Standard name | |
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Human Ortholog | |
Description | Cytoskeletal protein binding protein; required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 181 | 38 | 178 | 141 | 178 | 169 | 202 | 170 | 126 | 144 | 148 | 162 | 143 | 174 | 188 | 51 | 6 | 22 | 291 | 83 | 254 | 126 | 266 | 254 |
Bud | 54 | 12 | 49 | 50 | 95 | 67 | 86 | 81 | 69 | 59 | 63 | 94 | 37 | 42 | 48 | 8 | 0 | 3 | 6 | 8 | 17 | 7 | 9 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 | 2 | 2 |
Bud Site | 5 | 0 | 11 | 6 | 3 | 12 | 11 | 11 | 7 | 14 | 7 | 6 | 4 | 3 | 0 | 1 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 22 | 6 | 26 | 21 | 12 | 7 | 22 | 23 | 12 | 14 | 28 | 26 | 17 | 30 | 39 | 7 | 4 | 10 | 2 | 0 | 1 | 0 | 0 | 0 |
Cytoplasm | 10 | 7 | 14 | 16 | 20 | 16 | 23 | 30 | 15 | 17 | 10 | 10 | 9 | 14 | 5 | 34 | 4 | 28 | 1 | 1 | 4 | 0 | 0 | 1 |
Endoplasmic Reticulum | 13 | 6 | 16 | 10 | 15 | 15 | 22 | 14 | 12 | 14 | 21 | 6 | 11 | 18 | 19 | 4 | 0 | 3 | 2 | 1 | 1 | 1 | 0 | 0 |
Endosome | 3 | 0 | 3 | 3 | 4 | 9 | 5 | 2 | 1 | 1 | 1 | 9 | 2 | 0 | 1 | 5 | 0 | 0 | 3 | 1 | 5 | 1 | 8 | 2 |
Golgi | 99 | 6 | 29 | 18 | 26 | 21 | 38 | 43 | 15 | 21 | 18 | 24 | 56 | 48 | 61 | 60 | 7 | 23 | 8 | 1 | 3 | 1 | 6 | 8 |
Mitochondria | 12 | 23 | 85 | 125 | 73 | 219 | 239 | 289 | 239 | 289 | 261 | 262 | 41 | 55 | 117 | 22 | 1 | 8 | 3 | 3 | 2 | 0 | 1 | 1 |
Nucleus | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 1 | 0 | 0 | 2 | 1 | 2 | 5 | 2 | 2 | 4 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 3 | 1 | 0 | 3 | 6 | 6 | 13 | 13 | 7 | 10 | 7 | 13 | 1 | 0 | 1 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 3 | 1 | 18 | 26 | 37 | 37 | 61 | 50 | 25 | 47 | 37 | 55 | 24 | 41 | 46 | 3 | 0 | 0 | 2 | 0 | 5 | 1 | 2 | 10 |
SpindlePole | 6 | 0 | 2 | 2 | 2 | 1 | 6 | 15 | 1 | 3 | 5 | 8 | 5 | 1 | 0 | 6 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 2 | 0 | 4 | 3 | 1 | 1 | 2 | 4 | 0 | 1 | 0 | 11 | 1 | 0 | 0 | 4 | 1 | 2 | 0 | 0 | 1 | 0 | 2 | 1 |
Unique Cell Count | 246 | 64 | 243 | 221 | 255 | 326 | 411 | 450 | 305 | 369 | 351 | 404 | 197 | 239 | 253 | 137 | 19 | 63 | 329 | 105 | 300 | 146 | 303 | 291 |
Labelled Cell Count | 413 | 101 | 436 | 424 | 475 | 582 | 733 | 753 | 531 | 637 | 610 | 692 | 352 | 426 | 525 | 207 | 25 | 100 | 329 | 105 | 300 | 146 | 303 | 291 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 21.5 | 18.4 | 15.7 | 14.5 | 15.4 | 14.6 | 13.9 | 13.0 | 12.9 | 12.1 | 12.5 | 12.0 | 19.6 | 18.7 | 16.2 | 23.1 | 26.1 | 25.6 | 20.0 | 19.4 | 21.1 |
Std Deviation (1e-4) | 5.8 | 6.2 | 4.5 | 3.9 | 5.0 | 4.3 | 4.0 | 3.8 | 4.0 | 3.6 | 3.8 | 3.3 | 4.8 | 4.9 | 4.2 | 11.3 | 12.6 | 13.2 | 5.2 | 4.1 | 4.5 |
Intensity Change (Log2) | – | – | – | -0.11 | -0.03 | -0.1 | -0.18 | -0.27 | -0.28 | -0.37 | -0.32 | -0.39 | 0.32 | 0.26 | 0.04 | 0.56 | 0.74 | 0.71 | 0.35 | 0.31 | 0.43 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | -2.2 | -0.9 | -5.2 | -6.0 | -8.9 | -7.5 | -8.3 | -7.5 | -8.2 | -0.2 | -0.1 | 0.3 | -6.9 | -3.8 | -5.7 |
Bud | 0.6 | 4.2 | 0.1 | 0.2 | -0.7 | 0.7 | -1.3 | -0.7 | 0.9 | -0.4 | -0.7 | -0.3 | -3.8 | 0 | -2.9 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | -1.0 | -2.3 | -0.5 | -1.3 | -1.5 | -1.5 | -0.4 | -1.8 | -2.3 | -1.4 | -2.1 | -3.4 | 0 | 0 | 0 |
Cell Periphery | -0.4 | -2.5 | -4.3 | -2.5 | -2.7 | -3.1 | -3.4 | -1.1 | -1.9 | -0.7 | 0.6 | 1.6 | -1.9 | 0 | 1.1 |
Cytoplasm | 0.6 | 0.9 | -0.5 | -0.1 | 0.5 | -0.4 | -0.6 | -1.8 | -2.1 | -0.6 | 0 | -2.2 | 5.4 | 0 | 8.0 |
Endoplasmic Reticulum | -1.0 | -0.3 | -1.0 | -0.7 | -2.1 | -1.4 | -1.6 | -0.3 | -3.5 | -0.4 | 0.4 | 0.4 | -1.5 | 0 | 0 |
Endosome | 0 | 0 | 1.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | -1.4 | -0.6 | -2.3 | -1.1 | -1.0 | -3.0 | -2.8 | -3.0 | -2.7 | 4.4 | 2.4 | 3.5 | 7.0 | 0 | 4.6 |
Mitochondria | 4.7 | -1.5 | 7.6 | 5.7 | 7.4 | 10.3 | 10.8 | 9.6 | 7.4 | -3.3 | -2.9 | 2.6 | -3.9 | -2.7 | -3.4 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 1.6 | 2.5 | 1.6 | 2.8 | 1.6 | 0.3 | 2.1 | 1.3 | 2.4 | 1.7 | 3.3 | 3.6 | -2.1 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 2.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.9 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 23.3715 | 25.1085 | 23.7211 | 23.665 | 22.3941 | 24.5012 | 18.6002 | 20.8727 | 19.3974 | 17.5227 | 20.3158 | 20.7814 | 24.7392 | 17.1832 | 17.02 | 19.7055 | 19.7183 | 19.4061 |
Actin | 0.9519 | 0.8879 | 0.937 | 0.8049 | 0.9453 | 0.9022 | 0.8845 | 0.8488 | 0.8839 | 0.8743 | 0.9401 | 0.9444 | 0.9886 | 0.9898 | 0.9161 | 0.9899 | 0.9926 | 0.9794 |
Bud | 0.0002 | 0.0009 | 0.0014 | 0.0028 | 0.002 | 0.0004 | 0.0008 | 0.004 | 0.0033 | 0.005 | 0.0004 | 0.0007 | 0.0001 | 0.0003 | 0.0077 | 0.0016 | 0.0004 | 0.0001 |
Bud Neck | 0.0029 | 0.004 | 0.0023 | 0.0059 | 0.0026 | 0.02 | 0.0043 | 0.0087 | 0.0037 | 0.0041 | 0.0009 | 0.0111 | 0.0012 | 0.0012 | 0.0014 | 0.0013 | 0.0053 | 0.0041 |
Bud Periphery | 0.0002 | 0.0007 | 0.0015 | 0.0037 | 0.0052 | 0.0008 | 0.0009 | 0.0022 | 0.0037 | 0.0083 | 0.0005 | 0.0025 | 0.0001 | 0.0002 | 0.0126 | 0.0025 | 0.0006 | 0.0001 |
Bud Site | 0.0011 | 0.0347 | 0.0075 | 0.012 | 0.0029 | 0.0004 | 0.0167 | 0.1269 | 0.0223 | 0.0085 | 0.0007 | 0.0013 | 0.0081 | 0.0035 | 0.0049 | 0.001 | 0.0002 | 0.0002 |
Cell Periphery | 0.0001 | 0.0008 | 0.0003 | 0.0023 | 0.0007 | 0.001 | 0.0008 | 0.0008 | 0.0006 | 0.0008 | 0 | 0.0003 | 0.0001 | 0 | 0.0003 | 0.0002 | 0 | 0 |
Cytoplasm | 0 | 0.0257 | 0.0352 | 0.1308 | 0.0001 | 0.0126 | 0.0031 | 0.0035 | 0.0022 | 0.0026 | 0.0206 | 0.0003 | 0 | 0 | 0.0002 | 0.0001 | 0 | 0 |
Cytoplasmic Foci | 0.0004 | 0.0044 | 0.0008 | 0.0017 | 0.0006 | 0.0003 | 0.0199 | 0.0009 | 0.0118 | 0.045 | 0.0054 | 0.005 | 0.0002 | 0.0011 | 0.0281 | 0.0002 | 0 | 0.0001 |
Eisosomes | 0.0376 | 0.0255 | 0.0035 | 0.0133 | 0.0048 | 0.0503 | 0.0033 | 0.0017 | 0.0009 | 0.0007 | 0.0004 | 0.0042 | 0.0011 | 0.0005 | 0.0002 | 0.0003 | 0.0005 | 0.0154 |
Endoplasmic Reticulum | 0 | 0.0001 | 0.0001 | 0.0108 | 0.0001 | 0.0001 | 0.0025 | 0.0001 | 0.0037 | 0.0007 | 0.0044 | 0.0005 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0.0001 | 0.0008 | 0.0002 | 0.0013 | 0.0005 | 0.0002 | 0.0148 | 0.0001 | 0.0249 | 0.008 | 0.0139 | 0.0056 | 0 | 0 | 0.0013 | 0.0001 | 0 | 0 |
Golgi | 0.0045 | 0.0044 | 0.0097 | 0.0047 | 0.0336 | 0.0106 | 0.0127 | 0.001 | 0.0128 | 0.018 | 0.0013 | 0.007 | 0.0002 | 0.0007 | 0.0021 | 0.0025 | 0.0002 | 0.0004 |
Lipid Particles | 0.0002 | 0.0067 | 0.0002 | 0.0018 | 0.0006 | 0.0003 | 0.0072 | 0.0001 | 0.0059 | 0.0061 | 0.0007 | 0.0058 | 0 | 0.0001 | 0.0077 | 0.0001 | 0 | 0 |
Mitochondria | 0.0001 | 0.0007 | 0.0001 | 0.0004 | 0.0005 | 0.0005 | 0.0053 | 0.0001 | 0.0034 | 0.0022 | 0.0005 | 0.0067 | 0 | 0.0002 | 0.0003 | 0.0001 | 0 | 0 |
None | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0037 | 0 | 0.0008 | 0.0012 | 0.0047 | 0.0004 | 0 | 0 | 0.0001 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0.0004 | 0 | 0 | 0.0064 | 0 | 0.0034 | 0.0003 | 0.0021 | 0.0004 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0.0008 | 0.0001 | 0.0005 | 0.0002 | 0.0009 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0.0006 | 0.002 | 0.0002 | 0.0002 | 0.0003 | 0.0003 | 0.0068 | 0.0005 | 0.0087 | 0.0116 | 0.0003 | 0.002 | 0.0003 | 0.0024 | 0.0162 | 0.0001 | 0.0001 | 0.0002 |
Punctate Nuclear | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0022 | 0.0001 | 0.0006 | 0.0013 | 0.0011 | 0.0011 | 0 | 0 | 0.0005 | 0 | 0 | 0 |
Vacuole | 0 | 0.0003 | 0 | 0.0023 | 0 | 0 | 0.0017 | 0.0002 | 0.0019 | 0.0007 | 0.0007 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole Periphery | 0 | 0 | 0 | 0.0002 | 0 | 0 | 0.001 | 0 | 0.0009 | 0.0003 | 0.0003 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 106.6477 | 87.6779 | 97.9831 | 107.0404 | 93.076 | 101.8645 | 102.7364 | 112.6383 | 117.7337 | 104.7286 |
Translational Efficiency | 1.1509 | 1.1521 | 1.1551 | 1.1822 | 1.1354 | 1.2 | 0.9203 | 0.9568 | 0.9663 | 0.9874 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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