Standard name
Human Ortholog
Description Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0.08 0.08 0.13 0.08 0.11 0.11 0.19 0.2 0.19 0.2 0.25 0.46 0.6 0.8 0.09 0.14 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0 0 0 0 0.05 0 0 0 0 0.07
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.35 0.08 0.16 0 0.07 0.06 0.06 0.05 0.05 0.08 0.07 0.08 0 0 0 0.07 0 0 0 0 0 0 0 0
Nucleus 0.3 0.21 0.36 0.41 0.2 0.37 0.38 0.4 0.35 0.32 0.22 0.24 0.09 0 0 0.45 0.41 0.42 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.59 0.78 0.6 0.65 0.75 0.61 0.55 0.52 0.66 0.65 0.72 0.7 0.6 0.47 0.3 0.49 0.5 0.53 0.88 0.9 0.92 0.86 0.86 0.76
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 0 0 0 0 0 1 2 1 0 0 1 2 0 0 0 0 1 2 2 1 1 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 32 16 13 17 33 39 91 57 71 58 90 81 200 274 30 25 12 0 2 1 0 3 1
Endoplasmic Reticulum 0 1 0 1 0 0 1 4 2 0 0 1 0 2 1 7 6 0 0 1 0 0 0 1
Endosome 1 4 0 2 2 2 0 0 0 0 0 0 9 25 5 8 4 1 10 13 3 3 10 11
Golgi 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 2 6 1 1 2 1 0 0 2
Mitochondria 76 29 31 2 15 18 21 24 14 29 21 30 1 2 2 24 3 1 1 5 1 1 2 3
Nucleus 65 79 70 40 41 105 134 194 100 116 62 86 16 6 7 149 75 46 4 4 2 2 3 5
Nuclear Periphery 3 4 1 1 3 2 3 1 2 5 0 0 0 1 0 6 3 2 4 3 0 1 4 2
Nucleolus 4 2 0 0 3 2 4 2 0 1 2 2 1 1 0 8 6 1 1 1 0 1 1 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 1 0 1 1 0 1
Vac/Vac Membrane 127 298 117 63 155 175 192 251 188 236 206 255 107 156 103 161 91 58 199 362 175 120 212 128
Unique Cell Count 216 384 194 97 207 287 351 485 283 365 285 365 177 331 341 330 183 109 227 404 191 140 246 170
Labelled Cell Count 282 450 235 122 236 337 394 569 365 460 349 464 216 395 392 395 221 122 227 404 191 140 246 170


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 6.6 6.3 7.2 10.0 10.8 9.1 9.8 9.7 8.8 8.8 8.5 5.1 5.0 4.6 10.0 13.6 14.0 5.5 5.6 6.5
Std Deviation (1e-4) 1.1 1.5 2.5 2.5 2.3 4.1 3.4 3.8 3.6 3.3 3.0 2.7 1.4 1.5 1.1 3.1 4.4 5.3 1.3 1.9 2.0
Intensity Change (Log2) – – – 0.18 0.66 0.77 0.52 0.63 0.62 0.48 0.48 0.42 -0.31 -0.35 -0.45 0.65 1.1 1.14 -0.2 -0.19 0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.4 0 1.2 1.1 3.4 3.5 3.5 3.6 4.7 8.2 11.7 16.1 0.3 1.7 0.8
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 3.9 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -3.5 -2.7 -3.5 -3.8 -4.8 -4.0 -2.9 -3.0 -2.8 -5.3 -7.0 0 -3.1 -4.9 -4.1
Nucleus 0.9 -3.6 0.1 0.5 0.9 -0.2 -1.0 -3.4 -3.1 -6.2 -10.8 -10.8 2.0 1.0 1.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0.8 3.1 0.1 -1.3 -2.0 1.4 1.0 2.7 2.3 0 -2.9 -6.8 -2.6 -2.1 -1.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.4324 2.9202 2.1776 1.3712 1.6339 2.5689 2.8086 3.6392 3.1214 3.4996 3.1168 3.6159 3.518 3.8733 3.2105 3.5121 2.6628 3.818
Actin 0.0001 0 0.0001 0.0002 0 0 0.0137 0.0001 0.0111 0.0008 0.0018 0 0.0054 0.0001 0.0182 0.0975 0.0057 0.0003
Bud 0.0004 0.0003 0.0004 0.0005 0.0003 0.0003 0.0006 0.0004 0.0006 0.0025 0.0004 0.0003 0.0008 0.0001 0.0004 0.0003 0.0016 0.0005
Bud Neck 0.0016 0.0003 0.0012 0.0005 0.0018 0.0011 0.0012 0.0007 0.0015 0.0014 0.001 0.0016 0.0073 0.0003 0.0008 0.0009 0.0022 0.0018
Bud Periphery 0.001 0.0008 0.0012 0.0013 0.0008 0.0013 0.0015 0.0012 0.0016 0.0043 0.0013 0.0011 0.0019 0.0005 0.0014 0.0012 0.0028 0.0017
Bud Site 0.0018 0.0004 0.0029 0.0007 0.0027 0.0006 0.0093 0.0012 0.0034 0.024 0.0008 0.0008 0.0067 0.0004 0.0017 0.0009 0.003 0.001
Cell Periphery 0.004 0.0014 0.0039 0.0016 0.003 0.0031 0.0026 0.0032 0.0025 0.0022 0.0026 0.003 0.0046 0.002 0.0022 0.0015 0.0046 0.0025
Cytoplasm 0.0034 0.0298 0.0044 0.0138 0.008 0.0028 0.0077 0.0075 0.0087 0.0056 0.0081 0.0048 0.0122 0.0248 0.017 0.102 0.0169 0.0023
Cytoplasmic Foci 0.012 0.0128 0.0088 0.0299 0.0105 0.0033 0.0194 0.0105 0.018 0.0415 0.0203 0.0098 0.05 0.0062 0.0388 0.0082 0.0226 0.0072
Eisosomes 0.0002 0 0 0 0 0 0.0001 0 0.0007 0.0001 0.0001 0 0.0003 0 0.0005 0.0004 0 0
Endoplasmic Reticulum 0.0026 0.0022 0.0026 0.0036 0.0017 0.0013 0.0047 0.0075 0.0034 0.0026 0.0062 0.0019 0.0141 0.0048 0.0021 0.0013 0.0016 0.0031
Endosome 0.1613 0.1603 0.1768 0.2698 0.2093 0.1104 0.2231 0.1787 0.2268 0.1952 0.2517 0.2159 0.2598 0.0857 0.1772 0.1544 0.2907 0.1752
Golgi 0.0111 0.0035 0.0084 0.0215 0.0046 0.0052 0.0193 0.0059 0.011 0.0096 0.0272 0.0077 0.0495 0.0024 0.0073 0.007 0.046 0.0075
Lipid Particles 0.0647 0.0092 0.0119 0.0286 0.0238 0.039 0.0325 0.016 0.0176 0.0482 0.0158 0.019 0.112 0.0403 0.0256 0.0144 0.0061 0.0483
Mitochondria 0.0178 0.0014 0.0351 0.0174 0.0009 0.0285 0.036 0.0424 0.0808 0.0091 0.0561 0.0105 0.0478 0.0137 0.0269 0.0701 0.0295 0.0799
None 0.0437 0.0099 0.0173 0.014 0.0053 0.0136 0.0034 0.0229 0.028 0.0039 0.0228 0.0006 0.0106 0.0048 0.0888 0.1013 0.0003 0.0029
Nuclear Periphery 0.0099 0.0038 0.0096 0.0043 0.0024 0.0039 0.0142 0.0155 0.0035 0.0038 0.0023 0.0041 0.0096 0.0212 0.003 0.0012 0.0021 0.0099
Nucleolus 0.016 0.0009 0.0082 0.003 0.0131 0.0038 0.0038 0.0041 0.005 0.014 0.0041 0.0039 0.0236 0.0019 0.004 0.0031 0.0048 0.0037
Nucleus 0.0059 0.0032 0.0274 0.0033 0.0254 0.0041 0.0062 0.006 0.0088 0.0052 0.0027 0.0046 0.0093 0.0104 0.0028 0.0021 0.0062 0.0043
Peroxisomes 0.0109 0.0008 0.0015 0.0053 0.0022 0.0007 0.0102 0.0022 0.0073 0.0155 0.0023 0.0013 0.0086 0.001 0.0121 0.0013 0.002 0.0028
Punctate Nuclear 0.0005 0.0003 0.0002 0.0012 0.0007 0.0002 0.001 0.0004 0.0014 0.0025 0.0004 0.0002 0.0022 0.0003 0.0011 0.0001 0.0002 0.0002
Vacuole 0.476 0.5585 0.5083 0.4787 0.5947 0.5926 0.4513 0.5213 0.3944 0.4872 0.4843 0.5583 0.3028 0.5412 0.4469 0.3728 0.4667 0.4877
Vacuole Periphery 0.1549 0.2004 0.1697 0.1006 0.0886 0.1842 0.1386 0.1521 0.1637 0.1207 0.0877 0.1506 0.0606 0.2379 0.1209 0.0578 0.0843 0.1571

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.5101 17.4408 49.8501 71.0213 17.8007 23.1103 40.004 75.3796 83.5272 40.2992
Translational Efficiency 1.3001 1.2141 1.2729 1.0325 1.4844 1.5306 1.3175 0.9399 1.1625 1.0928

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1906 157 1115 1059 2149 514 2291 153 4055 671 3406 1212

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 799.65 862.84 797.92 891.10 787.79 758.22 897.40 966.77 793.36 782.70 864.83 900.65
Standard Deviation 108.59 261.05 104.60 106.27 102.25 93.26 100.38 142.13 105.45 156.74 111.97 114.23
Intensity Change Log 2 — 0.109724 -0.003125 0.156219 — -0.055195 0.187940 0.295362 — 0.030235 0.094856 0.226947

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000013 0.001418 0.000189 0.000333 0.000012 0.000077 0.000053 0.000191 0.000013 0.000391 0.000098 0.000315
Bud Neck 0.011116 0.019229 0.036985 0.020581 0.010456 0.025440 0.034731 0.032951 0.010767 0.023987 0.035469 0.022143
Bud Site 0.006673 0.014518 0.009190 0.023607 0.006124 0.013518 0.016680 0.042366 0.006382 0.013752 0.014228 0.025975
Cell Periphery 0.001665 0.000419 0.000104 0.000072 0.000524 0.000401 0.000079 0.000251 0.001060 0.000405 0.000087 0.000095
Cytoplasm 0.005852 0.074847 0.136383 0.232356 0.013384 0.060789 0.116325 0.076323 0.009843 0.064078 0.122891 0.212659
Cytoplasmic Foci 0.003415 0.042736 0.020276 0.073009 0.007048 0.040996 0.023837 0.021203 0.005340 0.041403 0.022671 0.066469
Eisosomes 0.000022 0.000061 0.000052 0.000038 0.000011 0.000050 0.000022 0.000035 0.000017 0.000053 0.000032 0.000037
Endoplasmic Reticulum 0.002463 0.002984 0.006993 0.001061 0.002616 0.001056 0.002638 0.000875 0.002544 0.001507 0.004063 0.001038
Endosome 0.070084 0.068154 0.077222 0.075012 0.058457 0.095497 0.092952 0.076073 0.063922 0.089099 0.087802 0.075146
Golgi 0.001202 0.002020 0.000768 0.000404 0.001055 0.002841 0.000735 0.000959 0.001124 0.002649 0.000746 0.000474
Lipid Particles 0.000422 0.002418 0.003798 0.002039 0.000857 0.002107 0.001889 0.001198 0.000652 0.002180 0.002514 0.001933
Mitochondria 0.001810 0.002071 0.002230 0.000176 0.001293 0.003742 0.000977 0.000328 0.001536 0.003351 0.001387 0.000195
Mitotic Spindle 0.000063 0.000232 0.010029 0.007716 0.000821 0.000764 0.005088 0.024965 0.000464 0.000640 0.006705 0.009894
None 0.000090 0.000328 0.002269 0.001195 0.000103 0.000512 0.000478 0.000582 0.000097 0.000469 0.001064 0.001118
Nuclear Periphery 0.000080 0.000422 0.007242 0.000884 0.000255 0.000151 0.002116 0.000572 0.000173 0.000215 0.003794 0.000845
Nuclear Periphery Foci 0.000086 0.000597 0.003277 0.002576 0.000121 0.000160 0.001792 0.000804 0.000104 0.000262 0.002278 0.002352
Nucleolus 0.000748 0.002624 0.021561 0.001481 0.000586 0.000803 0.005731 0.002387 0.000662 0.001229 0.010913 0.001595
Nucleus 0.002433 0.028571 0.315670 0.031860 0.003690 0.012142 0.078383 0.045201 0.003099 0.015986 0.156062 0.033544
Peroxisomes 0.000800 0.005172 0.003480 0.010876 0.000640 0.005257 0.002973 0.003439 0.000715 0.005237 0.003139 0.009937
Vacuole 0.851727 0.712159 0.335052 0.513096 0.859393 0.715978 0.604283 0.658111 0.855790 0.715084 0.516147 0.531402
Vacuole Periphery 0.039237 0.019019 0.007230 0.001628 0.032554 0.017719 0.008238 0.011185 0.035695 0.018023 0.007908 0.002834

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.16 -9.32 -4.23 0.97 -0.46 -3.44 -10.15 -2.04 -1.30 -1.44 -1.34 -12.55 -4.63 0.52 -2.46
Bud Neck -1.63 -10.15 -1.39 1.10 8.59 -4.70 -13.37 -4.12 -0.75 1.37 -4.93 -16.87 -3.05 2.82 10.75
Bud Site -2.63 -2.09 -5.02 0.11 -3.26 -4.02 -6.68 -3.49 -2.53 -2.32 -4.77 -7.03 -6.32 -1.38 -1.87
Cell Periphery 8.40 11.49 11.85 6.14 4.94 1.86 11.57 2.71 1.57 -1.07 8.07 14.44 14.26 6.92 0.59
Cytoplasm -4.85 -24.18 -29.37 -9.22 -8.83 -7.62 -29.10 -6.69 -2.83 2.31 -9.38 -38.21 -29.24 -16.12 -9.42
Cytoplasmic Foci -5.30 -13.18 -15.77 -0.01 -8.53 -7.77 -12.65 -4.25 2.70 -0.36 -9.59 -18.06 -15.62 0.33 -7.68
Eisosomes -3.11 -5.11 -2.55 2.23 6.41 -4.48 -8.56 -5.68 0.71 -3.76 -4.84 -5.61 -7.09 2.23 -3.28
Endoplasmic Reticulum -0.65 -14.68 9.26 2.34 20.41 5.01 0.09 3.21 -1.28 4.32 3.93 -7.17 7.85 1.53 20.13
Endosome 0.21 0.73 8.90 3.43 7.08 -5.08 -5.54 -0.27 2.99 2.02 -4.07 -3.71 8.45 8.46 11.01
Golgi -0.78 2.14 4.60 1.80 3.42 -1.21 1.50 0.71 1.43 -0.29 -1.33 2.55 4.50 2.12 4.25
Lipid Particles -3.32 -14.40 -6.95 1.34 8.23 -2.83 -4.70 -1.83 0.68 0.67 -4.43 -11.99 -5.42 1.50 5.37
Mitochondria -0.20 -0.78 3.84 1.67 11.79 -1.97 0.72 2.43 2.85 3.49 -1.83 0.50 4.76 3.33 10.20
Mitotic Spindle -1.32 -5.36 -4.62 -4.52 0.75 0.06 -5.67 -2.76 -2.77 -2.13 -0.37 -8.06 -5.15 -4.98 -1.29
None -1.90 -8.74 -5.94 -3.53 4.26 -1.39 -7.25 -2.87 -0.55 -0.82 -1.64 -10.91 -6.39 -1.98 0.68
Nuclear Periphery -2.95 -14.08 -13.17 -6.38 11.44 1.47 -9.22 -3.02 -3.40 3.73 -0.95 -16.44 -11.87 -11.54 11.02
Nuclear Periphery Foci -2.40 -5.88 -10.88 -5.91 2.63 -1.55 -4.66 -3.36 -3.21 -0.15 -3.03 -7.46 -11.29 -9.92 0.81
Nucleolus -1.11 -10.57 -0.76 1.00 10.46 -1.41 -10.60 -1.76 -1.48 3.04 -1.44 -14.06 -2.01 0.36 13.02
Nucleus -3.12 -35.81 -17.93 -3.21 27.69 -3.38 -26.65 -4.64 -3.66 3.48 -4.70 -39.55 -18.11 -10.11 20.71
Peroxisomes -2.57 -5.56 -4.90 0.22 -1.93 -3.11 -5.26 -2.32 1.12 -0.44 -3.76 -7.18 -5.45 0.54 -2.29
Vacuole 5.57 54.43 26.39 4.63 -20.36 10.42 37.33 8.49 2.44 -2.29 11.76 57.60 29.08 8.27 -8.84
Vacuole Periphery 4.62 19.99 24.26 4.32 10.09 7.58 19.43 7.96 2.94 -0.42 9.81 27.67 31.92 10.22 9.68
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar serine-type carboxypeptidase; involved, along with functional homolog Prc1p, in vacuolar zymogen activation, breakdown of the autophagic body, and autophagosome-dependent protein synthesis; role in phytochelatin synthesis; localizes to the vacuole lumen; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner; N-glycosylated
Localization
Cell Percentages vacuole (95%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Atg42

Atg42


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Atg42-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available