Standard name
Human Ortholog
Description Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.4 0.34 0.45 0.39 0.27 0.15 0.21 0.19 0.2 0.16 0.12 0.18 0.3 0.36 0.3 0.29 0.29 0.3 0.33 0.3 0.25 0.12 0.13 0.16
Bud 0.21 0.35 0.25 0.29 0.28 0.23 0.23 0.23 0.19 0.17 0.16 0.2 0.18 0.19 0.13 0.15 0.16 0.12 0.36 0.35 0.27 0.48 0.47 0.51
Bud Neck 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0.06 0 0.16 0.22 0.23 0.24 0.17 0.1
Bud Site 0.24 0.17 0.26 0.15 0.15 0.16 0.1 0.08 0.09 0.07 0.07 0.07 0.18 0.05 0 0.08 0 0 – – – – – –
Cell Periphery 0 0.06 0.07 0.13 0 0 0 0 0.06 0.05 0.06 0.09 0.12 0.22 0.2 0.15 0.11 0.12 0 0 0 0 0 0
Cytoplasm 0.19 0.19 0.23 0.26 0.33 0.29 0.36 0.36 0.28 0.28 0.33 0.29 0.27 0.3 0.37 0.24 0.28 0.35 0 0 0.05 0 0.07 0.09
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0.06 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.24 0.16 0 0.06 0 0.17 0.18 0.14 0.41 0.42 0.46 0.32 0.05 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.19 0.11 0 0.05 0 0.13 0 0 0 0.06 0.05 0.05 0.22 0.27 0.29 0.15 0.09 0.08 0 0 0 0 0 0
SpindlePole 0.06 0.13 0.22 0.23 0.26 0.17 0.15 0.18 0.09 0.09 0.08 0.11 0.12 0.08 0 0.23 0.21 0.12 0 0 0.06 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0.05 0.05 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 83 60 118 107 103 46 100 83 63 50 37 60 77 114 112 59 44 34 78 63 82 25 45 57
Bud 45 62 65 80 105 68 109 99 61 54 48 67 45 62 49 30 24 14 86 73 90 105 161 180
Bud Neck 3 3 8 12 12 12 24 14 10 5 7 9 0 1 1 2 9 0 38 45 76 52 58 35
Bud Site 50 30 69 42 56 48 50 35 29 22 22 24 46 17 15 16 4 3 – – – – – –
Cell Periphery 9 11 18 36 3 13 20 18 20 16 18 30 30 72 76 30 17 14 4 2 5 0 2 1
Cytoplasm 39 33 62 70 123 89 176 158 87 86 98 97 69 96 140 47 43 40 3 7 15 8 24 32
Endoplasmic Reticulum 4 5 3 2 5 6 10 10 1 6 4 8 4 7 11 8 9 4 1 1 1 1 8 3
Endosome 6 7 3 2 5 8 5 5 5 4 2 9 14 15 8 12 6 3 4 3 9 4 6 6
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 5 1 2 0 0 2 3 4
Mitochondria 50 28 2 16 8 50 86 60 128 129 137 104 12 7 12 6 5 5 3 4 14 3 8 10
Nucleus 10 4 8 4 14 3 15 21 5 5 8 8 5 2 1 2 1 1 0 0 0 0 0 0
Nuclear Periphery 0 1 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0 0 0 0 1 0 0 2
Nucleolus 1 1 2 1 5 9 7 12 6 3 6 5 4 1 0 4 0 1 0 0 0 0 0 0
Peroxisomes 40 20 11 13 7 38 20 12 11 17 16 15 57 86 109 30 14 9 4 1 6 3 5 3
SpindlePole 12 24 57 63 99 51 71 78 27 29 25 36 31 26 15 45 32 14 7 3 20 4 8 5
Vac/Vac Membrane 1 5 9 1 10 6 11 13 7 2 7 19 0 2 0 10 7 3 0 1 5 5 5 4
Unique Cell Count 210 178 265 272 378 302 484 436 315 309 299 330 255 321 377 200 153 115 239 210 331 219 346 353
Labelled Cell Count 354 294 435 449 555 447 704 618 460 428 436 491 394 509 550 304 220 146 239 210 331 219 346 353


Ambiguous, Bud, Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 5.9 6.4 5.9 6.3 5.2 5.3 5.6 4.7 4.5 4.5 5.2 6.3 6.4 6.5 9.2 9.5 9.2 5.8 6.1 6.4
Std Deviation (1e-4) 1.6 1.1 1.1 1.1 1.0 1.1 1.1 1.2 1.1 0.9 1.0 1.3 1.2 1.1 1.1 1.8 2.2 1.8 1.0 1.7 1.8
Intensity Change (Log2) – – – -0.14 -0.03 -0.31 -0.27 -0.2 -0.45 -0.51 -0.53 -0.31 -0.03 -0.02 0.02 0.51 0.56 0.52 -0.14 -0.09 -0.02

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.2 -4.5 -7.7 -6.9 -7.2 0 0 0 -7.0 -3.4 -2.2 -3.9 -3.3 -3.2 -2.7
Bud 1.3 0.9 -0.6 -0.6 -0.6 0 0 0 -1.2 -1.9 -1.5 -3.8 -2.5 -2.1 -2.7
Bud Neck 0.9 0.1 0.6 1.3 0.1 0 0 0 -0.2 0 0 0 0 1.4 0
Bud Site -3.0 -3.5 -3.0 -5.6 -6.5 0 0 0 -6.3 -2.2 -7.1 -8.2 -5.0 -6.1 -5.4
Cell Periphery 2.5 -4.2 -1.3 -1.6 -1.5 0 0 0 1.0 2.0 5.2 4.7 2.9 1.5 1.7
Cytoplasm 0.6 2.5 1.6 3.6 3.6 1.2 1.2 2.5 1.6 1.0 1.8 3.7 0 1.1 2.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 1.5 0 0 0
Endosome 0 0 1.3 0 0 0 0 0 1.4 2.8 2.5 0 2.9 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.3 0 6.5 6.9 5.9 0 0 0 9.7 2.8 0 2.1 0 0 0
Nucleus -1.2 0.5 -1.7 0.1 1.2 -1.2 -1.1 -0.2 -0.4 -0.8 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1.9 0 1.8 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.4 -1.7 3.6 0 -1.0 0 0 0 0.2 6.2 7.3 7.9 4.1 2.1 1.5
SpindlePole 0.5 1.4 -1.4 -2.4 -1.2 0 0 0 -3.5 -2.8 -4.6 -6.9 0.3 -0.1 -2.1
Vacuole 0 -0.6 -1.0 -0.9 -0.3 -0.9 -2.4 -0.8 1.4 0 0 0 0.9 0.6 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.6591 1.3635 1.1386 1.1893 0.7933 1.3672 1.6714 1.9858 1.6179 1.7675 1.1833 2.0799 1.7109 1.7152 1.4753 1.9072 1.5171 1.9567
Actin 0.1394 0.1089 0.1249 0.0652 0.5245 0.1932 0.2022 0.0633 0.1162 0.3059 0.3507 0.2034 0.1813 0.105 0.0849 0.1572 0.3873 0.1206
Bud 0.0221 0.06 0.226 0.0942 0.1164 0.0136 0.0205 0.0535 0.2979 0.1286 0.0512 0.011 0.0656 0.0763 0.3187 0.1123 0.0605 0.0155
Bud Neck 0.1344 0.0201 0.017 0.0946 0.0037 0.6027 0.0931 0.0154 0.006 0.0011 0.02 0.6148 0.0551 0.0118 0.0037 0.0028 0.0606 0.6601
Bud Periphery 0.0538 0.0349 0.316 0.4935 0.1494 0.0338 0.0439 0.0486 0.3499 0.3562 0.1761 0.0236 0.0912 0.0523 0.3618 0.5752 0.2362 0.0523
Bud Site 0.2536 0.5333 0.0715 0.0115 0.0145 0.0172 0.247 0.6347 0.0973 0.0131 0.0568 0.0272 0.2027 0.5982 0.069 0.076 0.0567 0.0235
Cell Periphery 0.0193 0.0057 0.0077 0.0029 0.0019 0.0042 0.0309 0.0131 0.0041 0.0026 0.0074 0.004 0.0079 0.0074 0.003 0.0064 0.0162 0.0072
Cytoplasm 0.0915 0.1127 0.076 0.0464 0.0297 0.0157 0.0965 0.0994 0.0531 0.0725 0.0578 0.0266 0.0946 0.0785 0.0794 0.0079 0.1559 0.0349
Cytoplasmic Foci 0.0907 0.0755 0.0827 0.0279 0.019 0.0338 0.1137 0.0313 0.0062 0.0107 0.0843 0.0286 0.0822 0.0242 0.0251 0.0094 0.0096 0.0433
Eisosomes 0.0012 0.0004 0.0007 0.0004 0.0011 0.0004 0.0013 0.0014 0.0005 0.0003 0.0006 0.0007 0.0012 0.0005 0.0002 0.0029 0.002 0.0004
Endoplasmic Reticulum 0.0103 0.0022 0.0042 0.0014 0.0009 0.0011 0.0052 0.0022 0.0013 0.002 0.0069 0.001 0.024 0.0007 0.0011 0.0003 0.0006 0.0004
Endosome 0.0394 0.0043 0.005 0.0054 0.013 0.0265 0.0284 0.0017 0.0175 0.0303 0.0875 0.0104 0.0428 0.0019 0.014 0.0002 0.001 0.0006
Golgi 0.0201 0.0061 0.003 0.0028 0.0116 0.0195 0.0192 0.0043 0.0058 0.0113 0.03 0.0082 0.0322 0.006 0.0083 0.0004 0.0027 0.002
Lipid Particles 0.0195 0.0021 0.0044 0.0011 0.0616 0.0045 0.0126 0.001 0.0023 0.0011 0.0113 0.0038 0.0106 0.0012 0.0047 0.0002 0.0007 0.0006
Mitochondria 0.017 0.0007 0.0015 0.0835 0.0028 0.0047 0.0094 0.002 0.0195 0.0356 0.0063 0.0058 0.0216 0.0134 0.0079 0.0012 0.001 0.0005
None 0.0154 0.0181 0.0165 0.0292 0.0096 0.0011 0.0198 0.0165 0.012 0.007 0.0042 0.0105 0.02 0.0116 0.0067 0.0433 0.003 0.0316
Nuclear Periphery 0.0142 0.0004 0.0008 0.0009 0.0021 0.001 0.0171 0.0003 0.0012 0.001 0.0047 0.0003 0.0243 0.0002 0.0015 0.0001 0.0002 0
Nucleolus 0.0049 0.0003 0.0037 0.0003 0.0003 0.0004 0.001 0.0005 0.0012 0.0001 0.0006 0.0005 0.0006 0.0004 0.0002 0.0006 0.0002 0.0002
Nucleus 0.0104 0.0007 0.0011 0.0013 0.001 0.0007 0.0069 0.0006 0.0013 0.0008 0.0017 0.0006 0.0082 0.0006 0.0013 0.0005 0.0003 0.0002
Peroxisomes 0.0197 0.0099 0.0174 0.0301 0.0263 0.0217 0.014 0.007 0.0022 0.0013 0.0294 0.0154 0.0121 0.0058 0.0056 0.0009 0.0042 0.0051
Punctate Nuclear 0.0138 0.0015 0.0175 0.0006 0.0061 0.0014 0.009 0.001 0.0008 0.0003 0.0023 0.001 0.0063 0.0022 0.0014 0.0009 0.0007 0.0006
Vacuole 0.0078 0.002 0.0022 0.0055 0.0039 0.0024 0.0039 0.0021 0.0028 0.0134 0.008 0.0021 0.0066 0.0015 0.0011 0.0011 0.0005 0.0003
Vacuole Periphery 0.0016 0.0002 0.0003 0.0014 0.0006 0.0005 0.0043 0.0001 0.0008 0.0048 0.002 0.0005 0.0091 0.0002 0.0004 0.0002 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 12.4389 10.4655 11.0017 15.4262 12.3329 9.7506 16.7543 19.4915 16.8538 19.1652
Translational Efficiency 1.3191 1.2648 1.4385 0.8751 1.1968 1.7114 1.1011 0.8799 1.0657 0.8688

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1958 228 355 1719 1216 1501 854 160 3174 1729 1209 1879

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 768.71 880.02 1067.14 1013.99 763.45 861.30 982.10 1017.52 766.69 863.77 1007.07 1014.29
Standard Deviation 85.96 113.25 110.31 128.98 93.70 113.27 122.73 138.81 89.04 113.45 125.35 129.85
Intensity Change Log 2 — 0.195097 0.473238 0.399532 — 0.173982 0.363336 0.414452 — 0.184614 0.419522 0.406986

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.070569 0.080693 0.079926 0.134779 0.099128 0.109955 0.066881 0.091463 0.081510 0.106096 0.070712 0.131090
Bud Neck 0.175462 0.114271 0.088223 0.053583 0.126551 0.134264 0.087230 0.068357 0.156724 0.131628 0.087521 0.054841
Bud Site 0.537509 0.500075 0.687602 0.618704 0.484265 0.564305 0.613392 0.659348 0.517110 0.555835 0.635183 0.622165
Cell Periphery 0.020579 0.014085 0.002904 0.007932 0.023465 0.019621 0.005687 0.004159 0.021685 0.018891 0.004870 0.007611
Cytoplasm 0.099670 0.109812 0.048703 0.125739 0.117911 0.085351 0.108580 0.086078 0.106658 0.088576 0.090998 0.122362
Cytoplasmic Foci 0.042728 0.056682 0.015707 0.008418 0.053576 0.025722 0.024524 0.016186 0.046884 0.029804 0.021935 0.009080
Eisosomes 0.003467 0.003766 0.000545 0.002675 0.007437 0.003489 0.001321 0.001299 0.004988 0.003525 0.001093 0.002558
Endoplasmic Reticulum 0.000259 0.003026 0.004470 0.000659 0.001145 0.000401 0.001021 0.000776 0.000599 0.000747 0.002033 0.000669
Endosome 0.004706 0.025417 0.002837 0.002765 0.011878 0.007592 0.003392 0.002264 0.007454 0.009942 0.003229 0.002722
Golgi 0.005202 0.014203 0.000642 0.002753 0.011705 0.009113 0.001457 0.004115 0.007693 0.009785 0.001218 0.002869
Lipid Particles 0.001635 0.002970 0.001269 0.000512 0.003343 0.000910 0.003132 0.001267 0.002289 0.001182 0.002585 0.000577
Mitochondria 0.006461 0.014840 0.000266 0.001720 0.010320 0.009391 0.000609 0.000113 0.007939 0.010109 0.000509 0.001583
Mitotic Spindle 0.000827 0.001892 0.001419 0.008338 0.001305 0.002712 0.002913 0.003674 0.001010 0.002603 0.002474 0.007941
None 0.000925 0.000103 0.000077 0.000103 0.000340 0.000405 0.000653 0.000087 0.000701 0.000365 0.000484 0.000102
Nuclear Periphery 0.000006 0.000035 0.000095 0.000029 0.000019 0.000018 0.000046 0.000018 0.000011 0.000020 0.000060 0.000028
Nuclear Periphery Foci 0.000129 0.000350 0.000634 0.000109 0.000278 0.000256 0.000391 0.000257 0.000186 0.000269 0.000462 0.000121
Nucleolus 0.000104 0.000326 0.000059 0.000023 0.000167 0.000093 0.000082 0.000022 0.000128 0.000124 0.000075 0.000023
Nucleus 0.001469 0.002223 0.010935 0.002399 0.002864 0.001152 0.013470 0.003621 0.002004 0.001293 0.012725 0.002503
Peroxisomes 0.023838 0.040016 0.008282 0.008734 0.035072 0.018325 0.018646 0.010288 0.028142 0.021186 0.015603 0.008866
Vacuole 0.004209 0.012505 0.045231 0.019311 0.008565 0.005514 0.046456 0.046509 0.005878 0.006435 0.046096 0.021627
Vacuole Periphery 0.000246 0.002712 0.000173 0.000715 0.000667 0.001412 0.000116 0.000097 0.000407 0.001584 0.000133 0.000662

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.80 -0.17 -7.70 -3.63 -4.93 -1.29 4.35 0.71 1.29 -1.26 -3.82 2.62 -6.33 -2.35 -7.61
Bud Neck 4.12 9.61 19.34 4.53 3.32 -0.91 5.52 5.11 5.75 1.47 3.60 12.07 20.60 13.00 5.30
Bud Site 1.57 -4.14 -4.87 -3.77 1.40 -5.94 -5.45 -4.32 -1.70 -1.37 -3.76 -5.75 -7.68 -3.38 -0.59
Cell Periphery 1.35 10.83 7.35 1.41 -5.31 1.32 7.08 7.93 8.02 0.98 1.33 11.08 9.60 6.54 -2.45
Cytoplasm -0.83 4.34 -6.73 -2.58 -8.97 4.90 -0.93 0.78 -1.35 1.26 3.61 -0.14 -5.81 -8.37 -4.60
Cytoplasmic Foci -1.62 6.10 12.02 5.67 2.43 6.98 6.11 7.00 1.73 1.80 5.61 7.51 16.37 8.36 5.81
Eisosomes -0.28 6.58 1.43 1.14 -3.99 4.13 6.97 6.89 3.84 -0.01 2.44 8.35 4.18 1.77 -2.76
Endoplasmic Reticulum -1.53 -6.17 -4.62 1.28 5.70 3.10 0.02 0.83 -1.55 0.89 -0.58 -6.20 -0.88 0.17 5.89
Endosome -3.95 1.65 2.85 4.34 0.91 2.96 6.56 6.12 3.82 1.01 -2.13 5.71 6.69 6.39 1.29
Golgi -3.87 9.15 3.43 4.95 -3.21 1.73 8.53 2.21 1.51 -0.69 -2.02 10.79 6.15 6.57 -2.24
Lipid Particles -1.29 -0.51 2.56 2.50 3.62 4.00 0.10 2.10 -0.58 1.36 2.84 -0.62 4.63 2.27 2.67
Mitochondria -1.60 6.80 4.87 2.55 -3.20 0.46 6.48 6.83 7.08 2.82 -1.40 9.21 7.29 6.25 -2.56
Mitotic Spindle -1.66 -2.47 -4.67 -3.73 -3.76 -1.40 -2.04 -0.89 -0.41 -0.38 -1.98 -3.26 -4.63 -3.15 -3.41
None 2.27 2.28 2.25 -0.30 -0.42 -0.23 -0.97 2.14 1.03 1.74 1.04 0.74 2.59 1.05 1.75
Nuclear Periphery -2.03 -5.92 -4.32 -0.25 4.89 0.05 -6.18 -1.71 -1.49 3.66 -1.56 -8.61 -3.89 -2.00 5.51
Nuclear Periphery Foci -2.17 -6.46 0.06 2.16 6.43 0.12 -2.33 -0.67 -0.65 1.43 -0.91 -6.01 1.04 1.33 6.49
Nucleolus -0.79 0.62 2.22 1.08 2.57 1.00 1.21 2.23 2.01 3.02 0.06 1.22 3.11 2.10 3.63
Nucleus -1.03 -5.60 -6.88 -1.47 4.97 3.77 -6.53 -0.92 -1.92 4.57 2.48 -8.87 -4.96 -6.53 7.85
Peroxisomes -2.43 7.00 7.46 4.83 -0.47 5.17 4.57 5.75 2.22 1.81 3.10 5.52 10.65 6.36 2.82
Vacuole -2.97 -8.32 -11.04 -5.49 5.43 2.38 -11.36 -4.50 -4.70 -0.24 -0.70 -14.41 -11.33 -10.92 7.25
Vacuole Periphery -1.99 0.63 -2.31 1.63 -2.46 -1.43 4.99 4.96 2.56 0.55 -2.47 5.30 -1.26 1.91 -2.86
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
Localization
Cell Percentages actin (32%), bud neck (22%), mixed (24%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Exo84

Exo84


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Exo84-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available