Standard name
Human Ortholog
Description Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0.1 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.62 0.76 0.53 0.62 0.55 0.56 – 0.38 0.45 0.41 0.44 0.39 0.43 0.59 0.48 0.84 0.8 0.75 0.4 0.49 0.6 0.5 0.6 0.58
Endoplasmic Reticulum 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0.14 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.08 0.18 0.07 0.2 – 0.2 0.33 0.34 0.3 0.35 0 0 0 0 0 0 0 0 0 0.05 0 0
Nucleus 0.08 0.07 0.08 0 0 0 – 0 0 0.06 0.11 0.11 0 0 0 0 0 0 0.44 0.34 0.2 0.19 0.17 0.2
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.47 0.28 0.38 0.27 0.41 0.27 – 0.43 0.24 0.28 0.21 0.17 0.6 0.32 0.33 0.2 0.24 0.27 0.07 0.1 0.06 0.13 0.12 0.11
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 1 0 2 1 0 3 12 25 0 0 0 0 1 2 1 0 2
Bud 0 0 5 0 0 1 – 1 1 7 3 5 0 3 8 0 0 0 9 4 2 1 5 6
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 1
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 4 4 – 12 5 11 5 6 2 1 2 0 3 7 0 0 0 0 0 0
Cytoplasm 174 128 82 70 95 128 – 118 105 100 97 97 93 120 126 108 139 172 126 96 105 56 128 152
Endoplasmic Reticulum 1 2 4 5 4 5 – 15 6 2 8 10 2 6 11 5 5 2 1 1 2 3 4 3
Endosome 0 0 0 1 4 1 – 0 1 1 0 0 6 6 6 0 0 0 3 1 2 2 1 2
Golgi 0 1 0 0 2 0 – 2 1 1 0 0 7 12 37 0 2 2 0 0 0 0 1 1
Mitochondria 2 3 13 20 12 45 – 61 78 83 65 88 1 3 0 1 2 1 1 1 1 5 2 2
Nucleus 22 11 12 3 1 1 – 13 10 14 25 28 1 4 1 0 0 3 137 66 34 21 35 53
Nuclear Periphery 0 0 0 0 0 1 – 2 2 1 0 1 0 0 1 0 0 0 2 0 2 0 1 2
Nucleolus 0 0 1 0 4 2 – 2 5 1 0 0 2 2 2 1 0 0 0 0 0 2 1 1
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 1 3 0 0 0 2 0 1 0 0 0
Vac/Vac Membrane 132 48 58 30 71 61 – 134 56 67 46 43 130 66 87 25 42 62 21 19 10 14 25 28
Unique Cell Count 282 169 154 112 172 228 311 235 243 220 250 218 205 260 128 174 229 313 198 177 113 214 266
Labelled Cell Count 331 193 175 130 197 249 361 270 290 250 278 247 237 309 140 193 249 313 198 177 113 214 266


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.9 16.3 9.4 12.1 12.9 11.5 – 11.5 10.8 11.4 11.6 11.2 14.6 14.5 14.7 18.9 19.8 19.5 13.6 15.9 16.2
Std Deviation (1e-4) 2.8 3.0 2.4 2.9 2.8 2.5 – 2.7 3.1 2.9 3.2 2.8 3.1 2.6 2.7 6.2 5.7 5.6 3.5 3.1 3.4
Intensity Change (Log2) – – – 0.36 0.45 0.29 – 0.29 0.19 0.27 0.29 0.24 0.63 0.61 0.64 1.0 1.07 1.04 0.53 0.75 0.77


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 3.1 4.0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.5 0.4 0.6 – -3.1 -1.7 -2.4 -1.7 -2.8 -2.0 1.0 -0.9 5.6 5.1 4.4
Endoplasmic Reticulum 0 0 0 – 1.1 0 0 0 0.7 0 0 0.9 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 3.1 4.9 0 0 0
Mitochondria 2.3 -0.5 3.0 – 3.1 5.6 5.8 4.9 6.0 -4.0 -3.2 0 -2.9 -3.2 -4.1
Nucleus -1.8 -3.3 -3.9 – -1.6 -1.5 -0.8 1.1 1.1 -3.8 -2.7 0 -3.2 -3.8 -3.2
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.9 0.7 -2.3 – 1.1 -2.9 -2.1 -3.6 -4.6 4.2 -1.1 -0.9 -3.3 -2.7 -2.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.2271 9.0697 8.024 7.8038 5.7876 7.7083 6.3655 8.7097 7.1507 6.5332 5.7903 7.6385 7.8377 10.3292 9.4229 8.0614 9.7947 9.4161
Actin 0.0195 0.0013 0.0009 0.0004 0.0293 0.0045 0.0244 0.0013 0.0142 0.0006 0.0012 0.0008 0.0192 0.0024 0.0279 0.0037 0.0018 0.0049
Bud 0.0019 0.0002 0.0004 0.0002 0.0008 0.0005 0.0016 0.0005 0.0011 0.0002 0.0007 0.0003 0.0013 0.0003 0.0007 0.0003 0.0001 0.0003
Bud Neck 0.0012 0.0004 0.0006 0.0008 0.0026 0.0024 0.0011 0.0003 0.0009 0.0011 0.0006 0.002 0.0012 0.0005 0.0007 0.0012 0.0005 0.002
Bud Periphery 0.002 0 0.0003 0 0.0006 0.0002 0.0009 0.0002 0.0008 0.0001 0.0015 0.0001 0.0009 0.0001 0.001 0.0001 0 0.0005
Bud Site 0.0096 0.0011 0.0007 0.0002 0.0018 0.0004 0.0038 0.0028 0.0025 0.0004 0.0004 0.0002 0.0157 0.002 0.0043 0.0003 0.0001 0.0012
Cell Periphery 0.0004 0 0.0001 0 0.0001 0.0001 0.0003 0 0.0001 0 0.0002 0 0.0002 0.0001 0.0002 0 0 0.0001
Cytoplasm 0.4844 0.811 0.7724 0.8037 0.5278 0.7463 0.4648 0.8038 0.7371 0.6812 0.7224 0.7255 0.6247 0.8248 0.7844 0.6378 0.7842 0.6256
Cytoplasmic Foci 0.0485 0.0076 0.0178 0.004 0.082 0.0103 0.0539 0.0092 0.024 0.0343 0.0065 0.0109 0.0396 0.0131 0.0174 0.0351 0.0142 0.0242
Eisosomes 0.0004 0 0 0 0.0002 0 0.0002 0 0.0001 0 0 0 0.0001 0 0.0003 0 0 0.0001
Endoplasmic Reticulum 0.0365 0.0023 0.0055 0.0042 0.0023 0.0084 0.0329 0.004 0.0073 0.0062 0.008 0.0078 0.0249 0.0037 0.0071 0.0046 0.0092 0.0149
Endosome 0.1624 0.0032 0.0248 0.0098 0.0573 0.0179 0.0818 0.0149 0.0364 0.016 0.0145 0.0264 0.0541 0.0028 0.01 0.0033 0.008 0.0281
Golgi 0.0185 0.0005 0.0047 0.0003 0.0785 0.0061 0.0149 0.0038 0.024 0.0007 0.0023 0.0026 0.0151 0.0005 0.0036 0.0011 0.0061 0.0035
Lipid Particles 0.0088 0 0.0014 0.0001 0.0047 0.0021 0.0132 0.0002 0.0032 0.0005 0.0001 0.0051 0.0075 0.0001 0.0019 0.0017 0.0093 0.0085
Mitochondria 0.0354 0.0003 0.005 0.0005 0.0877 0.027 0.0084 0.0018 0.0207 0.0005 0.0793 0.0014 0.0205 0.0003 0.0041 0.0004 0.0022 0.0049
None 0.0101 0.0022 0.0108 0.0011 0.0005 0.001 0.031 0.0016 0.0125 0.0036 0.0018 0.0017 0.0081 0.0018 0.002 0.0019 0.0009 0.0016
Nuclear Periphery 0.0441 0.0084 0.0109 0.0123 0.01 0.0189 0.0648 0.0109 0.0122 0.0136 0.015 0.0222 0.03 0.0101 0.0164 0.011 0.02 0.0383
Nucleolus 0.0012 0.0001 0.0002 0.0001 0.0001 0.0002 0.0013 0.0001 0.0001 0.0003 0.0001 0.0002 0.0004 0.0001 0.0004 0.0002 0 0.0005
Nucleus 0.0827 0.1583 0.1377 0.158 0.0976 0.1323 0.1662 0.1406 0.0928 0.229 0.1392 0.1797 0.112 0.1276 0.1087 0.2278 0.0802 0.224
Peroxisomes 0.0052 0.0004 0.0005 0.0001 0.0125 0.0134 0.0046 0.0002 0.004 0.0004 0.0002 0.0041 0.0122 0.0059 0.0046 0.0645 0.0595 0.0056
Punctate Nuclear 0.0097 0.0015 0.0017 0.0014 0.0006 0.002 0.019 0.0017 0.0013 0.0094 0.0013 0.0024 0.0078 0.0026 0.0022 0.0036 0.0024 0.0053
Vacuole 0.012 0.0009 0.0029 0.0024 0.0018 0.0046 0.0075 0.0017 0.0033 0.0017 0.0029 0.005 0.003 0.0009 0.0016 0.0011 0.0007 0.0041
Vacuole Periphery 0.0057 0.0002 0.0007 0.0006 0.0011 0.0012 0.0035 0.0004 0.0013 0.0004 0.002 0.0015 0.0015 0.0002 0.0007 0.0002 0.0003 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 53.6377 68.4983 50.8287 66.7758 49.674 53.608 71.8558 70.1173 48.8009 71.0875
Translational Efficiency 1.583 1.6718 1.9609 1.2679 1.6531 1.4893 1.4429 1.7266 2.1243 1.7503

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1413 1558 459 580 394 1954 2987 152 1807 3512 3446 732

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 936.83 1300.61 1431.40 1331.86 1017.30 1213.83 1449.39 1363.56 954.38 1252.33 1446.99 1338.44
Standard Deviation 219.55 218.79 257.95 259.44 217.31 196.65 233.64 260.32 221.57 211.21 237.10 259.94
Intensity Change Log 2 — 0.473329 0.611568 0.507583 — 0.254821 0.510701 0.422633 — 0.363711 0.559938 0.463984

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000996 0.000462 0.001988 0.002779 0.002810 0.000398 0.000358 0.006372 0.001392 0.000426 0.000575 0.003525
Bud Neck 0.005082 0.002797 0.005589 0.011376 0.013116 0.003483 0.002335 0.009946 0.006834 0.003179 0.002768 0.011079
Bud Site 0.009692 0.003022 0.012782 0.079462 0.038491 0.004584 0.005324 0.096069 0.015971 0.003891 0.006317 0.082910
Cell Periphery 0.000477 0.000101 0.000218 0.000266 0.000988 0.000085 0.000052 0.000778 0.000589 0.000092 0.000074 0.000372
Cytoplasm 0.455139* 0.480680* 0.595367* 0.375210* 0.316991* 0.578302* 0.780079* 0.261895* 0.425017* 0.534995* 0.755476* 0.351680*
Cytoplasmic Foci 0.020821 0.010097 0.030284 0.152557 0.024788 0.026626 0.024226 0.204354* 0.021686 0.019293 0.025033 0.163313
Eisosomes 0.000148 0.000008 0.000016 0.000030 0.000040 0.000011 0.000004 0.000031 0.000124 0.000010 0.000006 0.000031
Endoplasmic Reticulum 0.007701 0.003867 0.002909 0.002428 0.026210 0.003402 0.000526 0.000797 0.011737 0.003609 0.000844 0.002089
Endosome 0.001869 0.001219 0.004495 0.042620 0.003068 0.002036 0.002166 0.077028 0.002131 0.001673 0.002476 0.049765
Golgi 0.000899 0.000765 0.000709 0.012991 0.001518 0.000917 0.000913 0.006056 0.001034 0.000850 0.000886 0.011551
Lipid Particles 0.002045 0.000651 0.002063 0.007639 0.002143 0.000858 0.001601 0.010550 0.002066 0.000766 0.001662 0.008243
Mitochondria 0.001375 0.001000 0.000577 0.009824 0.011365 0.000914 0.000820 0.006367 0.003553 0.000952 0.000788 0.009106
Mitotic Spindle 0.003026 0.010705 0.034117 0.093891 0.006434 0.007171 0.034427 0.101782* 0.003769 0.008738 0.034386 0.095529
None 0.036858 0.006812 0.005200 0.000891 0.007672 0.006123 0.004359 0.000758 0.030495 0.006429 0.004471 0.000863
Nuclear Periphery 0.001135 0.001416 0.001695 0.000521 0.001167 0.001024 0.000589 0.002431 0.001142 0.001198 0.000736 0.000918
Nuclear Periphery Foci 0.007875 0.003999 0.006357 0.008394 0.005126 0.003706 0.002692 0.005478 0.007276 0.003836 0.003180 0.007788
Nucleolus 0.002325 0.000608 0.000387 0.001171 0.002322 0.000529 0.000324 0.000496 0.002324 0.000564 0.000333 0.001031
Nucleus 0.421283* 0.454942* 0.237236* 0.017491 0.503512* 0.338135* 0.113057 0.009216 0.439212* 0.389953* 0.129598 0.015772
Peroxisomes 0.000986 0.000187 0.000729 0.017931 0.001398 0.000854 0.000728 0.026795 0.001076 0.000558 0.000728 0.019772
Vacuole 0.018532 0.015862 0.055753 0.150987 0.017666 0.020371 0.024756 0.159301 0.018343 0.018371 0.028885 0.152714
Vacuole Periphery 0.001735 0.000799 0.001527 0.011541 0.013175 0.000472 0.000662 0.013498 0.004229 0.000617 0.000777 0.011948

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.32 -0.97 -2.71 -3.95 -0.81 7.72 7.67 -0.78 -2.13 -2.13 5.66 4.45 -2.42 -4.39 -4.11
Bud Neck 2.49 -2.63 -2.98 -4.65 -1.25 6.37 6.82 2.52 -4.23 -4.78 4.97 4.55 -2.00 -5.31 -5.02
Bud Site 5.56 -1.47 -10.15 -11.61 -9.23 8.07 7.79 -3.03 -6.37 -6.24 9.11 6.89 -10.21 -13.15 -12.52
Cell Periphery 4.92 2.36 3.40 -4.32 2.39 12.33 12.69 1.77 -1.40 -1.49 8.17 8.24 3.73 -2.81 -2.88
Cytoplasm -1.56 -4.23 4.02 5.22 6.81 -17.30 -29.81 1.57 12.15 19.20 -12.45 -35.24 4.16 12.60 27.16
Cytoplasmic Foci 6.26 -1.98 -15.81 -17.67 -14.31 -0.90 -1.00 -10.22 -10.16 -10.16 1.59 -2.77 -18.69 -19.34 -18.02
Eisosomes 2.63 2.39 2.32 -6.19 -1.13 7.17 9.02 2.43 -3.69 -5.46 2.76 2.85 2.40 -6.75 -8.50
Endoplasmic Reticulum 6.71 6.89 10.83 6.23 3.04 9.88 11.27 11.26 10.98 -0.03 11.97 16.92 15.05 7.77 -1.70
Endosome 2.64 -4.80 -11.88 -12.12 -10.69 2.00 1.71 -4.86 -4.96 -4.94 1.91 -1.67 -11.78 -11.92 -11.63
Golgi 0.61 1.65 -4.64 -4.70 -4.80 1.50 2.03 -2.15 -2.84 -3.03 1.04 1.78 -4.93 -5.07 -5.16
Lipid Particles 3.66 -1.80 -6.50 -8.50 -5.78 2.94 -0.64 -3.59 -4.28 -3.50 4.23 -1.32 -7.43 -9.41 -7.14
Mitochondria 1.24 3.39 -2.23 -2.41 -2.55 3.93 4.02 2.47 -1.29 -1.42 4.17 4.64 -1.02 -2.67 -2.83
Mitotic Spindle -3.88 -5.98 -10.30 -9.04 -5.47 -0.46 -10.10 -5.31 -5.28 -3.84 -4.05 -14.09 -11.46 -10.69 -6.85
None 7.92 8.54 9.54 10.44 10.56 1.29 2.72 5.32 10.13 11.42 8.07 8.80 9.97 15.02 19.90
Nuclear Periphery -1.59 -3.34 2.67 8.32 5.69 0.39 1.50 -0.29 -0.37 -0.58 -0.63 0.52 1.37 2.07 1.27
Nuclear Periphery Foci 4.22 1.05 0.30 -2.73 -0.47 0.90 1.26 -0.36 -1.21 -1.50 4.67 4.69 0.17 -3.12 -3.14
Nucleolus 5.21 7.35 4.34 -0.70 -1.80 1.94 2.08 2.08 0.91 0.09 5.88 6.84 4.68 -0.89 -1.96
Nucleus -3.62 11.06 47.16* 59.42* 23.14 9.91 24.02 31.08 48.37* 27.27 5.34 37.68 55.84 74.48* 37.95
Peroxisomes 1.86 0.65 -6.71 -7.32 -7.02 0.94 1.25 -4.95 -5.14 -5.19 1.34 0.90 -8.19 -8.67 -8.57
Vacuole -0.71 -10.79 -18.51 -18.31 -8.44 -3.76 -12.68 -10.36 -9.95 -8.92 -2.36 -14.90 -21.21 -20.79 -17.26
Vacuole Periphery 1.57 0.91 -3.65 -4.54 -4.19 3.91 3.89 1.16 -1.84 -1.82 4.26 4.26 -1.93 -4.89 -4.89
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
Localization
Cell Percentages cytoplasm (71%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-6

Lsm2

Lsm2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lsm2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available