Standard name
Human Ortholog
Description Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0.05 – 0.05 0.05 0.08 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 – 0 0 0 0 0 0.11 0.11 0 0.07 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0.07 0.07 0.1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.09 0.13
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0 0 0 0 0.16 0.2 – 0.28 0.38 0.37 0.22 0 0 0 0.11 0.09 0.06 0 0 0 0 0 0
Nucleus 0.4 0.33 0.28 0.09 0.2 0.2 0.21 – 0.18 0.21 0.25 0.16 0.07 0.09 0.08 0.27 0.28 0.32 0.22 0.22 0.18 0.07 0.08 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0
Nucleolus 0.53 0.67 0.68 0.9 0.72 0.66 0.62 – 0.65 0.58 0.56 0.62 0.9 0.82 0.8 0.62 0.62 0.6 0.62 0.65 0.62 0.62 0.48 0.41
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.11 0.47 0.2 0.27 0.28 – 0.24 0.25 0.22 0.36 0.22 0.17 0.16 0.05 0.05 0.05 0 0 0.07 0.12 0.14 0.2
Vac/Vac Membrane 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0.06 0.07 0 0.06 0 0.05 0.08 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Bud 0 0 0 1 1 4 8 – 9 16 14 10 2 0 0 0 0 0 0 1 2 2 2 3
Bud Neck 0 1 0 6 4 1 5 – 1 4 4 5 4 3 1 0 0 0 0 0 1 2 8 9
Bud Site 0 0 0 1 1 6 25 – 23 22 34 21 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1 3 5 6 9 10 20 – 7 13 8 5 14 37 39 12 16 8 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 1 – 0 0 0 0 0 1 0 4 2 2 0 0 0 0 0 0
Endosome 0 0 9 21 21 45 19 – 18 1 5 16 4 13 13 13 5 5 3 1 4 11 20 31
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 2 0 0 0 0 1 0 0 0
Mitochondria 6 8 0 10 11 76 94 – 135 176 164 84 14 1 9 40 21 11 0 1 3 5 4 7
Nucleus 48 108 86 29 60 94 99 – 85 99 109 63 24 30 29 96 66 59 31 86 64 15 19 10
Nuclear Periphery 5 5 11 0 1 7 4 – 2 6 5 3 0 0 1 2 2 1 8 13 15 1 2 5
Nucleolus 64 219 206 290 218 314 291 – 306 272 247 240 291 268 275 221 145 110 87 249 219 128 115 96
Peroxisomes 0 1 0 3 1 4 4 – 3 2 0 1 5 8 6 3 3 0 0 0 0 2 3 2
SpindlePole 2 2 33 153 61 126 132 – 114 116 96 138 70 54 56 18 11 9 2 5 26 23 33 47
Vac/Vac Membrane 6 11 10 2 4 4 5 – 7 7 5 3 2 0 2 20 13 12 4 22 13 10 18 12
Unique Cell Count 121 328 304 323 301 473 470 474 466 439 385 322 327 343 354 233 182 141 384 356 206 241 234
Labelled Cell Count 132 358 360 522 392 691 707 710 734 691 589 431 415 431 431 284 217 141 384 356 206 241 234


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.1 13.3 10.8 9.4 8.4 6.5 6.3 – 5.5 5.0 4.8 5.3 10.6 9.8 9.2 16.2 18.1 15.7 10.7 9.9 10.6
Std Deviation (1e-4) 3.7 3.3 2.8 3.1 2.0 1.5 1.7 – 1.5 1.3 1.3 1.1 3.0 3.6 3.2 6.7 6.7 6.9 3.4 2.1 2.7
Intensity Change (Log2) – – – -0.2 -0.37 -0.73 -0.77 – -0.96 -1.11 -1.17 -1.01 -0.02 -0.14 -0.23 0.59 0.75 0.55 -0.01 -0.12 -0.02

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 3.3 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 4.1 – 3.9 3.8 0 4.1 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 1.1 0.5 2.0 – 0 1.0 0.2 0 2.0 4.9 4.9 1.4 3.1 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 2.1 2.3 3.5 0.8 – 0.6 0 0 0.8 -1.5 0.7 0.6 0.5 -0.6 -0.1
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.4 7.4 8.3 – 10.2 12.2 0 8.7 3.7 0 0 6.0 5.3 0
Nucleus -6.2 -2.4 -2.7 -2.3 – -3.4 -2.2 -1.1 -3.8 -6.8 -6.2 -6.6 -0.3 0 1.0
Nuclear Periphery -3.4 -2.9 -1.9 -2.7 – -3.4 -2.2 0 -2.6 -3.4 -3.5 -3.1 -2.8 -2.1 0
Nucleolus 6.8 1.3 -0.4 -1.7 – -0.9 -2.6 0 -1.5 7.0 4.1 3.6 -1.4 -1.3 -1.6
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 10.0 3.2 5.3 5.7 – 4.6 4.8 0 7.5 3.7 2.1 2.0 -2.8 -2.6 -2.2
Vacuole -2.4 -1.6 -2.5 -2.2 – -1.7 -1.6 -2.0 -2.4 -2.4 0 -2.5 1.4 1.3 1.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.1765 6.8799 5.6606 5.4661 5.4851 5.8581 7.6968 11.8794 9.8155 9.0982 8.9857 9.193 7.2016 9.2579 8.1575 7.9347 7.4252 7.7763
Actin 0.0049 0 0.0112 0 0.0016 0.0074 0.0136 0 0.0061 0 0 0.0044 0.0114 0 0.0002 0.0025 0.0103 0.0005
Bud 0.0005 0.0001 0.0002 0 0.0005 0.0001 0.0004 0 0.0002 0.0001 0 0 0.0003 0 0 0.0002 0.0003 0.0001
Bud Neck 0.0016 0.0003 0.0005 0.0005 0.0012 0.0013 0.0005 0.0002 0.0071 0.0004 0.0001 0.0005 0.0006 0.0002 0.0001 0.0007 0.0011 0.0004
Bud Periphery 0.0019 0.0001 0.0004 0.0001 0.001 0.0003 0.0007 0.0001 0.0003 0.0002 0 0.0001 0.0005 0.0001 0 0.0004 0.0006 0.0002
Bud Site 0.0019 0.0003 0.0011 0.0001 0.0029 0.0002 0.002 0.0001 0.0009 0.0002 0.0001 0.0001 0.0008 0.0003 0.0001 0.0026 0.0021 0.0001
Cell Periphery 0.0032 0.0001 0.0006 0.0001 0.0002 0.0004 0.0005 0.0004 0.0002 0.001 0.0003 0.0002 0.0003 0.0001 0.0001 0.0003 0.0003 0.0002
Cytoplasm 0.0035 0.0001 0.0029 0.0001 0.0015 0.0004 0.0056 0 0.003 0 0 0.0034 0.0005 0 0.0005 0.0002 0.0004 0.0007
Cytoplasmic Foci 0.0065 0.0004 0.0061 0.0011 0.0008 0.0017 0.0444 0.0004 0.0063 0.0002 0.0019 0.0029 0.0058 0.0002 0.0011 0.0068 0.0069 0.0034
Eisosomes 0.0066 0 0.0001 0 0.0001 0.0001 0.0002 0 0.0001 0 0 0 0.0001 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0076 0 0.0046 0 0.0019 0.0016 0.002 0 0.0025 0 0 0.0002 0.0004 0 0.0053 0.0003 0.0009 0.0009
Endosome 0.0163 0.0001 0.0073 0.0001 0.0095 0.0042 0.0229 0 0.0099 0.0001 0 0.0066 0.0088 0.0001 0.0005 0.0025 0.01 0.0012
Golgi 0.0026 0 0.0023 0.0001 0.0007 0.0012 0.0097 0 0.0053 0 0 0.0032 0.0029 0 0.0001 0.0015 0.0042 0.0007
Lipid Particles 0.0096 0.0011 0.0054 0.0079 0.0016 0.011 0.0502 0.0008 0.0043 0.0005 0.005 0.0106 0.0083 0.0009 0.0008 0.0129 0.0217 0.0126
Mitochondria 0.0102 0.0001 0.0163 0.0001 0.0031 0.014 0.0094 0.0003 0.0021 0 0.0138 0.0054 0.0028 0.0001 0.0001 0.0056 0.0046 0.0006
None 0.0093 0 0.0013 0 0.0009 0.0003 0.0042 0 0.0007 0 0 0.0003 0.0008 0 0 0.0004 0.0009 0.0004
Nuclear Periphery 0.0281 0.0116 0.0072 0.0162 0.0328 0.012 0.0195 0.0049 0.0071 0.0001 0.0001 0.006 0.0042 0.0053 0.0095 0.0014 0.029 0.01
Nucleolus 0.7173 0.7436 0.7622 0.7878 0.5903 0.7408 0.6845 0.8885 0.8479 0.9186 0.909 0.861 0.7856 0.8109 0.8584 0.7842 0.6846 0.8246
Nucleus 0.134 0.2241 0.1376 0.1728 0.3283 0.1835 0.0731 0.1 0.0824 0.0713 0.0646 0.0841 0.15 0.1759 0.1168 0.1563 0.1613 0.1299
Peroxisomes 0.0044 0 0.0011 0 0.0004 0.0004 0.008 0 0.002 0 0.0004 0.0003 0.0019 0 0 0.0034 0.0094 0.0038
Punctate Nuclear 0.0196 0.0171 0.0164 0.0107 0.0135 0.0147 0.0364 0.0017 0.01 0.0005 0.0025 0.0081 0.0105 0.0042 0.0058 0.0134 0.0475 0.0077
Vacuole 0.0058 0.0006 0.0089 0.0006 0.0047 0.0016 0.0054 0.0012 0.0009 0.0063 0.0005 0.0007 0.0021 0.0009 0.0002 0.0014 0.0017 0.001
Vacuole Periphery 0.0046 0.0003 0.0063 0.0016 0.0025 0.0027 0.0069 0.0012 0.0007 0.0005 0.0016 0.0018 0.0015 0.0006 0.0002 0.0029 0.0023 0.0011

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 49.1828 43.754 40.9782 33.0651 35.7345 28.9709 28.133 26.0902 23.9087 39.5631
Translational Efficiency 1.2338 1.1261 1.0675 1.0957 1.2336 1.2125 1.2399 1.0336 1.0063 0.9453

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2012 191 979 1243 1702 2256 1467 2709 3714 2447 2446 3952

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 954.57 1176.63 1287.02 1438.65 993.98 1123.05 1287.36 1486.87 972.63 1127.23 1287.22 1471.70
Standard Deviation 159.53 236.16 231.81 319.93 193.34 209.55 233.70 314.59 176.92 212.23 232.95 317.07
Intensity Change Log 2 — 0.301738 0.431112 0.591793 — 0.176133 0.373127 0.580990 — 0.239032 0.401824 0.586292

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000412 0.000481 0.000400 0.000812 0.000351 0.000463 0.000440 0.000700 0.000384 0.000464 0.000424 0.000736
Bud Neck 0.002315 0.002013 0.003957 0.014176 0.001618 0.003978 0.004258 0.007063 0.001996 0.003824 0.004138 0.009300
Bud Site 0.000590 0.000382 0.000543 0.003226 0.000386 0.000661 0.000489 0.000850 0.000496 0.000639 0.000511 0.001597
Cell Periphery 0.000076 0.000020 0.000022 0.000150 0.000062 0.000062 0.000038 0.000097 0.000070 0.000059 0.000032 0.000113
Cytoplasm 0.000939 0.000847 0.000043 0.000671 0.001411 0.000940 0.000252 0.000429 0.001155 0.000933 0.000168 0.000505
Cytoplasmic Foci 0.000562 0.000571 0.001233 0.005942 0.000981 0.000696 0.000671 0.001504 0.000754 0.000686 0.000896 0.002900
Eisosomes 0.000097 0.000064 0.000084 0.000157 0.000083 0.000086 0.000086 0.000183 0.000091 0.000084 0.000085 0.000175
Endoplasmic Reticulum 0.001669 0.001454 0.000393 0.000569 0.001385 0.001341 0.000420 0.000566 0.001539 0.001350 0.000409 0.000567
Endosome 0.000665 0.000219 0.000142 0.001914 0.000876 0.001212 0.000188 0.000526 0.000761 0.001134 0.000170 0.000963
Golgi 0.000600 0.000230 0.000312 0.001900 0.000539 0.000343 0.000195 0.000319 0.000572 0.000334 0.000242 0.000816
Lipid Particles 0.000324 0.000370 0.000071 0.001328 0.000174 0.000366 0.000083 0.000256 0.000255 0.000366 0.000078 0.000593
Mitochondria 0.001716 0.001140 0.001503 0.007205 0.000965 0.002097 0.001672 0.003577 0.001372 0.002022 0.001604 0.004718
Mitotic Spindle 0.002081 0.006035 0.011925 0.037041 0.002194 0.004457 0.005268 0.007049 0.002133 0.004580 0.007932 0.016482
None 0.001264 0.000858 0.000302 0.000922 0.002381 0.000819 0.000848 0.000710 0.001776 0.000822 0.000629 0.000777
Nuclear Periphery 0.004476 0.002981 0.005655 0.008471 0.001959 0.002852 0.000997 0.007146 0.003322 0.002862 0.002861 0.007562
Nuclear Periphery Foci 0.008198 0.008580 0.004931 0.007806 0.005359 0.004134 0.001010 0.005371 0.006897 0.004481 0.002579 0.006137
Nucleolus 0.576590 0.595233 0.733785 0.673901 0.606972 0.518634 0.673624 0.662265 0.590513 0.524613 0.697703 0.665925
Nucleus 0.388830 0.364732 0.210697 0.194823 0.362661 0.449155 0.296736 0.282092 0.376838 0.442565 0.262299 0.254644
Peroxisomes 0.005534 0.011906 0.022054 0.017527 0.007791 0.004002 0.011089 0.007383 0.006569 0.004619 0.015478 0.010574
Vacuole 0.001539 0.000827 0.000805 0.008914 0.001054 0.001691 0.000691 0.003493 0.001317 0.001624 0.000737 0.005198
Vacuole Periphery 0.001523 0.001057 0.001142 0.012546 0.000798 0.002011 0.000947 0.008421 0.001191 0.001937 0.001025 0.009718

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.11 0.14 -8.64 -5.54 -9.21 -3.02 -4.11 -12.27 -5.77 -9.08 -2.29 -2.28 -13.75 -7.44 -12.96
Bud Neck -0.64 -4.59 -13.98 -7.67 -11.92 -7.12 -9.53 -15.29 -7.02 -6.34 -5.78 -9.48 -19.53 -12.34 -13.01
Bud Site -0.81 0.13 -6.87 -1.04 -7.08 -2.22 -1.79 -4.98 -1.68 -2.67 -1.48 -0.86 -7.71 -4.61 -7.52
Cell Periphery 2.15 2.18 -2.89 -7.38 -7.62 -0.01 1.57 -2.00 -2.42 -4.63 0.61 2.47 -2.79 -4.61 -8.35
Cytoplasm 0.12 2.39 0.25 -0.00 -5.65 0.69 2.48 1.83 0.96 -0.98 0.37 3.31 1.68 0.81 -2.53
Cytoplasmic Foci -0.90 -3.64 -7.23 -5.02 -6.26 0.92 0.25 -1.91 -2.65 -2.05 0.04 -1.48 -6.63 -6.30 -5.61
Eisosomes 4.01 2.05 -5.99 -8.59 -7.69 -0.70 -0.64 -10.29 -9.95 -10.00 1.35 1.32 -11.24 -11.96 -12.30
Endoplasmic Reticulum 0.54 4.99 4.00 2.55 -3.10 0.12 5.03 4.30 6.01 -2.83 0.87 6.92 5.83 6.27 -4.14
Endosome 1.99 2.61 -2.75 -4.14 -4.49 -0.85 2.46 1.11 2.13 -2.31 -1.20 3.48 -0.85 0.60 -4.96
Golgi 1.24 0.98 -2.13 -3.13 -2.98 0.90 1.71 1.08 0.32 -3.40 1.21 1.80 -0.95 -2.61 -3.39
Lipid Particles -0.36 2.75 -1.44 -1.15 -1.84 -1.49 1.44 -0.84 0.82 -1.84 -0.98 2.93 -1.46 -0.78 -2.33
Mitochondria 2.14 0.75 -9.10 -10.53 -10.00 -2.84 -4.95 -10.58 -3.27 -6.84 -1.70 -1.75 -12.30 -6.25 -11.99
Mitotic Spindle -1.16 -5.25 -9.76 -6.32 -5.95 -1.82 -2.51 -4.16 -2.23 -1.22 -2.44 -5.65 -10.50 -7.64 -4.90
None 0.90 7.12 1.76 -0.28 -8.02 3.26 3.06 3.52 0.69 0.67 3.80 4.57 4.18 0.11 -1.39
Nuclear Periphery 1.18 -0.75 -3.14 -3.62 -1.62 -1.40 2.05 -5.78 -4.69 -7.62 0.75 0.73 -5.54 -6.08 -5.72
Nuclear Periphery Foci -0.32 2.57 0.21 0.39 -2.41 1.23 5.50 0.04 -1.45 -7.70 2.50 5.90 0.93 -1.94 -6.17
Nucleolus -0.76 -17.82 -8.79 -3.40 7.00 10.12 -6.66 -6.56 -17.90 1.15 9.25 -15.88 -11.67 -18.92 5.26
Nucleus 1.30 21.22 22.85 8.35 1.08 -9.99 6.88 10.21 21.49 1.93 -9.19 17.60 21.15 26.63 1.03
Peroxisomes -3.30 -13.17 -13.69 -3.07 3.22 6.27 -4.57 0.40 -8.94 5.81 4.80 -13.46 -9.31 -13.99 7.21
Vacuole 1.76 2.16 -7.23 -8.16 -8.42 -1.84 1.13 -6.15 -4.64 -9.05 -1.04 2.45 -9.10 -8.25 -12.02
Vacuole Periphery 1.89 1.94 -9.31 -9.76 -9.77 -4.29 -1.64 -13.69 -10.35 -13.45 -2.75 1.38 -15.86 -13.20 -16.45
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Essential nucleolar protein; putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
Localization
Cell Percentages nucleolus (51%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-2

Mak5

Mak5


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mak5-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available