Standard name
Human Ortholog
Description WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Site 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.07 0 0 0.07 0 0 0.08 0 0 0 0 0 0.17 0.17 0.19 0.15 0.19 0.13 0 0 0 0 0.05 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0.05 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.27 0.35 0.33 0.2 0.64 0.7 0.48 0.6 0.69 0.68 0.74 0 0.08 0 0.14 0.06 0.07 0 0 0 0 0 0
Nucleus 0.71 0.65 0.76 0.75 0.8 0.61 0.52 0.66 0.6 0.57 0.57 0.52 0.77 0.71 0.72 0.72 0.73 0.77 0.52 0.65 0.56 0.56 0.43 0.32
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.2 0.13 0.08 0.08 0.05 0.09 0.13 0.17 0.26 0.19 0.24 0.24 0.09 0.08 0.18 0.05 0 0.05 0.2 0.14 0.21 0.26 0.21 0.23
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0.06 0.06 0.14
Vac/Vac Membrane 0 0.14 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0.08 0.06 0.09 0.07 0.08 0.11
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 2 0 0 4 0 2 1 5 0 0 0 0 0 0 1 1 3 2 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 1 1 0 0 1 5
Bud Site 1 0 0 0 1 4 7 12 14 17 5 8 0 0 0 3 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 13 2 4 9 7 10 21 14 9 12 4 5 18 16 18 43 36 20 1 1 0 0 5 0
Endoplasmic Reticulum 0 1 0 0 1 0 0 1 0 0 0 0 1 1 0 5 4 2 0 0 0 0 0 2
Endosome 3 1 2 0 4 0 0 1 0 0 0 0 1 4 2 15 3 1 9 3 5 0 2 3
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 3 2 2 0 1 0 0 0
Mitochondria 73 25 62 43 37 163 189 204 205 238 100 101 4 7 0 40 11 10 1 3 3 0 4 1
Nucleus 129 61 134 97 149 157 140 281 202 197 84 71 80 66 68 201 138 114 99 82 112 30 49 33
Nuclear Periphery 0 0 0 2 1 3 3 3 6 5 0 6 0 0 0 3 4 1 0 0 2 0 0 1
Nucleolus 36 12 14 10 9 24 35 71 89 64 36 33 9 7 17 13 7 8 37 17 42 14 23 24
Peroxisomes 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 9 3 3 2 6 8 3 0 1 0 1 1 1 2 5 2 12 5 10 3 7 14
Vac/Vac Membrane 4 13 2 3 4 4 1 2 1 3 0 0 3 2 3 6 11 7 14 7 19 3 9 11
Unique Cell Count 182 94 177 130 187 256 271 426 339 345 148 137 104 93 94 278 189 149 190 127 202 54 113 106
Labelled Cell Count 260 115 229 167 216 371 402 599 532 542 231 224 117 104 109 335 223 168 190 127 202 54 113 106


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.7 4.8 4.6 4.5 4.6 3.8 3.4 4.2 3.9 3.7 3.8 3.7 6.0 5.5 5.4 6.8 8.1 8.2 4.5 5.8 6.4
Std Deviation (1e-4) 1.5 0.8 1.1 1.4 1.0 1.0 1.0 1.5 1.1 1.5 1.2 0.9 2.1 2.1 1.6 2.2 2.5 2.7 0.7 2.7 2.7
Intensity Change (Log2) – – – -0.02 0.02 -0.27 -0.44 -0.12 -0.23 -0.3 -0.28 -0.31 0.39 0.27 0.24 0.58 0.82 0.84 -0.02 0.35 0.49

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – 0 –
Bud Neck – – – – – – – – – – – – – 0 –
Bud Site – – – – – – – – – – – – – 0 –
Cell Periphery – – – – – – – – – – – – – 0 –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – 0 –
Endosome – – – – – – – – – – – – – 0 –
Golgi – – – – – – – – – – – – – 0 –
Mitochondria – – – – – – – – – – – – – 0 –
Nuclear Periphery – – – – – – – – – – – – – 0 –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – 0 –
Peroxisomes – – – – – – – – – – – – – 0 –
SpindlePole – – – – – – – – – – – – – 0 –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – 0 –
Cytoplasm – – – – – – – – – – – – – 0 –
Nucleus – – – – – – – – – – – – – 0 –
Vacuole – – – – – – – – – – – – – 2.4 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration – – – – – – – – – – – – – – – – – –
Actin 0.461 0.0035 0.0331 0 0.0002 0.0015 – – – – – – 0.0006 0 0.0049 0 0.0044 0
Bud 0.0032 0.0004 0.0002 0 0.0001 0.0001 – – – – – – 0.0001 0.0001 0.0008 0 0.0002 0
Bud Neck 0.0045 0.0007 0.0008 0.0003 0.0016 0.0032 – – – – – – 0.0015 0.0003 0.0002 0.0001 0.0013 0.0016
Bud Periphery 0.0057 0.001 0.0002 0 0.0001 0.0003 – – – – – – 0.0001 0.0001 0.0009 0 0.0005 0
Bud Site 0.0211 0.0008 0.0015 0.0001 0.0002 0.0004 – – – – – – 0.0004 0.0004 0.0013 0.0001 0.0005 0.0001
Cell Periphery 0.0009 0.0003 0.0001 0 0 0.0001 – – – – – – 0 0 0.0001 0 0.0003 0
Cytoplasm 0.0022 0.012 0.0011 0.0001 0.0016 0.0005 – – – – – – 0.0029 0.0044 0.0038 0 0.0006 0.0002
Cytoplasmic Foci 0.0155 0.0002 0.0139 0 0.0003 0.0001 – – – – – – 0.0061 0.0001 0.0002 0 0.0159 0
Eisosomes 0.0037 0.0001 0.0002 0 0 0 – – – – – – 0 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0073 0.0007 0.0004 0 0.0002 0.0007 – – – – – – 0.0007 0 0.002 0 0.0004 0
Endosome 0.0256 0.0035 0.0119 0 0.0011 0.0014 – – – – – – 0.0082 0.0001 0.0017 0 0.0142 0
Golgi 0.0282 0.0017 0.0049 0 0.0001 0.0001 – – – – – – 0.0009 0 0.0002 0 0.0041 0
Lipid Particles 0.0243 0.0003 0.0041 0 0.0002 0.0001 – – – – – – 0.0067 0 0.0001 0 0.0038 0
Mitochondria 0.0146 0.0175 0.0011 0.0001 0.0006 0.0009 – – – – – – 0.0001 0.0007 0.004 0.0001 0.0016 0.0001
None 0.0091 0.0006 0.0003 0.0001 0.0035 0.0003 – – – – – – 0.0008 0.0854 0.0923 0 0.0003 0.0001
Nuclear Periphery 0.0069 0.0133 0.0018 0.0007 0.0135 0.0099 – – – – – – 0.114 0.0016 0.0326 0.0001 0.0307 0.0009
Nucleolus 0.0178 0.0707 0.0505 0.0651 0.1353 0.1245 – – – – – – 0.0321 0.0849 0.0417 0.0594 0.2208 0.0619
Nucleus 0.3176 0.8621 0.8587 0.9313 0.766 0.8429 – – – – – – 0.104 0.8139 0.7956 0.9389 0.3587 0.9243
Peroxisomes 0.0225 0.0002 0.003 0 0.0001 0.0001 – – – – – – 0.0005 0 0.0001 0 0.2215 0
Punctate Nuclear 0.0047 0.0047 0.0121 0.002 0.0748 0.0122 – – – – – – 0.7189 0.0077 0.0154 0.0011 0.0036 0.0104
Vacuole 0.0016 0.0021 0.0003 0.0001 0.0004 0.0005 – – – – – – 0.0006 0.0002 0.001 0 0.0737 0.0001
Vacuole Periphery 0.0019 0.0037 0.0001 0 0.0002 0.0003 – – – – – – 0.0006 0.0001 0.001 0 0.043 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.293 19.016 10.9244 11.4667 13.3453 11.6589 12.0944 14.8607 13.657 14.4467
Translational Efficiency 1.5562 0.6545 0.9302 0.7962 0.9857 1.0531 1.2756 0.6632 0.7611 0.8126

Hit Data

Dataset Hit
Protein Concentration –
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
74 1382 162 1450 1490 1401 276 2099 1564 2783 438 3549

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 725.42 715.21 877.96 856.17 759.55 775.80 910.05 916.73 757.94 745.71 898.18 891.99
Standard Deviation 67.06 115.67 92.57 118.44 84.29 101.79 84.45 126.79 83.87 113.04 88.90 126.99
Intensity Change Log 2 — -0.020450 0.275339 0.239081 — 0.030540 0.260801 0.271352 — 0.005856 0.267921 0.255677

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000347 0.001076 0.001160 0.001241 0.000065 0.001024 0.001392 0.001449 0.000079 0.001050 0.001306 0.001364
Bud Neck 0.001044 0.011189 0.010628 0.026834 0.008056 0.010473 0.002922 0.051462 0.007724 0.010828 0.005772 0.041399
Bud Site 0.000828 0.006430 0.001868 0.009246 0.000687 0.003634 0.001211 0.015748 0.000693 0.005023 0.001454 0.013091
Cell Periphery 0.000234 0.000199 0.000075 0.000176 0.000067 0.000197 0.000067 0.000158 0.000075 0.000198 0.000070 0.000166
Cytoplasm 0.075380 0.063252 0.005976 0.024795 0.045316 0.030161 0.007739 0.041688 0.046739 0.046594 0.007087 0.034786
Cytoplasmic Foci 0.073342 0.016914 0.000711 0.001332 0.003798 0.007540 0.000564 0.004114 0.007089 0.012195 0.000618 0.002977
Eisosomes 0.000128 0.000062 0.000061 0.000039 0.000018 0.000050 0.000071 0.000033 0.000023 0.000056 0.000067 0.000035
Endoplasmic Reticulum 0.001613 0.005258 0.004818 0.007634 0.000826 0.003810 0.005608 0.004409 0.000863 0.004529 0.005316 0.005727
Endosome 0.007222 0.005350 0.000460 0.002798 0.000642 0.003067 0.000445 0.005507 0.000954 0.004200 0.000451 0.004400
Golgi 0.001534 0.004023 0.000211 0.000679 0.000130 0.002713 0.000189 0.002642 0.000197 0.003364 0.000197 0.001840
Lipid Particles 0.012614 0.005201 0.000720 0.000753 0.001341 0.003580 0.000992 0.000533 0.001875 0.004385 0.000891 0.000623
Mitochondria 0.002275 0.015666 0.000803 0.004181 0.003843 0.012892 0.000885 0.007886 0.003769 0.014270 0.000855 0.006372
Mitotic Spindle 0.000455 0.020848 0.001022 0.018372 0.000802 0.031361 0.003579 0.077766 0.000785 0.026141 0.002633 0.053499
None 0.037108 0.037235 0.006859 0.010672 0.012351 0.016666 0.006774 0.010343 0.013523 0.026880 0.006805 0.010477
Nuclear Periphery 0.000544 0.002654 0.000453 0.002679 0.002242 0.002827 0.000438 0.004277 0.002161 0.002741 0.000444 0.003624
Nuclear Periphery Foci 0.006038 0.005131 0.001403 0.001732 0.000511 0.003447 0.001077 0.001806 0.000772 0.004283 0.001198 0.001776
Nucleolus 0.080712 0.098132 0.049896 0.013128 0.059303 0.093531 0.039723 0.021342 0.060316 0.095816 0.043486 0.017986
Nucleus 0.682495 0.687358 0.910137 0.861340 0.857973 0.764320 0.921581 0.727829 0.849670 0.726102 0.917348 0.782377
Peroxisomes 0.010465 0.004507 0.000639 0.000633 0.000508 0.002958 0.001282 0.001384 0.000979 0.003728 0.001044 0.001077
Vacuole 0.005203 0.006622 0.001931 0.009177 0.001170 0.004022 0.003308 0.015090 0.001360 0.005313 0.002799 0.012674
Vacuole Periphery 0.000417 0.002891 0.000170 0.002561 0.000350 0.001725 0.000154 0.004535 0.000353 0.002304 0.000160 0.003729

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.57 -5.67 -10.14 -4.06 0.14 -5.81 -8.69 -9.74 -1.23 2.22 -10.68 -11.22 -16.05 -2.66 2.00
Bud Neck -13.47 -3.45 -19.72 -12.32 -5.40 -2.73 1.53 -23.44 -21.54 -23.21 -3.88 -0.61 -26.08 -24.71 -19.16
Bud Site -6.00 -3.27 -7.67 -1.74 -4.82 -4.99 -3.62 -10.45 -5.10 -7.08 -7.88 -4.90 -12.97 -4.78 -8.55
Cell Periphery 0.87 3.44 2.09 2.58 -3.11 -1.48 -2.32 -6.29 0.92 -1.54 -2.82 -1.62 -7.08 1.55 -3.38
Cytoplasm 1.26 4.95 4.18 10.78 -4.32 3.34 8.14 5.54 1.90 -4.48 -0.02 10.49 7.52 9.16 -5.75
Cytoplasmic Foci 3.65 4.56 4.56 9.58 -0.00 -3.24 5.79 4.65 6.81 -1.34 -2.89 6.69 6.35 11.61 -1.16
Eisosomes 4.11 3.58 4.96 5.00 2.89 -11.42 -9.54 -13.25 4.29 6.71 -13.54 -10.21 -9.84 6.91 7.18
Endoplasmic Reticulum -8.37 -6.78 -16.39 -9.37 -5.50 -11.65 -11.25 -23.16 -5.90 2.76 -17.66 -14.03 -30.13 -10.33 -1.14
Endosome 0.97 2.08 1.82 4.78 -3.36 -4.81 -1.01 -3.59 1.72 -3.12 -6.56 1.30 -2.54 4.60 -4.34
Golgi -2.69 3.20 2.93 5.29 -0.71 -4.10 -3.07 -4.28 2.66 -3.61 -6.83 -1.69 -4.11 5.50 -3.61
Lipid Particles 3.31 4.98 5.03 8.44 0.66 -4.76 0.26 4.37 7.67 3.83 -5.66 2.88 5.70 11.48 3.67
Mitochondria -8.32 3.71 -2.40 7.68 -9.38 -5.75 3.59 -1.70 5.25 -9.70 -8.30 3.73 -1.20 9.03 -12.74
Mitotic Spindle -8.72 -2.63 -8.65 0.53 -7.45 -9.51 -1.76 -15.71 -5.47 -12.20 -12.68 -2.12 -17.57 -5.08 -13.69
None 0.23 2.87 2.80 11.93 -0.58 -2.54 3.90 3.03 5.60 -2.05 -7.20 4.55 4.07 12.95 -1.89
Nuclear Periphery -5.06 -0.65 -12.26 -2.95 -11.98 -1.19 3.12 -3.21 -2.50 -7.05 -1.24 3.54 -4.13 -3.70 -11.13
Nuclear Periphery Foci 1.08 1.60 2.28 4.90 0.63 -5.99 -1.71 -1.30 5.35 1.47 -8.29 -1.88 -1.45 7.56 1.52
Nucleolus -0.24 1.63 4.47 20.84 5.55 -6.74 4.16 9.37 16.85 2.21 -7.71 3.14 11.98 25.99 5.59
Nucleus -1.40 -6.36 -5.80 -17.82 2.36 11.07 -4.79 9.67 -2.68 11.87 15.80 -6.00 4.86 -13.17 10.70
Peroxisomes 1.33 2.24 2.32 8.11 2.02 -7.33 -1.30 0.08 6.91 1.29 -7.80 -0.22 2.07 10.51 1.60
Vacuole 1.00 1.55 -0.05 -4.30 -7.01 -5.00 -3.37 -9.91 -7.04 -1.82 -5.44 -3.19 -11.41 -7.90 -4.00
Vacuole Periphery -4.53 2.81 -1.35 2.40 -1.90 -3.51 0.76 -2.80 0.39 -3.30 -5.57 0.88 -3.00 2.12 -3.72
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
Localization
Cell Percentages nucleus (89%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Sif2

Sif2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sif2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available