Standard name
Human Ortholog
Description Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.11 0.06 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.19 0.31 0.25 0.26 0.46 0.2 0.14 0.13 0.13 0.13 0.11 0.11 0.19 0.23 0.3 0.35 0.33 0.3 0.13 0.16 0.11 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0.05 0 0.05 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0 0.05 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.06 0.17 0.15 0.22 0.24 0.21 0.26 0.2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.68 0.58 0.53 0.54 0.27 0.46 0.53 0.44 0.45 0.43 0.45 0.43 0.73 0.56 0.47 0.43 0.44 0.5 0.64 0.55 0.4 0.56 0.39 0.36
Nuclear Periphery 0 0 0 0 0 0 0.05 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.09 0 0.14 0.19 0.18 0.25 0.25 0.3 0.36 0.32 0.33 0.35 0.06 0.09 0.12 0.07 0.08 0.09 0.07 0.06 0.27 0.19 0.28 0.22
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0
Vac/Vac Membrane 0 0.07 0 0.06 0.07 0.05 0 0.05 0 0.05 0 0.06 0 0.09 0.09 0.13 0.14 0.1 0 0 0 0.09 0.17 0.17
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0
Bud 0 3 1 1 1 8 11 15 8 9 7 2 0 0 0 0 0 1 6 39 11 9 3 5
Bud Neck 0 0 0 0 1 2 4 6 4 7 0 4 0 0 0 0 0 0 0 4 1 0 1 4
Bud Site 0 0 0 0 0 6 5 6 7 12 11 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 6 3 1 3 1 4 1 3 1 0 1 7 6 3 0 0 0 0 0 0
Cytoplasm 21 101 47 55 130 77 56 64 52 55 44 40 30 93 98 73 64 60 15 56 23 12 0 1
Endoplasmic Reticulum 0 0 3 0 0 1 1 2 0 4 4 2 0 0 0 1 4 3 0 1 2 3 0 0
Endosome 4 9 9 7 14 8 8 7 0 8 2 3 3 22 18 5 5 4 1 4 3 8 23 38
Golgi 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 3 1 3 1 0 0 0 1 8
Mitochondria 2 3 4 4 17 66 60 109 95 92 108 73 0 2 0 4 3 5 0 3 1 5 11 22
Nucleus 74 192 101 114 75 178 214 222 174 183 187 159 117 225 152 90 86 100 74 195 82 188 175 190
Nuclear Periphery 0 1 4 7 2 16 19 14 12 24 10 7 1 8 8 3 1 4 1 0 3 3 14 15
Nucleolus 10 12 27 39 51 96 101 153 139 139 139 128 10 36 38 15 16 17 8 21 55 64 128 118
Peroxisomes 0 0 0 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 1 1 1 0 3 1 2 1 3 0 3 0 0 0 1 2 13 12 8 10 18
Vac/Vac Membrane 4 22 8 13 19 18 15 25 12 20 9 21 7 36 28 27 28 19 1 11 3 28 74 89
Unique Cell Count 109 330 189 210 282 389 403 505 391 429 415 366 161 405 322 209 194 200 115 356 204 338 450 529
Labelled Cell Count 115 343 204 242 318 481 496 629 505 560 523 446 169 426 343 228 215 220 115 356 204 338 450 529


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.1 9.2 8.9 8.9 8.5 7.3 7.9 7.7 7.4 7.6 7.5 7.6 9.9 10.1 10.5 13.0 13.0 12.9 9.1 9.8 10.0
Std Deviation (1e-4) 2.3 1.8 1.9 2.5 2.4 1.9 2.3 2.0 2.0 2.2 1.9 2.1 2.0 2.3 2.5 3.3 3.1 3.3 1.7 1.6 1.8
Intensity Change (Log2) – – – 0.0 -0.05 -0.28 -0.17 -0.2 -0.26 -0.22 -0.24 -0.21 0.17 0.19 0.24 0.56 0.55 0.55 0.04 0.14 0.17

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.3 4.7 -1.4 -3.3 -3.9 -3.5 -3.7 -4.5 -4.3 -1.4 -0.5 1.3 2.2 1.8 1.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -0.7 0.1 -1.8 -1.9 0 0 -2.0 0 0 -1.5 0.3 0.4 -1.3 -1.1 -1.5
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 2.0 5.1 4.7 6.2 6.7 6.1 7.0 5.8 0 0 0 0 0 0
Nucleus 0.2 -5.9 -1.7 -0.1 -2.2 -2.0 -2.5 -1.9 -2.2 3.7 0.5 -1.4 -2.1 -1.8 -0.7
Nuclear Periphery 0.7 0 1.2 1.5 0 0.7 1.9 0 0 0 0 0 0 0 0
Nucleolus 1.2 1.1 2.9 3.0 4.3 5.3 4.7 4.9 5.1 -2.4 -2.0 -0.8 -2.3 -1.9 -1.8
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.9 1.1 0.2 -0.3 0.4 -0.7 0.2 -1.4 0.8 0.1 2.0 1.9 3.1 3.4 2.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.4955 3.1073 3.2297 2.8103 2.1096 3.473 5.1991 5.4903 5.204 4.0687 3.75 4.9087 3.0169 4.6416 3.1649 2.9764 3.09 3.915
Actin 0.0243 0.0022 0.0025 0.0029 0.0023 0.0005 0.0164 0.0036 0.01 0.0193 0.047 0.0021 0.0012 0.0008 0.0479 0.0001 0.0006 0.0123
Bud 0.0001 0.0192 0.0362 0.067 0.0375 0.0023 0.0015 0.0215 0.0455 0.0774 0.0576 0.0083 0.0001 0.0035 0.0228 0.0003 0.01 0.0011
Bud Neck 0.0003 0.0019 0.0041 0.0192 0.0046 0.0067 0.0025 0.0027 0.0058 0.0051 0.0034 0.0081 0.0003 0.0008 0.002 0.0002 0.0021 0.002
Bud Periphery 0.0002 0.0091 0.0251 0.0549 0.0522 0.0027 0.0021 0.0127 0.0384 0.0553 0.0703 0.0096 0.0001 0.0016 0.0146 0.0001 0.0089 0.0005
Bud Site 0.0003 0.0339 0.0254 0.0315 0.0059 0.0024 0.0062 0.0563 0.0363 0.0207 0.0095 0.0013 0.0007 0.0037 0.0118 0.0002 0.0021 0.0004
Cell Periphery 0 0.0008 0.0013 0.0033 0.0028 0.0004 0.0005 0.0014 0.0018 0.0013 0.0021 0.0004 0 0.0001 0.0005 0 0.0009 0.0001
Cytoplasm 0.0276 0.2454 0.4469 0.4951 0.7209 0.127 0.0144 0.1572 0.2807 0.5977 0.5157 0.0821 0.0064 0.2326 0.5326 0.9597 0.8993 0.1264
Cytoplasmic Foci 0.0035 0.0082 0.0201 0.0097 0.0206 0.0049 0.0134 0.012 0.0222 0.0226 0.0421 0.0036 0.0518 0.001 0.0284 0.0114 0.0057 0.0082
Eisosomes 0.0002 0 0 0 0 0 0.0001 0.0001 0.0001 0.0001 0.0004 0 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.002 0.0078 0.0064 0.0065 0.0036 0.0016 0.0068 0.0035 0.0086 0.0058 0.0072 0.002 0.0002 0.0011 0.0119 0.0012 0.0135 0.0007
Endosome 0.0028 0.0032 0.0278 0.0241 0.1043 0.0073 0.0125 0.0126 0.0299 0.0327 0.0486 0.0085 0.0033 0.0004 0.0364 0.0179 0.0078 0.0064
Golgi 0.0013 0.0006 0.001 0.0007 0.0037 0.0002 0.0057 0.0013 0.0029 0.0144 0.0245 0.0012 0.0032 0.0001 0.0025 0.0006 0.0003 0.0031
Lipid Particles 0.0036 0.0018 0.0025 0.0002 0.0002 0.0003 0.0151 0.0009 0.013 0.0156 0.062 0.001 0.009 0.0001 0.0105 0 0.0002 0.0052
Mitochondria 0.0008 0.001 0.0017 0.0018 0.0007 0.0004 0.0071 0.0096 0.0094 0.0076 0.0067 0.0009 0.0013 0.001 0.0043 0.0001 0.0003 0.0008
None 0.0071 0.0103 0.0087 0.0358 0.003 0.0005 0.0033 0.0129 0.0067 0.0087 0.014 0.001 0.0006 0.0009 0.091 0.0024 0.004 0.001
Nuclear Periphery 0.0094 0.0183 0.0148 0.0099 0.0019 0.0046 0.0125 0.0169 0.0351 0.0084 0.0123 0.0133 0.0022 0.0165 0.035 0.0004 0.0082 0.0062
Nucleolus 0.0194 0.0391 0.0392 0.0076 0.0014 0.0822 0.0762 0.081 0.0717 0.0034 0.0036 0.1249 0.0192 0.017 0.0017 0 0.0004 0.0415
Nucleus 0.8879 0.5694 0.2772 0.1768 0.0121 0.7444 0.7748 0.5419 0.3025 0.0576 0.031 0.7091 0.8646 0.6267 0.1045 0.0007 0.0105 0.7577
Peroxisomes 0.002 0.0011 0.0005 0.0003 0.0002 0.0001 0.0105 0.0029 0.0012 0.0098 0.0144 0.0004 0.0231 0.0002 0.0048 0 0.0001 0.0065
Punctate Nuclear 0.0062 0.0222 0.0308 0.0031 0.0004 0.0072 0.0084 0.0321 0.0525 0.0059 0.0066 0.018 0.0119 0.091 0.0042 0.0001 0.0005 0.0186
Vacuole 0.0005 0.0038 0.0247 0.045 0.0187 0.0039 0.0074 0.0153 0.0225 0.0251 0.0173 0.0035 0.0003 0.0008 0.0279 0.0036 0.0223 0.0007
Vacuole Periphery 0.0003 0.0007 0.003 0.0045 0.0029 0.0003 0.0024 0.0013 0.0035 0.0054 0.0039 0.0007 0.0004 0.0003 0.0047 0.0008 0.0023 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.7182 6.4321 37.6214 40.2114 22.2247 24.5347 14.5371 24.1417 35.514 26.9798
Translational Efficiency 1.3012 0.9666 1.1213 1.2639 1.1237 1.138 0.9387 0.9721 1.0172 0.9913

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1092 1689 181 1206 1798 1769 2764 1900 2890 3458 2945 3106

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 916.76 1008.97 1252.07 1300.85 833.71 971.63 1152.86 1256.63 865.09 989.87 1158.96 1273.80
Standard Deviation 146.07 194.85 186.58 260.30 151.46 161.00 187.90 221.85 154.78 179.31 189.33 238.50
Intensity Change Log 2 — 0.138267 0.449699 0.504839 — 0.220861 0.467600 0.591942 — 0.178195 0.458253 0.546981

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000504 0.000889 0.001554 0.000865 0.000696 0.000824 0.000916 0.000562 0.000623 0.000856 0.000955 0.000679
Bud Neck 0.031981 0.028435 0.019135 0.019513 0.023484 0.031195 0.065395 0.028353 0.026695 0.029847 0.062552 0.024921
Bud Site 0.010525 0.011150 0.006854 0.031350 0.012191 0.011540 0.014480 0.022982 0.011562 0.011350 0.014011 0.026231
Cell Periphery 0.000799 0.000715 0.000180 0.000702 0.001105 0.000492 0.000324 0.000314 0.000989 0.000601 0.000315 0.000465
Cytoplasm 0.081407 0.093425 0.067431 0.595400 0.141702 0.079820 0.325982 0.547053 0.118919 0.086465 0.310092 0.565825
Cytoplasmic Foci 0.007432 0.009117 0.016592 0.023149 0.013677 0.009471 0.009038 0.019392 0.011317 0.009298 0.009502 0.020851
Eisosomes 0.000052 0.000044 0.000059 0.000018 0.000044 0.000054 0.000020 0.000012 0.000047 0.000049 0.000023 0.000015
Endoplasmic Reticulum 0.003302 0.002857 0.002244 0.001020 0.004192 0.003109 0.000870 0.000914 0.003855 0.002986 0.000955 0.000955
Endosome 0.003517 0.003515 0.003345 0.004747 0.006986 0.004976 0.000837 0.002046 0.005675 0.004262 0.000991 0.003094
Golgi 0.000357 0.001014 0.000424 0.004737 0.001097 0.001279 0.000272 0.000979 0.000817 0.001150 0.000282 0.002438
Lipid Particles 0.000387 0.000894 0.000813 0.001854 0.000804 0.000540 0.000252 0.000362 0.000646 0.000713 0.000286 0.000941
Mitochondria 0.001168 0.002123 0.002301 0.003280 0.001999 0.002195 0.001832 0.001717 0.001685 0.002160 0.001861 0.002324
Mitotic Spindle 0.005439 0.010162 0.020471 0.082238 0.006993 0.020945 0.047144 0.048693 0.006406 0.015678 0.045505 0.061718
None 0.006855 0.007107 0.001312 0.007631 0.022096 0.006251 0.009397 0.007991 0.016337 0.006669 0.008900 0.007851
Nuclear Periphery 0.000658 0.001389 0.000652 0.001267 0.000757 0.000917 0.000976 0.000933 0.000720 0.001148 0.000957 0.001063
Nuclear Periphery Foci 0.004419 0.008733 0.006016 0.002880 0.008221 0.003613 0.000766 0.001071 0.006784 0.006114 0.001089 0.001773
Nucleolus 0.141550 0.181106 0.123867 0.008201 0.117914 0.148104 0.030493 0.011989 0.126845 0.164223 0.036232 0.010518
Nucleus 0.690214 0.628347 0.703818 0.172446 0.612984 0.663539 0.477036 0.273242 0.642165 0.646350 0.490974 0.234105
Peroxisomes 0.000646 0.001389 0.003409 0.000790 0.000892 0.001625 0.000388 0.000634 0.000799 0.001510 0.000573 0.000695
Vacuole 0.007255 0.005773 0.019034 0.036456 0.018240 0.007418 0.012897 0.028988 0.014089 0.006615 0.013274 0.031888
Vacuole Periphery 0.001535 0.001816 0.000491 0.001456 0.003927 0.002091 0.000685 0.001773 0.003023 0.001957 0.000673 0.001650

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -8.42 -8.98 -7.42 -3.18 3.49 -2.23 -0.44 0.16 1.56 0.48 -6.00 -1.12 -3.85 -0.29 -0.16
Bud Neck 0.68 -0.51 -2.92 -3.90 -1.27 -4.58 -22.47 -9.58 -5.66 11.87 -3.02 -21.63 -9.37 -7.04 13.44
Bud Site -1.04 0.10 -9.31 -8.97 -8.07 0.20 -3.40 -5.61 -5.55 -3.25 -0.44 -4.25 -10.45 -10.14 -7.15
Cell Periphery 0.48 4.34 1.73 1.35 -4.33 5.81 8.34 8.18 4.82 -0.27 4.37 9.59 7.63 3.95 -4.76
Cytoplasm -1.48 0.59 -23.81 -23.66 -18.12 7.55 -12.80 -24.60 -32.26 -14.04 5.32 -16.49 -33.77 -39.87 -16.90
Cytoplasmic Foci -0.82 -1.56 -5.60 -5.13 -1.28 2.56 4.43 -0.38 -3.15 -5.54 1.84 3.20 -3.47 -5.63 -7.64
Eisosomes 2.37 -2.20 7.47 6.37 7.88 -3.51 11.75 14.26 17.56 5.29 -1.09 14.12 15.16 17.66 3.09
Endoplasmic Reticulum 1.89 1.45 5.03 4.00 2.04 3.25 12.54 10.87 7.18 -2.62 4.07 14.90 11.84 8.64 -4.33
Endosome -0.52 0.73 1.20 1.57 -0.03 2.14 9.57 8.28 4.57 -4.51 2.20 10.95 7.80 4.96 -4.89
Golgi -3.45 -0.56 -2.29 -1.45 -2.21 -0.38 9.95 2.62 1.95 -2.07 -1.73 9.61 -1.26 -0.38 -2.84
Lipid Particles -1.55 -1.52 -5.68 -2.34 -3.11 1.52 3.87 2.03 -0.06 -3.29 -0.33 3.24 -3.08 -1.69 -6.47
Mitochondria -6.61 -6.03 -3.83 -2.05 -0.65 -0.87 -2.11 -1.29 -0.38 0.45 -3.20 -5.65 -3.87 -1.97 -1.14
Mitotic Spindle -2.55 -2.16 -15.66 -14.87 -7.75 -5.27 -16.78 -14.24 -10.00 -0.59 -5.68 -17.33 -21.03 -17.79 -4.62
None -0.14 6.38 -1.14 -1.30 -10.65 9.97 9.03 9.34 -2.43 1.50 9.32 7.95 8.16 -2.74 0.86
Nuclear Periphery -2.57 -2.05 -8.35 -3.29 -4.92 -1.43 -7.49 -6.65 -5.19 -0.00 -2.84 -8.62 -10.55 -4.93 -2.31
Nuclear Periphery Foci -1.80 -0.28 1.01 3.09 0.70 3.04 6.42 5.69 2.84 -1.56 0.70 6.61 5.17 4.42 -2.76
Nucleolus -5.55 1.92 22.39 31.15 7.97 -5.18 17.86 23.87 27.68 8.40 -8.26 21.72 32.62 41.44 11.54
Nucleus 5.92 0.56 28.98 25.83 14.64 -4.45 12.68 22.74 27.85 12.31 -0.03 16.97 35.25 37.57 17.79
Peroxisomes -5.40 -6.32 -1.98 3.48 5.59 -3.18 5.07 4.06 5.35 -1.08 -5.26 2.88 2.06 6.74 -0.87
Vacuole 1.30 -2.88 -11.85 -12.64 -2.84 5.65 -0.51 -7.11 -12.80 -7.28 6.06 -3.43 -12.76 -18.21 -9.62
Vacuole Periphery -1.08 5.49 2.65 3.04 -1.27 3.14 6.63 4.62 2.12 -1.58 2.82 7.59 5.14 3.16 -1.95
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages nucleus (87%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Mcm2

Mcm2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mcm2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available