ORF
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.77 0.83 0.86 0.65 0.72 0.73 0.71 – 0.63 0.69 0.58 0.52 0.91 0.91 0.93 0.67 0.59 0.81 0.64 0.68 0.77 0.83 0.76 0.78
Endoplasmic Reticulum 0 0.06 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0.06 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.22 0.07 – 0.28 0.25 0.36 0.43 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.08 0.06 0 0.07 0 0 0.05 – 0.06 0.05 0.1 0.06 0 0 0 0.19 0.13 0.1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.18 0.1 0.18 0.33 0.28 0.08 0.27 – 0.12 0.14 0.09 0.11 0.11 0.12 0.1 0.23 0.4 0.17 0.14 0.15 0.06 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 1 7 6 11 2 16 11
Bud 0 0 0 1 0 5 1 – 4 3 6 1 0 1 0 0 0 0 6 1 2 0 5 3
Bud Neck 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 0 11 10 9 2 6 11
Bud Site 0 0 0 0 0 2 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 1 3 4 3 4 – 5 6 4 6 1 3 7 1 3 2 1 3 6 2 6 7
Cytoplasm 254 181 265 144 221 216 293 – 179 280 162 168 146 275 278 87 106 102 253 176 266 174 267 233
Endoplasmic Reticulum 14 13 10 7 2 2 1 – 1 0 3 0 2 1 1 4 4 2 23 4 10 6 22 12
Endosome 1 1 0 3 3 0 1 – 3 4 1 1 0 0 1 0 0 0 3 2 2 3 1 1
Golgi 3 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 2 0 2 1 0 1 2 2
Mitochondria 1 2 0 6 7 64 27 – 79 103 100 139 1 1 0 1 1 1 5 5 2 2 3 2
Nucleus 25 14 8 15 13 13 21 – 18 22 27 20 1 1 1 25 23 13 17 5 5 1 2 1
Nuclear Periphery 0 0 0 0 0 0 0 – 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 1 0 – 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 1 0 – 0 2 0 0 0 0 0 1 0 0 1 0 0 0 1 0
Vac/Vac Membrane 60 21 54 74 86 23 111 – 35 57 26 37 17 37 30 30 72 21 56 39 19 7 10 7
Unique Cell Count 328 217 308 222 306 294 410 286 408 277 326 160 302 298 129 180 126 396 261 345 211 351 300
Labelled Cell Count 358 234 338 253 336 330 460 327 478 329 373 168 320 318 149 211 142 396 261 345 211 351 300


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 7.0 7.6 7.1 7.0 4.8 5.7 – 4.8 5.2 4.8 4.9 7.6 6.9 7.9 9.8 11.0 10.5 6.7 7.0 7.3
Std Deviation (1e-4) 0.7 0.8 1.2 2.1 1.3 1.4 1.6 – 1.0 0.9 1.1 0.9 1.3 1.4 1.7 1.5 1.7 1.1 1.6 1.6 1.2
Intensity Change (Log2) – – – -0.08 -0.12 -0.66 -0.41 – -0.66 -0.55 -0.65 -0.62 -0.0 -0.13 0.07 0.38 0.54 0.47 -0.17 -0.11 -0.05

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -5.7 -4.2 -3.8 -4.6 – -6.6 -5.4 -7.5 -9.3 1.6 1.9 2.9 -4.5 -6.8 -1.3
Endoplasmic Reticulum -0.1 -2.3 0 0 – 0 0 0 0 0 -2.7 -2.7 0 -0.7 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.6 – 0 9.5 0 13.0 0 0 0 0 0 0
Nucleus 2.3 1.1 1.2 1.7 – 2.2 1.8 3.6 2.2 0 0 0 6.1 4.4 3.4
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 4.2 3.1 -3.6 3.0 – -1.8 -1.3 -2.9 -2.2 -2.0 -1.8 -2.7 1.4 5.5 -0.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.3133 1.8707 1.7987 1.6492 1.1306 1.7435 2.8298 3.2724 3.1906 3.212 3.5013 3.2802 6.5822 6.4472 6.4138 7.6172 6.3486 6.8677
Actin 0.0168 0.0007 0.0032 0.0002 0.0059 0.0038 0.0349 0.0028 0.0352 0.0029 0.0158 0.0032 0.0009 0.001 0.0012 0.0009 0.0009 0.0007
Bud 0.0004 0.0003 0.0105 0.0001 0.0003 0.0007 0.0011 0.0004 0.0007 0.0002 0.0005 0.0003 0.0002 0.0003 0.0002 0.0001 0.0001 0.0001
Bud Neck 0.0029 0.0007 0.0015 0.0008 0.0014 0.0042 0.0036 0.0011 0.0013 0.0017 0.003 0.0029 0.0011 0.0007 0.0008 0.0008 0.0018 0.0036
Bud Periphery 0.0008 0.0001 0.0019 0 0.0002 0.0003 0.0013 0.0002 0.001 0.0001 0.0005 0.0003 0.0001 0.0001 0.0002 0 0 0
Bud Site 0.0009 0.0023 0.0103 0.0002 0.0004 0.0002 0.0048 0.0128 0.005 0.0005 0.0015 0.0005 0.0008 0.0023 0.0013 0.0002 0.0002 0.0001
Cell Periphery 0.0002 0.0001 0.0001 0 0 0 0.0003 0.0003 0.0003 0.0001 0 0 0.0002 0.0001 0.0002 0.0001 0.0001 0
Cytoplasm 0.7213 0.8513 0.7324 0.7328 0.7311 0.7465 0.6423 0.8216 0.7255 0.7848 0.7751 0.7398 0.7293 0.8926 0.7944 0.8015 0.8563 0.789
Cytoplasmic Foci 0.0121 0.0048 0.0084 0.0034 0.0384 0.0125 0.0338 0.0045 0.0079 0.0149 0.0186 0.0083 0.005 0.003 0.004 0.0027 0.0037 0.0036
Eisosomes 0.0002 0 0 0 0 0 0.0002 0 0.0002 0 0.0001 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0135 0.0078 0.009 0.0065 0.0108 0.0076 0.0104 0.0064 0.0073 0.0075 0.0058 0.0066 0.0089 0.0068 0.0093 0.0078 0.0058 0.0063
Endosome 0.0186 0.0044 0.0094 0.0033 0.0168 0.0126 0.0224 0.002 0.0088 0.0078 0.0108 0.0071 0.004 0.0024 0.0021 0.0015 0.0018 0.0019
Golgi 0.0037 0.0002 0.0006 0.0001 0.0015 0.0012 0.0077 0.0002 0.0047 0.0005 0.0025 0.0013 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001
Lipid Particles 0.0046 0.0007 0.0008 0 0.001 0.0042 0.0153 0.0003 0.003 0.0005 0.002 0.0035 0.0002 0.0002 0.0003 0.0001 0.0001 0.0001
Mitochondria 0.0044 0.0014 0.0014 0.0002 0.0014 0.0043 0.0043 0.0002 0.0036 0.0005 0.002 0.0009 0.0003 0.0003 0.0003 0.0002 0.0002 0.0002
None 0.0541 0.0412 0.0384 0.0626 0.0847 0.043 0.1066 0.0936 0.0885 0.0314 0.0283 0.0593 0.1363 0.0137 0.0617 0.0827 0.0838 0.0436
Nuclear Periphery 0.0173 0.0081 0.0133 0.0099 0.0102 0.0101 0.009 0.0039 0.0074 0.0072 0.0188 0.0097 0.0067 0.0057 0.0059 0.0037 0.0046 0.0052
Nucleolus 0.0017 0.0007 0.0006 0.0002 0.0003 0.0006 0.0009 0.0002 0.0004 0.0002 0.0002 0.0008 0.0003 0.0002 0.0002 0.0001 0.0001 0.0001
Nucleus 0.1063 0.0675 0.1434 0.1724 0.0712 0.1297 0.072 0.0454 0.0869 0.1323 0.0982 0.144 0.0979 0.0666 0.1123 0.0951 0.0359 0.1402
Peroxisomes 0.0063 0.0002 0.0033 0.0001 0.0062 0.0024 0.0152 0.0001 0.0054 0.0013 0.0074 0.0027 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001
Punctate Nuclear 0.0077 0.0048 0.0093 0.0057 0.0161 0.0131 0.0105 0.0029 0.005 0.0043 0.0072 0.007 0.0053 0.0023 0.0042 0.002 0.0035 0.0043
Vacuole 0.0048 0.0022 0.0021 0.0013 0.0014 0.0023 0.0026 0.0011 0.0016 0.0011 0.0008 0.0014 0.0018 0.0011 0.001 0.0004 0.0009 0.0008
Vacuole Periphery 0.0014 0.0004 0.0003 0.0002 0.0003 0.0004 0.0008 0.0001 0.0003 0.0002 0.0008 0.0004 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.3074 13.574 11.1916 14.2482 17.4998 18.5485 15.6308 14.9241 12.6256 16.7735
Translational Efficiency 0.7043 1.3525 1.2205 0.8365 0.8467 0.7395 0.8166 1.1561 1.1497 0.8464

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
554 1279 2410 2945 2226 2549 1322 1928 2780 3828 3732 4873

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 709.15 870.65 1007.42 962.67 791.80 924.14 934.44 1051.33 775.33 906.27 981.57 997.75
Standard Deviation 85.46 116.10 119.03 130.09 94.58 117.34 134.03 137.25 98.53 119.62 129.35 139.86
Intensity Change Log 2 — 0.296002 0.506503 0.440951 — 0.222975 0.238966 0.409008 — 0.257939 0.371563 0.424188

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000805 0.001759 0.000247 0.000537 0.000221 0.000726 0.000619 0.000966 0.000337 0.001071 0.000379 0.000707
Bud Neck 0.018250 0.007702 0.009167 0.010798 0.005862 0.010061 0.003965 0.009146 0.008330 0.009273 0.007325 0.010144
Bud Site 0.021965 0.016227 0.007314 0.021685 0.003520 0.008096 0.007361 0.028372 0.007196 0.010813 0.007331 0.024330
Cell Periphery 0.001687 0.000632 0.000194 0.000350 0.000452 0.000344 0.000338 0.000331 0.000698 0.000440 0.000245 0.000343
Cytoplasm 0.450605 0.506468 0.370604 0.597772 0.469952 0.490244 0.470203 0.532214 0.466097 0.495665 0.405886 0.571834
Cytoplasmic Foci 0.175197 0.095828 0.003927 0.009882 0.068795 0.041837 0.010447 0.012203 0.089999 0.059876 0.006237 0.010800
Eisosomes 0.000729 0.000222 0.000026 0.000062 0.000222 0.000093 0.000049 0.000061 0.000323 0.000136 0.000035 0.000062
Endoplasmic Reticulum 0.006935 0.008581 0.004169 0.001582 0.001757 0.001612 0.005506 0.004370 0.002789 0.003940 0.004643 0.002685
Endosome 0.003881 0.005127 0.000857 0.001393 0.001408 0.002531 0.001997 0.001296 0.001901 0.003399 0.001261 0.001355
Golgi 0.002433 0.001753 0.000040 0.001374 0.000501 0.001179 0.000135 0.000473 0.000886 0.001371 0.000074 0.001018
Lipid Particles 0.009527 0.004540 0.000654 0.000673 0.002810 0.001567 0.001297 0.001175 0.004148 0.002560 0.000882 0.000872
Mitochondria 0.004236 0.001155 0.000591 0.002088 0.001414 0.001986 0.000604 0.002695 0.001976 0.001708 0.000596 0.002329
Mitotic Spindle 0.002251 0.000820 0.001482 0.032999 0.000182 0.005109 0.005125 0.010153 0.000595 0.003676 0.002772 0.023960
None 0.003251 0.004515 0.003389 0.004454 0.003813 0.004201 0.005154 0.005216 0.003701 0.004306 0.004014 0.004756
Nuclear Periphery 0.000320 0.000480 0.002019 0.000717 0.000343 0.000449 0.001213 0.000885 0.000339 0.000459 0.001734 0.000783
Nuclear Periphery Foci 0.000957 0.003419 0.001031 0.000504 0.000604 0.000550 0.003544 0.001697 0.000674 0.001509 0.001921 0.000976
Nucleolus 0.001075 0.000698 0.000165 0.000223 0.000321 0.000531 0.000209 0.000135 0.000472 0.000586 0.000181 0.000188
Nucleus 0.260549 0.282505 0.550251 0.218878 0.418077 0.405475 0.409317 0.283729 0.386685 0.364388 0.500327 0.244537
Peroxisomes 0.008328 0.004094 0.000072 0.000353 0.001023 0.001829 0.000169 0.000309 0.002478 0.002585 0.000106 0.000336
Vacuole 0.026505 0.052831 0.043725 0.092461 0.018593 0.021052 0.072577 0.104098 0.020170 0.031670 0.053945 0.097065
Vacuole Periphery 0.000512 0.000646 0.000074 0.001214 0.000131 0.000530 0.000169 0.000474 0.000207 0.000569 0.000107 0.000921

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.82 3.90 2.54 5.45 -2.70 -1.86 -8.20 -7.43 -0.53 -1.02 -3.77 -3.46 -5.14 2.26 -2.92
Bud Neck 3.37 2.68 2.93 -1.73 0.53 -4.18 1.02 -2.54 2.44 -3.80 -1.03 0.17 -0.29 1.01 -0.56
Bud Site 1.46 3.89 2.19 1.62 -4.55 -4.73 -4.72 -7.72 -4.32 -4.35 -3.39 -0.46 -6.08 -3.16 -6.27
Cell Periphery 4.59 6.59 6.37 7.67 -2.31 2.59 3.47 6.10 2.01 3.16 4.51 8.66 8.43 6.15 -0.48
Cytoplasm -4.11 10.97 -4.05 0.55 -24.45 -2.78 8.05 7.13 9.59 -1.63 -4.52 18.91 0.39 5.24 -19.85
Cytoplasmic Foci 10.22 25.28 24.44 22.66 -9.60 9.78 24.73 25.21 18.92 -0.07 10.28 34.63 33.07 28.85 -7.28
Eisosomes 6.11 8.82 8.42 6.01 -7.82 3.79 4.62 4.40 2.88 -2.08 5.69 8.79 8.04 6.75 -8.23
Endoplasmic Reticulum -1.56 1.16 5.30 8.65 16.35 0.44 -14.08 -7.18 -6.40 6.81 -3.13 -11.54 0.09 3.68 15.64
Endosome -2.00 6.86 7.16 8.37 1.46 -3.08 -2.24 2.58 4.85 5.18 -4.80 2.70 5.60 8.85 4.77
Golgi 1.59 7.41 4.77 2.90 -2.18 -1.99 5.09 2.77 2.91 -0.78 -1.78 9.25 2.85 3.34 -2.32
Lipid Particles 3.95 7.41 7.35 6.32 -1.65 5.11 5.23 5.34 -0.59 -0.06 4.53 10.13 9.91 6.23 -1.60
Mitochondria 3.16 3.72 3.09 -0.45 -3.64 -0.94 1.55 0.28 1.30 -1.26 0.57 3.03 1.55 1.35 -2.83
Mitotic Spindle 1.20 0.14 -6.99 -8.99 -8.21 -4.74 -3.25 -5.92 -1.67 -2.16 -4.14 -4.02 -10.47 -7.25 -8.29
None -1.20 0.39 -1.08 0.64 -2.40 -0.56 -0.71 -0.96 -0.45 -0.42 -0.95 0.45 -0.80 0.38 -2.23
Nuclear Periphery -2.45 -30.70 -23.82 -11.12 16.52 -2.62 -19.66 -18.75 -14.79 2.09 -3.46 -35.92 -30.11 -19.96 14.90
Nuclear Periphery Foci -7.86 -3.10 2.27 9.69 8.41 0.53 -10.27 -7.01 -7.34 6.34 -6.77 -11.52 -4.13 4.22 9.19
Nucleolus 1.57 3.79 3.74 6.07 -0.52 -2.62 2.77 3.86 5.61 2.17 -1.38 4.60 4.86 7.64 0.24
Nucleus -1.92 -27.37 0.28 3.36 46.62 1.60 -0.97 14.55 13.00 13.11 3.40 -19.38 18.80 16.46 43.70
Peroxisomes 3.03 6.40 6.28 7.01 -4.39 -2.40 7.30 7.08 5.47 -0.72 -0.18 8.53 8.13 8.70 -4.37
Vacuole -8.95 -13.73 -33.79 -25.84 -21.59 -2.24 -20.63 -35.31 -34.74 -12.31 -9.44 -26.72 -51.58 -46.64 -24.60
Vacuole Periphery -0.67 6.32 0.06 0.45 -1.68 -1.97 -0.21 -0.81 1.68 -0.61 -2.43 4.34 -1.07 0.91 -1.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene; relative distribution to the nucleus increases upon DNA replication stress; YBR197C has a paralog, YPL077C, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (37%), ER (2%), mixed (54%)
Cell Cycle Regulation No
Subcompartmental Group N/A

YBR197C

YBR197C


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ybr197c-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available