Standard name
Human Ortholog
Description Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0.05 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0 0.07 0.06 0.1 0.12 – 0.13 0.11 0.1 0.1 0.12 0.14 0.16 0.21 0.34 0.34 0.21 0 0 0 0 0 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0.12 0.07 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.16 0.2 0.63 0.6 0.24 0.55 – 0.61 0.67 0.68 0.69 0.68 0.05 0 0 0.07 0.1 0.1 0 0 0 0 0 0
Nucleus 0.85 0.84 0.66 0.74 0.72 0.65 – 0.59 0.59 0.62 0.58 0.55 0.79 0.76 0.7 0.52 0.49 0.57 0.77 0.71 0.61 0.59 0.53 0.36
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0.07
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.05 0.12 0.05 0 0.05 0 – 0 0 0 0 0.05 0 0.07 0.07 0.2 0.15 0.21 0.08 0.14 0.17 0.18 0.27 0.35
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud 1 0 7 3 6 5 – 4 7 16 13 7 0 1 0 1 1 0 10 1 3 1 4 4
Bud Neck 1 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 1 0 2 0 1 0 1 1
Bud Site 0 1 0 4 4 5 – 14 12 25 12 12 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 30 1 29 25 55 40 – 52 37 48 31 43 33 57 78 19 23 9 13 0 18 6 10 23
Endoplasmic Reticulum 2 0 3 0 0 0 – 1 0 0 0 0 0 2 0 4 8 3 0 0 1 0 1 0
Endosome 4 0 0 0 22 1 – 1 0 2 0 1 4 3 5 2 1 1 9 1 4 2 5 13
Golgi 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 2 0 0 0
Mitochondria 77 5 260 234 136 178 – 246 226 322 221 235 11 6 4 4 7 4 4 0 5 2 6 9
Nucleus 421 21 273 288 404 210 – 237 201 294 186 190 189 263 258 29 33 24 426 51 264 90 164 122
Nuclear Periphery 2 0 2 12 3 3 – 7 4 7 3 1 2 3 4 0 0 0 1 0 6 0 1 3
Nucleolus 1 0 1 2 5 7 – 3 11 7 7 6 4 5 3 0 1 0 21 1 19 11 11 22
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0
SpindlePole 1 0 2 1 3 0 – 2 1 3 3 1 2 2 1 1 2 1 13 1 18 6 8 10
Vac/Vac Membrane 26 3 22 14 31 13 – 8 12 13 14 16 9 24 24 11 10 9 46 10 75 26 84 118
Unique Cell Count 496 25 413 389 565 325 400 339 474 322 345 239 346 366 56 67 42 556 72 431 153 307 343
Labelled Cell Count 567 31 599 583 670 462 575 511 737 490 512 254 368 378 71 87 51 556 72 431 153 307 343


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.3 3.5 3.6 4.5 3.7 – 3.9 3.5 3.6 3.6 3.7 5.6 5.4 5.5 6.4 5.5 5.8 5.6 5.4 5.6
Std Deviation (1e-4) 0.7 1.8 0.8 1.4 1.5 1.6 – 1.7 2.0 1.4 2.0 2.0 2.6 1.3 1.9 2.0 2.0 1.6 2.8 1.6 2.2
Intensity Change (Log2) – – – 0.07 0.37 0.11 – 0.18 0.01 0.07 0.05 0.09 0.7 0.64 0.67 0.88 0.66 0.75 0.7 0.66 0.7


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.3 1.5 2.4 – 2.8 1.9 1.6 1.3 2.5 2.8 4.1 5.8 6.2 6.7 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 – 0 0 0 0 0 -14.6 -17.6 -18.2 -7.9 -8.0 -6.7
Nucleus 2.4 1.8 -0.4 – -2.0 -1.9 -1.3 -2.3 -3.1 3.5 3.0 1.3 -2.1 -2.7 -1.2
Nuclear Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole -1.2 0.1 -0.8 – -2.5 -1.2 -2.0 -0.6 -0.4 -0.9 0.9 0.7 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8608 1.7769 1.261 1.2888 1.2277 1.4841 1.7027 0.9534 1.0124 0.7733 0.9571 0.8535 2.9857 2.6799 2.3966 2.4285 2.7133 2.332
Actin 0.0418 0.0033 0.0047 0.001 0.0001 0.0131 0.0118 0 0.0152 0.0483 0.0205 0.0124 0.0352 0.0001 0.011 0.0012 0.0084 0.006
Bud 0.0012 0.0002 0.0003 0.0003 0 0.0002 0.0006 0.0001 0.001 0.0012 0.0002 0.0003 0.0006 0.0002 0.0006 0.0005 0.0001 0.0001
Bud Neck 0.0069 0.0007 0.0005 0.0005 0.0002 0.0018 0.0065 0.0005 0.0092 0.0004 0.0008 0.0018 0.0118 0.0008 0.0021 0.0008 0.0005 0.0017
Bud Periphery 0.0033 0.0003 0.0007 0.0007 0.0001 0.0006 0.0024 0.0001 0.0014 0.0013 0.0004 0.0015 0.0016 0.0003 0.0009 0.0006 0.0003 0.0001
Bud Site 0.0265 0.0012 0.0011 0.0011 0.0001 0.0005 0.0057 0.0004 0.0138 0.0102 0.0003 0.0006 0.002 0.0029 0.0032 0.0024 0.0002 0.0001
Cell Periphery 0.0102 0.0002 0.0002 0.0001 0 0.0001 0.0042 0.0001 0.0007 0.0001 0.0001 0.0006 0.0003 0.0001 0.0003 0.0001 0 0.0001
Cytoplasm 0.0034 0.0021 0.0057 0.0005 0.0003 0.0116 0.0095 0.0025 0.0067 0.0602 0.0004 0.0009 0.0073 0.001 0.0032 0.0024 0.0024 0.0006
Cytoplasmic Foci 0.0189 0.0012 0.0065 0.0088 0 0.0023 0.029 0.0001 0.0048 0.0037 0.0218 0.0006 0.004 0.0002 0.0007 0.0031 0.0037 0.0003
Eisosomes 0.0007 0.0001 0 0 0 0 0.0004 0 0.0028 0.0001 0.0003 0.0005 0.0007 0 0.0001 0 0.0001 0.0001
Endoplasmic Reticulum 0.0031 0.0017 0.0015 0.0002 0 0.0003 0.011 0.0006 0.0023 0.0007 0.0007 0.0064 0.0039 0.0001 0.0023 0.0011 0.0006 0.0004
Endosome 0.0356 0.005 0.01 0.0097 0.0001 0.0048 0.0438 0.0005 0.0075 0.0026 0.0064 0.007 0.0169 0.0003 0.004 0.0203 0.0123 0.001
Golgi 0.0121 0.0026 0.0027 0.0048 0 0.0062 0.0097 0 0.0043 0.002 0.0117 0.0027 0.0048 0.0001 0.0016 0.0019 0.0049 0.0005
Lipid Particles 0.0382 0.0013 0.0058 0.047 0 0.0024 0.0212 0.0001 0.0092 0.0009 0.0074 0.0014 0.0066 0.0001 0.0065 0.0021 0.0261 0.0003
Mitochondria 0.0579 0.0038 0.0027 0.0029 0.0009 0.0089 0.012 0.0003 0.0059 0.0012 0.0329 0.0152 0.0175 0.0003 0.0018 0.002 0.0014 0.0004
None 0.0034 0.0011 0.0048 0.0003 0.0001 0.0005 0.0153 0.0019 0.0194 0.0063 0.0004 0.0003 0.0136 0.0052 0.001 0.0043 0.0029 0.0089
Nuclear Periphery 0.0198 0.0202 0.0096 0.0023 0.0067 0.0124 0.0616 0.0158 0.0063 0.0067 0.0014 0.0069 0.0347 0.0047 0.0157 0.0092 0.0168 0.0109
Nucleolus 0.0535 0.0897 0.0544 0.0148 0.0293 0.0684 0.037 0.0669 0.0885 0.0175 0.0438 0.0739 0.0445 0.0576 0.0822 0.0946 0.0436 0.0796
Nucleus 0.5974 0.8564 0.8726 0.8785 0.9568 0.8593 0.6663 0.8972 0.7803 0.8318 0.8202 0.8449 0.7633 0.9226 0.8557 0.8397 0.8363 0.8828
Peroxisomes 0.0128 0.0002 0.0042 0.0209 0 0.0026 0.0049 0 0.0054 0.0032 0.0276 0.0001 0.004 0.0001 0.0004 0.0011 0.0083 0.0001
Punctate Nuclear 0.0275 0.0062 0.0064 0.0043 0.0048 0.0018 0.0265 0.0109 0.0047 0.0011 0.0019 0.0159 0.0203 0.0028 0.004 0.0078 0.0303 0.0053
Vacuole 0.0168 0.0013 0.0044 0.001 0.0002 0.0013 0.0137 0.0014 0.0088 0.0004 0.0003 0.0044 0.0038 0.0006 0.0018 0.0038 0.0003 0.0004
Vacuole Periphery 0.0087 0.0012 0.0015 0.0004 0.0003 0.0007 0.0069 0.0006 0.0018 0.0003 0.0005 0.0016 0.0024 0.0001 0.001 0.0009 0.0005 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 9.1298 9.3274 12.1124 14.4127 5.0731 7.8212 10.0204 14.3218 14.1211 15.6711
Translational Efficiency 3.6007 2.5378 1.821 1.3655 3.6241 3.6719 2.8239 1.3933 1.5109 1.6627

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1327 1539 1658 970 506 1797 136 1705 1833 3336 1794 2675

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 589.68 776.27 793.71 908.82 608.23 755.89 960.03 862.83 594.80 765.29 806.32 879.51
Standard Deviation 96.06 106.22 102.15 126.75 87.23 99.87 103.73 114.74 94.07 103.35 111.34 121.27
Intensity Change Log 2 — 0.396626 0.428680 0.624062 — 0.313559 0.658463 0.504459 — 0.355047 0.549915 0.564574

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000049 0.000158 0.000317 0.000909 0.000106 0.000162 0.000742 0.000657 0.000065 0.000160 0.000349 0.000749
Bud Neck 0.003095 0.003627 0.009898 0.021031 0.001695 0.007513 0.008471 0.023516 0.002708 0.005720 0.009790 0.022615
Bud Site 0.000499 0.000797 0.001629 0.008251 0.002411 0.001132 0.000820 0.009741 0.001027 0.000978 0.001568 0.009200
Cell Periphery 0.000949 0.000064 0.000081 0.000151 0.000238 0.000077 0.000085 0.000184 0.000753 0.000071 0.000081 0.000172
Cytoplasm 0.157957* 0.023806 0.015014 0.022695 0.033104 0.024697 0.002389 0.026722 0.123491* 0.024286 0.014057 0.025262
Cytoplasmic Foci 0.020016 0.003842 0.000180 0.002510 0.010940 0.006988 0.000081 0.005526 0.017511 0.005537 0.000172 0.004433
Eisosomes 0.002059 0.000017 0.000016 0.000029 0.000047 0.000026 0.000045 0.000038 0.001504 0.000022 0.000018 0.000035
Endoplasmic Reticulum 0.001486 0.003055 0.004108 0.010797 0.001948 0.003077 0.008527 0.008118 0.001613 0.003067 0.004443 0.009089
Endosome 0.000779 0.000944 0.000470 0.003384 0.001646 0.002087 0.000390 0.009228 0.001018 0.001560 0.000464 0.007109
Golgi 0.000568 0.000593 0.000052 0.010549 0.000506 0.001319 0.000057 0.003568 0.000551 0.000984 0.000053 0.006100
Lipid Particles 0.005593 0.001085 0.000218 0.000424 0.003982 0.003206 0.000377 0.002767 0.005148 0.002227 0.000230 0.001917
Mitochondria 0.000971 0.002171 0.000771 0.007452 0.001954 0.009030 0.000605 0.015233 0.001242 0.005866 0.000758 0.012412
Mitotic Spindle 0.000065 0.001390 0.001183 0.025694 0.000200 0.004679 0.000037 0.029549 0.000102 0.003162 0.001097 0.028151
None 0.065436 0.004384 0.004822 0.004767 0.021069 0.004988 0.002703 0.006437 0.053189 0.004710 0.004661 0.005831
Nuclear Periphery 0.000875 0.001892 0.000686 0.003727 0.001529 0.003981 0.000849 0.003317 0.001055 0.003017 0.000698 0.003466
Nuclear Periphery Foci 0.001152 0.000608 0.000229 0.001023 0.000666 0.001158 0.000246 0.002244 0.001018 0.000904 0.000230 0.001801
Nucleolus 0.009485 0.014499 0.006821 0.014941 0.043669 0.027128 0.013408 0.011532 0.018922 0.021302 0.007320 0.012768
Nucleus 0.725626* 0.933653* 0.950740* 0.846504* 0.870721* 0.890125* 0.954743* 0.812225* 0.765680* 0.910206* 0.951044* 0.824655*
Peroxisomes 0.001164 0.000990 0.000147 0.000328 0.001812 0.002719 0.000292 0.002560 0.001343 0.001921 0.000158 0.001751
Vacuole 0.002054 0.002059 0.002418 0.013543 0.001403 0.004626 0.005007 0.021926 0.001874 0.003442 0.002614 0.018887
Vacuole Periphery 0.000121 0.000365 0.000201 0.001292 0.000354 0.001281 0.000125 0.004909 0.000185 0.000858 0.000195 0.003598

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.26 -12.70 -8.56 -7.63 -6.41 -2.54 -6.56 -13.23 -11.06 1.80 -6.10 -13.92 -14.36 -12.28 -8.34
Bud Neck -0.87 -7.20 -12.24 -12.33 -7.20 -7.30 -7.15 -14.78 -10.26 -7.17 -5.06 -8.46 -18.10 -15.67 -9.49
Bud Site -0.87 -3.56 -6.18 -5.71 -5.01 0.79 0.77 -3.71 -7.26 -7.27 0.02 -1.28 -8.43 -9.21 -8.10
Cell Periphery 6.26 6.16 5.80 -3.18 -2.69 2.90 2.56 1.42 -4.49 -2.34 6.58 6.50 5.83 -5.51 -4.81
Cytoplasm 21.26 23.47 20.94 0.06 -3.38 1.71 6.98 1.47 -0.42 -11.02 20.36 22.69 20.09 -0.35 -5.70
Cytoplasmic Foci 8.76 11.50 10.56 3.07 -2.94 2.27 6.74 3.93 2.51 -7.02 8.42 13.05 10.35 3.26 -7.48
Eisosomes 3.93 3.93 3.88 -9.37 -10.92 5.74 -0.82 2.06 -6.29 1.87 3.93 3.94 3.88 -11.16 -13.51
Endoplasmic Reticulum -5.71 -10.17 -16.33 -13.57 -11.72 -4.53 -6.39 -13.78 -11.68 1.62 -7.65 -12.04 -21.21 -17.49 -11.74
Endosome -0.49 2.07 -3.33 -2.54 -4.08 -0.40 1.19 -3.84 -4.85 -6.73 -1.49 1.87 -6.10 -5.55 -7.50
Golgi -0.07 5.10 -2.29 -2.25 -2.57 -1.69 1.33 -3.19 -1.90 -4.56 -1.64 4.24 -3.67 -3.00 -4.36
Lipid Particles 5.29 6.47 6.02 2.97 -4.80 1.28 7.22 2.70 1.54 -3.77 4.36 8.03 5.13 1.57 -4.72
Mitochondria -2.26 1.45 -4.39 -2.86 -4.58 -5.62 5.50 -6.66 -1.65 -7.55 -6.45 4.03 -8.17 -3.11 -8.64
Mitotic Spindle -2.16 -2.57 -6.15 -5.70 -5.76 -4.50 -0.46 -8.79 -6.68 -8.67 -5.04 -2.54 -10.74 -8.97 -10.04
None 12.75 12.67 12.57 -0.92 -0.60 4.67 5.32 4.46 -0.49 -2.56 13.41 13.37 13.14 -0.94 -1.11
Nuclear Periphery -5.60 1.36 -9.94 -6.39 -10.51 -5.10 0.84 -5.10 0.67 -5.90 -7.67 2.73 -10.64 -2.43 -12.12
Nuclear Periphery Foci 1.65 4.74 0.19 -1.60 -5.25 -1.63 1.49 -3.04 -1.72 -4.45 0.44 4.93 -2.04 -2.35 -5.83
Nucleolus -2.16 2.91 -1.37 0.53 -3.77 3.81 6.39 7.38 8.07 0.12 -0.60 7.81 4.52 6.52 -4.60
Nucleus -21.82 -24.49 -10.14 10.94 13.62 -2.06 -7.38 4.11 8.06 14.20 -18.91 -24.87 -7.45 13.37 21.03
Peroxisomes 0.48 5.15 4.17 3.13 -3.35 -1.29 3.85 -0.11 1.26 -4.64 -1.61 6.61 0.12 1.61 -5.38
Vacuole -0.53 -1.16 -9.49 -9.36 -9.15 -4.21 -3.47 -12.55 -10.31 -6.24 -3.75 -2.61 -15.59 -14.05 -14.35
Vacuole Periphery -2.32 -1.67 -3.05 -1.73 -2.62 -3.22 3.17 -5.13 -3.40 -5.49 -4.21 -0.25 -5.83 -3.94 -5.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of RNase MRP, nuclear RNase P and telomerase; forms a soluble heterodimer with Pop6p that binds P3 domain of RNase MRP and RNase P RNAs; RNase MRP cleaves pre-rRNA, nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs, while telomerase replenishes telomeric DNA
Localization
Cell Percentages nucleus (68%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Pop7

Pop7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pop7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available