Standard name
Human Ortholog
Description Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.07 0.06 0.07 0.08 0.05 0 – 0 0 0 0.05 0.07 0.07 0.1 0.06 0.22 0.21 0.17 0.06 0.05 0.08 0.1 0.12 0.1
Bud 0 0 0.05 0.05 0 0 – 0 0.05 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0.08 0.08 0 0.06 0.09 0.1 0.06 0.22 0 0 0 0 0 0
Cytoplasm 0.3 0.46 0.28 0.14 0.14 0.12 – 0.14 0.08 0.09 0.11 0.09 0.23 0.28 0.47 0.5 0.39 0.44 0.07 0.12 0 0 0 0
Endoplasmic Reticulum 0.54 0.43 0.4 0.31 0.36 0.35 – 0.24 0.3 0.32 0.32 0.33 0.74 0.64 0.47 0 0 0.05 0.63 0.61 0.54 0.64 0.6 0.63
Endosome 0 0 0 0 0.11 0 – 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0 0 0
Golgi 0 0 0 0 0.06 0 – 0 0 0 0 0 0 0 0 0.07 0.07 0 0 0 0 0.06 0.07 0.05
Mitochondria 0.1 0.07 0.4 0.74 0.37 0.63 – 0.56 0.72 0.68 0.73 0.73 0 0 0 0.05 0.14 0.07 0.09 0.07 0.22 0.05 0.07 0.05
Nucleus 0 0.06 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0.1 0 0.05 0 0.1 0.07 – 0.17 0.13 0.09 0.05 0 0 0 0 0.11 0.06 0.06 0 0.05 0.05 0.06 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 30 4 14 23 13 16 – 19 7 19 19 38 22 28 17 27 23 15 30 5 19 13 33 33
Bud 5 2 10 15 8 14 – 22 19 25 16 20 3 3 1 2 3 0 6 1 3 1 1 2
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 11 0 2 1 1 1
Bud Site 1 0 1 0 0 0 – 0 0 1 0 1 0 0 0 0 0 1 – – – – – –
Cell Periphery 4 1 5 9 10 8 – 17 13 19 30 45 7 16 25 12 7 19 3 0 2 0 3 9
Cytoplasm 122 32 58 39 41 54 – 78 29 38 44 49 71 78 136 61 43 38 34 14 6 0 3 7
Endoplasmic Reticulum 218 30 83 89 103 162 – 130 109 139 122 179 228 174 137 3 3 4 313 70 137 81 172 212
Endosome 10 0 0 2 30 10 – 18 1 5 1 2 10 11 8 1 10 2 12 3 3 5 9 10
Golgi 2 0 2 2 17 1 – 1 0 2 1 2 0 0 2 9 8 3 7 0 3 7 18 17
Mitochondria 40 5 82 211 104 290 – 306 265 296 282 403 2 4 3 6 15 6 46 8 55 6 19 18
Nucleus 1 4 0 0 0 2 – 4 0 1 1 1 1 0 1 1 1 2 0 0 0 0 1 2
Nuclear Periphery 2 1 0 0 1 4 – 9 10 9 5 13 1 0 0 0 0 1 1 0 1 0 0 0
Nucleolus 1 1 0 0 1 0 – 3 1 0 0 1 0 1 0 0 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 2 1 1 – 1 1 0 1 1 0 0 0 1 1 0 0 0 1 1 0 0
SpindlePole 0 0 1 0 0 0 – 0 0 0 0 0 0 0 1 2 4 4 1 0 0 0 0 0
Vac/Vac Membrane 40 1 10 5 29 31 – 95 49 41 19 23 5 5 6 14 6 5 22 6 13 7 14 13
Unique Cell Count 403 70 206 285 283 458 548 366 436 385 550 309 274 292 122 109 86 497 116 256 127 286 335
Labelled Cell Count 476 81 266 397 358 593 703 504 595 541 778 350 320 337 139 125 100 497 116 256 127 286 335


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 6.2 5.1 6.4 7.1 5.7 – 6.0 5.3 5.8 5.8 6.0 7.3 7.4 7.5 9.8 9.2 9.1 8.4 9.0 9.1
Std Deviation (1e-4) 0.9 1.1 1.2 1.4 1.6 1.0 – 1.4 1.1 1.2 1.5 1.6 1.1 1.3 1.3 2.9 2.3 2.2 1.5 1.8 1.5
Intensity Change (Log2) – – – 0.32 0.47 0.16 – 0.23 0.07 0.17 0.19 0.23 0.51 0.54 0.55 0.94 0.84 0.84 0.71 0.82 0.83

WT3RAP60RAP140RAP220RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.5 -1.1 -1.9 – -2.0 -3.0 -1.3 -0.9 0.1 0.1 1.3 -0.4 4.1 3.8 2.8
Bud 0.2 -1.2 -1.1 – -0.5 0.2 0.5 -0.4 -0.8 -2.8 -2.5 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.5 0.7 0 – 0.5 0.7 1.2 2.6 2.8 0 1.8 2.8 2.9 0 5.6
Cytoplasm -4.0 -3.7 -5.2 – -4.4 -6.5 -6.4 -5.1 -6.8 -1.3 0.1 4.2 4.0 2.0 2.7
Endoplasmic Reticulum -2.1 -0.9 -1.2 – -4.5 -2.6 -2.1 -2.1 -2.0 7.6 5.0 1.5 -7.5 -7.1 -6.1
Endosome 0 4.8 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 2.8 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 7.6 -0.7 5.6 – 3.9 7.7 6.8 8.0 8.5 -11.8 -10.8 -11.3 -6.9 -4.8 -5.6
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -2.0 2.2 0.9 – 4.4 3.2 2.0 0 -0.4 -2.1 -1.9 -1.7 2.2 0.3 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 6.6219 6.3723 6.2596 5.6007 5.2887 6.1214 6.2067 5.6402 5.6865 5.5592 5.4911 5.6551 9.6982 8.8672 8.0943 7.6737 6.5147 8.4968
Actin 0.033 0.0082 0.0199 0.0167 0.0144 0.0046 0.0239 0.0293 0.0216 0.0038 0.0095 0.0067 0.0383 0.0071 0.0103 0.0034 0.0886 0.0118
Bud 0.0003 0.0003 0.0003 0.0005 0.0001 0.0001 0.0005 0.0003 0.0002 0.0001 0.0008 0.0001 0.0003 0.0002 0.0001 0.0001 0.0003 0.0001
Bud Neck 0.0009 0.0005 0.0017 0.0061 0.001 0.0017 0.0006 0.0011 0.0016 0.0039 0.001 0.0022 0.0017 0.0008 0.0006 0.0004 0.0009 0.0042
Bud Periphery 0.0006 0.0009 0.0006 0.0021 0.0002 0.0004 0.0006 0.0006 0.0003 0.0001 0.0012 0.0004 0.0004 0.0005 0.0004 0.0006 0.0005 0.0003
Bud Site 0.0048 0.0018 0.0024 0.0012 0.0003 0.0002 0.0046 0.0025 0.0066 0.0002 0.0023 0.0003 0.0016 0.002 0.0004 0.0001 0.0016 0.0002
Cell Periphery 0.0026 0.0094 0.0033 0.0133 0.0026 0.0017 0.0044 0.0062 0.0022 0.0017 0.0026 0.0021 0.0016 0.0097 0.0051 0.009 0.0011 0.0016
Cytoplasm 0.0205 0.0542 0.0239 0.0171 0.0412 0.0367 0.0317 0.108 0.051 0.0825 0.0159 0.0209 0.0364 0.0397 0.0552 0.0062 0.0039 0.0215
Cytoplasmic Foci 0.0149 0.022 0.0108 0.0217 0.0126 0.0113 0.0172 0.0242 0.0128 0.0061 0.0166 0.0157 0.0153 0.0116 0.0099 0.0029 0.0121 0.0136
Eisosomes 0.0007 0.0004 0.0004 0.0005 0.0004 0.0002 0.0005 0.0011 0.0002 0.0001 0.0007 0.0003 0.0004 0.001 0.0003 0.0012 0.0008 0.0002
Endoplasmic Reticulum 0.7044 0.7154 0.7917 0.7082 0.7423 0.7875 0.7161 0.5941 0.7758 0.8113 0.7623 0.8122 0.7444 0.7387 0.7774 0.8633 0.5994 0.7726
Endosome 0.0702 0.0653 0.0402 0.054 0.0839 0.0603 0.0588 0.0838 0.0437 0.0391 0.0569 0.0535 0.0448 0.0641 0.0425 0.0308 0.1086 0.0572
Golgi 0.037 0.0422 0.0297 0.0439 0.0417 0.0364 0.0269 0.0565 0.0261 0.0067 0.0662 0.0364 0.0432 0.0347 0.0394 0.0501 0.0614 0.0623
Lipid Particles 0.0429 0.0456 0.0269 0.0416 0.0221 0.0227 0.0223 0.0561 0.0272 0.0103 0.0416 0.0188 0.0307 0.0622 0.0354 0.0055 0.0513 0.0258
Mitochondria 0.0283 0.0123 0.0158 0.0372 0.0035 0.012 0.0141 0.0123 0.0056 0.0016 0.0063 0.0071 0.0066 0.0057 0.0073 0.0143 0.026 0.0101
None 0.0032 0.0012 0.0009 0.0021 0.0036 0.0012 0.0086 0.002 0.0009 0.0145 0.0006 0.0017 0.0012 0.0009 0.0007 0.0008 0.0022 0.0004
Nuclear Periphery 0.0213 0.0083 0.0084 0.0072 0.0173 0.0122 0.043 0.0098 0.012 0.0092 0.0055 0.0098 0.0216 0.0107 0.008 0.0065 0.012 0.0091
Nucleolus 0.0002 0.0001 0.0002 0.0003 0.0001 0.0001 0.0005 0.0001 0.0001 0.0002 0.0001 0.0001 0.0002 0.0001 0 0 0.0003 0.0001
Nucleus 0.0012 0.001 0.0011 0.0013 0.0015 0.001 0.0056 0.001 0.0009 0.0009 0.0005 0.0006 0.0013 0.0007 0.0004 0.0003 0.0008 0.0008
Peroxisomes 0.0015 0.001 0.0108 0.0148 0.0005 0.0017 0.0057 0.0008 0.0048 0.0007 0.0037 0.0012 0.0032 0.0002 0.0002 0.0001 0.0152 0.0016
Punctate Nuclear 0.0027 0.0004 0.0043 0.0024 0.0016 0.0004 0.0043 0.0007 0.0009 0.0013 0.0011 0.002 0.0015 0.0003 0.0002 0.0001 0.0044 0.0003
Vacuole 0.0059 0.0079 0.0051 0.0057 0.0061 0.0054 0.0064 0.0072 0.0042 0.0041 0.003 0.0059 0.004 0.0078 0.0047 0.0029 0.0052 0.0042
Vacuole Periphery 0.0031 0.0016 0.0017 0.0019 0.003 0.0023 0.0038 0.0021 0.0013 0.0014 0.0015 0.002 0.0016 0.0014 0.0014 0.0017 0.0035 0.002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 119.8141 174.3594 158.9553 172.4782 245.6607 133.672 163.7022 186.9796 177.4578 196.4304
Translational Efficiency 3.2203 2.4378 1.8907 2.4008 1.9154 2.7642 1.7595 1.7052 1.8148 1.6317

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
17 871 387 1045 1713 1626 2268 1457 1730 2497 2655 2502

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1354.55 860.25 1110.31 1244.80 796.58 854.91 1122.41 1229.54 802.06 856.77 1120.65 1235.91
Standard Deviation 232.36 124.46 148.68 206.92 111.91 125.52 170.04 194.05 126.33 125.18 167.15 199.67
Intensity Change Log 2 — -0.654986 -0.286851 -0.121900 — 0.101953 0.494709 0.626228 — -0.326752 0.053708 0.201949

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.043899 0.004320 0.008286 0.021928 0.002883 0.004813 0.011847 0.021675 0.003286 0.004641 0.011328 0.021781
Bud Neck 0.004306 0.002555 0.002856 0.005153 0.001993 0.002664 0.000953 0.006599 0.002016 0.002626 0.001230 0.005995
Bud Site 0.051377 0.007631 0.022233 0.039848 0.004225 0.004478 0.007322 0.038415 0.004689 0.005578 0.009496 0.039013
Cell Periphery 0.004977 0.001476 0.000802 0.004163 0.001526 0.001800 0.003282 0.004123 0.001560 0.001687 0.002920 0.004140
Cytoplasm 0.087822 0.092978 0.108618 0.036444 0.139510 0.124214 0.022838 0.051192 0.139002 0.113318 0.035342 0.045032
Cytoplasmic Foci 0.064015 0.103127 0.052862 0.046821 0.070969 0.095364 0.015277 0.037363 0.070901 0.098071 0.020756 0.041313
Eisosomes 0.000666 0.001691 0.000239 0.000841 0.002656 0.002640 0.001091 0.001271 0.002637 0.002309 0.000967 0.001091
Endoplasmic Reticulum 0.416192 0.442303 0.579289 0.624687 0.462511 0.391581 0.824020 0.626764 0.462056 0.409274 0.788347 0.625896
Endosome 0.068237 0.030774 0.026611 0.049095 0.015868 0.025112 0.020521 0.038483 0.016383 0.027087 0.021409 0.042915
Golgi 0.072208 0.120144 0.008896 0.032424 0.090228 0.105444 0.021597 0.034779 0.090051 0.110572 0.019746 0.033795
Lipid Particles 0.008691 0.112541 0.034682 0.063654 0.128190 0.152496 0.049910 0.073819 0.127016 0.138559 0.047690 0.069574
Mitochondria 0.004980 0.026934 0.000377 0.002892 0.027522 0.031963 0.002163 0.004293 0.027301 0.030208 0.001903 0.003708
Mitotic Spindle 0.003070 0.002234 0.007568 0.008552 0.000188 0.000591 0.000359 0.006474 0.000216 0.001164 0.001410 0.007342
None 0.000389 0.002607 0.000480 0.000704 0.002878 0.002023 0.004874 0.000929 0.002854 0.002227 0.004233 0.000835
Nuclear Periphery 0.000623 0.001631 0.004845 0.000902 0.001433 0.001577 0.000154 0.000669 0.001425 0.001596 0.000838 0.000767
Nuclear Periphery Foci 0.004530 0.006933 0.092656 0.020303 0.004705 0.004880 0.003666 0.015332 0.004703 0.005596 0.016637 0.017408
Nucleolus 0.004376 0.000202 0.000117 0.000071 0.000218 0.000394 0.000018 0.000068 0.000259 0.000327 0.000033 0.000069
Nucleus 0.076080 0.003610 0.011607 0.001494 0.008281 0.008498 0.000312 0.002885 0.008948 0.006793 0.001958 0.002304
Peroxisomes 0.001673 0.016208 0.001151 0.002453 0.022197 0.020245 0.006137 0.004496 0.021995 0.018837 0.005411 0.003643
Vacuole 0.060802 0.012329 0.034799 0.034121 0.007729 0.012449 0.002612 0.027217 0.008250 0.012407 0.007304 0.030101
Vacuole Periphery 0.021088 0.007773 0.001027 0.003452 0.004289 0.006772 0.001046 0.003153 0.004454 0.007121 0.001043 0.003278

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.32 1.18 0.70 -7.17 -4.12 -2.04 -6.17 -8.66 -7.43 -3.90 -1.75 -6.05 -11.06 -10.18 -5.24
Bud Neck 1.29 1.01 -0.71 -3.89 -3.46 -1.85 3.41 -5.59 -4.76 -6.93 -1.82 2.61 -7.09 -6.09 -8.84
Bud Site 1.56 1.01 0.34 -9.06 -3.45 -0.30 -3.04 -11.77 -11.65 -10.49 -1.02 -4.26 -15.19 -14.89 -12.54
Cell Periphery 1.21 1.46 0.23 -5.43 -6.94 -0.81 -6.08 -5.15 -3.93 -1.46 -0.54 -5.37 -7.07 -5.96 -2.86
Cytoplasm 0.19 -0.18 1.28 10.61 7.79 2.88 29.21 18.36 15.28 -9.83 5.46 24.70 21.33 18.88 -4.06
Cytoplasmic Foci -1.07 0.22 0.40 9.75 1.13 -5.92 19.43 9.72 15.06 -9.29 -7.25 17.13 9.08 17.52 -9.36
Eisosomes -2.50 1.04 -0.48 3.76 -3.78 0.05 6.06 5.27 4.45 -0.87 1.13 6.75 6.41 5.70 -0.76
Endoplasmic Reticulum -0.41 -1.66 -2.10 -10.32 -2.18 5.95 -35.86 -12.33 -17.88 18.40 4.83 -32.23 -13.96 -20.57 18.12
Endosome 1.54 1.71 0.72 -6.09 -7.02 -6.67 -3.84 -12.24 -6.56 -9.13 -8.60 -4.33 -16.36 -9.20 -12.71
Golgi -1.06 1.27 0.78 15.78 -8.49 -3.41 21.38 15.37 17.93 -5.24 -5.05 22.28 16.80 23.91 -7.09
Lipid Particles -17.17 -6.47 -11.43 7.43 -6.18 -3.98 16.52 10.12 13.38 -5.47 -2.18 17.46 12.03 15.52 -6.43
Mitochondria -6.66 2.12 0.89 9.08 -3.45 -1.64 14.09 12.35 13.17 -3.29 -1.22 14.28 12.93 16.06 -3.55
Mitotic Spindle 0.39 -1.48 -2.67 -3.65 -0.35 -2.03 -1.63 -4.84 -4.48 -4.71 -2.73 -2.88 -7.22 -5.97 -5.61
None -2.48 -0.19 -0.75 2.14 -0.58 1.79 -2.17 4.12 2.50 4.44 1.24 -1.70 4.84 3.34 4.55
Nuclear Periphery -1.77 -5.36 -0.79 1.49 5.42 -0.40 5.03 2.69 3.17 -5.00 -0.51 2.17 2.35 3.29 0.22
Nuclear Periphery Foci -0.63 -11.74 -4.78 -5.61 9.68 -0.37 1.53 -6.60 -6.50 -7.18 -1.44 -8.93 -9.36 -8.71 -0.62
Nucleolus 0.98 1.00 1.01 2.03 1.16 -1.73 4.29 3.11 3.38 -4.06 -0.83 3.60 2.94 3.84 -2.36
Nucleus 1.70 1.52 1.74 4.00 6.73 -0.23 13.48 7.17 5.78 -7.32 2.35 8.78 7.98 6.82 -1.61
Peroxisomes -9.65 0.68 -1.19 9.75 -3.27 1.13 11.49 12.87 13.09 2.21 2.04 12.21 13.99 16.56 3.11
Vacuole 2.22 1.16 1.16 -7.50 -0.06 -4.30 7.53 -9.30 -6.93 -11.84 -4.21 0.80 -12.51 -10.19 -13.01
Vacuole Periphery 1.03 1.55 1.36 4.38 -3.62 -3.86 9.76 2.10 4.91 -4.31 -4.80 9.91 2.43 6.48 -5.50
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein of unknown function; expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion
Localization
Cell Percentages ER (98%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Ysy6

Ysy6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ysy6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available