Standard name
Human Ortholog
Description Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.12 0.05 0 0 0 0 0 0
Cytoplasm 0.99 0.93 0.99 0.97 0.93 0.9 0.78 0.8 0.66 0.69 0.6 0.68 0.99 0.95 0.86 0.95 0.84 0.9 0.97 0.93 0.96 0.83 0.81 0.83
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.11 0.06 0 0 0 0.07 0.06 0.06
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.15 0.22 0.17 0.45 0.36 0.54 0.36 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.07 0.06 0 0.05 0 0 0 0 0.05 0.13 0.08 0 0 0 0 0.05 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 1 6 1 2 4 1 2 1 2 0 1 8 0 0 1 0 1 0 0 3 1
Bud 0 0 1 5 3 0 5 8 14 10 11 8 3 0 9 0 0 0 0 0 0 0 4 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1
Bud Site 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 1 11 9 4 7 10 9 14 23 11 11 2 4 3 1 9 4 0 0 0 0 0 0
Cytoplasm 198 140 308 269 329 210 298 320 313 359 195 248 279 287 319 81 64 70 192 155 308 159 254 274
Endoplasmic Reticulum 2 2 3 2 3 4 6 5 2 4 4 4 2 4 7 5 8 5 2 2 2 13 18 18
Endosome 0 0 0 1 3 2 6 3 5 5 2 4 0 8 32 0 2 1 0 0 0 1 3 3
Golgi 0 0 0 1 2 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0 0 0 0 1
Mitochondria 0 6 0 11 11 34 82 69 217 188 178 130 0 0 0 1 0 3 1 0 3 3 9 6
Nucleus 0 0 0 0 0 1 5 8 3 7 1 3 1 1 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 1 4 0 0 0 0 0 0 1 0 1 0 0 0 1 0 0 0 0 1 0 1 0 0
Nucleolus 0 0 0 0 0 0 1 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 0 0 2 1 0 2 0 2 0 1 6 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 2 0 1 11 4 8 29 31 17 15 14 0 2 0 4 10 6 0 3 3 6 14 15
Unique Cell Count 200 150 312 276 354 234 380 399 477 519 327 364 281 303 370 85 76 78 198 166 321 192 316 331
Labelled Cell Count 204 156 323 301 372 263 425 456 601 619 420 426 287 309 388 93 94 90 198 166 321 192 316 331


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.4 6.4 7.0 6.5 7.2 5.9 5.8 6.3 5.4 5.2 5.1 5.5 6.8 7.1 7.1 12.0 13.0 12.3 6.6 6.8 7.2
Std Deviation (1e-4) 0.7 1.1 0.9 1.2 1.5 1.1 1.1 1.5 1.2 0.9 1.3 1.0 0.9 1.3 1.1 2.8 2.8 2.5 1.2 1.3 1.4
Intensity Change (Log2) – – – -0.11 0.04 -0.24 -0.28 -0.16 -0.37 -0.43 -0.45 -0.35 -0.04 0.02 0.01 0.78 0.9 0.81 -0.08 -0.04 0.04


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 2.6 0 2.8 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.2 -2.1 -0.3 -0.7 -1.0 -0.5 0.6 -0.1 -0.4 -2.3 -1.8 -2.5 0 0 0
Cytoplasm -1.1 -3.6 -4.7 -8.1 -7.6 -11.1 -10.4 -12.1 -10.4 0.7 -2.8 -6.0 -2.0 -5.7 -4.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 5.3 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.6 3.1 7.0 8.7 7.7 14.0 12.1 15.3 11.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 3.1 0 0 4.9 4.6 3.2 3.8 3.5 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9491 2.6139 2.0217 1.9147 1.8007 2.1766 2.2737 3.1366 2.8175 2.3523 2.2849 2.84 2.0118 3.3298 2.5993 2.8988 2.5432 3.1197
Actin 0.0426 0.0055 0.0235 0.0102 0.0162 0.0056 0.031 0.005 0.0471 0.008 0.0221 0.0008 0.0617 0.0002 0.0407 0.001 0.0043 0.0052
Bud 0.0028 0.0043 0.0004 0.0013 0.0063 0.0002 0.0117 0.0006 0.0065 0.0009 0.0006 0.0002 0.0007 0.0001 0.0005 0.0008 0.0002 0.0024
Bud Neck 0.0088 0.0003 0.0007 0.0069 0.0015 0.0018 0.0034 0.0003 0.004 0.0006 0.001 0.0007 0.0076 0.0001 0.0041 0.0004 0.0002 0.0006
Bud Periphery 0.0032 0.0021 0.0003 0.0012 0.0066 0.0002 0.0043 0.0003 0.0021 0.0006 0.0005 0.0001 0.0011 0 0.0004 0.0002 0.0001 0.0014
Bud Site 0.0138 0.0101 0.0007 0.0437 0.0234 0.0002 0.0111 0.0053 0.0162 0.0013 0.0016 0.0001 0.0047 0.0003 0.0012 0.0009 0.0002 0.0011
Cell Periphery 0.0007 0.0003 0.0002 0.0002 0.0011 0.0001 0.0004 0.0002 0.0004 0.0001 0.0001 0 0.0005 0.0001 0.0001 0.0001 0 0.0001
Cytoplasm 0.6379 0.9136 0.8526 0.6269 0.4601 0.8698 0.6874 0.9511 0.7826 0.75 0.8276 0.9313 0.7143 0.9365 0.8445 0.9242 0.8933 0.9226
Cytoplasmic Foci 0.0323 0.017 0.0212 0.0887 0.0325 0.0328 0.0415 0.0116 0.0227 0.0339 0.0343 0.0135 0.0225 0.0083 0.0212 0.0097 0.0088 0.0117
Eisosomes 0.0004 0 0.0002 0.0001 0.0001 0.0001 0.0003 0 0.0001 0 0.0001 0 0.0005 0 0.0003 0 0.0001 0
Endoplasmic Reticulum 0.0133 0.0063 0.0066 0.0036 0.0123 0.0023 0.0171 0.0014 0.0039 0.0052 0.0064 0.0023 0.0237 0.0048 0.0034 0.0237 0.008 0.0029
Endosome 0.0551 0.0143 0.0252 0.0524 0.1477 0.0239 0.0506 0.0042 0.0371 0.0641 0.0462 0.0145 0.0414 0.0128 0.0117 0.0143 0.0138 0.0157
Golgi 0.0192 0.0028 0.012 0.0118 0.0514 0.0182 0.0203 0.0005 0.017 0.0254 0.0185 0.0033 0.0155 0.0095 0.0086 0.0006 0.0014 0.0021
Lipid Particles 0.0141 0.0008 0.0078 0.0137 0.0416 0.0116 0.0112 0.0002 0.0089 0.0208 0.0125 0.0008 0.0107 0.0002 0.0149 0.0001 0.0044 0.0012
Mitochondria 0.0111 0.0021 0.0047 0.0817 0.042 0.0129 0.0143 0.0001 0.0044 0.0108 0.0041 0.0039 0.0046 0.0002 0.0039 0.0004 0.0213 0.0006
None 0.0635 0.0147 0.0284 0.0077 0.0831 0.0085 0.0555 0.0156 0.019 0.0508 0.0074 0.0248 0.0561 0.0236 0.017 0.0156 0.0238 0.0297
Nuclear Periphery 0.0262 0.0008 0.0033 0.0017 0.0165 0.0006 0.0068 0.0003 0.0013 0.0015 0.0073 0.0004 0.0066 0.0005 0.0012 0.0023 0.0048 0.0004
Nucleolus 0.0025 0 0.0001 0.0009 0.0011 0.0001 0.0017 0 0.0008 0.0001 0.0001 0 0.0007 0 0.0001 0 0.0001 0
Nucleus 0.0269 0.001 0.0012 0.0017 0.0032 0.0006 0.0066 0.0008 0.0076 0.0011 0.001 0.0007 0.0022 0.0005 0.0008 0.0018 0.0014 0.0006
Peroxisomes 0.0076 0.0004 0.004 0.0304 0.0046 0.0079 0.0135 0.0003 0.0113 0.0182 0.0045 0.0005 0.0096 0.0001 0.0202 0.0001 0.0099 0.0001
Punctate Nuclear 0.0084 0.0006 0.0034 0.0067 0.0019 0.0004 0.0018 0.0004 0.0016 0.0008 0.0018 0.0002 0.0088 0.0001 0.0028 0.0009 0.0018 0.0001
Vacuole 0.0066 0.0026 0.0026 0.0064 0.0326 0.0018 0.0071 0.0014 0.0044 0.0041 0.0014 0.0013 0.0048 0.0018 0.002 0.0022 0.0016 0.0014
Vacuole Periphery 0.0032 0.0004 0.001 0.0019 0.0141 0.0006 0.0025 0.0002 0.001 0.0017 0.001 0.0004 0.0019 0.0003 0.0004 0.0006 0.0005 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.512 19.1868 18.1204 20.2689 19.9223 9.2631 23.4781 19.7891 21.5915 20.9027
Translational Efficiency 0.8435 0.8669 0.8894 0.7599 0.7009 1.4739 0.7772 0.7794 0.6858 0.6683

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1427 153 385 1247 1264 1924 1182 542 2691 2077 1567 1789

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 789.42 951.18 1256.00 1087.71 819.13 929.15 1111.95 1095.68 803.38 930.77 1147.34 1090.12
Standard Deviation 95.35 122.06 131.22 147.70 105.66 122.95 141.46 145.34 101.42 123.02 152.21 147.03
Intensity Change Log 2 — 0.268925 0.669971 0.462429 — 0.181819 0.440928 0.419662 — 0.225225 0.557878 0.440809

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000274 0.000225 0.000503 0.003819 0.000138 0.000427 0.000267 0.000430 0.000210 0.000412 0.000325 0.002792
Bud Neck 0.007645 0.006799 0.002432 0.003211 0.006759 0.007474 0.001054 0.001293 0.007229 0.007424 0.001393 0.002630
Bud Site 0.016435 0.025957 0.015312 0.055718 0.010568 0.023443 0.009793 0.013145 0.013679 0.023629 0.011149 0.042820
Cell Periphery 0.000222 0.000109 0.000131 0.000107 0.000153 0.000101 0.000049 0.000052 0.000190 0.000102 0.000070 0.000091
Cytoplasm 0.589764* 0.509172* 0.671868* 0.634697* 0.477210* 0.592825* 0.823241* 0.711843* 0.536895* 0.586662* 0.786050* 0.658069*
Cytoplasmic Foci 0.251167* 0.285491* 0.050124 0.070560 0.251348* 0.209223* 0.051344 0.074311 0.251252* 0.214841* 0.051045 0.071696
Eisosomes 0.000121 0.000041 0.000023 0.000018 0.000091 0.000056 0.000009 0.000014 0.000107 0.000055 0.000013 0.000017
Endoplasmic Reticulum 0.004459 0.000575 0.001152 0.000422 0.005260 0.000676 0.000253 0.000253 0.004836 0.000668 0.000473 0.000371
Endosome 0.020291 0.033913 0.008160 0.012174 0.032559 0.027108 0.002550 0.005289 0.026054 0.027609 0.003929 0.010088
Golgi 0.011257 0.004096 0.000489 0.006428 0.006205 0.008849 0.000303 0.000369 0.008884 0.008499 0.000348 0.004592
Lipid Particles 0.003921 0.001922 0.001993 0.001135 0.005141 0.001625 0.000501 0.001489 0.004494 0.001647 0.000868 0.001242
Mitochondria 0.004391 0.001268 0.000074 0.002714 0.001815 0.002763 0.000755 0.000041 0.003181 0.002653 0.000588 0.001904
Mitotic Spindle 0.000865 0.006424 0.009859 0.038809 0.001240 0.005403 0.005096 0.004434 0.001041 0.005478 0.006266 0.028395
None 0.000798 0.000230 0.001734 0.000870 0.000581 0.000590 0.000817 0.000583 0.000696 0.000563 0.001043 0.000783
Nuclear Periphery 0.000123 0.000367 0.000511 0.000237 0.000258 0.000066 0.000089 0.000107 0.000186 0.000089 0.000193 0.000198
Nuclear Periphery Foci 0.000426 0.001211 0.007871 0.001555 0.000501 0.000362 0.002295 0.002344 0.000461 0.000424 0.003665 0.001794
Nucleolus 0.000422 0.000281 0.000108 0.000111 0.000332 0.000401 0.000096 0.000109 0.000380 0.000392 0.000099 0.000110
Nucleus 0.014753 0.010659 0.043809 0.013776 0.028506 0.009998 0.017502 0.013428 0.021213 0.010047 0.023966 0.013671
Peroxisomes 0.001752 0.003253 0.003332 0.011869 0.001603 0.003219 0.001661 0.005579 0.001682 0.003221 0.002071 0.009963
Vacuole 0.065917 0.104317 0.180209 0.138091 0.164604 0.102116 0.082136 0.164696 0.112271 0.102278 0.106232 0.146151
Vacuole Periphery 0.004999 0.003689 0.000306 0.003678 0.005127 0.003276 0.000187 0.000192 0.005059 0.003307 0.000216 0.002622

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.00 -5.03 -3.06 -3.14 -2.54 -3.64 -2.56 -1.80 0.92 -0.52 -2.63 -3.05 -3.23 -2.74 -2.92
Bud Neck 0.53 7.31 7.29 2.31 0.18 -1.07 12.29 12.10 11.28 -1.38 -0.29 14.00 11.31 9.38 -3.06
Bud Site -2.00 1.47 -6.35 -1.85 -6.78 -7.53 1.30 -1.10 6.35 -2.32 -6.44 3.65 -6.91 -1.96 -8.44
Cell Periphery 5.56 4.68 10.42 1.49 6.95 4.29 9.24 9.27 7.89 0.32 8.96 12.86 12.87 4.24 0.52
Cytoplasm 3.66 0.75 -0.25 -3.64 -0.87 -11.88 -29.76 -12.62 -4.51 8.71 -6.35 -23.04 -8.48 -2.62 11.66
Cytoplasmic Foci -1.88 36.17 33.53 13.03 -3.61 6.00 34.00 27.46 24.90 -3.98 6.60 50.11 43.30 31.56 -4.85
Eisosomes 10.99 15.66 17.95 5.12 5.63 6.01 16.24 15.08 12.28 -4.58 10.79 23.82 23.25 12.56 -2.37
Endoplasmic Reticulum 4.55 3.76 4.98 1.67 7.38 4.58 5.01 4.99 4.92 -0.31 6.44 6.70 7.04 5.07 4.95
Endosome -2.98 10.83 9.33 5.94 -0.04 2.82 21.01 18.30 16.77 -2.71 -1.10 25.07 17.80 15.61 -3.88
Golgi 7.51 16.33 8.09 1.18 -2.87 -3.30 13.96 13.89 12.63 -0.08 0.58 21.04 9.82 7.60 -2.99
Lipid Particles 2.72 3.93 7.67 0.85 5.26 5.71 7.41 5.38 1.06 -1.08 8.11 10.16 8.81 1.69 -1.09
Mitochondria 2.74 5.21 3.20 0.09 -1.85 -1.18 2.26 3.90 4.16 1.00 0.70 4.93 3.72 2.49 -0.93
Mitotic Spindle -0.92 -3.83 -7.53 -3.19 -3.71 -3.34 -2.98 -2.28 0.29 0.47 -3.90 -4.72 -7.76 -5.61 -4.86
None 4.21 -2.74 0.38 -3.97 2.95 -0.08 -1.79 -0.38 -0.36 0.98 1.27 -2.75 -0.18 -1.42 2.50
Nuclear Periphery -0.84 -8.93 -2.95 0.30 6.79 5.76 2.82 2.12 -5.10 -0.64 2.93 -4.65 -1.70 -4.36 2.36
Nuclear Periphery Foci -1.87 -14.97 -10.07 -1.28 12.35 2.11 -11.32 -7.59 -8.09 0.41 0.38 -17.58 -12.81 -12.76 9.11
Nucleolus 0.62 1.43 1.35 1.36 -0.96 -0.66 3.64 3.48 2.66 -0.85 -0.19 2.41 2.17 2.56 -2.02
Nucleus 1.06 -11.07 -6.44 -3.65 8.71 10.04 2.34 4.98 -5.88 3.69 10.69 -6.42 0.13 -12.31 6.97
Peroxisomes -3.05 -0.00 -4.15 -2.72 -3.34 -4.85 0.59 -0.89 0.11 -1.05 -4.97 0.62 -4.05 -2.32 -3.84
Vacuole -3.96 -15.44 -21.94 -10.44 2.53 9.88 4.47 -5.62 -12.04 -8.72 2.29 -8.89 -17.84 -19.70 -8.43
Vacuole Periphery 1.12 11.63 5.15 1.61 -2.46 3.11 9.91 9.92 9.79 0.15 3.99 15.26 8.02 4.48 -2.60
Standard name
Human Ortholog
Description Putative tubulin tyrosine ligase associated with P-bodies; may have a role in mRNA metabolism; yeast knockout collection strain identified as a pby1 null mutant is actually wild-type for PBY1 and deleted for mms4
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pby1

Pby1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pby1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available