Standard name
Human Ortholog
Description Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.18 0.37 0.54 0.65 0.64 0.71 0.79 – 0.82 0.86 0.85 0.84 0.79 0.9 0.97 0.21 0.13 0.19 0 0 0 0.08 0.06 0.08
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.06 0.05 0 0 0 0 0 0
Endosome 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0.05
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.11 0.1 0 0 0 0.08 0 – 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.11 0.08 0.06 0.05 0 0.1 0 – 0 0 0 0 0 0 0 0.42 0.39 0.35 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.78 0.67 0.58 0.59 0.6 0.32 0.4 – 0.28 0.22 0.21 0.22 0.3 0.12 0.05 0.49 0.6 0.61 0.89 0.87 0.89 0.85 0.82 0.7
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3
Bud 0 1 0 0 1 4 0 – 5 2 6 3 0 0 0 0 0 0 3 7 1 1 2 7
Bud Neck 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 67 237 119 140 150 179 321 – 380 446 410 406 130 244 280 58 39 44 5 24 9 20 18 24
Endoplasmic Reticulum 3 2 2 1 0 0 0 – 1 0 0 1 1 1 0 15 18 11 0 2 1 2 2 4
Endosome 19 11 9 3 7 0 5 – 2 4 2 5 3 6 2 5 14 5 16 20 3 4 10 13
Golgi 4 0 0 1 1 0 0 – 0 0 0 0 0 0 0 0 2 0 3 4 1 0 0 1
Mitochondria 41 61 2 3 0 19 5 – 14 18 18 40 1 0 0 10 6 10 5 9 3 2 10 10
Nucleus 42 49 14 11 9 24 10 – 10 9 4 3 0 0 0 117 115 82 2 7 0 1 0 5
Nuclear Periphery 1 3 0 1 0 1 0 – 2 0 1 2 0 1 0 0 0 1 1 1 0 1 1 5
Nucleolus 0 0 0 0 0 0 0 – 1 1 0 1 0 0 0 0 1 2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 1 0 0 0 0 0 – 0 0 1 1 0 1 0 0 1 1 3 3 1 0 2 4
Vac/Vac Membrane 285 430 128 126 142 80 161 – 130 115 103 105 50 33 15 137 180 141 344 598 221 209 242 205
Unique Cell Count 366 639 220 214 235 252 404 466 517 483 485 165 272 288 281 298 231 389 685 250 247 295 293
Labelled Cell Count 462 795 274 286 310 307 503 545 595 546 569 185 286 297 342 376 297 389 685 250 247 295 293


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.1 4.7 5.8 5.8 7.4 4.7 5.7 – 4.9 5.0 4.9 4.8 5.3 5.2 5.4 7.5 8.2 7.0 4.7 5.0 5.6
Std Deviation (1e-4) 1.1 1.0 1.6 1.3 6.4 1.7 1.7 – 1.4 1.4 1.2 1.0 1.5 2.0 1.9 2.1 2.3 1.9 1.3 1.7 2.4
Intensity Change (Log2) – – – 0.0 0.35 -0.3 -0.03 – -0.23 -0.21 -0.23 -0.25 -0.14 -0.15 -0.11 0.39 0.51 0.27 -0.31 -0.22 -0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -2.1 0.5 0.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.2182 1.269 0.9773 0.5163 0.5387 1.1376 1.7956 3.6024 2.7615 2.3774 2.4512 2.7989 3.6608 5.5461 4.7124 5.0208 4.8643 5.2253
Actin 0.0064 0 0.02 0 0.0001 0.0014 0.0069 0 0 0 0 0.0015 0 0 0.0001 0 0 0
Bud 0.0005 0.0004 0.0006 0.0004 0.0004 0.0006 0.0003 0.0004 0.0004 0.0003 0.0004 0.0004 0.0002 0.0003 0.0003 0.0002 0.0002 0.0002
Bud Neck 0.0008 0.001 0.0024 0.0008 0.0007 0.002 0.0009 0.0015 0.0014 0.0005 0.0012 0.0019 0.0005 0.0007 0.0043 0.0006 0.0011 0.0009
Bud Periphery 0.001 0.0008 0.0014 0.0006 0.001 0.0015 0.0009 0.001 0.001 0.0007 0.0012 0.0012 0.0006 0.0009 0.0009 0.0005 0.0009 0.0007
Bud Site 0.0011 0.0015 0.0025 0.004 0.0007 0.0014 0.0006 0.0013 0.0014 0.0005 0.001 0.001 0.0005 0.0006 0.0016 0.0004 0.0004 0.0005
Cell Periphery 0.0011 0.0022 0.0019 0.0012 0.0009 0.0029 0.0013 0.0023 0.0016 0.0007 0.0025 0.0022 0.0018 0.0023 0.0018 0.0016 0.0037 0.0024
Cytoplasm 0.0155 0.0096 0.0106 0.0085 0.0023 0.0044 0.0044 0.0043 0.0056 0.0011 0.0016 0.0033 0.0111 0.0053 0.0036 0.0022 0.001 0.0036
Cytoplasmic Foci 0.0261 0.005 0.0092 0.0111 0.0028 0.002 0.0086 0.0068 0.0065 0.0051 0.0037 0.0068 0.0059 0.0103 0.0065 0.0047 0.0005 0.0034
Eisosomes 0.0001 0 0.0003 0 0 0 0.0002 0 0 0 0 0 0.0001 0.0001 0 0 0 0
Endoplasmic Reticulum 0.0083 0.0027 0.0068 0.0021 0.0038 0.0032 0.0023 0.0032 0.0029 0.0007 0.0014 0.0022 0.0032 0.0022 0.0034 0.0009 0.0016 0.0017
Endosome 0.2472 0.1563 0.2272 0.3802 0.2285 0.1132 0.2416 0.1303 0.2177 0.2109 0.1524 0.1973 0.2312 0.1357 0.2085 0.1173 0.0763 0.1146
Golgi 0.0077 0.0022 0.0188 0.0061 0.0046 0.0028 0.0072 0.0029 0.0064 0.0072 0.0025 0.0045 0.0048 0.0025 0.0075 0.0013 0.0011 0.0022
Lipid Particles 0.0163 0.0036 0.0267 0.0079 0.0136 0.0031 0.0163 0.0048 0.0115 0.0043 0.0072 0.0112 0.0109 0.0221 0.0201 0.0059 0.0018 0.0101
Mitochondria 0.0065 0.0023 0.0267 0.0024 0.004 0.0035 0.018 0.0118 0.0302 0.0069 0.0042 0.0125 0.0052 0.0123 0.0136 0.002 0.0007 0.0176
None 0.035 0.0005 0.0268 0.0006 0.0002 0.001 0.0092 0.0085 0.0014 0.0001 0.0002 0.0006 0.0149 0.0209 0.0016 0.0161 0 0.0024
Nuclear Periphery 0.0172 0.008 0.0354 0.0025 0.0289 0.0178 0.0071 0.0064 0.0091 0.0015 0.0026 0.0062 0.008 0.0035 0.0055 0.0022 0.0029 0.0037
Nucleolus 0.0021 0.0033 0.0071 0.0031 0.0018 0.0037 0.0032 0.0047 0.0036 0.0013 0.0029 0.0036 0.0031 0.0026 0.0028 0.0025 0.0023 0.0038
Nucleus 0.017 0.0085 0.0141 0.0039 0.0031 0.0148 0.0064 0.0042 0.0055 0.0021 0.0037 0.004 0.0052 0.0023 0.002 0.0021 0.0031 0.0031
Peroxisomes 0.0047 0.0002 0.0025 0.0011 0.0005 0.0005 0.0043 0.0008 0.0011 0.0009 0.0005 0.0015 0.0004 0.0009 0.0024 0.0005 0.0002 0.0003
Punctate Nuclear 0.0054 0.0001 0.0025 0.0002 0.0005 0.0044 0.0006 0.0001 0.0009 0 0 0.0005 0.0005 0.0004 0.0002 0.0003 0 0.0001
Vacuole 0.4345 0.6344 0.428 0.4788 0.5957 0.6289 0.4919 0.6301 0.52 0.5952 0.6581 0.559 0.5368 0.6083 0.5533 0.6698 0.7564 0.6289
Vacuole Periphery 0.1454 0.1572 0.1286 0.0843 0.1059 0.1867 0.1677 0.1747 0.1718 0.16 0.1527 0.1784 0.155 0.1658 0.16 0.1691 0.1457 0.1997

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 27.0442 37.0697 16.7436 28.0224 24.5448 28.8312 34.6293 41.2455 39.3278 36.712
Translational Efficiency 2.1412 1.625 2.3275 1.566 1.6031 2.2085 2.0878 1.2791 1.4894 1.3785

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1975 1006 2194 1524 1444 2430 519 1158 3419 3436 2713 2682

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 741.98 753.63 825.15 788.91 659.02 802.78 875.37 819.33 706.94 788.39 834.76 802.04
Standard Deviation 92.65 99.16 98.46 108.07 85.11 98.57 96.77 115.36 98.47 101.25 100.11 112.29
Intensity Change Log 2 — 0.022476 0.153276 0.088480 — 0.284682 0.409571 0.314122 — 0.151765 0.279519 0.199026

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000024 0.000068 0.000168 0.000293 0.000030 0.000088 0.000217 0.000602 0.000027 0.000082 0.000177 0.000427
Bud Neck 0.015572 0.024650 0.033885 0.029245 0.022489 0.019089 0.028128 0.031482 0.018493 0.020717 0.032784 0.030211
Bud Site 0.006700 0.021784 0.013733 0.032827 0.007344 0.014654 0.019472 0.044163 0.006972 0.016742 0.014831 0.037722
Cell Periphery 0.000347 0.000273 0.000061 0.000077 0.000128 0.000294 0.000108 0.000069 0.000254 0.000288 0.000070 0.000073
Cytoplasm 0.039305 0.122705 0.353641 0.153670 0.164468 0.047097 0.190900 0.235775 0.092167 0.069234 0.322508 0.189120
Cytoplasmic Foci 0.018002 0.059074 0.034986 0.060270 0.056154 0.019262 0.064988 0.080133 0.034116 0.030918 0.040725 0.068846
Eisosomes 0.000020 0.000029 0.000029 0.000027 0.000037 0.000023 0.000069 0.000030 0.000028 0.000025 0.000036 0.000028
Endoplasmic Reticulum 0.001676 0.001324 0.003059 0.001336 0.001295 0.002728 0.003466 0.000871 0.001515 0.002317 0.003137 0.001135
Endosome 0.052790 0.091796 0.049304 0.175745 0.069722 0.062667 0.128042 0.143690 0.059941 0.071195 0.064367 0.161905
Golgi 0.000881 0.001636 0.000452 0.003469 0.000832 0.001580 0.000503 0.005804 0.000860 0.001597 0.000462 0.004477
Lipid Particles 0.001270 0.001514 0.003389 0.002815 0.003058 0.001247 0.004625 0.002202 0.002025 0.001325 0.003626 0.002551
Mitochondria 0.002073 0.001723 0.001784 0.002247 0.001437 0.002201 0.000611 0.005528 0.001804 0.002061 0.001559 0.003664
Mitotic Spindle 0.000193 0.000408 0.020462 0.019444 0.001719 0.001499 0.006594 0.043774 0.000837 0.001179 0.017809 0.029949
None 0.000104 0.000876 0.002698 0.001010 0.000897 0.000732 0.001378 0.001251 0.000439 0.000774 0.002446 0.001114
Nuclear Periphery 0.000160 0.000151 0.005960 0.001182 0.000320 0.000172 0.002660 0.001130 0.000227 0.000166 0.005329 0.001160
Nuclear Periphery Foci 0.000079 0.000202 0.003160 0.002600 0.000221 0.000067 0.006365 0.001543 0.000139 0.000107 0.003773 0.002144
Nucleolus 0.000446 0.001128 0.005050 0.002253 0.001150 0.000844 0.007295 0.002443 0.000743 0.000927 0.005479 0.002335
Nucleus 0.006585 0.012699 0.243833 0.029756 0.026383 0.012904 0.122398 0.038358 0.014947 0.012844 0.220603 0.033470
Peroxisomes 0.000976 0.002823 0.003445 0.010780 0.002741 0.001317 0.007151 0.016175 0.001722 0.001758 0.004154 0.013109
Vacuole 0.840691 0.636970 0.218689 0.463677 0.631650 0.793177 0.402434 0.339832 0.752404 0.747443 0.253839 0.410205
Vacuole Periphery 0.012106 0.018165 0.002213 0.007276 0.007925 0.018359 0.002598 0.005144 0.010340 0.018302 0.002287 0.006356

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.56 -10.63 -4.03 -3.23 -1.12 -1.25 -11.03 -2.76 -2.48 -1.83 -1.72 -13.38 -3.91 -3.26 -2.20
Bud Neck -3.64 -9.58 -6.08 -1.25 3.57 1.63 -1.82 -2.26 -3.88 0.11 -1.54 -8.92 -6.00 -4.42 3.51
Bud Site -8.43 -3.67 -8.92 -1.70 -6.37 -5.22 -3.27 -8.37 -5.47 -4.12 -8.72 -4.77 -12.22 -5.96 -8.30
Cell Periphery 1.78 10.96 10.60 6.05 -0.83 -7.35 2.04 6.87 11.27 5.19 -1.42 11.71 12.00 12.57 1.61
Cytoplasm -12.57 -45.35 -21.83 -6.67 16.92 18.51 -2.95 -9.89 -25.73 -5.05 5.74 -34.63 -21.39 -26.48 11.34
Cytoplasmic Foci -11.29 -8.14 -14.40 0.69 -8.37 13.11 0.06 -1.46 -13.08 -1.33 1.76 -2.13 -10.62 -12.36 -9.06
Eisosomes -3.11 -6.53 -4.17 0.41 2.84 3.84 -7.21 1.94 -2.70 8.51 1.04 -7.18 -1.78 -2.11 6.23
Endoplasmic Reticulum 1.74 -9.46 1.85 0.00 15.50 -6.08 -9.01 1.49 7.74 10.24 -4.35 -13.95 2.36 7.01 19.61
Endosome -8.06 4.40 -13.80 -6.19 -16.24 1.90 -3.16 -3.39 -4.81 0.54 -4.07 3.61 -13.06 -10.09 -14.77
Golgi -2.41 2.44 -2.22 -1.17 -3.13 -2.51 2.83 -2.62 -1.71 -3.17 -3.07 3.54 -3.41 -2.02 -4.49
Lipid Particles -1.18 -6.98 -6.30 -5.51 0.96 5.55 -3.31 2.30 -4.73 5.81 3.58 -6.01 -3.53 -7.18 3.20
Mitochondria 0.44 0.29 0.25 -0.26 -0.00 -1.82 2.38 -2.07 -1.27 -3.13 -0.56 0.40 -1.23 -0.93 -1.99
Mitotic Spindle -1.14 -11.58 -8.05 -7.91 0.70 0.56 -2.88 -8.52 -8.79 -5.18 -0.57 -11.44 -11.70 -11.65 -2.29
None -1.35 -19.77 -2.94 -0.37 4.28 0.55 -1.90 -1.71 -2.65 0.72 -1.40 -13.17 -3.45 -1.53 5.31
Nuclear Periphery 0.21 -23.92 -11.63 -11.88 18.28 4.13 -9.81 -10.11 -11.27 4.91 2.49 -25.31 -15.41 -16.29 18.74
Nuclear Periphery Foci -5.68 -8.01 -4.93 -4.73 1.73 6.00 -6.37 -4.48 -4.92 4.74 2.16 -9.90 -6.30 -6.38 4.05
Nucleolus -2.38 -14.08 -8.05 -3.89 8.95 2.26 -6.03 -5.07 -6.90 4.60 -0.97 -14.85 -9.46 -8.24 10.18
Nucleus -3.65 -46.26 -14.43 -10.28 37.06 6.90 -13.55 -9.77 -14.33 8.85 1.74 -46.06 -16.73 -17.69 36.19
Peroxisomes -5.09 -5.59 -9.57 -6.88 -6.70 2.28 -2.76 -5.68 -7.58 -3.48 0.05 -4.17 -10.33 -10.95 -8.02
Vacuole 18.56 80.36 38.92 12.61 -25.26 -16.95 15.00 20.19 39.92 1.35 0.60 67.73 40.91 40.46 -21.60
Vacuole Periphery -4.87 18.28 8.61 10.47 -6.43 -11.06 11.13 8.13 17.38 -2.67 -10.44 21.52 11.53 18.74 -7.14
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (96%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Grx7

Grx7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available