Standard name
Human Ortholog
Description Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.38 0.52 0.42 0.41 0.31 0.3 0.19 0.22 0.3 0.23 0.29 0.37 0.49 0.42 0.35 0.27 0.27 0.29 0.25 0.21 0.26 0.12 0.13 0.13
Bud 0.19 0.22 0.21 0.21 0.22 0.21 0.18 0.23 0.17 0.18 0.18 0.21 0.2 0.19 0.07 0.08 0.05 0.1 0.31 0.31 0.27 0.49 0.51 0.41
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.24 0.26 0.21 0.27 0.2 0.22
Bud Site 0.25 0.15 0.26 0.16 0.1 0.14 0.1 0.05 0.05 0.05 0.05 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.11 0.13 0.12 0.1 0.07 0.11 0.13 0.08 0.17 0.15 0.15 0.25 0.37 0.43 0.59 0.12 0.19 0.17 0.06 0.07 0.09 0 0 0
Cytoplasm 0.21 0.24 0.19 0.21 0.33 0.3 0.35 0.33 0.3 0.33 0.33 0.23 0.31 0.29 0.25 0.41 0.31 0.32 0.06 0 0.06 0.06 0.06 0.1
Endoplasmic Reticulum 0 0.11 0.07 0 0.05 0.09 0.07 0.07 0.07 0.08 0.09 0.07 0 0 0.06 0 0.05 0 0 0 0 0 0 0
Endosome 0.09 0 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.12 0 0.09 0.08 0.05 0.21 0.2 0.19 0.33 0.31 0.35 0.37 0 0 0 0.06 0.05 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.09 0.07 0.15 0.16 0.11 0.09 0.07 0.07 0.06 0.05 0.06 0 0 0.06 0 0 0 0.11 0 0 0 0 0 0
SpindlePole 0.07 0.06 0.12 0.05 0.09 0 0.07 0.06 0 0 0 0 0.06 0 0 0.2 0.27 0.19 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0.08 0.06 0.06 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 131 134 143 104 86 123 92 119 128 111 79 79 188 207 163 78 41 42 100 70 114 44 76 72
Bud 68 57 71 53 61 88 85 123 73 83 48 46 78 95 34 23 8 14 121 105 118 184 294 228
Bud Neck 1 3 2 2 1 1 1 2 4 0 1 0 0 0 2 1 4 0 95 86 92 101 115 125
Bud Site 86 40 87 41 29 57 45 27 23 25 14 7 15 13 0 10 4 3 – – – – – –
Cell Periphery 39 34 40 25 19 45 60 45 73 69 40 54 140 213 277 36 29 25 24 24 37 4 11 10
Cytoplasm 72 62 66 55 93 122 165 177 126 155 88 50 118 143 117 121 47 46 24 13 23 21 37 57
Endoplasmic Reticulum 7 28 24 11 15 36 31 37 30 37 23 16 17 11 26 8 8 3 6 8 8 2 10 10
Endosome 32 3 10 9 19 15 15 18 4 9 3 2 1 1 0 6 1 8 3 5 7 3 10 9
Golgi 0 1 0 0 0 0 0 0 0 0 0 0 1 0 0 2 6 6 1 2 3 2 0 1
Mitochondria 42 3 29 21 13 85 93 101 142 147 95 80 3 0 0 18 7 6 4 6 10 2 6 9
Nucleus 9 9 4 4 6 3 6 13 5 4 3 1 1 0 0 10 5 5 0 0 0 1 0 0
Nuclear Periphery 0 1 2 0 0 1 0 0 1 1 2 0 0 0 1 0 0 0 0 0 0 2 2 4
Nucleolus 17 3 7 6 7 7 11 24 8 11 2 3 1 0 1 3 2 2 0 0 0 0 1 0
Peroxisomes 31 17 50 42 31 39 34 35 25 22 15 7 17 28 7 7 5 16 0 0 3 0 0 1
SpindlePole 26 15 42 14 25 17 31 32 15 20 6 1 23 17 6 58 41 27 3 2 4 2 1 5
Vac/Vac Membrane 5 5 7 5 11 4 19 25 7 16 3 2 2 2 2 22 9 9 1 8 3 2 4 10
Unique Cell Count 349 260 340 256 281 413 473 530 424 473 268 216 382 493 469 293 150 145 393 338 434 380 582 562
Labelled Cell Count 566 415 584 392 416 643 688 778 664 710 422 348 605 730 636 403 217 212 393 338 434 380 582 562


Ambiguous, Bud, Bud Neck, Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.6 8.8 7.5 7.6 7.7 6.7 6.2 6.4 6.3 6.1 5.9 6.2 9.2 9.2 9.1 9.6 12.3 11.3 7.6 7.7 8.2
Std Deviation (1e-4) 1.4 1.6 1.3 1.5 2.7 1.5 1.6 1.8 1.2 1.6 1.4 1.2 1.8 1.7 1.6 2.3 2.8 2.8 1.2 1.5 1.9
Intensity Change (Log2) – – – 0.01 0.03 -0.18 -0.29 -0.25 -0.27 -0.32 -0.35 -0.29 0.29 0.29 0.27 0.34 0.71 0.58 0.01 0.04 0.11

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.4 -2.9 -3.5 -7.0 -6.2 -3.4 -5.6 -3.2 -1.3 1.9 0 -2.1 -4.1 -3.1 -2.7
Bud -0.1 0.3 0.1 -1.0 0.8 -1.3 -1.2 -0.9 0.1 -0.2 -0.6 -5.7 -4.6 -4.3 -3.0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site -2.8 -4.9 -4.1 -6.1 -8.7 -7.9 -8.3 -6.7 -6.9 -8.3 -10.0 -11.6 -7.7 -6.0 -6.1
Cell Periphery -0.8 -2.1 -0.4 0.4 -1.6 2.1 1.2 1.1 4.1 7.7 9.7 13.6 0.2 2.2 1.6
Cytoplasm 0.6 3.9 3.2 4.8 4.5 3.3 4.2 3.8 1.1 3.5 3.1 1.9 6.0 2.9 2.9
Endoplasmic Reticulum -1.4 -0.9 0.8 -0.3 0 0 0.4 0.7 0.2 -1.5 -3.4 -0.9 -2.5 -0.7 -2.2
Endosome 0.4 2.2 0.5 0.2 0.4 -2.0 -1.0 -1.5 0 -2.9 0 0 -0.7 0 1.4
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria -0.1 -1.9 4.6 4.4 4.2 8.2 7.7 8.2 8.3 -5.0 -6.6 -6.4 -1.1 -1.5 -1.7
Nucleus 0 0 0 0 1.3 0 0 0 0 0 0 0 1.9 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.2 0.4 -0.4 0.3 1.9 -0.2 0.3 0 0 0 0 0 0 0 0
Peroxisomes 0.6 -1.4 -2.2 -3.5 -3.9 -4.1 -5.0 -3.6 -4.3 -4.7 -4.4 -7.2 -5.4 -3.7 -1.1
SpindlePole -2.9 -1.4 -4.2 -2.9 -3.3 -4.6 -4.3 -4.6 -5.1 -3.0 -4.9 -6.6 2.6 4.1 1.8
Vacuole -0.1 1.4 0 1.6 2.0 -0.4 1.1 0 0 0 0 0 3.3 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.124 5.2442 5.6935 4.958 5.1346 5.6514 6.1913 6.9202 6.5212 6.2528 6.0131 6.5253 7.9505 7.6597 7.574 7.4978 7.322 8.155
Actin 0.1287 0.0154 0.0343 0.0941 0.0762 0.099 0.1847 0.0462 0.0998 0.1393 0.1385 0.1217 0.0954 0.0508 0.061 0.0404 0.0668 0.067
Bud 0.0151 0.0245 0.2596 0.0867 0.0641 0.0089 0.0044 0.0501 0.1833 0.13 0.0421 0.0075 0.0235 0.041 0.1738 0.1099 0.0827 0.0117
Bud Neck 0.1252 0.0104 0.0055 0.0025 0.1456 0.6062 0.0634 0.0083 0.0441 0.0003 0.0023 0.5484 0.0896 0.0097 0.0181 0.0017 0.0541 0.66
Bud Periphery 0.0736 0.0507 0.3844 0.439 0.4423 0.0473 0.0073 0.0336 0.338 0.6835 0.3145 0.0596 0.0765 0.0471 0.4343 0.6554 0.3936 0.0548
Bud Site 0.2432 0.3034 0.108 0.0091 0.0572 0.0174 0.3603 0.5522 0.142 0.0111 0.0099 0.0117 0.2955 0.5288 0.1678 0.0058 0.0829 0.0218
Cell Periphery 0.0646 0.0124 0.0101 0.0235 0.0604 0.036 0.0448 0.0124 0.0175 0.0155 0.0067 0.0323 0.1129 0.0278 0.0214 0.0163 0.0704 0.0318
Cytoplasm 0.1689 0.4951 0.1124 0.3201 0.0773 0.1306 0.0826 0.2626 0.1098 0.0159 0.158 0.17 0.1519 0.2442 0.0543 0.1613 0.0826 0.0976
Cytoplasmic Foci 0.1134 0.0105 0.0157 0.0014 0.002 0.0233 0.0772 0.0099 0.0075 0.0002 0.0832 0.0131 0.0236 0.0091 0.0092 0.0004 0.0251 0.0262
Eisosomes 0.0015 0.0005 0.0003 0.0008 0.0004 0.0004 0.0028 0.0007 0.0004 0.0002 0.0003 0.0009 0.0022 0.0006 0.0002 0.0001 0.0005 0.0003
Endoplasmic Reticulum 0.0043 0.0056 0.0034 0.0071 0.0009 0.0021 0.002 0.0015 0.0021 0.0006 0.0037 0.0027 0.0084 0.0015 0.0049 0.0018 0.004 0.0006
Endosome 0.0102 0.005 0.0061 0.0015 0.0015 0.0012 0.0349 0.0008 0.003 0.0003 0.0857 0.0112 0.0286 0.0036 0.0121 0.0003 0.037 0.0062
Golgi 0.0092 0.0028 0.0037 0.001 0.0029 0.0021 0.0315 0.0016 0.0071 0.0005 0.1058 0.0061 0.0131 0.0013 0.003 0.0003 0.0325 0.0056
Lipid Particles 0.0109 0.0015 0.0031 0.0005 0.0003 0.009 0.0197 0.0004 0.0118 0 0.0056 0.0013 0.0095 0.0005 0.0046 0.0001 0.02 0.0033
Mitochondria 0.0013 0.0008 0.002 0.0005 0.0626 0.0004 0.0128 0.0002 0.0213 0.0004 0.0207 0.002 0.01 0.0003 0.0071 0.0002 0.0089 0.0013
None 0.0023 0.0473 0.026 0.0036 0.0007 0.0045 0.003 0.0153 0.0023 0.0004 0.0018 0.0026 0.0292 0.0267 0.0126 0.0014 0.005 0.0029
Nuclear Periphery 0.0008 0.0014 0.0018 0.0009 0.0002 0.0002 0.0013 0.0004 0.0004 0.0002 0.0006 0.0012 0.0044 0.0004 0.0026 0.0006 0.004 0.0001
Nucleolus 0.0005 0.0003 0.0008 0.0001 0.0004 0.0002 0.0006 0.0001 0.0002 0 0.0001 0.0001 0.0005 0.0003 0.0003 0.0001 0.0031 0.0001
Nucleus 0.0007 0.002 0.0031 0.0008 0.0005 0.0004 0.0008 0.0006 0.0006 0.0002 0.0004 0.0005 0.0013 0.001 0.0012 0.0006 0.008 0.0004
Peroxisomes 0.0068 0.0002 0.0112 0.0001 0.0018 0.0081 0.0597 0.0014 0.0063 0 0.0169 0.0053 0.0146 0.0012 0.0079 0 0.0044 0.0064
Punctate Nuclear 0.0129 0.0006 0.0037 0.0002 0.0002 0.0009 0.0043 0.0003 0.0003 0 0.0006 0.0005 0.0041 0.0008 0.0006 0.0001 0.0059 0.0005
Vacuole 0.0053 0.0089 0.0043 0.0061 0.002 0.0017 0.0013 0.0012 0.0019 0.001 0.0018 0.0009 0.0036 0.0031 0.0024 0.0029 0.0074 0.0011
Vacuole Periphery 0.0005 0.0007 0.0005 0.0004 0.0005 0.0001 0.0005 0.0001 0.0003 0.0001 0.001 0.0002 0.0013 0.0002 0.0004 0.0002 0.0011 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.3256 15.4866 15.9116 26.4589 14.6862 17.9803 18.3686 22.7627 25.2492 21.7859
Translational Efficiency 0.9501 1.0638 1.4267 1.0312 0.9513 0.8654 1.0063 0.8726 0.9138 0.8412

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2883 1360 162 1013 1514 1915 214 331 4397 3275 376 1344

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 869.63 905.16 1200.62 1052.81 837.04 961.51 1116.61 1148.61 858.41 938.11 1152.81 1076.40
Standard Deviation 98.36 127.52 144.90 159.16 122.33 148.82 143.38 190.93 108.33 143.09 149.92 172.55
Intensity Change Log 2 — 0.057771 0.465306 0.275771 — 0.200005 0.415757 0.456521 — 0.129283 0.441217 0.367250

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.027237 0.019928 0.162791 0.071457 0.048455 0.024820 0.058663 0.084398 0.034543 0.022789 0.103527 0.074644
Bud Neck 0.229535 0.069704 0.073404 0.030088 0.125368 0.111863 0.078512 0.029620 0.193668 0.094356 0.076311 0.029973
Bud Site 0.551669 0.637346 0.574746 0.622449 0.607648 0.642380 0.612844 0.613731 0.570944 0.640289 0.596429 0.620302
Cell Periphery 0.086625 0.006526 0.039689 0.032525 0.057560 0.023699 0.005022 0.055345 0.076617 0.016568 0.019959 0.038145
Cytoplasm 0.086310 0.192389 0.049648 0.195477 0.099137 0.140370 0.089049 0.151010 0.090726 0.161972 0.072073 0.184526
Cytoplasmic Foci 0.004918 0.029087 0.014021 0.005362 0.022606 0.014001 0.022336 0.005602 0.011009 0.020266 0.018754 0.005421
Eisosomes 0.002683 0.000310 0.006954 0.004774 0.002824 0.000879 0.001166 0.008613 0.002731 0.000643 0.003660 0.005719
Endoplasmic Reticulum 0.000409 0.000939 0.009886 0.001567 0.001731 0.000413 0.001011 0.002908 0.000864 0.000631 0.004835 0.001897
Endosome 0.001097 0.008303 0.002876 0.002965 0.007148 0.005666 0.004468 0.002038 0.003181 0.006761 0.003782 0.002737
Golgi 0.001081 0.005717 0.001033 0.003027 0.005769 0.005297 0.001332 0.001067 0.002696 0.005471 0.001203 0.002544
Lipid Particles 0.000161 0.000550 0.002764 0.001101 0.001749 0.000240 0.002504 0.002375 0.000708 0.000369 0.002616 0.001415
Mitochondria 0.002133 0.003071 0.000116 0.002058 0.003565 0.002982 0.000142 0.002173 0.002626 0.003019 0.000131 0.002086
Mitotic Spindle 0.000237 0.001779 0.001049 0.001761 0.000609 0.001204 0.001140 0.003074 0.000365 0.001443 0.001101 0.002084
None 0.000213 0.000094 0.000030 0.000046 0.000322 0.000195 0.000067 0.000183 0.000251 0.000153 0.000051 0.000080
Nuclear Periphery 0.000004 0.000018 0.000052 0.000020 0.000060 0.000010 0.000041 0.000068 0.000023 0.000013 0.000046 0.000032
Nuclear Periphery Foci 0.000031 0.000305 0.001083 0.000177 0.000175 0.000093 0.000967 0.000556 0.000080 0.000181 0.001017 0.000270
Nucleolus 0.000016 0.000502 0.000017 0.000006 0.000050 0.005762 0.000039 0.000055 0.000028 0.003578 0.000029 0.000018
Nucleus 0.000709 0.001806 0.002798 0.002151 0.001207 0.008020 0.008097 0.004243 0.000881 0.005439 0.005814 0.002666
Peroxisomes 0.001741 0.005498 0.003112 0.001948 0.004912 0.003990 0.004875 0.000679 0.002833 0.004616 0.004116 0.001635
Vacuole 0.003034 0.014334 0.053868 0.019835 0.008281 0.007063 0.107620 0.028737 0.004841 0.010082 0.084461 0.022027
Vacuole Periphery 0.000157 0.001795 0.000062 0.001206 0.000823 0.001053 0.000103 0.003525 0.000386 0.001361 0.000085 0.001777

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.69 -6.39 -8.11 -9.29 4.10 6.01 -0.32 -2.74 -5.53 -1.53 5.35 -5.47 -7.82 -10.61 2.07
Bud Neck 24.70 13.73 35.75 10.04 3.44 1.97 4.61 14.94 14.41 3.71 19.84 14.49 38.12 19.23 5.08
Bud Site -8.00 1.17 -2.50 3.94 -2.12 -3.09 2.12 2.93 4.62 0.11 -9.25 1.78 -0.19 6.12 -1.75
Cell Periphery 21.86 5.97 12.10 -7.35 0.61 7.92 13.66 1.20 -3.10 -5.75 20.44 13.37 10.63 -5.55 -3.62
Cytoplasm -13.60 2.20 -14.49 -2.35 -11.55 -5.93 -0.79 -6.05 -3.13 -4.15 -14.14 0.19 -15.52 -5.78 -10.91
Cytoplasmic Foci -10.64 -3.05 -1.48 9.13 2.60 3.48 -0.87 5.31 2.61 4.34 -6.46 -4.03 3.14 8.75 5.26
Eisosomes 8.73 -2.42 -2.23 -5.64 1.10 5.07 3.28 -2.91 -4.25 -4.00 9.12 -0.77 -3.45 -6.73 -2.01
Endoplasmic Reticulum -1.62 -3.20 -3.54 -1.40 2.76 3.93 1.69 -1.36 -3.22 -2.29 1.18 -3.04 -3.13 -3.77 2.15
Endosome -8.18 -4.15 -2.43 5.03 1.14 1.50 2.26 4.93 3.69 2.69 -6.05 -2.11 1.01 5.54 2.45
Golgi -6.04 0.53 -1.89 2.54 -2.01 0.44 4.89 5.08 4.26 0.32 -4.38 3.67 0.51 3.53 -1.60
Lipid Particles -2.48 -3.55 -2.39 -1.24 2.18 2.42 -0.45 -0.99 -2.93 -0.25 1.41 -2.33 -1.93 -3.04 1.30
Mitochondria -1.12 8.52 0.31 1.07 -2.29 0.75 5.19 0.95 0.65 -1.05 -0.79 9.07 0.98 1.39 -2.47
Mitotic Spindle -3.10 -1.90 -2.51 0.23 0.06 -1.96 -1.61 -2.04 -1.65 -1.73 -4.09 -2.69 -3.16 -1.16 -1.23
None 1.61 2.49 2.29 2.79 -1.14 0.95 2.11 -0.73 -1.25 -1.78 1.30 3.08 0.93 -0.16 -1.72
Nuclear Periphery -2.02 -4.72 -5.40 -1.24 3.60 1.18 -0.06 -1.82 -4.05 -2.59 0.66 -3.30 -2.16 -4.59 1.50
Nuclear Periphery Foci -2.70 -5.10 -3.78 1.07 4.52 1.50 -4.72 -3.05 -3.35 1.32 -2.11 -7.12 -4.25 -2.15 5.31
Nucleolus -1.63 -1.02 5.34 1.65 2.36 -4.19 0.51 -0.20 4.19 -0.41 -4.43 -0.77 0.77 4.44 1.21
Nucleus -2.00 -2.82 -8.62 -2.33 1.27 -4.23 -3.10 -4.11 -1.77 -1.23 -4.78 -4.11 -6.21 -0.45 0.89
Peroxisomes -6.46 -1.96 -0.26 5.53 1.63 1.10 0.31 7.94 5.10 3.21 -3.70 -1.39 3.35 5.85 2.95
Vacuole -7.47 -6.08 -10.14 -6.71 3.86 0.96 -7.96 -6.85 -6.99 4.28 -6.40 -10.09 -12.04 -10.40 6.52
Vacuole Periphery -3.46 3.11 -1.72 0.95 -1.86 -0.81 6.04 -1.27 -1.13 -1.69 -3.86 6.54 -2.00 -0.34 -2.49
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein containing SH3-domains; involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p
Localization
Cell Percentages cytoplasm (16%), bud neck (14%), mixed (32%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Bem1

Bem1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Bem1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available