Standard name
Human Ortholog
Description Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.08 0.06 0 0.05 0.06
Bud 0 0 0 0 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.12 0.16 0.19 0.22 0.32 0.19 0.09 0.09 0.06 0.06 0.05 0 0.13 0.15 0.17 0.06 0.11 0.09 0 0 0 0 0.05 0.06
Endoplasmic Reticulum 0 0.12 0 0 0 0 0 0 0 0 0 0 0.15 0.13 0.05 0 0 0 0 0 0 0 0 0
Endosome 0.42 0.35 0.29 0.38 0.26 0 0 0 0 0 0 0 0.45 0.43 0.54 0.64 0.5 0.51 0.53 0.39 0.38 0.31 0.33 0.31
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.08 0.07 0.06 0.07 0 0.05 0 0.05
Mitochondria 0.31 0.31 0.33 0.33 0.46 0.78 0.87 0.85 0.89 0.87 0.89 0.92 0 0 0 0.19 0.1 0.09 0.12 0.22 0.15 0.26 0.25 0.26
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.11 0.11 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.1 0.12 0 0 0 0 0 0
Peroxisomes 0 0 0.22 0.25 0.08 0 0 0 0 0 0 0 0.06 0.1 0.05 0.08 0.12 0.22 0.09 0.11 0.22 0.16 0.14 0.09
SpindlePole 0.1 0.08 0.18 0.2 0.07 0 0 0.05 0 0 0 0 0.33 0.25 0.23 0.19 0.17 0.16 0 0 0.06 0 0 0.05
Vac/Vac Membrane 0.13 0.1 0 0 0 0 0.06 0.08 0.09 0.12 0.13 0.1 0 0.06 0.08 0.07 0.1 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 8 4 0 0 0 0 0 0 0 0 0 2 8 3 1 2 0 18 42 23 9 20 21
Bud 2 7 11 12 26 35 26 35 20 23 20 23 0 1 1 0 0 0 1 1 2 2 3 6
Bud Neck 0 0 2 0 2 1 0 0 0 0 0 0 1 2 2 0 0 0 0 1 2 1 3 2
Bud Site 0 0 0 0 0 4 2 4 5 6 5 7 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 1 0 0 2 0 1 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0
Cytoplasm 40 61 59 60 129 132 79 81 47 53 38 31 22 24 29 13 22 19 16 12 7 10 17 21
Endoplasmic Reticulum 14 46 6 2 1 10 13 3 9 5 6 4 25 21 8 1 9 5 6 6 8 6 4 9
Endosome 138 133 89 102 103 29 26 37 13 37 11 7 73 71 91 131 100 109 248 214 159 82 125 114
Golgi 0 3 2 0 0 0 0 0 0 0 0 0 0 1 0 19 16 14 28 36 17 13 15 17
Mitochondria 101 119 101 89 184 549 765 766 690 729 667 786 6 5 2 40 21 20 55 121 63 69 96 95
Nucleus 4 0 1 0 1 7 9 12 16 16 12 17 1 0 1 0 0 1 0 0 0 0 0 0
Nuclear Periphery 2 1 0 0 0 3 12 1 23 14 10 15 1 1 0 14 23 23 6 5 4 2 1 1
Nucleolus 19 0 1 1 3 3 8 30 18 13 26 30 1 1 0 26 20 26 1 0 0 0 2 0
Peroxisomes 10 16 69 66 31 13 17 8 13 10 3 5 10 16 8 16 24 48 43 61 90 42 52 32
SpindlePole 33 29 54 55 28 27 30 41 18 30 19 13 54 41 39 40 34 34 20 21 24 11 14 18
Vac/Vac Membrane 42 39 6 1 18 31 56 71 73 104 95 85 4 10 14 15 21 14 13 11 3 9 16 16
Unique Cell Count 327 380 308 269 401 708 884 903 777 840 752 856 163 165 170 206 202 214 471 546 416 267 380 366
Labelled Cell Count 405 463 406 388 526 846 1043 1090 945 1040 912 1023 200 204 198 316 292 313 471 546 416 267 380 366


Lipid Particles

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 5.0 4.4 4.4 3.9 4.0 3.6 4.0 3.9 4.2 4.2 4.2 5.7 5.5 5.5 8.0 7.7 7.7 6.3 6.2 6.1
Std Deviation (1e-4) 1.0 0.8 1.3 1.6 1.4 1.4 1.2 1.4 1.1 1.2 1.1 1.0 1.0 1.0 0.9 1.4 1.4 1.4 1.8 1.4 1.8
Intensity Change (Log2) – – – -0.02 -0.17 -0.14 -0.28 -0.15 -0.18 -0.09 -0.07 -0.06 0.37 0.31 0.33 0.85 0.79 0.81 0.51 0.49 0.47

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.9 3.9 -0.2 -4.8 -4.8 -6.6 -6.5 -7.2 -8.8 -1.5 -1.3 -0.6 -4.1 -2.5 -3.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 5.6 4.8 0 0 1.6 0
Endosome 0 0 0 0 0 0 0 0 0 3.5 3.1 5.3 7.8 4.7 5.1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 4.8 4.4 3.8
Mitochondria 0 0 0 0 0 0 0 0 0 -7.2 -7.4 -8.0 -3.3 -5.8 -6.2
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 4.6 6.1 5.9
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 6.1 5.3 6.0
Peroxisomes 0 0 0 0 0 0 0 0 0 -4.5 -3.4 -5.0 -4.4 -3.0 0
SpindlePole 0 0 0 0 0 0 0 0 0 3.8 1.9 1.4 0.5 -0.2 -0.5
Vacuole 0 1.9 1.9 3.0 3.7 4.3 5.3 5.4 4.5 0 2.4 3.3 3.0 4.2 2.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8688 1.6533 1.2092 0.9963 1.0191 1.2987 3.3872 4.0266 3.9272 3.8636 3.311 3.9249 1.1306 2.1475 1.6064 1.1833 1.384 1.6448
Actin 0.0173 0.0024 0.013 0.0038 0.0019 0.0078 0.0208 0.0013 0.0279 0.0004 0.0011 0.004 0.0003 0.0006 0.0003 0.0001 0.0001 0.0001
Bud 0.0003 0.0009 0.0011 0.0002 0.0001 0.0001 0.0003 0.0001 0.0004 0 0.0001 0 0 0 0 0 0 0
Bud Neck 0.0007 0.0011 0.0005 0.0002 0.0003 0.0005 0.0026 0.0004 0.0002 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001 0.0008
Bud Periphery 0.0004 0.0005 0.0005 0.0002 0.0002 0.0002 0.0004 0.0002 0.0004 0 0.0001 0.0001 0 0.0001 0 0.0001 0.0001 0
Bud Site 0.0042 0.0109 0.0009 0.0002 0.0004 0.0004 0.0026 0.0006 0.0037 0.0001 0.0003 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001
Cell Periphery 0.0002 0.0007 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0 0 0.0001 0 0.0001 0 0
Cytoplasm 0.0082 0.0035 0.0102 0.0019 0.0004 0.0045 0.0017 0.0013 0.001 0.0002 0.001 0.0011 0.0003 0.0004 0.0007 0.0009 0.0019 0.0001
Cytoplasmic Foci 0.0951 0.1036 0.0691 0.0964 0.0698 0.0746 0.0638 0.0757 0.0697 0.0413 0.0583 0.0473 0.0564 0.0574 0.0567 0.0638 0.045 0.043
Eisosomes 0.0005 0.0001 0.0002 0.0001 0 0.0001 0.0002 0 0.0001 0 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0015 0.0014 0.0007 0.0005 0.0003 0.0008 0.0017 0.0008 0.001 0.0002 0.0004 0.0006 0.0002 0.0003 0.0005 0.0002 0.0002 0.0001
Endosome 0.0827 0.1351 0.0781 0.0559 0.1033 0.06 0.0822 0.0854 0.0889 0.0703 0.0739 0.0272 0.054 0.085 0.0461 0.0659 0.0509 0.024
Golgi 0.0451 0.0568 0.0576 0.0467 0.1107 0.0568 0.0477 0.0541 0.0673 0.0863 0.0492 0.0311 0.0331 0.0406 0.04 0.0357 0.0364 0.0254
Lipid Particles 0.569 0.5101 0.5318 0.4785 0.5566 0.6232 0.5885 0.6746 0.5553 0.6462 0.6276 0.758 0.7375 0.6943 0.6774 0.6603 0.7474 0.7892
Mitochondria 0.0188 0.0298 0.0169 0.0272 0.0681 0.0116 0.0169 0.0039 0.0132 0.0228 0.0195 0.0034 0.0029 0.0081 0.0095 0.0043 0.0038 0.0069
None 0.0021 0.0016 0.0181 0.001 0.0001 0.0017 0.006 0.0046 0.0021 0.0003 0.0031 0.001 0.003 0.0016 0.0029 0.0044 0.0116 0.0001
Nuclear Periphery 0.0173 0.0048 0.002 0.0048 0.0004 0.0016 0.0051 0.0049 0.0014 0.0041 0.003 0.0064 0.0023 0.0009 0.0027 0.0021 0.0042 0.0017
Nucleolus 0.0034 0.0146 0.0051 0.0007 0.0002 0.0008 0.0011 0.0012 0.0002 0.0002 0.0007 0.0009 0.0025 0.0024 0.0007 0.0034 0.0009 0.0016
Nucleus 0.0024 0.0022 0.0031 0.0014 0.0001 0.0003 0.0019 0.0002 0.0001 0.0001 0.0005 0.0004 0.0005 0.0007 0.0002 0.0025 0.0003 0.0003
Peroxisomes 0.1111 0.0958 0.1771 0.255 0.0833 0.1454 0.1381 0.0815 0.1601 0.1233 0.1521 0.1079 0.0919 0.1011 0.1567 0.1485 0.0887 0.0976
Punctate Nuclear 0.0169 0.0076 0.01 0.023 0.0009 0.0068 0.0143 0.0038 0.0016 0.0011 0.0054 0.0082 0.0131 0.0021 0.0032 0.0039 0.0053 0.0066
Vacuole 0.0013 0.0138 0.0024 0.0009 0.0014 0.0016 0.0023 0.0023 0.0033 0.001 0.0019 0.0008 0.0008 0.0023 0.0011 0.0026 0.0017 0.0011
Vacuole Periphery 0.0016 0.0029 0.0015 0.0012 0.0016 0.0013 0.0018 0.003 0.0019 0.002 0.0016 0.0012 0.001 0.0013 0.0012 0.001 0.0012 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 39.7373 24.7833 14.0992 22.209 21.567 16.625 16.4968 16.9127 14.2724 31.3947
Translational Efficiency 0.9205 0.633 1.0255 0.7545 1.0269 1.7108 1.1035 0.7967 0.9947 0.743

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1571 1378 1079 1120 1028 1771 2360 440 2599 3149 3439 1560

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 688.47 689.58 827.95 931.54 642.14 732.46 921.84 1028.55 670.14 713.70 892.38 958.90
Standard Deviation 81.47 110.14 109.02 147.89 93.72 98.64 114.15 168.03 89.44 105.98 120.70 159.91
Intensity Change Log 2 — 0.002324 0.266150 0.436224 — 0.189862 0.521629 0.679652 — 0.095874 0.395094 0.558832

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001063 0.004982 0.006273 0.026476 0.002457 0.001044 0.038550 0.013939 0.001614 0.002767 0.028423 0.022939
Bud Neck 0.003041 0.000828 0.010180 0.005160 0.001281 0.001355 0.000564 0.002090 0.002345 0.001125 0.003581 0.004294
Bud Site 0.000705 0.000893 0.010723 0.015026 0.000426 0.000987 0.002255 0.009567 0.000595 0.000946 0.004912 0.013486
Cell Periphery 0.000073 0.000053 0.000274 0.000153 0.000074 0.000055 0.000054 0.000126 0.000074 0.000054 0.000123 0.000145
Cytoplasm 0.023924 0.004281 0.212946 0.004867 0.012513 0.007009 0.001235 0.004701 0.019410 0.005816 0.067660 0.004820
Cytoplasmic Foci 0.239698 0.223071 0.102836 0.249546 0.239633 0.211054 0.368117 0.281640 0.239672 0.216312 0.284884 0.258598
Eisosomes 0.000216 0.000091 0.000155 0.000100 0.000140 0.000090 0.000082 0.000070 0.000186 0.000090 0.000105 0.000091
Endoplasmic Reticulum 0.001425 0.000727 0.016046 0.002731 0.001110 0.000494 0.000820 0.001583 0.001300 0.000596 0.005597 0.002407
Endosome 0.097019 0.162154 0.057027 0.203574 0.124339 0.197387 0.184474 0.305039 0.107825 0.181969 0.144487 0.232192
Golgi 0.140300 0.196625 0.003286 0.096463 0.178157 0.181166 0.078422 0.134135 0.155274 0.187931 0.054848 0.107089
Lipid Particles 0.373484 0.294818 0.080266 0.081246 0.314163 0.283706 0.168687 0.076496 0.350020 0.288568 0.140945 0.079907
Mitochondria 0.017301 0.012372 0.002047 0.017063 0.018121 0.025739 0.004140 0.008462 0.017625 0.019890 0.003483 0.014637
Mitotic Spindle 0.012490 0.019600 0.058528 0.141746 0.010037 0.023222 0.057140 0.058050 0.011520 0.021637 0.057576 0.118140
None 0.001191 0.000428 0.005254 0.000317 0.005313 0.000784 0.000018 0.000413 0.002821 0.000628 0.001661 0.000344
Nuclear Periphery 0.000763 0.000306 0.015454 0.002055 0.000449 0.000571 0.000234 0.001361 0.000639 0.000455 0.005010 0.001859
Nuclear Periphery Foci 0.005259 0.006596 0.102507 0.015957 0.003500 0.004904 0.003700 0.016643 0.004563 0.005645 0.034701 0.016151
Nucleolus 0.002263 0.002044 0.011745 0.002725 0.004409 0.001898 0.000091 0.000947 0.003112 0.001962 0.003748 0.002224
Nucleus 0.004640 0.001960 0.216283 0.005171 0.003196 0.001806 0.000127 0.000560 0.004069 0.001874 0.067947 0.003871
Peroxisomes 0.068162 0.064799 0.018448 0.085722 0.075991 0.047781 0.086248 0.038190 0.071259 0.055228 0.064976 0.072315
Vacuole 0.005398 0.002362 0.069127 0.037981 0.003654 0.006645 0.004465 0.039597 0.004708 0.004771 0.024753 0.038437
Vacuole Periphery 0.001586 0.001011 0.000594 0.005922 0.001038 0.002303 0.000577 0.006389 0.001369 0.001738 0.000582 0.006054

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.50 -3.04 -8.35 -6.77 -6.42 2.33 -13.72 -3.62 -4.08 6.09 -2.50 -14.27 -9.00 -8.40 1.83
Bud Neck 2.97 -6.34 -2.33 -5.64 4.59 -0.30 3.38 -2.37 -2.30 -4.74 2.68 -3.28 -3.09 -5.81 -0.29
Bud Site -0.64 -6.17 -10.45 -10.20 -2.43 -3.22 -6.00 -5.07 -4.76 -3.99 -2.13 -7.82 -11.63 -11.27 -7.17
Cell Periphery 2.87 -13.68 -7.25 -9.69 6.86 2.01 2.45 -2.18 -3.17 -3.30 3.35 -7.06 -7.01 -9.41 -2.54
Cytoplasm 8.69 -23.07 7.53 -1.64 26.25 2.97 6.57 3.29 0.96 -2.65 8.73 -13.77 8.03 -0.36 19.62
Cytoplasmic Foci 2.69 20.21 -0.16 -2.52 -17.81 4.49 -16.39 -2.93 -6.11 8.13 5.23 -7.45 -1.54 -5.81 4.70
Eisosomes 5.93 2.63 5.46 -1.53 6.28 5.20 6.35 5.80 2.17 1.27 7.22 6.07 6.91 -0.47 2.44
Endoplasmic Reticulum 2.18 -12.05 -3.63 -6.26 10.55 1.09 0.46 -0.83 -3.60 -2.47 2.43 -9.05 -3.55 -7.48 6.28
Endosome -10.96 9.19 -15.18 -5.07 -22.33 -10.21 -9.90 -15.09 -8.91 -10.40 -16.06 -8.98 -20.13 -7.47 -14.21
Golgi -8.46 30.23 7.51 15.81 -22.79 -0.63 15.04 4.37 5.31 -6.69 -6.76 25.06 9.45 16.49 -12.79
Lipid Particles 6.58 32.64 30.70 22.36 -1.46 2.43 13.62 19.86 19.92 10.56 7.19 29.06 36.46 30.81 11.06
Mitochondria 2.44 10.29 0.15 -1.71 -6.59 -2.96 7.15 3.55 6.20 -1.96 -1.42 11.37 1.52 2.61 -6.21
Mitotic Spindle -2.52 -8.56 -16.66 -15.56 -9.28 -5.20 -13.35 -7.10 -5.09 -0.51 -5.11 -15.24 -18.02 -16.09 -9.55
None 2.94 -5.42 2.77 0.38 6.82 3.01 3.81 3.48 1.24 -1.28 3.42 2.01 4.18 1.39 4.77
Nuclear Periphery 3.26 -11.97 -2.14 -2.94 10.04 -0.66 1.34 -2.93 -2.71 -4.15 1.53 -10.65 -2.76 -3.21 5.70
Nuclear Periphery Foci -0.71 -17.68 -5.14 -4.18 15.12 -1.29 0.20 -4.02 -3.60 -4.07 -0.97 -15.21 -6.66 -5.96 7.72
Nucleolus 0.08 -7.94 -0.83 -0.86 7.16 2.58 4.87 3.59 1.96 -1.59 1.78 -2.21 1.20 -0.31 3.34
Nucleus 3.10 -25.00 -1.19 -2.67 24.27 1.96 5.23 4.37 2.16 -1.95 3.92 -19.97 -0.65 -2.47 18.45
Peroxisomes 0.60 13.52 -2.73 -3.09 -12.06 5.39 -1.90 5.85 1.92 8.26 4.56 1.71 -0.13 -3.51 -1.44
Vacuole 4.79 -19.77 -11.90 -12.95 8.17 -2.97 -1.27 -7.51 -6.95 -7.32 -0.09 -16.64 -14.15 -14.11 -4.46
Vacuole Periphery 2.08 4.74 -5.05 -5.79 -6.46 -4.73 2.65 -5.25 -3.95 -5.74 -1.86 5.18 -6.94 -6.37 -8.28
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Acyltransferase; enzyme mainly responsible for the introduction of saturated very long chain fatty acids into neo-synthesized molecules of phosphatidylinositol; required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed; CST26 has a paralog, YDR018C, that arose from the whole genome duplication
Localization
Cell Percentages —
Cell Cycle Regulation No
Subcompartmental Group N/A

Cst26

Cst26


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cst26-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available