery Foci 0.000328 0.000368 0.000231 0.002284 0.000333 0.000511 0.000688 0.000914 0.000331 0.000503 0.000250 0.001610
Nucleolus 0.003211 0.003439 0.000773 0.001952 0.001586 0.003557 0.000813 0.000551 0.002251 0.003551 0.000775 0.001263
Nucleus 0.725470 0.820145 0.845046 0.493909 0.614285 0.738363 0.859535 0.573173 0.659811 0.742811 0.845662 0.532908
Peroxisomes 0.002828 0.009245 0.000092 0.001092 0.000286 0.004514 0.001874 0.001049 0.001327 0.004772 0.000168 0.001071
Vacuole 0.007578 0.011132 0.009119 0.078811 0.005135 0.009206 0.026073 0.062743 0.006135 0.009311 0.009840 0.070905
Vacuole Periphery 0.000246 0.001236 0.000541 0.002221 0.000162 0.000645 0.000180 0.000856 0.000196 0.000677 0.000526 0.001549

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.05 -8.55 -3.65 -1.38 -3.01 -2.19 -4.64 -4.00 -2.17 -2.57 -2.29 -12.67 -5.43 -2.42 -4.48
Bud Neck -1.09 -5.47 -4.50 -0.89 0.06 -9.09 -0.99 -7.00 1.68 -3.43 -8.68 -7.80 -8.39 2.00 -0.45
Bud Site -2.28 -4.64 -6.19 -5.42 -4.85 -1.83 -0.52 -4.84 -4.03 -2.69 -3.08 -1.46 -7.30 -5.21 -6.85
Cell Periphery 1.02 4.21 -1.45 -2.16 -6.53 -0.95 1.42 0.66 1.61 -0.86 -1.13 6.26 -0.60 0.67 -7.39
Cytoplasm 5.63 8.81 -5.89 -9.53 -16.20 17.17 15.40 10.73 -5.48 -8.06 14.28 23.47 4.65 -9.95 -19.45
Cytoplasmic Foci 1.60 12.73 8.42 1.85 -9.93 -2.93 6.70 8.94 10.23 -0.52 1.31 17.66 11.11 8.62 -11.73
Eisosomes -0.30 10.06 -3.82 -1.24 -16.35 -3.73 -4.66 -9.30 -5.00 0.13 -1.03 9.43 -10.15 -6.76 -18.48
Endoplasmic Reticulum -3.53 -14.26 -15.87 -3.19 -9.86 -7.61 -6.31 -17.86 -14.31 0.41 -7.95 -16.49 -22.78 -18.16 -11.05
Endosome 0.81 3.74 -5.19 -5.22 -8.15 -5.77 -3.03 -3.18 -0.41 -1.55 -4.75 2.35 -5.59 -1.41 -6.36
Golgi -0.80 -0.12 -1.78 -0.78 -1.61 -2.16 0.50 -1.26 0.06 -1.64 -2.44 -0.27 -2.19 -0.95 -1.66
Lipid Particles -0.42 5.59 2.69 1.63 -10.76 -4.98 -2.10 -1.95 4.52 1.12 -2.21 6.79 1.82 3.76 -13.70
Mitochondria -0.68 1.72 -1.51 -0.57 -2.77 -6.89 -0.57 -3.47 5.87 -1.86 -5.91 0.58 -2.41 3.56 -2.93
Mitotic Spindle 1.35 -2.85 -5.15 -5.79 -3.81 -5.64 -0.97 -5.48 -2.13 -3.43 -5.14 -4.36 -7.63 -3.07 -5.02
None -0.20 4.25 2.12 0.97 -3.49 6.16 9.06 7.70 2.49 -3.51 5.59 9.47 7.42 1.80 -3.93
Nuclear Periphery -0.79 -11.77 -13.18 -9.31 -6.79 -10.15 -8.21 -21.96 -10.07 -5.55 -7.86 -19.39 -23.02 -12.86 -8.08
Nuclear Periphery Foci -0.02 0.36 -8.05 -8.14 -8.64 -1.47 -3.14 -7.11 -3.63 -0.67 -1.31 -0.30 -10.49 -6.83 -10.16
Nucleolus 0.09 4.75 2.77 2.37 -2.02 -5.80 5.40 7.72 8.86 1.37 -3.22 6.02 4.08 6.72 -1.40
Nucleus -3.43 -10.96 14.52 11.40 30.95 -10.54 -9.62 3.33 13.76 11.48 -8.35 -23.01 11.98 20.50 37.46
Peroxisomes -0.90 3.42 2.51 1.21 -5.13 -6.85 -0.95 -2.33 6.13 0.64 -4.45 3.49 1.79 5.77 -4.81
Vacuole -1.39 -4.21 -20.13 -18.21 -19.20 -4.11 -4.76 -20.60 -19.92 -9.13 -3.25 -7.55 -28.89 -28.02 -26.48
Vacuole Periphery -1.07 -0.98 -2.64 0.04 -1.90 -5.45 -0.19 -1.85 1.50 -1.68 -4.93 -1.26 -3.16 -0.54 -1.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (41%), cytoplasm (13%), mixed (40%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Ntg1

Ntg1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ntg1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available