Standard name
Human Ortholog
Description Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.06 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0.13 0.06 0.05 0.1 0.08 0.12 0.11
Bud 0 0 0 0 0 0 – 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0.05 0 0 – 0 0 0 0 0 0 0 0 – 0.12 0.23 0 0 0 0.05 0.08 0.09
Cytoplasm 0.53 0.56 0.62 0.46 0.55 0.48 – 0.44 0.43 0.43 0.4 0.36 0.77 0.77 0.89 – 0.74 0.55 0.06 0.18 0 0.12 0.1 0.13
Endoplasmic Reticulum 0.4 0.39 0.08 0.14 0 0.09 – 0 0.05 0.05 0.08 0.07 0.18 0.19 0.06 – 0 0 0.7 0.53 0.67 0.43 0.41 0.37
Endosome 0 0 0.12 0.11 0.16 0 – 0.05 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0.05 0.08 0.13 0.33 0.18 0.5 – 0.56 0.55 0.61 0.67 0.62 0 0 0 – 0.07 0.08 0.09 0.14 0.12 0.22 0.2 0.19
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – 0 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0.06 0.06 0.15 0.07 – 0.06 0.06 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 10 8 0 1 0 0 – 0 0 3 2 4 4 5 4 – 5 13 13 22 29 16 44 37
Bud 0 4 1 5 2 4 – 15 17 15 21 12 1 1 0 – 1 0 1 5 1 1 1 3
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 2 1 2 – 7 1 3 8 2 2 7 7
Bud Site 0 1 0 0 0 0 – 1 2 3 1 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 3 8 6 11 5 6 – 11 10 10 13 9 7 7 1 – 22 23 2 8 6 9 31 30
Cytoplasm 90 199 136 105 125 132 – 257 173 195 164 140 130 130 133 – 131 56 15 78 8 24 37 46
Endoplasmic Reticulum 69 139 17 31 9 24 – 20 21 21 33 28 30 32 9 – 7 3 163 234 197 88 157 128
Endosome 2 0 26 24 36 6 – 27 11 13 2 9 3 1 1 – 5 2 5 2 2 4 7 6
Golgi 1 0 0 2 0 0 – 0 0 0 0 0 0 0 0 – 0 0 2 2 1 0 2 3
Mitochondria 9 30 28 76 41 137 – 331 220 275 279 239 0 0 0 – 13 8 21 60 36 45 77 68
Nucleus 0 0 0 0 2 1 – 0 1 2 3 2 2 2 1 – 3 2 0 0 0 0 1 0
Nuclear Periphery 0 1 1 1 0 1 – 1 1 1 1 2 0 0 0 – 0 0 0 3 1 2 1 0
Nucleolus 0 0 0 0 0 0 – 0 1 1 1 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 7 3 8 0 – 12 1 5 0 12 0 0 0 – 6 1 0 0 1 0 1 0
SpindlePole 1 1 1 1 1 1 – 8 0 3 1 3 1 2 0 – 6 5 0 2 0 0 0 1
Vac/Vac Membrane 3 5 14 14 34 20 – 34 23 12 8 15 1 1 2 – 5 1 4 8 2 5 8 10
Unique Cell Count 171 356 219 228 227 275 589 403 452 414 385 168 169 150 177 101 234 443 297 206 385 352
Labelled Cell Count 188 396 237 274 263 332 717 481 559 529 475 181 182 153 211 115 234 443 297 206 385 352


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 4.8 5.2 5.7 5.2 4.6 – 4.3 4.1 3.9 3.9 4.1 6.0 6.0 6.2 4.7 5.4 6.6 6.5 6.5 6.9
Std Deviation (1e-4) 0.8 0.6 1.8 2.3 1.4 2.2 – 1.1 1.2 0.9 1.1 0.9 0.8 0.8 1.4 0.8 0.9 1.6 1.2 1.3 1.9
Intensity Change (Log2) – – – 0.14 0.01 -0.18 – -0.28 -0.33 -0.43 -0.41 -0.35 0.21 0.21 0.26 -0.16 0.05 0.34 0.31 0.31 0.41

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – 0 –
Bud Neck – – – – – – – – – – – – – 0 –
Bud Site – – – – – – – – – – – – – 0 –
Cell Periphery – – – – – – – – – – – – – 0 –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – 0 –
Endosome – – – – – – – – – – – – – 0 –
Golgi – – – – – – – – – – – – – 0 –
Mitochondria – – – – – – – – – – – – – 0 –
Nuclear Periphery – – – – – – – – – – – – – 0 –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – 0 –
Peroxisomes – – – – – – – – – – – – – 0 –
SpindlePole – – – – – – – – – – – – – 0 –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – 0 –
Cytoplasm – – – – – – – – – – – – – 0 –
Nucleus – – – – – – – – – – – – – 0 –
Vacuole – – – – – – – – – – – – – -1.7 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5891 3.2965 2.9085 3.1661 1.9719 2.4123 5.0946 4.7781 5.1835 4.8769 4.48 4.7019 5.4816 6.0501 5.8648 5.7186 5.3936 5.5197
Actin 0.0182 0.0249 0.0258 0.0148 0.1449 0.0078 0.0985 0.0047 0.005 0.0016 0.0484 0.0026 0.0101 0.005 0.0075 0.002 0.0018 0.0035
Bud 0.0003 0.0001 0.0004 0.0016 0.0035 0.0002 0.0009 0.0001 0.0001 0.0002 0.0001 0 0.0001 0.0002 0.0003 0 0 0.0013
Bud Neck 0.0193 0.0025 0.0013 0.0056 0.0041 0.0144 0.0046 0.0004 0.0016 0.0055 0.0016 0.0011 0.0003 0.0004 0.0029 0.0011 0.0009 0.0039
Bud Periphery 0.0004 0.0001 0.0005 0.0028 0.0035 0.0004 0.0016 0.0006 0.0003 0.0016 0.0004 0.0002 0.0003 0.001 0.0005 0.0002 0.0001 0.0017
Bud Site 0.01 0.0019 0.0022 0.0034 0.0577 0.0002 0.0063 0.0011 0.0037 0.0003 0.0013 0.0001 0.0011 0.0032 0.0034 0.0002 0.0002 0.0003
Cell Periphery 0.0031 0.004 0.002 0.0028 0.0024 0.0024 0.0045 0.0136 0.0083 0.0084 0.0031 0.002 0.0084 0.0045 0.0074 0.0064 0.0027 0.0039
Cytoplasm 0.0791 0.1051 0.0987 0.2 0.0391 0.1139 0.061 0.1276 0.1349 0.1096 0.1239 0.0901 0.0578 0.1144 0.098 0.0294 0.0459 0.135
Cytoplasmic Foci 0.0828 0.0158 0.0175 0.027 0.0109 0.0064 0.0242 0.0045 0.014 0.0219 0.0153 0.0069 0.0072 0.0095 0.0079 0.0094 0.0067 0.01
Eisosomes 0.0003 0.0003 0.0002 0.0001 0.0011 0.0003 0.0009 0.0006 0.0003 0.0004 0.0005 0.0005 0.0005 0.0003 0.0004 0.0002 0.0002 0.0003
Endoplasmic Reticulum 0.5751 0.7442 0.7322 0.6162 0.6476 0.7576 0.6094 0.7629 0.7485 0.7668 0.6759 0.8214 0.8458 0.7707 0.7759 0.8894 0.865 0.7612
Endosome 0.0567 0.0167 0.03 0.0172 0.017 0.0234 0.0254 0.0067 0.0155 0.0083 0.0279 0.0131 0.0113 0.0187 0.0206 0.0155 0.0208 0.0192
Golgi 0.0132 0.0084 0.0139 0.0113 0.0097 0.0094 0.0135 0.0045 0.0043 0.0027 0.0146 0.0019 0.0055 0.0054 0.0094 0.0069 0.006 0.0057
Lipid Particles 0.0597 0.0518 0.037 0.008 0.0122 0.0117 0.0246 0.015 0.0234 0.0163 0.0591 0.0233 0.0238 0.0362 0.0255 0.0252 0.0344 0.0172
Mitochondria 0.0012 0.0014 0.0038 0.0505 0.0074 0.0018 0.0063 0.0003 0.001 0.0014 0.0024 0.0004 0.0004 0.0031 0.0052 0.0011 0.0019 0.0055
None 0.0146 0.0022 0.0026 0.0208 0.0028 0.0349 0.0345 0.044 0.0159 0.0412 0.0135 0.0267 0.0134 0.0074 0.0168 0.002 0.0015 0.0209
Nuclear Periphery 0.0102 0.0096 0.0107 0.0051 0.0105 0.0081 0.0262 0.0063 0.0086 0.0056 0.0047 0.0048 0.0066 0.0097 0.0092 0.0055 0.0055 0.0048
Nucleolus 0.0005 0.0001 0.0002 0.0003 0.0009 0.0001 0.0023 0.0002 0.0002 0.0002 0.0001 0 0 0.0001 0.0001 0 0.0001 0.0001
Nucleus 0.0016 0.0006 0.0009 0.0015 0.003 0.0009 0.0164 0.001 0.0012 0.0007 0.0008 0.0005 0.0004 0.0034 0.0009 0.0004 0.0006 0.0008
Peroxisomes 0.0258 0.005 0.0131 0.0031 0.0088 0.0004 0.0086 0.0001 0.0048 0.0006 0.0018 0.0001 0.0026 0.0003 0.0004 0.0004 0.0002 0.0003
Punctate Nuclear 0.0222 0.0007 0.0013 0.002 0.0088 0.0005 0.0219 0.0004 0.0013 0.0012 0.0007 0.0003 0.0005 0.0005 0.0005 0.0003 0.0018 0.0004
Vacuole 0.0048 0.004 0.0048 0.004 0.0034 0.0035 0.0055 0.0052 0.0063 0.0053 0.0037 0.0036 0.0037 0.0053 0.0062 0.0037 0.0032 0.0035
Vacuole Periphery 0.0009 0.0005 0.0008 0.0019 0.0007 0.0018 0.0028 0.0003 0.0006 0.0005 0.0004 0.0003 0.0004 0.0006 0.001 0.0005 0.0005 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 236.6512 202.8993 138.6822 151.7402 216.1605 209.434 198.3712 159.2771 151.7965 212.6515
Translational Efficiency 0.7644 0.7889 0.7755 0.7201 0.7145 0.8297 0.6899 0.6605 0.6838 0.6514

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
948 1161 1500 1821 2187 1473 2186 1264 3135 2634 3686 3085

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 887.69 770.52 895.46 1021.04 754.27 797.30 922.69 954.93 794.62 785.50 911.61 993.95
Standard Deviation 116.17 102.03 109.95 149.42 82.98 100.29 149.34 133.84 112.43 101.93 135.37 146.89
Intensity Change Log 2 — -0.204224 0.012573 0.201912 — 0.080042 0.290765 0.340314 — -0.066659 0.147052 0.267142

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001228 0.000757 0.000312 0.004208 0.000188 0.000473 0.001139 0.006611 0.000502 0.000599 0.000802 0.005192
Bud Neck 0.005158 0.007747 0.003863 0.006693 0.003572 0.007224 0.004723 0.011070 0.004051 0.007454 0.004373 0.008487
Bud Site 0.021876 0.003844 0.003579 0.015919 0.001928 0.004350 0.006520 0.034584 0.007960 0.004127 0.005323 0.023567
Cell Periphery 0.000672 0.000474 0.000323 0.002931 0.000612 0.000542 0.000992 0.001531 0.000630 0.000512 0.000720 0.002358
Cytoplasm 0.227938 0.319609 0.325206 0.125419 0.374353 0.294540 0.224008 0.219074 0.330078 0.305590 0.265190 0.163792
Cytoplasmic Foci 0.059831 0.177572 0.025526 0.010416 0.117534 0.145737 0.018562 0.039129 0.100085 0.159769 0.021396 0.022180
Eisosomes 0.000380 0.000652 0.000071 0.000970 0.000940 0.000799 0.000254 0.000769 0.000771 0.000734 0.000179 0.000888
Endoplasmic Reticulum 0.206060 0.172982 0.093866 0.693037 0.197262 0.220463 0.481858 0.367607 0.199922 0.199534 0.323966 0.559700
Endosome 0.020051 0.020354 0.009155 0.006601 0.009603 0.017515 0.007083 0.013119 0.012762 0.018766 0.007926 0.009272
Golgi 0.006115 0.011433 0.000191 0.002985 0.014902 0.018754 0.001068 0.003876 0.012245 0.015527 0.000711 0.003350
Lipid Particles 0.052383 0.108473 0.012310 0.019326 0.126021 0.146787 0.016501 0.036420 0.103754 0.129899 0.014796 0.026330
Mitochondria 0.003569 0.005631 0.001398 0.002115 0.007276 0.012644 0.001413 0.004445 0.006155 0.009553 0.001407 0.003070
Mitotic Spindle 0.010288 0.000783 0.000770 0.001291 0.000499 0.001940 0.000692 0.003557 0.003459 0.001430 0.000724 0.002220
None 0.002340 0.004280 0.002582 0.001261 0.003705 0.002666 0.003848 0.000674 0.003292 0.003377 0.003333 0.001021
Nuclear Periphery 0.035405 0.006400 0.086005 0.001953 0.006674 0.006556 0.031189 0.006122 0.015362 0.006487 0.053496 0.003662
Nuclear Periphery Foci 0.058102 0.010405 0.065630 0.017043 0.005157 0.007301 0.055362 0.039108 0.021167 0.008669 0.059540 0.026084
Nucleolus 0.000455 0.001113 0.001132 0.000175 0.000622 0.000713 0.000648 0.000285 0.000572 0.000889 0.000845 0.000220
Nucleus 0.069644 0.081970 0.300187 0.036655 0.098764 0.062194 0.108647 0.082794 0.089959 0.070911 0.186593 0.055559
Peroxisomes 0.003274 0.005549 0.000594 0.001406 0.004343 0.006734 0.001241 0.002114 0.004020 0.006212 0.000978 0.001696
Vacuole 0.212844 0.058011 0.066869 0.049160 0.025008 0.039461 0.033974 0.125875 0.081808 0.047637 0.047360 0.080592
Vacuole Periphery 0.002389 0.001961 0.000431 0.000435 0.001037 0.002606 0.000277 0.001234 0.001446 0.002322 0.000340 0.000762

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.28 4.38 -6.11 -6.38 -8.29 -3.18 -6.35 -4.77 -4.55 -3.99 -0.61 -3.12 -7.76 -7.45 -7.15
Bud Neck -2.30 1.22 -2.64 0.16 -3.82 -4.46 -1.93 -7.12 -3.23 -5.30 -5.17 -1.14 -7.76 -2.01 -6.14
Bud Site 5.31 5.29 0.92 -7.29 -7.26 -2.63 -5.26 -9.91 -8.98 -8.22 2.94 1.54 -8.76 -11.47 -10.56
Cell Periphery 1.81 3.90 -7.98 -8.66 -9.21 1.09 -3.02 -4.80 -5.21 -2.26 2.09 -1.48 -9.29 -9.95 -8.17
Cytoplasm -9.06 -9.39 10.43 22.42 23.49 10.21 21.05 18.41 8.15 0.49 3.71 10.86 27.70 22.78 16.86
Cytoplasmic Foci -19.75 10.04 15.46 31.15 9.85 -5.54 31.23 21.77 22.34 -8.61 -15.04 31.98 31.08 39.22 -0.70
Eisosomes -4.08 5.76 -5.64 -2.81 -9.13 1.59 8.23 1.58 0.51 -4.42 0.46 9.95 -1.23 -1.74 -9.23
Endoplasmic Reticulum 0.24 8.71 -38.64 -41.70 -60.03 -2.45 -29.34 -11.41 -8.73 11.33 -1.18 -17.25 -38.32 -35.92 -22.27
Endosome -1.21 6.84 8.89 11.28 4.55 -7.70 3.20 -2.83 3.97 -5.38 -7.40 6.39 4.33 11.71 -1.70
Golgi -3.85 3.46 1.55 9.64 -7.40 -2.99 20.40 12.76 12.28 -3.93 -3.72 17.48 12.37 15.88 -7.25
Lipid Particles -12.52 12.11 8.65 20.62 -5.54 -3.82 32.76 24.04 23.41 -8.87 -7.05 34.12 27.70 31.92 -9.29
Mitochondria -2.40 1.61 0.97 5.93 -1.42 -3.34 7.55 2.43 4.80 -2.23 -3.47 7.24 4.03 6.97 -2.76
Mitotic Spindle 3.70 3.69 3.18 -1.70 -1.72 -1.77 -1.10 -3.34 -1.59 -3.01 2.06 3.03 0.58 -1.87 -3.36
None -1.77 -0.48 1.06 3.18 3.38 1.39 -0.14 5.87 3.64 4.50 -0.23 -0.12 4.92 4.50 5.06
Nuclear Periphery 8.70 -10.61 10.44 7.51 20.23 0.16 -15.25 1.06 0.82 14.86 7.46 -17.94 10.80 5.49 25.11
Nuclear Periphery Foci 12.62 -2.82 9.95 -5.32 14.47 -2.71 -22.02 -15.33 -13.76 5.61 8.97 -18.93 -4.42 -14.05 15.41
Nucleolus -4.26 -7.08 5.53 6.11 10.15 -0.66 -0.36 3.78 3.62 2.54 -3.00 -2.93 5.64 7.13 6.77
Nucleus -2.40 -32.73 6.82 10.49 39.98 11.13 -2.87 2.75 -5.76 4.81 7.08 -23.96 10.43 3.80 31.19
Peroxisomes -3.79 5.06 3.31 9.86 -3.74 -4.46 7.52 5.57 10.43 -2.55 -5.51 9.44 7.15 14.56 -3.42
Vacuole 21.84 19.93 19.95 -2.70 1.01 -7.00 -6.48 -21.58 -18.56 -19.31 13.27 12.19 -1.62 -15.78 -14.68
Vacuole Periphery 0.10 2.71 2.71 9.12 0.09 -5.81 13.09 -0.23 3.89 -2.92 -4.06 5.45 2.91 7.94 -2.87
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein O-mannosyltransferase of the ER membrane; transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5p; antifungal drug target; PMT2 has a paralog, PMT3, that arose from the whole genome duplication
Localization
Cell Percentages ER (89%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Pmt2

Pmt2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pmt2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available