Standard name
Human Ortholog
Description Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0.05 0 0 0 0.06 0 0 0 0 0 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.99 1.0 0.98 0.97 0.93 0.82 0.86 0.88 0.83 0.84 0.81 0.99 0.99 1.0 0.96 0.96 0.95 0.99 0.96 0.93 0.94 0.92 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0.05 0.08 0 0.05 0.09 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.11 0 0 0.08 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 2 1 1 2 2 2 2 8 0 0 0 0 0 1 0 0 0 0 0 0
Bud 1 0 0 0 0 1 1 1 0 0 2 2 0 2 0 0 0 0 0 3 0 3 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 6 2 4 1 5 12 15 6 5 2 15 4 9 9 4 10 16 0 0 0 0 0 0
Cytoplasm 320 646 123 197 249 213 237 266 126 167 145 189 182 497 527 216 277 334 308 628 123 233 258 342
Endoplasmic Reticulum 0 8 0 2 6 6 14 24 5 11 15 16 2 1 2 9 13 14 0 3 3 0 2 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Golgi 1 1 0 0 0 0 2 0 0 0 1 0 0 3 0 3 4 4 0 0 0 0 0 2
Mitochondria 0 0 0 0 0 0 0 3 5 1 11 4 0 0 0 0 0 3 0 0 0 0 0 1
Nucleus 2 0 0 0 0 1 2 4 1 3 0 4 0 0 0 0 0 0 0 2 2 2 0 2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 2
Nucleolus 0 0 0 1 0 1 1 0 0 0 0 0 0 1 0 3 7 8 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 2 1
Vac/Vac Membrane 0 0 0 0 2 6 33 7 5 17 2 15 1 1 1 4 4 6 0 6 1 1 4 4
Unique Cell Count 322 653 123 200 258 228 288 310 143 202 173 232 184 502 529 224 290 351 312 654 133 247 281 370
Labelled Cell Count 327 661 125 204 260 234 303 322 150 207 180 253 189 514 539 239 315 386 312 654 133 247 281 370


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 45.9 59.5 44.2 38.6 30.5 24.9 22.6 20.0 16.7 17.0 15.8 14.5 46.4 43.2 40.2 87.2 87.8 76.0 43.0 43.5 44.4
Std Deviation (1e-4) 9.5 10.6 8.7 10.5 7.4 6.0 5.4 5.1 4.1 3.9 4.1 2.9 11.9 10.3 9.4 23.9 21.2 21.6 10.8 12.0 11.7
Intensity Change (Log2) – – – -0.2 -0.54 -0.83 -0.97 -1.14 -1.41 -1.38 -1.48 -1.61 0.07 -0.03 -0.14 0.98 0.99 0.78 -0.04 -0.02 0.01

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100WT3HU80HU120HU160050100WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100WT1AF100AF140AF180050100
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 2.0 0 0 0 0 0 0
Cytoplasm -1.4 -2.1 -2.9 -5.0 -4.4 -4.0 -4.9 -4.7 -5.1 -1.2 -1.1 -0.7 -2.1 -2.4 -2.5
Endoplasmic Reticulum 0 0 0 0 3.2 0 0 3.4 3.0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 3.9 0 0 3.3 0 2.9 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 39.1525 49.145 45.273 40.6955 39.4884 45.4661 36.9681 49.11 46.5475 41.9554 42.0225 44.7478 39.7734 56.9943 49.3697 50.0311 42.6403 44.7178
Actin 0.0053 0.0002 0.0062 0.0004 0.0283 0.0004 0.0047 0.0001 0.0008 0.0002 0.0193 0.0003 0.052 0.0001 0.013 0 0.0027 0.0209
Bud 0.001 0.0001 0.0002 0.0003 0.0004 0.0002 0.0005 0 0.0001 0 0.0001 0.0001 0.0017 0 0.0002 0 0.0017 0.0004
Bud Neck 0.0009 0.0002 0.0003 0.0002 0.0007 0.0008 0.0004 0.0001 0.0013 0.0002 0.0007 0.0009 0.0011 0.0001 0.0012 0.0001 0.0003 0.0008
Bud Periphery 0.0008 0 0.0001 0.0004 0.0005 0.0001 0.0006 0 0.0001 0 0.0001 0.0001 0.0015 0 0.0001 0 0.0022 0.0003
Bud Site 0.0016 0.0002 0.0003 0.0003 0.0026 0 0.0003 0 0.0014 0 0.0004 0 0.0042 0 0.0006 0 0.001 0.0002
Cell Periphery 0.0007 0.0001 0.0002 0.0013 0.0003 0 0.0002 0 0.0001 0 0.0001 0 0.0005 0 0.0001 0 0.0007 0.0002
Cytoplasm 0.8753 0.9853 0.9469 0.9008 0.8103 0.9755 0.9075 0.9957 0.9671 0.9619 0.8984 0.9671 0.8293 0.9969 0.9424 0.9899 0.893 0.8749
Cytoplasmic Foci 0.0114 0.0013 0.0049 0.0032 0.0145 0.0007 0.0055 0.0002 0.0036 0.0011 0.006 0.0015 0.0097 0.0002 0.0088 0.0002 0.0065 0.0022
Eisosomes 0.0001 0 0.0001 0.0001 0.0006 0 0.0001 0 0 0 0.0001 0 0.0006 0 0.0002 0 0.0001 0.0004
Endoplasmic Reticulum 0.0073 0.0011 0.0016 0.0032 0.0036 0.0029 0.0037 0.0003 0.0011 0.0046 0.0064 0.0011 0.005 0.0005 0.0021 0.0001 0.0062 0.0021
Endosome 0.0165 0.0021 0.0058 0.0068 0.012 0.0007 0.0094 0.0002 0.0039 0.0018 0.0093 0.0012 0.0102 0 0.0039 0.0001 0.0107 0.0052
Golgi 0.0037 0.0013 0.0023 0.0004 0.0054 0 0.0014 0 0.0006 0.0001 0.002 0.0024 0.0043 0 0.001 0 0.0013 0.0027
Lipid Particles 0.0077 0.0002 0.0018 0.0021 0.0115 0 0.0055 0 0.0018 0.0003 0.0038 0.0009 0.009 0 0.0027 0 0.0036 0.0034
Mitochondria 0.0068 0.0004 0.0047 0.0058 0.0226 0.0002 0.0054 0 0.0003 0.0002 0.0006 0.0049 0.0103 0 0.0012 0 0.0256 0.0152
None 0.0044 0.0002 0.0048 0.0037 0.0057 0.0003 0.0022 0.0001 0.0008 0.0025 0.0055 0.0002 0.0044 0.0001 0.0065 0.0001 0.0046 0.0076
Nuclear Periphery 0.0121 0.0012 0.0048 0.0079 0.0377 0.0044 0.0214 0.0005 0.0025 0.0178 0.0165 0.0021 0.0096 0.0003 0.0025 0.0014 0.0082 0.0201
Nucleolus 0.0037 0.0001 0.0017 0.0022 0.0043 0.0001 0.0009 0 0.0008 0.0002 0.0003 0 0.0022 0 0.0015 0 0.0023 0.0028
Nucleus 0.0183 0.0037 0.0067 0.0126 0.0195 0.0114 0.0189 0.0024 0.0102 0.0051 0.0166 0.012 0.0243 0.0016 0.0057 0.0077 0.0133 0.0256
Peroxisomes 0.0017 0.0001 0.0009 0.0002 0.0039 0 0.0017 0 0.0003 0 0.0007 0.0045 0.0072 0 0.0007 0 0.0008 0.001
Punctate Nuclear 0.0027 0.0001 0.0011 0.0015 0.009 0.0008 0.002 0 0.0023 0.0016 0.0116 0.0001 0.0044 0 0.0037 0.0001 0.0016 0.0039
Vacuole 0.0137 0.0014 0.0032 0.031 0.0033 0.0012 0.0051 0.0002 0.0009 0.0012 0.0009 0.0005 0.006 0.0001 0.0012 0.0002 0.01 0.0048
Vacuole Periphery 0.0043 0.0008 0.0014 0.0155 0.0032 0.0003 0.0027 0 0.0002 0.0013 0.0005 0.0002 0.0024 0 0.0007 0.0001 0.0037 0.005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 246.3636 273.2375 238.9301 172.2261 221.5804 132.462 161.9218 126.5013 108.439 168.3006
Translational Efficiency 1.428 1.3722 1.2206 1.3122 1.2309 1.5297 1.3677 1.1625 1.0829 1.1662

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
791 1027 173 173 1482 2009 1145 748 2273 3036 1318 921

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 2189.63 2836.07 4047.79 4924.97 2895.64 2948.60 4469.70 4881.51 2649.95 2910.53 4414.32 4889.67
Standard Deviation 394.68 747.35 743.20 1217.50 586.73 641.65 854.92 1055.76 625.91 681.34 853.08 1088.11
Intensity Change Log 2 — 0.373206 0.886447 1.169428 — 0.026148 0.626296 0.753445 — 0.185910 0.744104 0.947411

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000114 0.000175 0.000336 0.000375 0.000113 0.000119 0.000133 0.001251 0.000114 0.000138 0.000160 0.001087
Bud Neck 0.000207 0.000762 0.007333 0.020341 0.000671 0.000587 0.001812 0.004028 0.000509 0.000646 0.002537 0.007092
Bud Site 0.001738 0.002992 0.002918 0.039346 0.002538 0.003756 0.004740 0.014676 0.002260 0.003498 0.004500 0.019310
Cell Periphery 0.000713 0.000690 0.007728 0.002379 0.000780 0.000312 0.002235 0.004435 0.000757 0.000439 0.002956 0.004049
Cytoplasm 0.942465 0.900890 0.670783 0.592071 0.908324 0.913673 0.831480 0.813709 0.920205 0.909349 0.810387 0.772076
Cytoplasmic Foci 0.007388 0.008623 0.034943 0.088721 0.008231 0.008778 0.017470 0.017752 0.007938 0.008725 0.019764 0.031083
Eisosomes 0.000001 0.000001 0.000007 0.000059 0.000001 0.000001 0.000002 0.000012 0.000001 0.000001 0.000003 0.000021
Endoplasmic Reticulum 0.000634 0.000151 0.000085 0.001978 0.000217 0.000114 0.000046 0.000084 0.000362 0.000127 0.000051 0.000440
Endosome 0.000412 0.000470 0.000784 0.008853 0.000453 0.000592 0.000212 0.001508 0.000439 0.000550 0.000287 0.002888
Golgi 0.010507 0.005412 0.009656 0.011095 0.010025 0.003458 0.002581 0.002181 0.010193 0.004119 0.003509 0.003856
Lipid Particles 0.000916 0.002586 0.012207 0.011065 0.003183 0.001430 0.005558 0.009637 0.002394 0.001821 0.006431 0.009905
Mitochondria 0.000116 0.000299 0.000224 0.001098 0.000092 0.000157 0.000120 0.002336 0.000100 0.000205 0.000134 0.002103
Mitotic Spindle 0.001159 0.001027 0.002403 0.027807 0.002011 0.002958 0.002675 0.004625 0.001715 0.002305 0.002640 0.008980
None 0.003610 0.006982 0.003622 0.001926 0.005480 0.005992 0.004129 0.005028 0.004829 0.006327 0.004063 0.004445
Nuclear Periphery 0.000306 0.000123 0.001371 0.001343 0.000159 0.000094 0.000358 0.000319 0.000210 0.000104 0.000491 0.000511
Nuclear Periphery Foci 0.004591 0.005083 0.008997 0.015595 0.006182 0.002875 0.003488 0.003622 0.005628 0.003622 0.004211 0.005871
Nucleolus 0.000040 0.000115 0.000178 0.001923 0.000058 0.000102 0.000113 0.000627 0.000052 0.000106 0.000122 0.000870
Nucleus 0.014977 0.049624 0.160149 0.036737 0.037514 0.042671 0.085339 0.058277 0.029671 0.045023 0.095158 0.054231
Peroxisomes 0.000010 0.000040 0.000019 0.004714 0.000019 0.000038 0.000059 0.001048 0.000016 0.000039 0.000054 0.001737
Vacuole 0.003976 0.011589 0.073675 0.122996 0.010905 0.010746 0.036196 0.052102 0.008494 0.011031 0.041115 0.065419
Vacuole Periphery 0.006122 0.002366 0.002579 0.009579 0.003043 0.001549 0.001254 0.002742 0.004115 0.001826 0.001427 0.004026

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.41 -6.16 -3.35 -1.82 2.27 -0.21 -4.51 -2.07 -2.06 -1.83 -1.64 -6.95 -2.21 -2.10 -1.77
Bud Neck -6.57 -7.12 -4.73 -4.48 -1.14 0.28 -10.12 -6.33 -6.40 -1.81 -2.76 -12.60 -7.76 -7.46 -2.56
Bud Site -2.64 -3.76 -3.41 -3.15 -3.11 -1.61 -3.39 -4.93 -4.36 -3.21 -2.53 -4.01 -6.07 -5.42 -4.24
Cell Periphery -0.23 -9.32 -4.56 -5.41 7.23 5.16 -7.89 -8.59 -9.97 -3.57 2.99 -10.92 -9.26 -10.49 -1.24
Cytoplasm 8.47 17.37 15.09 12.99 1.36 -0.35 17.78 14.82 15.60 0.24 4.38 24.24 20.69 19.16 1.75
Cytoplasmic Foci -1.82 -8.21 -3.89 -3.70 -0.96 -0.44 -5.20 -3.84 -3.76 0.17 -1.26 -7.37 -5.53 -5.24 -0.72
Eisosomes -3.89 -6.91 -2.53 -2.47 -1.73 0.83 -7.16 -3.35 -3.39 -2.23 -1.80 -9.82 -4.14 -4.08 -2.89
Endoplasmic Reticulum 1.26 1.36 -0.27 -1.17 -1.24 3.06 5.45 4.57 2.22 -0.92 1.75 2.25 0.90 -0.75 -1.37
Endosome -0.79 -3.70 -1.80 -1.75 -1.47 -1.32 2.61 -1.35 -0.98 -1.72 -1.55 0.59 -2.26 -1.99 -2.32
Golgi 2.99 0.14 1.80 -0.35 1.94 5.72 6.65 7.32 3.33 2.76 6.37 7.08 7.67 2.62 2.19
Lipid Particles -5.14 -6.38 -6.79 -5.60 0.66 2.98 -5.61 -6.60 -8.21 -2.90 0.83 -8.78 -8.87 -9.41 -2.70
Mitochondria -0.98 -2.32 -2.28 -1.30 -1.70 -2.03 -3.97 -2.11 -2.01 -2.00 -1.61 -3.09 -2.28 -2.08 -2.14
Mitotic Spindle 0.24 -1.21 -2.34 -2.37 -2.09 -1.51 -2.63 -1.38 -0.44 0.76 -1.36 -2.99 -2.73 -2.21 -0.71
None -3.39 0.81 2.77 4.99 2.48 -0.53 2.77 1.77 2.65 -0.64 -2.43 2.51 1.98 4.31 0.05
Nuclear Periphery 0.67 -5.17 -2.21 -3.48 2.38 1.82 -6.37 -3.39 -4.81 2.84 1.10 -5.30 -2.69 -5.66 2.89
Nuclear Periphery Foci -1.05 -4.15 -1.56 -1.30 0.03 5.57 2.81 3.11 -2.65 0.23 3.43 0.50 0.07 -1.95 -0.25
Nucleolus -3.51 -8.94 -2.26 -2.09 -1.88 -4.49 -7.05 -2.60 -2.33 -2.07 -5.65 -9.28 -3.41 -3.06 -2.75
Nucleus -14.38 -15.37 -7.22 -0.19 10.12 -2.85 -16.97 -8.39 -6.88 6.71 -9.79 -23.37 -11.69 -6.22 9.96
Peroxisomes -2.57 -4.13 -1.74 -1.72 -1.73 -2.32 -2.86 -2.31 -2.24 -2.16 -3.40 -3.36 -2.89 -2.81 -2.75
Vacuole -6.72 -8.46 -11.21 -10.62 -5.01 -0.80 -13.22 -13.51 -13.40 -3.02 -3.93 -16.22 -17.07 -16.30 -5.76
Vacuole Periphery 2.17 2.07 0.21 -1.89 -1.77 2.64 3.47 1.24 -0.49 -0.89 3.22 3.93 1.56 -1.14 -1.71
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Major CTP synthase isozyme (see also URA8); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA7 has a paralog, URA8, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Ura7

Ura7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ura7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available