Standard name
Human Ortholog
Description Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 0.22 0.4 0.41 0.38 0.41 0.44 0.38 0.29 – 0.35 0.26 0.28 0.48 0.42 0.37 0.33 0.42 0 0.09 0.15 0.35 0.36 0.44
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.08 0 0.08 0 0 0 0 0 0
Endosome 0.15 0.08 0 0 0.22 0 0 0 0 – 0 0 0.09 0.13 0.14 0.13 0.21 0.17 0.11 0.07 0.05 0.05 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.07 0.22 0.36 0.57 0.31 0.53 0.54 0.63 0.8 – 0.69 0.81 0.24 0.17 0.22 0.12 0 0.06 0.06 0.07 0.2 0.06 0.1 0.11
Nucleus 0.5 0.2 0.13 0.09 0.05 0 0.05 0.08 0 – 0 0.08 0.21 0.14 0.08 0.22 0.23 0.19 0.24 0.28 0.12 0.11 0.05 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0.06 0 0.09 0.07 0.1 0.07 0 0.05 0 – 0 0.05 0 0 0 0 0.07 0.05 0.16 0.13 0.12 0.13 0.11 0.11
Vac/Vac Membrane 0.21 0.38 0.07 0 0.09 0.05 0 0 0 – 0.08 0 0.24 0.16 0.21 0.23 0.27 0.19 0.18 0.21 0.23 0.22 0.21 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 0 0 0 0 0 0 – 0 0 0 0 0 1 0 0 2 2 0 0 4 3
Bud 1 0 2 5 0 3 7 13 8 – 8 12 0 2 12 1 0 0 3 3 1 2 10 9
Bud Neck 1 0 1 0 1 1 1 5 0 – 0 2 0 0 0 1 0 1 3 3 2 1 1 4
Bud Site 0 0 0 1 1 5 2 9 7 – 2 8 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 20 44 40 50 67 82 120 132 73 – 46 50 53 155 145 109 60 73 8 27 26 65 107 147
Endoplasmic Reticulum 2 2 2 0 0 1 0 0 0 – 0 0 0 1 0 23 7 14 1 1 2 0 1 5
Endosome 22 16 2 0 39 9 5 6 0 – 1 2 17 43 47 37 37 29 26 20 8 9 12 11
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 1 1 1 2 0 0 0 0
Mitochondria 10 44 36 69 54 106 148 216 202 – 90 157 46 53 76 34 6 11 14 21 35 11 30 36
Nucleus 74 40 13 11 9 8 14 26 11 – 4 15 40 44 29 65 42 34 57 83 20 20 15 9
Nuclear Periphery 1 2 0 0 0 0 1 0 0 – 0 0 0 1 2 0 0 1 4 1 0 0 0 1
Nucleolus 0 1 0 0 0 0 1 1 1 – 0 1 1 1 1 0 0 1 19 12 3 5 3 2
Peroxisomes 0 0 0 0 2 0 0 0 0 – 0 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 9 4 9 9 18 13 11 16 8 – 1 10 4 11 3 13 13 9 39 39 21 23 32 35
Vac/Vac Membrane 31 76 7 2 15 9 7 5 6 – 10 6 45 52 73 66 49 33 43 63 41 40 62 55
Unique Cell Count 149 200 100 122 175 200 275 344 254 130 195 188 320 344 292 180 175 239 301 178 188 296 338
Labelled Cell Count 172 231 113 147 206 237 317 429 316 162 263 206 363 388 351 215 207 239 301 178 188 296 338


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 4.0 3.5 3.3 3.6 3.2 3.1 3.1 2.7 – 3.0 2.5 3.9 4.0 3.9 5.2 5.6 5.7 4.2 4.5 4.9
Std Deviation (1e-4) 0.8 1.0 0.6 1.3 1.6 0.9 1.3 0.9 1.4 – 2.0 1.0 0.7 1.1 1.3 1.1 1.4 1.7 1.4 2.3 1.8
Intensity Change (Log2) – – – -0.08 0.07 -0.1 -0.16 -0.18 -0.35 – -0.19 -0.47 0.17 0.2 0.16 0.57 0.68 0.72 0.29 0.37 0.48

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.5 4.1 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9488 0.7253 0.9902 1.0528 0.4324 0.8058 1.5655 1.4663 1.4146 1.3947 0.3952 1.5382 1.8065 1.6724 1.5765 2.396 1.3976 2.2063
Actin 0.059 0.0006 0.0215 0.0206 0.0138 0.0043 0.0221 0.0008 0.0067 0.0045 0.0004 0.0011 0.02 0.0006 0.0006 0.035 0.0016 0.0047
Bud 0.0012 0.0004 0.0003 0.0004 0.0008 0.0002 0.0008 0.0024 0.0009 0.0003 0.0002 0.0006 0.0003 0.0005 0.0008 0.0002 0.0001 0.0004
Bud Neck 0.0082 0.0024 0.0042 0.0024 0.0022 0.0066 0.0179 0.0013 0.0026 0.0011 0.0031 0.0068 0.0027 0.0016 0.0009 0.0017 0.0016 0.0069
Bud Periphery 0.0019 0.0012 0.0005 0.0008 0.0016 0.0004 0.0011 0.0027 0.0003 0.0003 0.0002 0.0017 0.0004 0.0005 0.0014 0.0002 0.0001 0.0006
Bud Site 0.0066 0.0081 0.0019 0.0019 0.0021 0.0004 0.0062 0.0113 0.0022 0.0032 0.0003 0.0009 0.0028 0.0201 0.0011 0.0008 0.0002 0.0004
Cell Periphery 0.0005 0.0008 0.0004 0.0003 0.0003 0.0001 0.0003 0.0003 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001
Cytoplasm 0.1157 0.2168 0.1557 0.1576 0.1752 0.1286 0.1081 0.1832 0.1199 0.1028 0.1448 0.127 0.1054 0.1375 0.1055 0.0588 0.0908 0.0989
Cytoplasmic Foci 0.018 0.0058 0.0083 0.0181 0.0203 0.0054 0.0291 0.0059 0.011 0.0099 0.0074 0.0036 0.0155 0.0085 0.012 0.0148 0.0052 0.0106
Eisosomes 0.0007 0.0001 0.0007 0.0002 0.0002 0.0001 0.0002 0 0.0001 0.0001 0 0 0.0003 0.0001 0.0001 0.0001 0.0002 0.0001
Endoplasmic Reticulum 0.0151 0.0067 0.0059 0.0061 0.0102 0.0035 0.0082 0.0054 0.0034 0.0042 0.0039 0.0026 0.003 0.0058 0.0031 0.0025 0.0026 0.0028
Endosome 0.0464 0.0045 0.0092 0.0256 0.0238 0.0105 0.0361 0.0088 0.0111 0.0137 0.0149 0.0084 0.0115 0.0106 0.0067 0.0048 0.0022 0.0046
Golgi 0.0115 0.0002 0.0034 0.0117 0.0078 0.0018 0.0068 0.0005 0.0015 0.0017 0.0004 0.0022 0.0014 0.0002 0.0003 0.0024 0.0001 0.0006
Lipid Particles 0.0189 0.0008 0.0044 0.0196 0.0086 0.0023 0.0262 0.0007 0.0041 0.0018 0.0007 0.0007 0.0026 0.0016 0.0008 0.004 0.0004 0.0018
Mitochondria 0.008 0.0009 0.0063 0.0411 0.0217 0.0066 0.0057 0.0029 0.0016 0.0033 0.0008 0.002 0.0014 0.0008 0.0013 0.049 0.0013 0.0008
None 0.1489 0.2741 0.2358 0.0305 0.0808 0.1187 0.2087 0.2166 0.2326 0.1988 0.1667 0.1589 0.2104 0.2726 0.2533 0.1521 0.3231 0.2192
Nuclear Periphery 0.0696 0.0142 0.0197 0.0088 0.0199 0.0211 0.0431 0.0161 0.019 0.0216 0.0201 0.0118 0.0431 0.0293 0.0289 0.0394 0.0503 0.0218
Nucleolus 0.008 0.0064 0.0104 0.0076 0.008 0.0146 0.0089 0.008 0.0089 0.0068 0.0116 0.0125 0.0135 0.0099 0.0077 0.0095 0.0083 0.0137
Nucleus 0.3269 0.3943 0.4351 0.5281 0.5159 0.5454 0.3286 0.4495 0.4629 0.5373 0.504 0.5627 0.4419 0.374 0.4584 0.5177 0.3525 0.5203
Peroxisomes 0.0156 0.0002 0.0021 0.0113 0.0017 0.0007 0.0221 0.0005 0.0022 0.0022 0.0004 0.0006 0.0287 0.0003 0.0005 0.0077 0.0004 0.0008
Punctate Nuclear 0.1087 0.0568 0.0699 0.092 0.0774 0.1258 0.1112 0.0752 0.1049 0.0831 0.1174 0.0926 0.0909 0.1193 0.1137 0.0978 0.158 0.0891
Vacuole 0.0069 0.0042 0.0035 0.0079 0.005 0.0023 0.006 0.0065 0.003 0.0022 0.002 0.0027 0.0027 0.0051 0.0021 0.0011 0.0006 0.0015
Vacuole Periphery 0.0037 0.0004 0.0008 0.0075 0.0026 0.0009 0.0027 0.0014 0.0009 0.001 0.0006 0.0006 0.0015 0.0009 0.0006 0.0006 0.0004 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 8.0939 6.0576 8.4905 10.4509 6.5893 10.535 21.9473 22.2768 14.6852 17.3125
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1659 109 365 1149 1567 1967 1397 768 3226 2076 1762 1917

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 601.53 743.79 813.57 760.77 623.40 742.24 840.76 781.88 612.15 742.32 835.13 769.23
Standard Deviation 67.34 89.26 110.05 109.39 74.97 94.72 103.44 148.62 71.98 94.45 105.42 127.00
Intensity Change Log 2 — 0.306259 0.435630 0.338824 — 0.251728 0.431536 0.326789 — 0.278764 0.433548 0.332711

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000081 0.001094 0.000862 0.000539 0.000127 0.000242 0.000279 0.001242 0.000103 0.000287 0.000400 0.000820
Bud Neck 0.009171 0.009548 0.005456 0.008064 0.004446 0.011265 0.009309 0.016756 0.006876 0.011174 0.008511 0.011546
Bud Site 0.001703 0.003089 0.003957 0.011915 0.000687 0.004082 0.002973 0.018613 0.001209 0.004030 0.003177 0.014599
Cell Periphery 0.000117 0.000200 0.000136 0.000290 0.000129 0.000114 0.000164 0.002209 0.000123 0.000119 0.000158 0.001058
Cytoplasm 0.390319 0.181757 0.063603 0.264447 0.319703 0.235278 0.178359 0.205922 0.356018 0.232468 0.154588 0.241000
Cytoplasmic Foci 0.144321 0.125795 0.002066 0.018868 0.103831 0.084566 0.005378 0.021354 0.124653 0.086731 0.004692 0.019864
Eisosomes 0.000105 0.000150 0.000057 0.000085 0.000082 0.000064 0.000039 0.013423 0.000094 0.000069 0.000043 0.005429
Endoplasmic Reticulum 0.001062 0.003580 0.007846 0.002762 0.001207 0.002212 0.003543 0.005912 0.001132 0.002284 0.004435 0.004024
Endosome 0.004650 0.005791 0.001650 0.013457 0.003664 0.006485 0.002091 0.011550 0.004171 0.006449 0.002000 0.012693
Golgi 0.000723 0.001011 0.000120 0.006412 0.000588 0.002713 0.000383 0.005099 0.000657 0.002624 0.000328 0.005886
Lipid Particles 0.017350 0.020601 0.001447 0.002683 0.015656 0.015312 0.001153 0.017212 0.016527 0.015590 0.001213 0.008503
Mitochondria 0.004593 0.009579 0.001037 0.010527 0.005545 0.012765 0.001444 0.010171 0.005055 0.012598 0.001360 0.010384
Mitotic Spindle 0.001560 0.014650 0.001621 0.040868 0.001084 0.019539 0.017950 0.025721 0.001329 0.019282 0.014568 0.034800
None 0.017323 0.009563 0.012438 0.022060 0.019577 0.009400 0.013944 0.042066 0.018418 0.009409 0.013632 0.030075
Nuclear Periphery 0.002244 0.002987 0.001721 0.002193 0.002847 0.006868 0.002702 0.003263 0.002537 0.006664 0.002499 0.002621
Nuclear Periphery Foci 0.001650 0.004522 0.002600 0.001447 0.002315 0.002642 0.000961 0.003422 0.001973 0.002740 0.001300 0.002238
Nucleolus 0.007101 0.019856 0.005793 0.005937 0.010562 0.015235 0.002806 0.003522 0.008783 0.015477 0.003425 0.004970
Nucleus 0.375799 0.548353 0.876162 0.534206 0.494628 0.547671 0.734233 0.529735 0.433519 0.547707 0.763634 0.532414
Peroxisomes 0.005359 0.019063 0.000415 0.002525 0.005334 0.007619 0.000424 0.020596 0.005347 0.008220 0.000422 0.009765
Vacuole 0.014325 0.017949 0.010730 0.045689 0.007390 0.014191 0.020555 0.040432 0.010956 0.014388 0.018520 0.043583
Vacuole Periphery 0.000443 0.000862 0.000284 0.005027 0.000599 0.001736 0.001309 0.001781 0.000519 0.001690 0.001096 0.003727

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.44 -9.84 -9.99 1.68 5.89 -2.32 -7.32 -6.97 -6.28 -4.22 -4.49 -13.15 -10.83 -6.12 -1.00
Bud Neck -0.16 0.66 0.21 0.21 -0.51 -6.55 -4.22 -5.71 -1.74 -2.40 -4.20 -2.35 -4.55 -0.02 -1.44
Bud Site -2.32 -2.45 -6.05 -3.00 -2.06 -4.21 -5.41 -5.85 -4.07 -4.67 -3.86 -4.86 -8.51 -5.13 -6.07
Cell Periphery -3.55 -3.42 -5.85 0.91 -1.82 2.47 -1.08 -4.36 -4.50 -4.28 0.85 -2.89 -5.08 -5.17 -4.66
Cytoplasm 9.94 38.60 18.67 -0.99 -16.47 9.54 20.77 15.90 8.53 -1.76 17.63 36.12 23.45 5.96 -9.48
Cytoplasmic Foci 1.02 33.47 30.17 6.85 -9.02 4.26 26.73 23.81 21.88 -4.36 8.90 42.21 38.17 23.53 -8.59
Eisosomes -3.58 2.20 1.63 4.17 -1.01 4.89 6.64 -3.10 -3.11 -3.12 5.96 7.95 -3.08 -3.12 -3.14
Endoplasmic Reticulum -4.26 -11.31 -14.33 -1.83 6.52 -5.20 -16.75 -15.31 -13.09 -4.50 -6.92 -19.99 -20.78 -15.13 1.59
Endosome -1.75 5.06 -1.73 0.24 -4.05 -4.40 4.17 -1.25 1.21 -2.88 -4.03 6.36 -2.23 0.56 -4.94
Golgi -1.63 6.67 -2.42 -1.90 -3.17 -3.26 2.78 -2.52 1.30 -3.45 -3.23 4.01 -3.14 0.42 -4.06
Lipid Particles -1.46 13.05 13.20 5.72 -0.63 0.67 14.17 6.10 5.72 -3.65 0.80 19.64 13.87 11.21 -4.17
Mitochondria -1.68 7.34 -0.29 1.41 -3.09 -5.64 5.58 0.75 4.88 -2.18 -6.85 8.45 0.30 5.69 -3.65
Mitotic Spindle -1.93 -1.86 -7.64 -1.56 -5.53 -8.12 -5.61 -7.38 -3.01 -3.92 -8.34 -5.86 -10.61 -3.39 -5.43
None 2.77 4.12 2.43 -0.22 -1.27 6.47 5.82 0.81 -2.48 -2.39 7.75 7.01 2.38 -2.75 -2.64
Nuclear Periphery -1.31 -1.69 -5.96 -1.34 -3.92 -6.46 -3.94 -6.64 0.95 -4.61 -7.28 -5.52 -8.66 2.19 -4.96
Nuclear Periphery Foci -2.97 -2.56 -0.52 2.81 2.37 -0.38 0.86 -0.40 -0.02 -1.30 -1.75 -1.00 -0.45 1.40 0.67
Nucleolus -2.71 2.61 4.04 3.36 1.28 -3.07 6.94 6.31 9.74 0.14 -5.72 7.60 7.41 11.06 0.32
Nucleus -4.22 -39.98 -18.83 -2.64 18.98 -4.85 -26.10 -8.16 -4.62 11.13 -12.43 -44.26 -18.51 -5.72 18.95
Peroxisomes -2.75 7.85 6.20 3.52 -2.30 -2.24 8.10 -0.19 0.97 -3.40 -3.63 10.92 2.90 5.44 -3.82
Vacuole -1.69 -2.58 -16.07 -12.34 -12.01 -5.66 -12.16 -13.98 -12.79 -8.26 -3.40 -11.41 -21.48 -19.96 -12.97
Vacuole Periphery -2.37 1.78 -3.06 -2.31 -3.28 -2.81 -0.35 -0.56 2.10 -0.05 -3.14 -0.41 -3.05 -0.03 -2.19
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting PDRE sites (PDR responsive elements); has a role in response to drugs and organic solvents; post-translationally up-regulated in cells lacking functional mitochondrial genome; involved in diauxic shift; relative distribution to nucleus increases upon DNA replication stress; APCC(Cdh1) substrate
Localization
Cell Percentages nucleus (39%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Pdr3

Pdr3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdr3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available