Standard name
Human Ortholog
Description Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm 0.63 0.61 0.89 0.89 0.93 0.94 0.94 0.94 0.91 0.89 0.9 0.9 0.94 0.95 0.97 – – – 0.07 0.1 0.14 0.23 0.21 0.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria 0.15 0 0 0 0 0 0.05 0 0.09 0.08 0.15 0.1 0 0 0 – – – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane 0.37 0.47 0.17 0.17 0.15 0.11 0.07 0.06 0.07 0.08 0.06 0.06 0 0.05 0 – – – 0.82 0.81 0.75 0.66 0.66 0.67
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – – – 4 0 1 1 1 3
Bud 2 0 0 0 0 1 2 2 6 8 9 5 1 0 0 – – – 4 2 0 6 7 10
Bud Neck 0 0 3 0 0 0 0 0 0 0 0 3 1 2 2 – – – 0 0 3 0 2 3
Bud Site 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 – – – – – – – – –
Cell Periphery 0 0 1 1 0 0 0 1 2 1 1 0 1 0 0 – – – 0 0 0 0 0 1
Cytoplasm 410 123 280 237 424 382 433 548 381 447 350 310 299 552 496 – – – 52 22 46 70 86 94
Endoplasmic Reticulum 2 2 4 0 1 0 0 0 1 0 0 1 1 3 2 – – – 6 1 3 1 3 4
Endosome 3 4 2 0 0 1 0 2 0 0 0 0 4 11 5 – – – 29 5 6 6 7 7
Golgi 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 – – – 4 0 2 1 4 3
Mitochondria 96 6 0 2 2 12 25 26 38 42 60 35 0 0 0 – – – 14 4 12 10 15 14
Nucleus 17 4 7 2 2 5 1 5 1 5 3 3 0 2 0 – – – 3 1 0 0 1 0
Nuclear Periphery 1 0 1 0 1 0 1 3 4 3 0 0 0 0 0 – – – 0 1 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 1 0 0 1 2 0 0 – – – 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole 1 1 2 0 0 0 1 1 0 1 0 2 0 0 1 – – – 2 0 1 1 4 5
Vac/Vac Membrane 242 94 55 45 67 46 33 36 30 38 23 21 14 29 18 – – – 580 176 247 208 278 318
Unique Cell Count 647 201 316 265 456 405 461 585 417 500 389 345 319 583 512 710 218 330 315 421 476
Labelled Cell Count 774 234 357 287 497 447 496 624 464 545 447 381 323 599 524 710 218 330 315 421 476


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 5.0 5.1 4.8 5.2 4.2 3.9 4.5 3.7 3.9 3.5 4.0 5.1 5.3 5.1 – – – 5.2 5.5 5.7
Std Deviation (1e-4) 0.6 1.0 1.2 1.1 1.6 1.4 1.1 1.3 0.9 0.8 0.7 1.3 1.0 1.2 1.0 – – – 1.7 2.0 1.9
Intensity Change (Log2) – – – -0.09 0.01 -0.27 -0.38 -0.18 -0.46 -0.38 -0.56 -0.36 -0.01 0.05 -0.01 – – – 0.03 0.1 0.16

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Cytoplasm 0.3 2.1 2.8 2.6 2.7 1.2 0.4 0.6 0.5 2.3 3.3 4.8 – – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleus 0 0 -1.0 0 0 0 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – – –
Vacuole -0.1 -1.0 -2.3 -4.4 -5.3 -4.3 -4.3 -4.8 -4.6 -5.3 -6.1 -6.8 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8315 2.0479 1.7359 1.3675 1.697 1.6657 -0.173 1.5214 1.0919 0.3691 0.536 0.9049 -0.1139 1.588 0.9967 0.8941 0.6398 0.7562
Actin 0.0005 0 0.0002 0 0 0.0002 0.0001 0.0001 0.0007 0 0 0 0.0002 0.0001 0.0001 0 0 0
Bud 0.0003 0.0009 0.0019 0.0003 0.0003 0.0007 0.001 0.0014 0.0016 0.0005 0.0016 0.0013 0.0005 0.0017 0.0013 0.0007 0.0007 0.0008
Bud Neck 0.0005 0.0046 0.0013 0.0007 0.0006 0.0032 0.0012 0.0029 0.0036 0.0011 0.0021 0.0033 0.0007 0.0028 0.0019 0.0008 0.0022 0.002
Bud Periphery 0.0005 0.0015 0.0013 0.0004 0.0005 0.0019 0.0031 0.0024 0.0022 0.0007 0.0048 0.0031 0.0007 0.0023 0.0014 0.001 0.0011 0.0014
Bud Site 0.0008 0.0033 0.0035 0.0006 0.001 0.0012 0.0029 0.0062 0.0073 0.002 0.0037 0.0025 0.0011 0.0159 0.0023 0.0022 0.0034 0.0011
Cell Periphery 0.0005 0.001 0.0007 0.0003 0.0003 0.001 0.0011 0.0018 0.0009 0.0004 0.0012 0.0012 0.0005 0.0015 0.0007 0.0004 0.0007 0.0011
Cytoplasm 0.064 0.0673 0.0635 0.0382 0.0238 0.0725 0.0649 0.0687 0.0926 0.0241 0.0293 0.0874 0.0531 0.0969 0.0713 0.0495 0.0244 0.0691
Cytoplasmic Foci 0.0473 0.034 0.0469 0.027 0.0452 0.0356 0.0529 0.0257 0.0526 0.0257 0.0406 0.035 0.0422 0.0259 0.0383 0.0367 0.01 0.028
Eisosomes 0 0 0.0001 0 0 0 0.0001 0 0.0001 0 0 0 0.0001 0 0 0 0 0
Endoplasmic Reticulum 0.0054 0.007 0.005 0.002 0.0018 0.0039 0.0095 0.0096 0.0108 0.0022 0.0045 0.0065 0.0081 0.006 0.0051 0.0021 0.0025 0.005
Endosome 0.3821 0.2287 0.3867 0.3982 0.3853 0.2346 0.2766 0.1698 0.2756 0.3013 0.2338 0.2321 0.3238 0.1734 0.353 0.3614 0.1861 0.2596
Golgi 0.0051 0.0028 0.0062 0.0027 0.0039 0.0024 0.0038 0.002 0.0052 0.0029 0.0036 0.0027 0.0036 0.0023 0.0052 0.0041 0.001 0.0028
Lipid Particles 0.0126 0.0057 0.0084 0.0012 0.0058 0.0064 0.0131 0.0068 0.0136 0.0089 0.0076 0.0083 0.0181 0.0047 0.0039 0.0024 0.0023 0.0043
Mitochondria 0.0099 0.0034 0.0076 0.002 0.0025 0.0059 0.0113 0.003 0.0265 0.0018 0.0031 0.0061 0.0051 0.005 0.0116 0.0036 0.0006 0.0042
None 0.0871 0.088 0.0529 0.033 0.0095 0.0512 0.1075 0.0677 0.1141 0.0268 0.0378 0.0344 0.0465 0.0557 0.0248 0.0138 0.0056 0.0214
Nuclear Periphery 0.0058 0.008 0.0072 0.002 0.0035 0.0068 0.007 0.0111 0.0107 0.0034 0.0055 0.0074 0.0089 0.0118 0.0111 0.0029 0.0032 0.009
Nucleolus 0.0023 0.0048 0.0036 0.001 0.0015 0.0051 0.0048 0.0072 0.0076 0.0041 0.0049 0.0054 0.0025 0.0041 0.0032 0.0018 0.0069 0.0025
Nucleus 0.0042 0.0152 0.0089 0.0027 0.0044 0.0218 0.0108 0.0184 0.0152 0.0109 0.0162 0.0231 0.0087 0.0126 0.0093 0.0039 0.0116 0.0184
Peroxisomes 0.0017 0.0011 0.0016 0.0005 0.0013 0.0011 0.0017 0.0011 0.0023 0.0009 0.0031 0.0012 0.0013 0.0007 0.0008 0.0006 0.0004 0.0007
Punctate Nuclear 0.0031 0.0039 0.0011 0.0003 0.0009 0.0016 0.0035 0.0015 0.0083 0.0017 0.0075 0.0024 0.0027 0.0013 0.0014 0.0003 0.0005 0.0016
Vacuole 0.3184 0.4711 0.3408 0.4318 0.442 0.487 0.3743 0.5459 0.3106 0.5322 0.5359 0.485 0.4235 0.5264 0.4006 0.4561 0.6821 0.5093
Vacuole Periphery 0.0478 0.0475 0.0506 0.0547 0.0658 0.056 0.0486 0.0468 0.0378 0.0483 0.0534 0.0517 0.0478 0.0491 0.0527 0.0556 0.0547 0.0575

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.9998 7.8491 2.5886 9.2908 7.5895 16.576 9.6999 8.6298 6.8347 15.5603
Translational Efficiency 0.7245 0.9768 1.4953 0.7852 1.5022 0.9843 0.6895 0.6015 1.1224 0.732

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
37 1333 2590 898 1444 1546 185 1105 1481 2879 2775 2003

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 877.00 667.37 708.35 831.14 632.67 690.09 800.35 923.63 638.77 679.57 714.48 882.16
Standard Deviation 214.57 98.19 87.85 121.81 74.57 87.73 97.20 232.98 89.59 93.41 91.43 196.75
Intensity Change Log 2 — -0.394090 -0.308114 -0.077485 — 0.125331 0.339178 0.545862 — -0.153324 -0.000927 0.217049

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001836 0.000637 0.000093 0.000348 0.000083 0.000204 0.000193 0.009682 0.000127 0.000404 0.000100 0.005497
Bud Neck 0.017417 0.037362 0.013578 0.011728 0.023598 0.029971 0.003303 0.015194 0.023444 0.033393 0.012893 0.013640
Bud Site 0.151055 0.041521 0.023731 0.025002 0.009490 0.019673 0.004786 0.057211 0.013026 0.029789 0.022468 0.042771
Cell Periphery 0.000379 0.000182 0.000163 0.000107 0.000146 0.000135 0.000227 0.001045 0.000152 0.000157 0.000167 0.000624
Cytoplasm 0.245636 0.277641 0.554343 0.395476 0.318073 0.317028 0.424882 0.270755 0.316263 0.298792 0.545712 0.326671
Cytoplasmic Foci 0.065027 0.163242 0.026697 0.030351 0.094797 0.100803 0.047837 0.037328 0.094053 0.129712 0.028106 0.034200
Eisosomes 0.000096 0.000096 0.000027 0.000038 0.000079 0.000061 0.000071 0.000183 0.000079 0.000077 0.000030 0.000118
Endoplasmic Reticulum 0.019703 0.001088 0.000794 0.002611 0.001094 0.001060 0.002231 0.114210 0.001559 0.001073 0.000890 0.064177
Endosome 0.048606 0.093983 0.003567 0.019520 0.041077 0.059191 0.005637 0.036354 0.041265 0.075300 0.003705 0.028807
Golgi 0.005542 0.006009 0.000166 0.001767 0.000976 0.003673 0.000062 0.008306 0.001090 0.004755 0.000159 0.005374
Lipid Particles 0.012379 0.005108 0.001084 0.002031 0.003438 0.003304 0.002226 0.037388 0.003662 0.004139 0.001160 0.021537
Mitochondria 0.005563 0.005482 0.000943 0.002151 0.001451 0.005429 0.000819 0.004192 0.001554 0.005454 0.000935 0.003277
Mitotic Spindle 0.047183 0.002914 0.007149 0.031973 0.001306 0.008223 0.004691 0.040775 0.002452 0.005765 0.006985 0.036829
None 0.001438 0.001847 0.004491 0.005099 0.001298 0.001535 0.006977 0.003334 0.001301 0.001679 0.004657 0.004125
Nuclear Periphery 0.003229 0.000179 0.001653 0.003476 0.000308 0.000381 0.001464 0.001694 0.000381 0.000288 0.001641 0.002493
Nuclear Periphery Foci 0.013288 0.000583 0.000424 0.002657 0.000511 0.000246 0.001375 0.017011 0.000831 0.000402 0.000488 0.010576
Nucleolus 0.015359 0.001365 0.000970 0.002145 0.001054 0.001468 0.000704 0.001495 0.001412 0.001421 0.000952 0.001786
Nucleus 0.128552 0.022701 0.302937 0.140677 0.057516 0.047254 0.360634 0.081337 0.059291 0.035886 0.306783 0.107941
Peroxisomes 0.005704 0.010114 0.000630 0.002013 0.002245 0.004626 0.000325 0.002344 0.002331 0.007167 0.000610 0.002195
Vacuole 0.199932 0.319037 0.055974 0.317833 0.438718 0.389314 0.131230 0.255065 0.432752 0.356775 0.060991 0.283205
Vacuole Periphery 0.012076 0.008909 0.000586 0.002998 0.002741 0.006420 0.000325 0.005095 0.002974 0.007573 0.000569 0.004155

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.01 3.30 2.94 1.15 -3.90 -1.88 -1.67 -5.24 -5.14 -5.14 -1.95 0.72 -5.28 -4.81 -5.30
Bud Neck -3.20 0.50 0.78 9.83 1.05 -2.56 8.01 4.24 6.85 -4.83 -4.57 5.19 5.23 11.75 -0.16
Bud Site 2.77 3.31 3.45 7.14 1.74 -5.02 3.03 -8.84 -5.97 -9.88 -7.84 -3.12 -6.77 -0.78 -3.92
Cell Periphery 2.32 2.69 3.52 5.35 4.64 0.81 -0.44 -5.11 -5.22 -4.25 -0.28 -0.10 -4.52 -4.48 -4.47
Cytoplasm -0.92 -7.28 -2.60 -5.83 17.27 0.00 -2.82 2.33 2.33 3.95 1.88 -22.74 0.05 -1.96 24.47
Cytoplasmic Foci -6.88 2.78 3.00 27.37 1.43 -1.22 7.31 15.94 17.16 1.86 -8.15 18.60 18.41 31.20 -0.20
Eisosomes 0.43 3.60 3.07 8.06 -4.98 3.26 0.18 -2.89 -3.79 -2.84 0.48 10.47 -1.27 -1.52 -5.46
Endoplasmic Reticulum 2.63 2.65 2.38 -8.53 -10.06 0.28 -3.93 -11.49 -11.49 -11.19 2.16 1.99 -11.27 -11.42 -11.40
Endosome -4.34 4.44 3.51 21.45 -6.60 -5.60 17.88 4.26 8.89 -10.54 -11.96 20.35 8.70 20.95 -13.25
Golgi -0.22 2.07 1.84 8.73 -2.19 -4.02 3.16 -4.39 -1.64 -5.46 -7.29 3.25 -3.62 1.92 -5.68
Lipid Particles 1.37 2.15 1.95 3.34 -7.16 0.33 2.09 -7.35 -7.40 -7.67 -0.85 6.59 -6.73 -6.38 -8.24
Mitochondria -0.04 2.06 1.88 5.72 -0.76 -4.74 2.14 -2.11 2.32 -3.17 -6.84 2.44 -1.35 4.89 -3.03
Mitotic Spindle 1.48 1.34 0.57 -6.73 -5.68 -4.09 -1.37 -8.82 -6.74 -5.03 -2.55 -3.33 -10.63 -9.44 -8.99
None -0.63 -5.08 -3.00 -2.01 0.54 -0.64 -2.10 -1.86 -1.57 1.21 -0.97 -6.67 -3.34 -2.50 1.66
Nuclear Periphery 2.24 0.88 -1.17 -11.01 -6.55 -0.69 -9.50 -9.09 -7.50 0.69 1.33 -16.45 -12.93 -13.18 -5.18
Nuclear Periphery Foci 2.29 2.30 1.77 -7.94 -8.98 1.43 -4.30 -7.41 -7.63 -6.57 1.75 0.85 -8.19 -8.91 -8.68
Nucleolus 1.63 1.64 1.52 -2.53 -2.96 -1.69 -0.28 -2.23 -0.68 -1.08 0.20 0.76 -1.48 -2.36 -3.06
Nucleus 2.98 -5.16 -0.83 -20.85 19.26 2.97 -13.64 -6.21 -8.41 11.90 7.65 -46.06 -13.11 -20.67 31.64
Peroxisomes -2.23 3.34 2.96 10.09 -2.15 -4.63 7.10 0.41 4.31 -4.20 -9.11 5.71 1.80 10.48 -3.70
Vacuole -3.14 4.06 -4.68 -4.42 -29.10 4.28 12.02 9.78 6.03 -5.60 7.68 41.17 8.42 1.61 -35.34
Vacuole Periphery 0.74 2.91 2.68 10.24 -1.80 -6.14 11.48 -1.10 3.05 -4.51 -9.85 8.88 0.79 8.21 -4.36
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (82%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Csh1

Csh1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Csh1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available