Standard name
Human Ortholog
Description N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 1.0 1.0 0.96 0.93 0.91 0.85 0.91 0.89 0.89 0.81 1.0 0.99 1.0 0.99 0.99 0.99 0.97 0.96 0.96 0.91 0.93 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0.08 0.1 0.05 0.1 0 0.05 0 0 0 0.05 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 0 4 2 6 8 0 0 0 0 0 0 0 0 0 1 0 0
Bud 2 0 0 0 0 1 1 1 0 0 1 0 0 2 0 0 1 0 1 4 1 11 14 11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 1 4 3 4 9 4 9 10 5 0 3 3 2 1 3 0 0 0 3 1 0
Cytoplasm 421 685 229 205 234 255 260 357 290 279 151 122 408 508 531 293 266 199 398 649 206 387 419 441
Endoplasmic Reticulum 0 3 0 0 7 9 22 41 17 30 7 7 0 2 0 15 13 11 2 2 1 0 3 2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 0 0 0 0
Golgi 0 0 0 0 0 0 1 1 2 0 1 1 0 1 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 4 0 0 2 0 0 0 0 1 0 0 1 0 0 0 0
Nucleus 0 2 0 0 0 0 1 1 2 1 2 1 0 0 0 1 1 0 1 6 0 5 2 3
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Peroxisomes 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Vac/Vac Membrane 2 0 1 0 1 7 3 16 1 2 2 10 0 0 1 0 2 3 2 6 0 5 3 2
Unique Cell Count 422 690 230 205 243 273 287 418 318 314 170 150 408 511 532 295 268 202 412 679 214 427 453 470
Labelled Cell Count 425 691 231 206 246 275 293 426 324 323 180 156 408 516 535 312 285 216 412 679 214 427 453 470


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 109.3 98.7 90.9 76.7 54.8 50.4 46.9 46.2 40.5 39.2 35.7 34.2 122.0 113.9 106.3 81.9 104.9 115.5 89.4 94.0 99.6
Std Deviation (1e-4) 25.5 22.1 18.0 16.7 14.2 12.3 10.5 9.1 9.0 7.9 9.6 9.0 30.8 28.9 27.3 28.1 31.0 36.4 30.7 31.0 28.7
Intensity Change (Log2) – – – -0.24 -0.73 -0.85 -0.96 -0.98 -1.17 -1.21 -1.35 -1.41 0.43 0.33 0.23 -0.15 0.21 0.35 -0.02 0.05 0.13

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100150WT3HU80HU120HU160050100150WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100150WT1AF100AF140AF180050100150
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.9 -2.5 -3.6 -4.5 -5.9 -4.3 -5.0 -4.9 -6.5 1.3 -0.3 0.6 -0.4 -0.4 -1.1
Endoplasmic Reticulum 0 0 0 4.3 4.9 3.6 4.8 0 0 0 0 0 3.5 3.4 3.6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 2.6 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 84.2425 101.1161 97.0251 92.4355 75.2124 92.9827 85.883 101.1004 99.2473 82.2166 75.6708 95.2382 93.7699 103.9921 101.3314 98.5306 91.5104 94.9721
Actin 0.0139 0.0001 0.0035 0.0003 0.0009 0.0002 0.0253 0.0012 0.0046 0.0471 0.0005 0.0038 0.0076 0.0001 0.0001 0 0.0003 0.0002
Bud 0.0002 0 0.0004 0.0001 0.0009 0.0003 0.0011 0.0013 0.0011 0.0005 0.0002 0.0003 0.0003 0 0 0 0.0001 0.0001
Bud Neck 0.0009 0.0001 0.0003 0.0001 0.0001 0.0004 0.0006 0.0002 0.0002 0.0003 0.0003 0.0002 0.004 0.0001 0.0001 0.0001 0.0002 0.0003
Bud Periphery 0.0002 0 0.0004 0.0001 0.0006 0.0001 0.0012 0.0004 0.0004 0.0003 0.0002 0.0001 0.0003 0 0 0 0 0
Bud Site 0.0005 0 0.0001 0.0004 0.0005 0 0.0017 0.0003 0.0002 0.0012 0.0003 0 0.0046 0 0 0 0.0003 0
Cell Periphery 0.0001 0 0.0002 0 0.0011 0 0.0107 0.0001 0.0001 0.0005 0.0011 0 0.0007 0 0 0 0.0001 0
Cytoplasm 0.8937 0.9964 0.9615 0.9486 0.7712 0.9771 0.8344 0.9871 0.9646 0.833 0.7631 0.9766 0.9298 0.9963 0.9917 0.9699 0.9173 0.9888
Cytoplasmic Foci 0.0164 0.0001 0.0019 0.0172 0.0212 0.0003 0.0075 0.0005 0.0021 0.0144 0.0191 0.0006 0.0043 0.0001 0 0 0.0283 0.0004
Eisosomes 0.0002 0 0 0.0001 0.0005 0 0.0012 0 0 0.0011 0 0 0.0002 0 0 0 0.0001 0
Endoplasmic Reticulum 0.0005 0.0001 0.0006 0.0002 0.0014 0.0025 0.0056 0.0002 0.0002 0.0009 0.0098 0.0003 0.0003 0 0 0 0.0007 0.0001
Endosome 0.0013 0 0.0014 0.0005 0.0024 0.001 0.0139 0.0001 0.0018 0.0014 0.0043 0.0003 0.0017 0 0 0 0.0023 0.0001
Golgi 0.0013 0 0.0004 0.0003 0.0006 0 0.0027 0 0.0032 0.0043 0.0005 0.0003 0.0005 0 0 0 0.0006 0
Lipid Particles 0.0132 0 0.0016 0.0089 0.0192 0 0.0036 0 0.0016 0.0062 0.0012 0 0.0009 0 0 0 0.0087 0
Mitochondria 0.0027 0 0.0014 0.0023 0.034 0.0005 0.0038 0.0001 0.0057 0.048 0.0006 0.0006 0.0006 0 0 0.0001 0.0013 0.0001
None 0.0053 0.0001 0.0029 0.0029 0.0254 0.0001 0.0092 0.0004 0.0009 0.0185 0.0049 0.0003 0.0018 0.0001 0.0001 0.0001 0.0056 0.0002
Nuclear Periphery 0.0066 0.0006 0.0041 0.0015 0.0149 0.005 0.0222 0.0014 0.0009 0.0026 0.014 0.0021 0.0036 0.0004 0.0007 0.0013 0.0046 0.0015
Nucleolus 0.003 0 0.0019 0.0013 0.0309 0 0.0028 0.0001 0.0008 0.004 0.0068 0 0.0024 0 0 0 0.0026 0
Nucleus 0.0274 0.0024 0.0108 0.0102 0.0327 0.0075 0.0338 0.0055 0.0067 0.0075 0.0299 0.0137 0.0273 0.0028 0.0071 0.0283 0.0151 0.0079
Peroxisomes 0.0087 0 0.0006 0.0015 0.0018 0 0.0007 0 0.0025 0.0039 0.0002 0 0.0007 0 0 0 0.0006 0
Punctate Nuclear 0.0026 0 0.0025 0.0027 0.0055 0 0.0134 0.0003 0.0001 0.0011 0.0825 0.0003 0.0038 0 0 0 0.0098 0.0001
Vacuole 0.0008 0.0001 0.0017 0.0004 0.0108 0.0034 0.003 0.0006 0.0011 0.0014 0.0545 0.0002 0.0035 0 0 0.0001 0.0008 0.0002
Vacuole Periphery 0.0006 0 0.0018 0.0003 0.0233 0.0016 0.0016 0.0001 0.001 0.0015 0.006 0.0001 0.0013 0 0 0 0.0007 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 145.5631 66.401 72.3192 52.3641 59.803 120.9361 72.0109 66.5087 70.3878 71.465
Translational Efficiency 1.8207 1.9539 1.3867 1.7761 1.5801 1.9639 1.7965 1.7787 1.4785 1.7419

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1878 1111 2069 1832 2300 1839 2642 1387 4178 2950 4711 3219

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 6070.86 6759.27 3501.22 2894.30 6265.18 7139.94 3451.06 2966.64 6177.83 6996.58 3473.09 2925.47
Standard Deviation 1344.68 1507.92 750.72 761.13 1250.62 1559.93 738.17 756.81 1297.35 1551.55 744.12 760.12
Intensity Change Log 2 — 0.154967 -0.794043 -1.068686 — 0.188556 -0.860316 -1.078526 — 0.172124 -0.827321 -1.073675

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000035 0.000095 0.000077 0.000205 0.000018 0.000097 0.000056 0.002687 0.000026 0.000097 0.000065 0.001275
Bud Neck 0.000204 0.000413 0.000779 0.003811 0.000124 0.000393 0.000870 0.001608 0.000160 0.000400 0.000830 0.002862
Bud Site 0.000375 0.001190 0.001013 0.016119 0.000236 0.000819 0.003282 0.008071 0.000299 0.000959 0.002286 0.012651
Cell Periphery 0.000393 0.000515 0.000140 0.000232 0.000165 0.000374 0.000158 0.000176 0.000268 0.000427 0.000150 0.000208
Cytoplasm 0.725788 0.693793 0.676987 0.734829 0.777865 0.716279 0.851964 0.792138 0.754457 0.707810 0.775117 0.759522
Cytoplasmic Foci 0.002402 0.004931 0.002741 0.004073 0.001122 0.004346 0.002577 0.006094 0.001697 0.004566 0.002649 0.004944
Eisosomes 0.000000 0.000001 0.000001 0.000003 0.000000 0.000001 0.000001 0.000003 0.000000 0.000001 0.000001 0.000003
Endoplasmic Reticulum 0.000012 0.000020 0.000048 0.000125 0.000011 0.000032 0.000021 0.000093 0.000011 0.000028 0.000033 0.000111
Endosome 0.000009 0.000399 0.000072 0.002142 0.000007 0.000066 0.000270 0.002452 0.000008 0.000191 0.000183 0.002275
Golgi 0.000226 0.000240 0.000245 0.002541 0.000123 0.000532 0.000843 0.002982 0.000169 0.000422 0.000580 0.002731
Lipid Particles 0.000278 0.000144 0.000202 0.000552 0.000058 0.000214 0.000309 0.000922 0.000157 0.000188 0.000262 0.000711
Mitochondria 0.000121 0.000412 0.000185 0.000628 0.000100 0.000135 0.000119 0.003310 0.000109 0.000240 0.000148 0.001784
Mitotic Spindle 0.000134 0.000190 0.001815 0.036768 0.000200 0.000532 0.002682 0.011760 0.000171 0.000403 0.002302 0.025993
None 0.018537 0.021231 0.011245 0.017666 0.022112 0.025444 0.006869 0.008887 0.020505 0.023857 0.008791 0.013883
Nuclear Periphery 0.000059 0.000083 0.000240 0.000503 0.000031 0.000081 0.000081 0.000316 0.000044 0.000082 0.000151 0.000423
Nuclear Periphery Foci 0.000320 0.000373 0.001046 0.001645 0.000171 0.000483 0.000500 0.001019 0.000238 0.000442 0.000740 0.001375
Nucleolus 0.000041 0.000066 0.000117 0.000792 0.000037 0.000079 0.000127 0.000436 0.000039 0.000074 0.000123 0.000638
Nucleus 0.249335 0.273505 0.297491 0.149126 0.196381 0.247426 0.117127 0.139437 0.220184 0.257247 0.196340 0.144951
Peroxisomes 0.000003 0.000071 0.000028 0.000492 0.000005 0.000014 0.000033 0.000715 0.000004 0.000036 0.000030 0.000588
Vacuole 0.001640 0.002235 0.005445 0.025374 0.001183 0.002435 0.011633 0.012224 0.001388 0.002360 0.008915 0.019708
Vacuole Periphery 0.000087 0.000094 0.000081 0.002374 0.000049 0.000219 0.000478 0.004671 0.000066 0.000172 0.000304 0.003364

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.37 -7.24 -5.44 -1.40 -0.74 -2.19 -8.66 -1.29 -1.15 -1.18 -2.83 -11.05 -1.51 -1.24 -1.23
Bud Neck -4.43 -10.11 -12.21 -10.31 -5.06 -5.80 -8.88 -8.84 -5.76 -1.30 -7.09 -13.37 -14.91 -11.86 -5.49
Bud Site -2.17 -4.27 -6.63 -5.46 -5.29 -4.21 -6.77 -7.44 -6.10 -2.10 -4.22 -7.91 -9.31 -7.82 -5.15
Cell Periphery -1.87 2.21 3.21 7.87 3.32 -4.37 -0.38 -1.32 3.82 -1.54 -3.78 1.75 2.17 8.18 1.11
Cytoplasm 6.17 15.67 6.25 -0.19 -8.11 14.16 -7.41 2.97 -8.76 8.67 13.88 5.74 8.31 -4.28 3.08
Cytoplasmic Foci -5.18 -5.27 -4.79 1.92 0.19 -8.11 -10.95 -12.94 -4.28 -6.37 -9.06 -10.81 -12.90 -1.47 -4.37
Eisosomes -3.42 -10.22 -13.35 -6.13 -5.50 -4.32 -12.05 -8.98 -5.62 -4.66 -5.36 -15.42 -16.08 -9.21 -7.81
Endoplasmic Reticulum -1.29 -7.41 -9.52 -5.86 -0.48 -1.70 -3.59 -3.88 -0.80 -2.21 -1.98 -8.15 -9.41 -3.34 -2.70
Endosome -1.02 -8.36 -3.99 -0.88 -3.21 -2.50 -3.75 -3.34 -3.08 -2.41 -1.32 -5.31 -5.13 -3.03 -3.79
Golgi -0.11 -0.84 -1.49 -1.46 -1.34 -2.30 -1.82 -2.43 -1.21 -1.10 -2.20 -1.92 -2.88 -1.54 -1.46
Lipid Particles 1.04 -1.67 -4.93 -9.79 -5.48 -4.49 -9.19 -5.82 -3.94 -1.68 -1.22 -6.15 -8.53 -8.63 -4.49
Mitochondria -1.07 -10.49 -4.52 0.31 -1.35 -2.20 -1.13 -1.61 -1.54 -1.58 -1.32 -7.19 -2.01 -1.45 -1.77
Mitotic Spindle -0.80 -6.69 -8.16 -8.08 -6.46 -1.67 -3.35 -4.56 -4.28 -2.80 -1.92 -6.19 -9.32 -9.07 -7.03
None -0.88 8.84 8.18 7.31 2.13 -0.78 15.04 13.67 12.64 -2.75 -1.38 17.43 14.64 13.55 0.19
Nuclear Periphery -5.08 -13.11 -14.60 -13.00 -2.98 -10.24 -11.33 -5.61 -3.66 -2.74 -10.64 -16.38 -14.74 -12.14 -5.48
Nuclear Periphery Foci -1.66 -2.71 -6.62 -5.73 -0.08 -8.54 -8.41 -7.60 -4.13 -2.47 -7.33 -5.28 -10.36 -6.72 -1.41
Nucleolus -2.60 -14.92 -6.61 -6.17 -4.75 -3.15 -7.55 -2.56 -1.87 -1.14 -3.86 -13.53 -6.81 -5.93 -4.53
Nucleus -4.80 -12.42 14.60 17.30 27.11 -12.16 13.82 8.50 18.91 -3.32 -11.44 0.10 15.42 24.96 14.71
Peroxisomes -1.07 -1.86 -2.13 -0.88 -1.72 -1.19 -5.20 -1.44 -1.38 -1.28 -1.31 -3.94 -2.26 -1.82 -1.94
Vacuole -4.05 -15.31 -27.21 -26.57 -20.32 -8.06 -22.52 -18.19 -16.67 -7.07 -8.56 -26.98 -32.04 -30.68 -20.64
Vacuole Periphery -0.22 -0.42 -2.27 -2.24 -2.24 -1.22 -2.92 -2.63 -2.28 -2.14 -1.20 -2.93 -3.42 -2.92 -2.83
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Ade1

Ade1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ade1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available