Standard name
Human Ortholog
Description Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in phosphate transport, interacting with pho88, and in the maturation of secretory proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0.06 0.07 0 0.05 0 0 0 0 0 0.05 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.06 0.11 0.07 0.12 0 0.08 0 0.1 0.12 0 0.11 0.14 0.13 0.16 0.53 0.64 0.32 0 0 0 0 0 0
Cytoplasm 0.06 0.12 0.07 0.07 0.1 0.2 0.07 0.13 0.11 0.08 0.18 0.11 0 0 0.05 0.33 0.19 0.5 0 0.06 0 0 0 0
Endoplasmic Reticulum 0.93 0.86 0.88 0.84 0.82 0.7 0.82 0.83 0.82 0.81 0.77 0.79 0.94 0.89 0.87 0 0 0.09 0.93 0.86 0.94 0.88 0.91 0.88
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.06 0.06 0 0 0.08 0 0 0 0 0 0 0 0 0.06 0.31 0.09 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 9 1 4 2 6 4 8 12 17 1 7 3 8 3 2 1 1 3 5 0 6 10 19
Bud 1 8 0 2 1 4 2 1 1 1 1 1 0 0 1 0 0 0 1 3 0 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 5 26 13 12 19 2 21 14 22 27 2 15 53 101 109 27 38 7 1 2 1 5 14 25
Cytoplasm 14 50 8 12 16 33 18 51 23 18 12 14 13 29 32 17 11 11 4 27 2 9 4 9
Endoplasmic Reticulum 223 358 106 146 130 117 212 331 174 187 51 105 356 706 594 0 0 2 224 389 115 328 517 554
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Golgi 7 2 7 10 6 6 20 9 3 7 2 5 9 11 13 3 18 2 1 3 0 8 6 4
Mitochondria 0 1 0 0 0 1 0 0 0 0 1 1 0 0 1 2 0 3 2 2 0 3 5 6
Nucleus 0 0 0 0 0 1 1 2 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 1 0 2 3 4 2 2 0 0 0 0 0 0 1 1 0 0 1 1
Nucleolus 1 0 0 0 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 4 2 2 0 1 7 9 7 4 5 0 2 0 2 2 2 0 0 0 13 0 3 1 1
Unique Cell Count 240 416 120 173 159 167 258 399 212 231 66 133 378 791 684 51 59 22 242 454 122 371 569 631
Labelled Cell Count 257 456 137 186 175 179 287 425 243 266 73 152 434 857 755 53 68 26 242 454 122 371 569 631


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 67.9 58.8 59.3 60.4 59.1 36.8 45.7 42.5 38.7 39.5 36.3 36.9 73.9 69.7 63.9 72.7 76.3 68.1 58.8 60.0 58.9
Std Deviation (1e-4) 14.9 12.2 11.3 12.9 15.3 14.7 10.6 10.1 9.5 9.0 8.4 9.2 13.9 12.8 12.6 20.0 16.0 19.6 13.4 12.8 13.0
Intensity Change (Log2) – – – 0.03 -0.01 -0.69 -0.38 -0.48 -0.62 -0.59 -0.71 -0.69 0.32 0.23 0.11 0.29 0.36 0.2 -0.01 0.02 -0.01

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700020406080WT3HU80HU120HU160020406080WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3020406080WT1AF100AF140AF180020406080
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 2.6 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -1.2 0.3 -3.6 -0.9 -3.2 -0.1 0.2 -1.9 0.1 0.9 0.6 1.4 6.0 7.5 0
Cytoplasm 0.1 1.0 3.1 0.1 1.9 1.3 0.4 2.4 1.1 -1.5 0 -0.9 4.5 2.4 0
Endoplasmic Reticulum -1.0 -1.5 -3.7 -1.5 -1.4 -1.5 -1.8 -2.0 -2.0 2.2 0.3 -0.4 -10.9 -11.3 -8.0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 -0.8 -0.9 0.7 0 0 0 0 -0.8 0 0 0 0 4.5 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 76.1787 72.683 72.951 71.2406 71.2472 70.5694 100.4203 93.016 91.1449 93.3239 96.9741 91.6893 89.0733 85.1175 82.126 81.7429 74.4334 81.8188
Actin 0.0017 0.0001 0.0001 0 0 0.0001 0.0019 0.0015 0.0002 0 0 0.0001 0.0049 0.0006 0.0004 0.0012 0.0011 0.0011
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0.0001 0.0001 0 0 0.0007 0
Bud Neck 0.0002 0.0002 0.0008 0.0001 0.0001 0.0005 0.0001 0.0003 0.0003 0.0001 0.0002 0.0009 0.0007 0.0006 0.0006 0.0021 0.0026 0.0035
Bud Periphery 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 0.0001 0.0003 0.0003 0.0001 0.0002 0.0018 0.0002
Bud Site 0.0002 0.0001 0 0 0 0 0 0.0001 0 0 0 0 0.0002 0.0005 0 0 0.0018 0
Cell Periphery 0.0321 0.0598 0.0443 0.046 0.057 0.0223 0.0378 0.076 0.0435 0.051 0.065 0.0258 0.05 0.083 0.0395 0.0253 0.0114 0.0146
Cytoplasm 0.0064 0.019 0.0052 0.0015 0.0013 0.0017 0.0087 0.0123 0.0125 0.0056 0.0037 0.004 0.0198 0.029 0.0209 0.0063 0.004 0.0118
Cytoplasmic Foci 0.0035 0.0001 0.0001 0 0 0 0.0003 0.0001 0.0001 0 0 0.0001 0.0017 0.0003 0.0001 0.0001 0.0015 0.0001
Eisosomes 0.0019 0.0017 0.001 0 0.0005 0.0001 0.0003 0.0019 0.0013 0.0003 0.0005 0.0003 0.0054 0.0084 0.0015 0.0007 0.0004 0.0008
Endoplasmic Reticulum 0.7912 0.8567 0.896 0.9185 0.892 0.9038 0.8715 0.8538 0.9003 0.896 0.8604 0.9312 0.7413 0.8017 0.8224 0.8767 0.865 0.8493
Endosome 0.0031 0.0002 0.0002 0 0.0002 0.0002 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0017 0.0004 0.0005 0.0004 0.0017 0.0006
Golgi 0.0024 0.0009 0.0006 0.0001 0.003 0.0008 0.0003 0.0015 0.0018 0.0004 0.0002 0.0003 0.0018 0.0019 0.0045 0.0032 0.0015 0.0018
Lipid Particles 0.0071 0.0088 0.0074 0.0021 0.0034 0.0059 0.0042 0.0174 0.0061 0.0051 0.006 0.004 0.0049 0.0206 0.0074 0.0015 0.0027 0.0021
Mitochondria 0.0009 0 0.0003 0 0 0 0.0002 0 0 0 0 0 0.0006 0.0004 0.0001 0.0001 0.0024 0.0001
None 0.001 0.0001 0.0001 0 0.0001 0 0.0003 0.0001 0.0001 0 0.0001 0 0.0029 0.0002 0.0002 0.0001 0.0014 0.0001
Nuclear Periphery 0.1284 0.0397 0.0315 0.0201 0.0298 0.0546 0.0621 0.0229 0.0251 0.0322 0.0531 0.0277 0.1436 0.0377 0.0865 0.0734 0.0472 0.1043
Nucleolus 0.0007 0 0.0001 0 0 0 0 0 0 0 0 0 0.0016 0.0001 0.0001 0.0001 0.0235 0.0001
Nucleus 0.0029 0.0004 0.0055 0.0001 0.0002 0.0008 0.0006 0.0004 0.0002 0.0001 0.0002 0.0006 0.0031 0.001 0.0018 0.0024 0.0091 0.0029
Peroxisomes 0.0024 0 0 0 0 0 0.0014 0 0 0 0 0 0.0002 0 0 0 0.0004 0
Punctate Nuclear 0.0003 0 0 0 0 0 0.0001 0 0 0 0 0 0.001 0.0001 0.0001 0.0001 0.012 0.0002
Vacuole 0.0114 0.0115 0.0063 0.0113 0.0118 0.0068 0.0092 0.0111 0.0078 0.0085 0.0101 0.0044 0.0108 0.0124 0.0117 0.005 0.0051 0.0041
Vacuole Periphery 0.0021 0.0006 0.0004 0.0001 0.0006 0.002 0.0006 0.0002 0.0004 0.0004 0.0004 0.0003 0.0036 0.0008 0.0016 0.0011 0.0028 0.0024

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 955.5054 828.0689 739.679 649.9472 648.4432 797.4345 740.5174 689.7468 706.1414 701.7771
Translational Efficiency 1.1768 1.1462 1.2219 1.3983 1.4674 1.3835 1.2841 1.3037 1.2365 1.2878

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1672 1038 1521 109 1660 1112 439 1303 3332 2150 1960 1412

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 3515.54 3706.70 5150.34 7045.02 3276.42 4263.69 6366.56 6018.39 3396.41 3994.78 5422.75 6097.64
Standard Deviation 745.01 1050.03 936.02 1237.05 683.22 806.49 914.60 1334.55 724.82 972.72 1060.36 1355.27
Intensity Change Log 2 — 0.076389 0.550921 1.002857 — 0.379982 0.958394 0.877257 — 0.230822 0.761853 0.943632

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000615 0.001931 0.001081 0.001305 0.000382 0.000595 0.000517 0.002765 0.000499 0.001240 0.000955 0.002652
Bud Neck 0.000400 0.002269 0.004025 0.004537 0.000399 0.000433 0.009343 0.006443 0.000400 0.001320 0.005216 0.006296
Bud Site 0.000198 0.003807 0.002412 0.003014 0.000376 0.001167 0.001521 0.014697 0.000286 0.002442 0.002213 0.013795
Cell Periphery 0.007064 0.017601 0.018325 0.113666 0.008543 0.006551 0.047724 0.035930 0.007801 0.011886 0.024910 0.041931
Cytoplasm 0.000159 0.002214 0.001220 0.000212 0.000278 0.000259 0.000125 0.007679 0.000218 0.001203 0.000975 0.007102
Cytoplasmic Foci 0.000254 0.001432 0.000153 0.000216 0.000287 0.000253 0.000080 0.004218 0.000270 0.000822 0.000137 0.003909
Eisosomes 0.001736 0.002152 0.001179 0.006933 0.001876 0.000978 0.007466 0.000756 0.001806 0.001545 0.002587 0.001233
Endoplasmic Reticulum 0.948418 0.779639 0.885806 0.594980 0.956443 0.966314 0.791827 0.591829 0.952416 0.876189 0.864757 0.592072
Endosome 0.002795 0.012779 0.006917 0.006825 0.003238 0.002970 0.007295 0.024381 0.003016 0.007706 0.007002 0.023026
Golgi 0.014032 0.045825 0.007131 0.058417 0.012082 0.009753 0.018589 0.038837 0.013061 0.027168 0.009697 0.040349
Lipid Particles 0.005300 0.054764 0.031002 0.044618 0.004065 0.003318 0.029680 0.165198 0.004685 0.028156 0.030706 0.155889
Mitochondria 0.001602 0.001541 0.000517 0.000859 0.000546 0.000334 0.000226 0.001837 0.001076 0.000916 0.000452 0.001761
Mitotic Spindle 0.000063 0.000252 0.000187 0.000421 0.000069 0.000046 0.000272 0.002344 0.000066 0.000145 0.000206 0.002195
None 0.000603 0.002832 0.000308 0.000258 0.000786 0.000865 0.000071 0.004165 0.000694 0.001815 0.000255 0.003863
Nuclear Periphery 0.003304 0.004695 0.009014 0.037775 0.002866 0.001724 0.020922 0.007580 0.003086 0.003158 0.011681 0.009911
Nuclear Periphery Foci 0.001211 0.015855 0.005439 0.003816 0.000864 0.000426 0.006928 0.029971 0.001038 0.007875 0.005773 0.027952
Nucleolus 0.000026 0.000099 0.000015 0.000058 0.000014 0.000007 0.000023 0.000053 0.000020 0.000052 0.000017 0.000053
Nucleus 0.000068 0.000512 0.000277 0.000799 0.000055 0.000051 0.000121 0.000871 0.000062 0.000273 0.000242 0.000866
Peroxisomes 0.000035 0.000046 0.000013 0.000008 0.000038 0.000058 0.000006 0.000141 0.000037 0.000052 0.000012 0.000131
Vacuole 0.005528 0.035084 0.022487 0.106202 0.004543 0.002636 0.051719 0.053493 0.005037 0.018302 0.029034 0.057562
Vacuole Periphery 0.006590 0.014671 0.002491 0.015081 0.002249 0.001261 0.005544 0.006815 0.004428 0.007735 0.003175 0.007453

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.35 -1.28 -1.08 0.10 -0.36 -0.80 -0.58 -4.56 -3.87 -3.97 -1.52 -1.53 -4.48 -2.41 -2.64
Bud Neck -6.43 -7.65 -2.45 -1.50 -0.42 -0.37 -5.19 -9.18 -8.52 1.06 -4.62 -9.07 -9.49 -7.94 -2.01
Bud Site -4.67 -3.68 -1.30 -0.24 -0.56 -1.71 -3.34 -8.70 -8.00 -7.84 -4.85 -4.05 -8.85 -7.30 -7.19
Cell Periphery -6.39 -8.04 -7.18 -6.44 -6.37 1.68 -9.03 -11.63 -12.57 2.39 -4.08 -11.59 -13.93 -11.88 -6.11
Cytoplasm -4.39 -2.82 -0.59 3.85 2.38 -0.01 0.99 -7.30 -7.27 -7.50 -3.92 -2.62 -7.39 -6.20 -6.06
Cytoplasmic Foci -3.60 2.22 0.31 3.53 -0.49 0.20 2.05 -7.63 -7.60 -8.13 -3.11 2.22 -7.73 -6.26 -8.01
Eisosomes -0.40 1.34 -3.50 -2.79 -3.95 2.06 -3.45 2.70 1.11 4.27 0.51 -1.67 1.86 0.65 3.29
Endoplasmic Reticulum 17.13 10.46 11.39 5.67 9.09 -2.55 12.05 35.67 36.39 12.08 13.99 15.85 37.31 26.50 24.79
Endosome -14.98 -11.14 -2.46 3.49 0.16 0.96 -5.92 -20.05 -20.20 -13.59 -12.87 -12.25 -20.38 -14.73 -15.48
Golgi -10.35 6.44 -6.16 -1.54 -7.16 2.07 -4.28 -9.96 -10.74 -6.96 -8.61 4.14 -10.85 -4.42 -12.23
Lipid Particles -12.76 -9.33 -3.64 0.94 -1.15 0.97 -6.39 -24.30 -24.35 -17.13 -11.84 -11.32 -24.26 -19.53 -18.68
Mitochondria 0.11 2.04 0.25 0.18 -0.74 1.51 2.48 -3.47 -4.09 -4.39 0.52 2.02 -1.99 -2.43 -3.53
Mitotic Spindle -2.28 -2.40 -7.08 -1.58 -2.70 1.42 -2.98 -4.47 -4.50 -4.02 -2.00 -3.24 -4.52 -4.34 -4.19
None -2.71 2.44 1.04 2.94 -0.15 -0.16 2.03 -3.34 -3.28 -4.27 -2.40 2.29 -3.54 -2.13 -4.08
Nuclear Periphery -3.52 -8.49 -8.22 -7.85 -6.69 4.70 -10.28 -8.24 -10.50 7.21 -0.43 -12.95 -10.62 -10.25 2.06
Nuclear Periphery Foci -7.59 -7.55 -1.94 5.20 1.36 2.30 -5.05 -12.79 -12.95 -8.96 -7.23 -9.38 -12.75 -8.76 -10.15
Nucleolus -2.57 2.26 -2.51 1.19 -3.25 1.55 -2.79 -3.86 -4.21 -3.02 -2.34 0.74 -3.62 -0.54 -3.80
Nucleus -3.20 -3.28 -1.11 -0.72 -0.87 -0.14 -2.99 -4.68 -4.66 -4.37 -3.16 -3.65 -4.76 -3.77 -3.74
Peroxisomes -0.75 5.15 6.33 2.88 2.03 -1.37 4.30 -3.87 -2.89 -5.31 -1.54 5.73 -3.93 -3.11 -5.07
Vacuole -10.98 -9.73 -7.04 -4.83 -5.71 2.19 -10.21 -17.63 -18.16 -0.81 -9.59 -14.00 -18.81 -12.94 -8.89
Vacuole Periphery -5.43 4.26 -4.05 -0.22 -6.48 2.73 -4.42 -7.42 -8.63 -1.33 -4.38 2.14 -4.24 0.31 -6.83
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in SRP-independent targeting of substrates to the ER; component of an alternative ER targeting pathway that has partial functional redundancy with the GET pathway; preference for substrates with downstream transmembrane domains; interacts with Snd1p, Env10p/Snd2p, and Sec61p-translocon subunits; can compensate for loss of SRP; role in phosphate transport, interacting with pho88, and in the maturation of secretory proteins
Localization
Cell Percentages ER (97%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Snd3

Snd3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Snd3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available