Standard name
Human Ortholog
Description Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.65 0.55 0.6 0.57 0.54 0.41 – 0.48 0.34 0.39 0.36 0.34 0.51 0.6 0.69 0.27 0.28 0.29 0.47 0.37 0.4 0.41 0.45 0.49
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.11 0 – 0 0 0 0 0 0 0 0 0.08 0.06 0.11 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.2 0.05 0.45 0.58 0.28 0.61 – 0.61 0.77 0.71 0.78 0.76 0 0 0 0.08 0.14 0.06 0 0.05 0.11 0.05 0.07 0.05
Nucleus 0.07 0.11 0 0.09 0.08 0.11 – 0.1 0.11 0.08 0.09 0.06 0.2 0.11 0.13 0.38 0.28 0.34 0.2 0.25 0.1 0.16 0.07 0.07
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.05
Vac/Vac Membrane 0.24 0.38 0.17 0.07 0.18 0.18 – 0.07 0.1 0.06 0 0.05 0.34 0.3 0.2 0.39 0.39 0.31 0.2 0.25 0.26 0.28 0.27 0.22
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 3 3 0 2 2
Bud 0 1 5 5 0 4 – 5 8 7 6 10 0 2 0 0 0 0 1 2 3 1 10 11
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 3 6
Bud Site 0 0 0 0 0 0 – 2 4 2 2 9 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 129 130 151 107 148 143 – 217 144 180 150 156 141 193 249 20 18 10 124 107 105 84 136 148
Endoplasmic Reticulum 0 0 0 1 0 0 – 1 1 0 2 0 2 4 0 4 1 1 0 1 3 0 1 1
Endosome 0 1 1 2 30 2 – 2 0 2 0 0 11 12 7 6 4 4 1 3 2 4 5 6
Golgi 0 2 0 0 0 0 – 3 0 0 0 0 1 0 0 0 0 0 1 1 0 1 5 1
Mitochondria 39 11 114 109 76 213 – 277 329 324 329 349 7 9 6 6 9 2 4 13 29 10 20 13
Nucleus 13 25 5 16 23 39 – 46 46 37 38 27 55 35 46 28 18 12 53 74 26 32 22 19
Nuclear Periphery 0 0 0 0 1 0 – 1 1 0 1 3 0 0 0 1 0 0 0 0 0 1 0 0
Nucleolus 1 0 0 0 1 0 – 2 0 2 0 1 0 0 0 0 1 0 0 0 0 1 0 1
Peroxisomes 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0
SpindlePole 0 0 0 2 2 0 – 7 2 6 6 10 0 0 0 0 0 0 14 7 7 5 7 14
Vac/Vac Membrane 48 90 42 13 49 61 – 33 44 26 11 22 93 97 73 29 25 11 53 72 69 58 81 65
Unique Cell Count 200 236 252 188 276 347 456 426 458 421 458 277 320 361 74 64 35 265 293 265 209 306 301
Labelled Cell Count 230 260 318 255 330 462 596 579 586 547 588 310 352 381 94 76 40 265 293 265 209 306 301


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.6 4.3 3.6 3.4 4.3 3.1 – 3.6 2.9 3.1 2.8 2.7 4.6 4.7 4.9 6.1 5.7 6.2 4.4 5.0 4.8
Std Deviation (1e-4) 0.5 0.9 1.4 2.0 2.7 1.2 – 3.8 1.6 1.1 1.3 0.6 1.0 1.5 1.8 1.4 1.5 1.6 1.3 1.9 1.8
Intensity Change (Log2) – – – -0.06 0.25 -0.19 – 0.01 -0.32 -0.23 -0.33 -0.41 0.36 0.4 0.46 0.77 0.68 0.79 0.3 0.47 0.42


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.1 3.9 2.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.5842 -0.2949 -0.5411 -0.2456 -0.669 -0.5411 -0.6376 -0.718 -0.449 -0.2913 -0.3925 -0.6291 0.2428 0.5516 0.32 -0.0587 0.0872 0.3856
Actin 0.0374 0.0004 0.0005 0.0002 0.0001 0.001 0.017 0.0004 0.0073 0.0467 0.0309 0.0067 0.035 0.0001 0.0122 0.0003 0.0005 0.0003
Bud 0.0004 0.0001 0.0001 0 0 0.0001 0.0021 0.0006 0.0017 0.008 0.0012 0.0004 0.0002 0.0001 0.0003 0.0002 0 0.0001
Bud Neck 0.0044 0.0008 0.0005 0.0003 0.0003 0.003 0.004 0.0004 0.0062 0.0023 0.0014 0.004 0.0041 0.0002 0.0004 0.0011 0.0006 0.005
Bud Periphery 0.0005 0.0001 0.0001 0 0 0.0001 0.0027 0.0021 0.0031 0.0028 0.0023 0.001 0.0003 0.0001 0.0004 0.0001 0.0001 0.0001
Bud Site 0.0029 0.0041 0.0004 0.0001 0.0001 0.0002 0.0127 0.0032 0.0216 0.0201 0.0072 0.0035 0.0022 0.0005 0.0011 0.0005 0.0001 0.0002
Cell Periphery 0.0002 0.0001 0.0001 0 0 0.0001 0.0006 0.0002 0.0005 0.0005 0.0003 0.0001 0.0002 0.0001 0.0001 0.0001 0 0.0001
Cytoplasm 0.2001 0.1507 0.1562 0.1614 0.178 0.1955 0.1314 0.1976 0.1558 0.1601 0.137 0.188 0.1345 0.1364 0.1278 0.1284 0.1586 0.1947
Cytoplasmic Foci 0.0263 0.0066 0.0058 0.0024 0.0047 0.0088 0.0394 0.0161 0.0113 0.0219 0.0316 0.0119 0.016 0.0033 0.0066 0.0029 0.004 0.006
Eisosomes 0.0006 0.0001 0.0001 0.0001 0 0.0003 0.0006 0.0001 0.0001 0.0006 0.0002 0.0001 0.0008 0.0001 0.0002 0.0001 0.0002 0
Endoplasmic Reticulum 0.0058 0.0023 0.0039 0.0017 0.0027 0.0028 0.0127 0.0055 0.0045 0.0049 0.0076 0.0039 0.005 0.0039 0.003 0.0015 0.0025 0.0033
Endosome 0.0173 0.002 0.0066 0.0017 0.0036 0.0038 0.0316 0.0061 0.0162 0.0224 0.0452 0.0169 0.0089 0.0016 0.0069 0.0028 0.0036 0.0035
Golgi 0.0024 0.0001 0.0002 0 0 0.0001 0.0088 0.0006 0.0067 0.0096 0.0256 0.0027 0.0029 0.0001 0.001 0.0001 0.0001 0.0001
Lipid Particles 0.0045 0.0004 0.0013 0.0001 0.0004 0.0009 0.0215 0.003 0.0042 0.0075 0.0358 0.0093 0.0052 0.0009 0.0028 0.0003 0.0005 0.0005
Mitochondria 0.0013 0.0009 0.0007 0.0005 0.0006 0.0007 0.0096 0.0076 0.0056 0.0087 0.0619 0.0037 0.0022 0.0005 0.0036 0.0018 0.0016 0.001
None 0.4489 0.5174 0.4935 0.5807 0.5479 0.39 0.4118 0.4624 0.4444 0.4174 0.305 0.3563 0.6251 0.6306 0.5155 0.4447 0.6868 0.3865
Nuclear Periphery 0.0147 0.008 0.0235 0.0084 0.0126 0.0102 0.0384 0.022 0.0206 0.0228 0.0204 0.0128 0.0097 0.0097 0.0161 0.0104 0.0182 0.0166
Nucleolus 0.0028 0.0029 0.0028 0.0013 0.0019 0.0061 0.0086 0.005 0.0035 0.0027 0.0031 0.0056 0.003 0.0021 0.0033 0.0042 0.0044 0.0054
Nucleus 0.1923 0.2714 0.2492 0.2118 0.2318 0.3189 0.1701 0.223 0.2449 0.1758 0.2146 0.303 0.1173 0.1987 0.264 0.3847 0.0945 0.3493
Peroxisomes 0.0038 0.0002 0.0002 0.0001 0.0001 0.0003 0.0142 0.0017 0.0029 0.0055 0.0267 0.0039 0.0055 0.0001 0.0008 0.0002 0.0002 0.0002
Punctate Nuclear 0.0287 0.0293 0.0523 0.0279 0.0131 0.0555 0.0518 0.0378 0.0323 0.0549 0.0329 0.0621 0.0192 0.0093 0.0299 0.0135 0.0209 0.0246
Vacuole 0.0038 0.0016 0.0015 0.001 0.0018 0.0016 0.0077 0.0037 0.0045 0.0037 0.0059 0.003 0.0022 0.0015 0.003 0.0017 0.0019 0.0019
Vacuole Periphery 0.0009 0.0003 0.0006 0.0002 0.0004 0.0002 0.0027 0.0009 0.0021 0.0011 0.0034 0.0009 0.0006 0.0003 0.001 0.0005 0.0008 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.8328 2.3757 2.8206 7.4969 4.8238 6.9057 5.7649 5.5121 6.0084 7.2057
Translational Efficiency 0.6143 1.4709 1.1516 0.4655 0.881 1.2781 0.6498 0.6836 0.7518 0.9443

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
168 209 608 170 1764 258 116 1547 1932 467 724 1717

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 605.52 761.97 823.45 879.44 661.80 737.95 915.38 821.08 656.91 748.70 838.18 826.86
Standard Deviation 83.05 100.83 125.72 102.90 75.90 87.68 106.45 107.83 78.17 94.55 127.38 108.76
Intensity Change Log 2 — 0.331560 0.443506 0.538411 — 0.157128 0.467975 0.311128 — 0.243105 0.456336 0.424195

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000231 0.003187 0.000392 0.000782 0.000233 0.000222 0.000391 0.001540 0.000233 0.001549 0.000392 0.001465
Bud Neck 0.011056 0.026498 0.002490 0.004572 0.004526 0.015806 0.001356 0.013883 0.005093 0.020591 0.002308 0.012961
Bud Site 0.001051 0.013553 0.001847 0.020514 0.001962 0.007091 0.000500 0.017156 0.001883 0.009983 0.001631 0.017488
Cell Periphery 0.000152 0.000451 0.000095 0.000159 0.000141 0.000144 0.000074 0.000169 0.000142 0.000281 0.000092 0.000168
Cytoplasm 0.289877* 0.234251* 0.079041 0.085496 0.334147* 0.267808* 0.024777 0.153885* 0.330297* 0.252790* 0.070347 0.147113*
Cytoplasmic Foci 0.211152* 0.177854 0.002144 0.008331 0.127699 0.205493* 0.000998 0.004129 0.134956 0.193124* 0.001961 0.004545
Eisosomes 0.000199 0.000142 0.000032 0.000081 0.000088 0.000136 0.000054 0.000033 0.000098 0.000139 0.000036 0.000038
Endoplasmic Reticulum 0.000696 0.001654 0.005231 0.008440 0.000599 0.000846 0.008704 0.004143 0.000607 0.001207 0.005787 0.004569
Endosome 0.006133 0.014852 0.000631 0.006224 0.002304 0.016802 0.000632 0.004328 0.002637 0.015929 0.000631 0.004516
Golgi 0.000666 0.003545 0.000051 0.000146 0.000887 0.001907 0.000034 0.003455 0.000868 0.002640 0.000048 0.003127
Lipid Particles 0.013395 0.008043 0.000799 0.001853 0.010022 0.009764 0.001078 0.001050 0.010315 0.008993 0.000844 0.001130
Mitochondria 0.003981 0.012515 0.000435 0.001071 0.004987 0.005596 0.000395 0.005522 0.004900 0.008693 0.000429 0.005081
Mitotic Spindle 0.001592 0.011388 0.000265 0.019627 0.001142 0.002160 0.000119 0.020986 0.001181 0.006290 0.000242 0.020852
None 0.003064 0.004646 0.005583 0.007502 0.004240 0.004504 0.002128 0.010583 0.004138 0.004568 0.005030 0.010278
Nuclear Periphery 0.000871 0.001219 0.000840 0.002418 0.001273 0.000959 0.001355 0.002420 0.001238 0.001075 0.000923 0.002420
Nuclear Periphery Foci 0.000288 0.000626 0.000430 0.001331 0.000538 0.000406 0.000287 0.000971 0.000516 0.000504 0.000407 0.001007
Nucleolus 0.002026 0.003248 0.001076 0.002095 0.001444 0.003989 0.000905 0.001014 0.001495 0.003657 0.001049 0.001121
Nucleus 0.405256* 0.382212* 0.888422* 0.751348* 0.487044* 0.383930* 0.939705* 0.718901* 0.479932* 0.383161* 0.896639* 0.722113*
Peroxisomes 0.021171 0.028742 0.000178 0.001131 0.004699 0.020704 0.000164 0.000727 0.006132 0.024301 0.000175 0.000767
Vacuole 0.026463 0.070010 0.009912 0.076251 0.011720 0.050433 0.016257 0.032695 0.013002 0.059195 0.010928 0.037008
Vacuole Periphery 0.000679 0.001365 0.000104 0.000626 0.000306 0.001301 0.000088 0.002412 0.000339 0.001329 0.000102 0.002235

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.36 -2.34 -3.53 1.03 -2.37 0.03 -2.11 -2.06 -2.27 -1.15 -1.35 -2.19 -2.24 0.47 -1.38
Bud Neck -2.05 3.27 1.78 2.84 -3.48 -3.90 2.27 -6.76 0.44 -7.61 -4.42 3.05 -6.36 1.87 -7.72
Bud Site -2.82 -1.74 -2.19 0.28 -1.75 -1.54 0.87 -5.83 -1.48 -6.81 -2.93 -0.70 -6.20 -0.77 -5.39
Cell Periphery -0.99 2.62 0.39 1.02 -1.95 -0.09 2.22 0.19 0.33 -2.51 -1.02 2.20 0.23 1.06 -2.60
Cytoplasm 1.79 10.60 9.78 8.39 -0.34 4.67 38.93 27.28 8.53 -14.53 6.43 34.16 28.99 10.66 -8.55
Cytoplasmic Foci 2.02 12.87 12.68 12.82 -1.48 -5.99 31.61 31.09 16.50 -4.18 -5.58 33.63 33.26 20.90 -2.98
Eisosomes 2.29 7.72 4.16 2.06 -6.87 -5.11 2.12 11.70 10.13 3.52 -4.68 11.41 11.69 10.52 -1.45
Endoplasmic Reticulum -3.10 -11.53 -9.42 -8.69 -4.46 -2.13 -7.82 -18.79 -16.81 4.30 -4.74 -14.66 -20.73 -17.51 1.98
Endosome -2.41 3.36 1.21 3.33 -2.81 -3.63 4.66 -0.81 3.51 -3.89 -5.07 6.60 -0.38 4.96 -4.97
Golgi -1.37 4.03 3.22 1.67 -2.18 -1.28 2.68 -0.83 0.26 -2.23 -1.63 2.83 -0.75 0.94 -2.23
Lipid Particles 2.04 4.79 4.40 4.65 -4.06 0.15 10.62 10.75 5.22 0.19 1.12 11.88 11.56 7.16 -2.04
Mitochondria -1.59 1.94 1.65 2.43 -3.01 -0.24 4.64 1.41 1.56 -4.09 -1.41 4.95 1.66 2.35 -4.24
Mitotic Spindle -1.56 0.69 -2.09 -0.75 -2.26 -0.63 1.36 -6.90 -5.76 -7.28 -1.77 1.24 -7.21 -3.63 -7.58
None -0.59 -2.23 -2.02 -0.37 -0.41 -0.51 3.14 -3.21 -2.00 -4.86 -0.44 -0.68 -3.43 -1.72 -2.56
Nuclear Periphery -1.59 -0.60 -7.11 -6.18 -7.52 1.36 -3.38 -10.68 -12.85 -6.57 0.40 0.27 -11.96 -13.32 -15.55
Nuclear Periphery Foci -1.90 -2.03 -3.94 -3.11 -3.51 0.42 0.34 -1.96 -2.69 -2.68 -0.18 -0.18 -2.55 -2.88 -2.99
Nucleolus -0.55 2.04 1.53 1.29 -1.00 -2.72 4.06 0.33 2.74 -1.90 -2.60 3.36 0.68 2.73 -1.26
Nucleus 0.62 -20.83 -7.95 -8.48 8.76 5.27 -35.68 -24.09 -18.07 14.94 6.07 -45.17 -25.20 -21.61 17.63
Peroxisomes -0.57 3.46 3.41 4.85 -1.24 -2.90 8.46 7.75 3.78 -3.15 -4.36 8.15 7.71 6.03 -3.01
Vacuole -4.43 2.10 -7.72 -4.90 -8.53 -6.12 -4.28 -14.86 -1.62 -4.55 -8.74 -3.44 -16.37 -1.91 -13.46
Vacuole Periphery -1.58 2.08 1.18 3.04 -1.60 -3.11 3.07 -1.99 0.13 -2.48 -4.26 3.50 -1.91 0.40 -2.51
Standard name
Human Ortholog
Description Subunit of structure-specific Mms4p-Mus81p endonuclease; cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdc5p during mitotic cell cycle activates the function of Mms4p-Mus81p
Localization
Cell Percentages nucleus (15%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Mms4

Mms4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mms4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available