Standard name | |
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Human Ortholog | |
Description | Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 |
Bud | 0 | 0 | 1 | 1 | 4 | 8 | 11 | 4 | 3 | 4 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 11 | 8 | 1 | 1 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Bud Site | 2 | 0 | 3 | 3 | 6 | 8 | 29 | 10 | 23 | 38 | 46 | 37 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 7 | 16 | 23 | 20 | 28 | 44 | 28 | 85 | 17 | 25 | 27 | 10 | 4 | 24 | 21 | 7 | 3 | 4 | 2 | 3 | 3 | 1 | 1 | 4 |
Endoplasmic Reticulum | 0 | 0 | 4 | 0 | 1 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 4 | 1 | 0 | 0 | 0 | 2 | 0 | 1 |
Endosome | 2 | 2 | 1 | 4 | 6 | 2 | 2 | 4 | 1 | 2 | 1 | 5 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 1 | 4 |
Golgi | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 |
Mitochondria | 6 | 22 | 47 | 26 | 55 | 380 | 247 | 162 | 198 | 220 | 326 | 168 | 1 | 0 | 0 | 8 | 6 | 4 | 0 | 4 | 4 | 3 | 5 | 11 |
Nucleus | 185 | 305 | 577 | 520 | 530 | 746 | 800 | 647 | 532 | 680 | 592 | 595 | 51 | 111 | 71 | 115 | 127 | 93 | 181 | 302 | 549 | 123 | 140 | 150 |
Nuclear Periphery | 0 | 22 | 7 | 15 | 7 | 11 | 25 | 20 | 3 | 21 | 11 | 17 | 0 | 0 | 1 | 2 | 0 | 1 | 0 | 0 | 4 | 1 | 0 | 4 |
Nucleolus | 1 | 7 | 10 | 11 | 13 | 53 | 78 | 97 | 60 | 89 | 99 | 86 | 1 | 4 | 0 | 6 | 2 | 2 | 0 | 1 | 12 | 3 | 4 | 11 |
Peroxisomes | 0 | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 1 | 2 | 4 | 3 | 1 | 2 | 6 | 0 | 1 | 1 | 2 | 0 | 2 | 4 | 0 | 2 | 0 | 5 | 2 | 4 | 0 | 2 | 3 |
Vac/Vac Membrane | 9 | 11 | 8 | 17 | 27 | 29 | 16 | 54 | 15 | 7 | 9 | 8 | 0 | 5 | 4 | 8 | 5 | 3 | 13 | 23 | 29 | 25 | 45 | 67 |
Unique Cell Count | 205 | 336 | 623 | 574 | 613 | 945 | 968 | 885 | 659 | 825 | 766 | 722 | 56 | 140 | 98 | 133 | 141 | 103 | 208 | 357 | 629 | 167 | 208 | 271 |
Labelled Cell Count | 212 | 387 | 685 | 622 | 681 | 1285 | 1239 | 1091 | 852 | 1089 | 1118 | 933 | 58 | 147 | 105 | 149 | 149 | 108 | 208 | 357 | 629 | 167 | 208 | 271 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.6 | 6.2 | 5.6 | 5.4 | 5.3 | 4.3 | 4.7 | 6.1 | 5.0 | 4.9 | 4.5 | 5.1 | 6.3 | 6.3 | 6.5 | 9.0 | 8.5 | 8.7 | 5.9 | 5.9 | 6.1 |
Std Deviation (1e-4) | 1.0 | 1.6 | 1.6 | 1.4 | 1.6 | 1.4 | 1.5 | 3.3 | 1.5 | 1.2 | 1.5 | 1.3 | 1.4 | 1.5 | 1.7 | 2.5 | 2.3 | 2.6 | 1.2 | 1.3 | 1.4 |
Intensity Change (Log2) | – | – | – | -0.04 | -0.07 | -0.36 | -0.24 | 0.12 | -0.16 | -0.18 | -0.3 | -0.13 | 0.19 | 0.18 | 0.22 | 0.7 | 0.6 | 0.64 | 0.08 | 0.08 | 0.14 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 1.3 | 3.8 | 4.7 | 0 | 5.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -0.2 | 0.8 | 0.9 | -0.9 | 4.4 | -1.1 | -0.7 | -0.2 | -2.7 | 0 | 6.0 | 6.8 | 0.8 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | -2.2 | 0.9 | 0 | 0 | 6.0 | 10.2 | 9.3 | 0 | 7.8 | 0 | -3.4 | -2.8 | -0.6 | -1.4 | -1.3 |
Nucleus | -1.3 | -3.5 | -7.3 | -5.7 | -9.5 | -6.2 | -5.7 | -7.8 | -5.6 | -0.4 | -4.8 | -6.2 | -2.3 | -1.0 | -0.8 |
Nuclear Periphery | 1.9 | 0 | 0 | 0 | 1.6 | 0 | 1.9 | 0 | 1.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0.4 | 0.7 | 0 | 0 | 7.0 | 5.9 | 6.9 | 0 | 7.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 2.0 | 3.3 | 2.3 | 0.6 | 4.6 | 1.3 | -0.8 | -0.2 | -0.3 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.031 | 2.4169 | 2.3021 | 1.6786 | 1.7469 | 2.2145 | 3.7285 | 3.9349 | 4.2526 | 3.4875 | 3.504 | 4.2126 | 2.5147 | 3.0961 | 2.5092 | 2.7832 | 1.1888 | 2.5164 |
Actin | 0.0032 | 0 | 0 | 0 | 0.0116 | 0.0019 | 0.0123 | 0 | 0.0054 | 0.0002 | 0.0002 | 0.0051 | 0.0008 | 0 | 0.0109 | 0.0014 | 0 | 0 |
Bud | 0.0002 | 0.0002 | 0 | 0 | 0.0002 | 0.0001 | 0.0005 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0006 | 0 | 0.0002 | 0.0003 | 0 | 0.0001 |
Bud Neck | 0.0004 | 0.0002 | 0 | 0.0001 | 0.0027 | 0.0008 | 0.0014 | 0 | 0.0003 | 0.0001 | 0.0004 | 0.0008 | 0.0005 | 0 | 0 | 0.0003 | 0.0001 | 0.0007 |
Bud Periphery | 0.0003 | 0.0002 | 0 | 0 | 0.0003 | 0.0002 | 0.001 | 0 | 0.0003 | 0 | 0.0001 | 0.0005 | 0.0008 | 0 | 0.0002 | 0.0003 | 0 | 0.0001 |
Bud Site | 0.0016 | 0.0048 | 0 | 0 | 0.0018 | 0.0001 | 0.002 | 0 | 0.0005 | 0 | 0 | 0.0002 | 0.0057 | 0 | 0.0004 | 0.0029 | 0 | 0 |
Cell Periphery | 0.0001 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 |
Cytoplasm | 0.0024 | 0.0005 | 0.0004 | 0 | 0.0004 | 0.0004 | 0.0075 | 0 | 0.0017 | 0.0011 | 0.0008 | 0.0003 | 0.0232 | 0.0001 | 0.001 | 0.0035 | 0.0001 | 0.0015 |
Cytoplasmic Foci | 0.0045 | 0 | 0 | 0 | 0.0018 | 0.0001 | 0.0124 | 0 | 0.004 | 0.0006 | 0.0003 | 0.0018 | 0.0136 | 0 | 0.001 | 0.0053 | 0 | 0 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0.0003 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.0011 | 0 | 0 | 0 | 0.0005 | 0.0003 | 0.0031 | 0 | 0.0014 | 0.0003 | 0.0003 | 0.0004 | 0.0021 | 0 | 0.0003 | 0.0009 | 0 | 0 |
Endosome | 0.0062 | 0 | 0 | 0 | 0.0038 | 0.0008 | 0.0122 | 0 | 0.007 | 0.0009 | 0.0029 | 0.0042 | 0.0058 | 0 | 0.0009 | 0.0089 | 0 | 0 |
Golgi | 0.001 | 0 | 0 | 0 | 0.0018 | 0.0001 | 0.003 | 0 | 0.0021 | 0.0007 | 0.0002 | 0.0016 | 0.0014 | 0 | 0.0004 | 0.0014 | 0 | 0 |
Lipid Particles | 0.004 | 0 | 0 | 0 | 0.0039 | 0.0001 | 0.012 | 0 | 0.0028 | 0.0219 | 0.0001 | 0.0036 | 0.0075 | 0 | 0.0001 | 0.0022 | 0 | 0 |
Mitochondria | 0.0012 | 0.0001 | 0.0001 | 0.0001 | 0.0009 | 0.0004 | 0.0055 | 0.0001 | 0.0075 | 0.0009 | 0.0009 | 0.0042 | 0.0031 | 0.0002 | 0.0024 | 0.003 | 0.0001 | 0.0002 |
None | 0.0041 | 0.0001 | 0.0013 | 0 | 0.0014 | 0.0024 | 0.0041 | 0 | 0.0008 | 0.0032 | 0.0003 | 0.0003 | 0.0067 | 0.0001 | 0.0006 | 0.0028 | 0 | 0 |
Nuclear Periphery | 0.0094 | 0.0031 | 0.0021 | 0.0012 | 0.0057 | 0.0042 | 0.0236 | 0.0031 | 0.0115 | 0.017 | 0.0119 | 0.0052 | 0.0082 | 0.0013 | 0.0017 | 0.0098 | 0.0005 | 0.001 |
Nucleolus | 0.0153 | 0.019 | 0.0093 | 0.0118 | 0.0292 | 0.0213 | 0.0129 | 0.0078 | 0.0064 | 0.005 | 0.0229 | 0.0187 | 0.0148 | 0.0066 | 0.0112 | 0.0106 | 0.0045 | 0.0164 |
Nucleus | 0.9304 | 0.9695 | 0.9847 | 0.9864 | 0.9119 | 0.9623 | 0.8617 | 0.9871 | 0.9385 | 0.933 | 0.9544 | 0.9474 | 0.878 | 0.9911 | 0.9671 | 0.9169 | 0.9945 | 0.9794 |
Peroxisomes | 0.0015 | 0 | 0 | 0 | 0.0013 | 0 | 0.0094 | 0 | 0.0017 | 0.0007 | 0 | 0.0022 | 0.0058 | 0 | 0.0009 | 0.0009 | 0 | 0 |
Punctate Nuclear | 0.0087 | 0.0009 | 0.0016 | 0.0003 | 0.0194 | 0.0037 | 0.0101 | 0.0017 | 0.0051 | 0.0134 | 0.0033 | 0.0026 | 0.0188 | 0.0002 | 0.0004 | 0.026 | 0.0001 | 0.0002 |
Vacuole | 0.0032 | 0.0008 | 0.0002 | 0 | 0.0005 | 0.0005 | 0.0029 | 0 | 0.0012 | 0.0003 | 0.0004 | 0.0005 | 0.0016 | 0.0001 | 0.0002 | 0.0015 | 0 | 0.0001 |
Vacuole Periphery | 0.0012 | 0.0001 | 0.0001 | 0 | 0.0004 | 0.0002 | 0.0018 | 0.0001 | 0.0015 | 0.0007 | 0.0005 | 0.0005 | 0.0009 | 0.0001 | 0.0002 | 0.0008 | 0 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 52.3211 | 35.1946 | 22.6796 | 33.323 | 34.2541 | 42.455 | 31.6053 | 28.758 | 29.0331 | 45.608 |
Translational Efficiency | 1.1949 | 1.0807 | 1.4309 | 1.0498 | 1.38 | 1.4876 | 1.2266 | 1.1834 | 1.2567 | 1.053 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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