Standard name
Human Ortholog
Description Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0.07 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.09 0.08 0.07 0.11 0.11 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.98 0.96 0.95 0.92 0.93 0.81 0.77 0.76 0.77 0.71 0.77 1.0 0.98 0.98 0.95 0.97 0.97 0.97 0.94 0.92 0.9 0.91 0.87
Endoplasmic Reticulum 0 0 0 0 0.09 0.05 0.13 0.15 0.12 0.1 0.11 0.1 0 0 0 0 0.05 0.07 0 0 0 0 0 0.08
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.05 0 0.09 0.1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 5 18 16 11 26 17 27 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 1 3 0 3 6 5 3 6 4 5 1 1 3 1 0 0 2 0 2 1 2 4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 4 0 6 5 16 15 44 47 21 42 29 47 6 7 7 6 7 2 0 0 0 1 0 0
Cytoplasm 310 145 332 214 377 347 412 451 234 298 193 308 227 253 251 216 167 132 293 139 337 130 172 246
Endoplasmic Reticulum 3 3 11 5 37 20 65 86 36 40 31 39 1 3 4 9 9 9 1 1 13 2 7 23
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 1 0 0
Golgi 0 1 0 0 0 1 0 2 1 3 4 4 0 0 0 4 0 1 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 3 9 14 15 16 24 39 0 0 1 1 0 0 1 0 1 0 0 0
Nucleus 0 0 1 0 0 1 1 0 0 0 1 0 0 0 0 0 1 1 0 0 0 1 0 0
Nuclear Periphery 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 1 2 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 3 4 3 1 3 12 11 7 7 4 0 1 1 1 1 0 1 2 3 1 1 1
Unique Cell Count 311 148 346 225 410 374 508 584 306 385 271 401 228 257 257 228 173 136 302 148 365 144 189 282
Labelled Cell Count 318 149 355 232 435 398 558 633 333 438 310 473 235 265 267 238 185 146 302 148 365 144 189 282


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 69.5 61.6 37.9 32.5 36.4 27.2 29.8 28.5 22.9 27.2 21.0 25.7 50.0 43.7 37.3 79.3 83.2 77.9 52.1 56.4 60.2
Std Deviation (1e-4) 20.2 19.4 11.6 12.3 10.1 10.8 8.7 7.8 8.6 8.1 7.5 8.9 13.6 11.4 9.3 24.4 28.7 27.5 19.7 18.8 22.0
Intensity Change (Log2) – – – -0.22 -0.06 -0.48 -0.35 -0.41 -0.73 -0.48 -0.85 -0.56 0.4 0.2 -0.02 1.06 1.13 1.04 0.46 0.57 0.67

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100WT3HU80HU120HU160050100WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100WT1AF100AF140AF180050100
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 3.5 3.1 3.6 4.9 4.7 4.9 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 1.8 1.8 4.2 4.0 3.3 5.0 4.8 5.3 0 0.8 0.8 0 0 0
Cytoplasm -0.5 -2.3 -1.8 -6.4 -7.6 -7.3 -7.3 -8.6 -7.4 2.7 1.8 1.2 -0.7 0.3 0.6
Endoplasmic Reticulum -0.7 3.3 1.4 4.8 5.6 4.2 3.8 4.0 3.6 0 -1.6 -1.3 0.5 1.1 1.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 2.9 4.2 3.8 5.6 6.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 1.4 2.4 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9351 3.8895 3.4464 2.6892 1.9451 3.4371 3.5382 4.7462 3.9956 3.7927 2.7138 4.5114 4.0888 5.214 4.7802 4.4038 5.0705 5.1451
Actin 0.0252 0.0057 0.0158 0.0059 0.0036 0.0003 0.0069 0.0005 0.0092 0.001 0.0013 0.0044 0.0027 0.0006 0.0011 0.0009 0.0073 0.004
Bud 0.0009 0.0008 0.0004 0.0019 0.0043 0.0002 0.0007 0.001 0.0088 0.0017 0.002 0.0004 0.0044 0.0006 0.0016 0.0035 0.0012 0.0011
Bud Neck 0.0008 0.0004 0.0007 0.0019 0.0005 0.0006 0.0012 0.0002 0.0005 0.0004 0.0002 0.0006 0.0043 0.0004 0.0005 0.0004 0.0004 0.0007
Bud Periphery 0.0013 0.0007 0.0004 0.0008 0.0063 0.0008 0.0009 0.0004 0.0053 0.0022 0.0036 0.001 0.0037 0.0005 0.0013 0.0024 0.0014 0.0015
Bud Site 0.0051 0.0179 0.0166 0.0029 0.0018 0.0001 0.0033 0.0065 0.0044 0.0009 0.0057 0.0001 0.0055 0.0075 0.0056 0.001 0.0016 0.0002
Cell Periphery 0.0008 0.0009 0.0012 0.0002 0.0009 0.0001 0.0004 0.0003 0.0004 0.0001 0.0002 0.0001 0.0007 0.0004 0.0005 0.0002 0.0002 0.0001
Cytoplasm 0.612 0.82 0.8077 0.8692 0.6939 0.821 0.6323 0.828 0.7565 0.6838 0.7629 0.7903 0.6572 0.7513 0.7628 0.8353 0.6014 0.8203
Cytoplasmic Foci 0.0286 0.0178 0.0105 0.0078 0.0253 0.0034 0.03 0.0081 0.0181 0.0282 0.0201 0.0108 0.0152 0.0135 0.0206 0.0208 0.0222 0.0143
Eisosomes 0.0008 0.0001 0.0001 0 0 0 0.0001 0 0.0001 0 0 0 0.0001 0.0001 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0211 0.0043 0.0085 0.0173 0.0138 0.0034 0.0064 0.0024 0.0027 0.0022 0.0022 0.0048 0.0086 0.0036 0.0028 0.0072 0.0058 0.0019
Endosome 0.0184 0.0064 0.0087 0.0157 0.0729 0.0086 0.044 0.0049 0.0141 0.015 0.0285 0.0126 0.0064 0.0055 0.0121 0.0401 0.0272 0.0089
Golgi 0.0049 0.0045 0.0028 0.001 0.0339 0.0017 0.0083 0.0004 0.0066 0.0034 0.0051 0.0058 0.0011 0.0006 0.0009 0.0024 0.0079 0.0007
Lipid Particles 0.0107 0.0004 0.0031 0.0001 0.0383 0.0001 0.0023 0.0001 0.0054 0.0122 0.0005 0.0026 0.0009 0.0007 0.0004 0.0004 0.0008 0.0001
Mitochondria 0.0107 0.0045 0.0057 0.0039 0.0113 0.0235 0.002 0.0002 0.0069 0.0029 0.002 0.0041 0.001 0.0004 0.0005 0.0011 0.0056 0.0005
None 0.1983 0.1055 0.0979 0.0436 0.0136 0.1279 0.238 0.1412 0.1518 0.2146 0.1549 0.1543 0.2755 0.2093 0.1778 0.0615 0.3049 0.1419
Nuclear Periphery 0.0079 0.0007 0.0012 0.0049 0.0136 0.0004 0.0015 0.0004 0.0007 0.0011 0.001 0.0005 0.0008 0.0005 0.0006 0.0019 0.001 0.0003
Nucleolus 0.0017 0.0002 0.0002 0.0002 0.0007 0.0001 0.0003 0.0001 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0002 0.0001 0.0001 0
Nucleus 0.0056 0.0014 0.0138 0.0107 0.0101 0.0008 0.0014 0.0011 0.0013 0.0012 0.0012 0.0006 0.0009 0.001 0.0011 0.0015 0.0008 0.0007
Peroxisomes 0.0219 0.0004 0.0003 0.0008 0.0352 0 0.0076 0.0001 0.0019 0.0183 0.001 0.0044 0.007 0.0001 0.0016 0.0002 0.0049 0.0002
Punctate Nuclear 0.0182 0.0008 0.0007 0.0009 0.0018 0.0001 0.0021 0.0002 0.0008 0.0007 0.0005 0.0002 0.0006 0.0004 0.0008 0.0006 0.0006 0.0003
Vacuole 0.0043 0.0062 0.0034 0.0091 0.0132 0.0037 0.0093 0.0036 0.0039 0.0087 0.0059 0.0019 0.0029 0.0026 0.0063 0.016 0.0038 0.0017
Vacuole Periphery 0.0009 0.0003 0.0005 0.0015 0.0048 0.003 0.001 0.0003 0.0005 0.0012 0.0011 0.0004 0.0003 0.0002 0.0007 0.0026 0.0008 0.0004

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.3267 14.1474 17.0094 26.4926 60.6478 11.2121 14.3949 14.5429 16.5221 25.2521
Translational Efficiency 0.5389 0.3835 0.4233 0.4594 0.5846 0.2772 0.2668 0.2469 0.2624 0.3934

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
151 210 1723 1019 1449 2028 1910 1641 1600 2238 3633 2660

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 3750.79 2442.91 2134.21 815.47 3527.61 2917.92 2719.02 814.14 3548.67 2873.35 2441.67 814.65
Standard Deviation 1035.28 799.68 847.54 132.13 990.72 1001.70 1204.61 130.32 997.14 994.21 1090.33 131.02
Intensity Change Log 2 — -0.618594 -0.813492 -2.201491 — -0.273751 -0.375604 -2.115342 — -0.441165 -0.584676 -2.159095

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000278 0.000822 0.000284 0.002577 0.000072 0.000145 0.000215 0.000275 0.000091 0.000209 0.000248 0.001156
Bud Neck 0.001609 0.001529 0.002398 0.011914 0.000429 0.000645 0.001677 0.010736 0.000541 0.000728 0.002019 0.011188
Bud Site 0.018170 0.038830 0.013572 0.059981 0.003762 0.008387 0.016167 0.049486 0.005122 0.011244 0.014936 0.053507
Cell Periphery 0.085349 0.011849 0.001077 0.000219 0.005870 0.001622 0.003039 0.000162 0.013371 0.002582 0.002109 0.000184
Cytoplasm 0.263968 0.737234 0.875110 0.479663 0.869461 0.897268 0.841993 0.572694 0.812318 0.882252 0.857699 0.537055
Cytoplasmic Foci 0.018400 0.054252 0.020502 0.039972 0.009459 0.014658 0.015356 0.026464 0.010303 0.018373 0.017797 0.031639
Eisosomes 0.000008 0.000005 0.000002 0.000059 0.000001 0.000001 0.000003 0.000039 0.000002 0.000001 0.000002 0.000047
Endoplasmic Reticulum 0.003893 0.002106 0.000235 0.001554 0.000768 0.000396 0.000287 0.000714 0.001063 0.000557 0.000262 0.001036
Endosome 0.002931 0.006346 0.001228 0.016531 0.000782 0.001494 0.001544 0.006239 0.000984 0.001949 0.001394 0.010182
Golgi 0.175081 0.063261 0.006432 0.006526 0.032578 0.022135 0.011663 0.003021 0.046027 0.025994 0.009182 0.004364
Lipid Particles 0.029566 0.017668 0.002141 0.003800 0.008182 0.003106 0.005937 0.000886 0.010200 0.004472 0.004137 0.002002
Mitochondria 0.000253 0.000081 0.000207 0.007794 0.000139 0.000152 0.000271 0.001017 0.000150 0.000145 0.000240 0.003613
Mitotic Spindle 0.001978 0.003691 0.008923 0.068213 0.001326 0.002906 0.005357 0.026687 0.001388 0.002980 0.007049 0.042594
None 0.001101 0.000686 0.002463 0.004726 0.001800 0.002199 0.001958 0.005633 0.001734 0.002057 0.002197 0.005286
Nuclear Periphery 0.000737 0.000225 0.000225 0.001050 0.000195 0.000119 0.000165 0.000877 0.000246 0.000129 0.000194 0.000944
Nuclear Periphery Foci 0.009582 0.006979 0.003128 0.001121 0.007000 0.005050 0.003998 0.000869 0.007243 0.005231 0.003585 0.000965
Nucleolus 0.000128 0.000040 0.000102 0.000916 0.000043 0.000071 0.000096 0.000621 0.000051 0.000068 0.000099 0.000734
Nucleus 0.004436 0.004109 0.038287 0.124651 0.005706 0.008357 0.020262 0.150666 0.005586 0.007958 0.028811 0.140700
Peroxisomes 0.000135 0.000243 0.000092 0.004516 0.000029 0.000058 0.000093 0.000770 0.000039 0.000076 0.000092 0.002205
Vacuole 0.139391 0.027740 0.019835 0.151991 0.027869 0.019733 0.058778 0.140563 0.038394 0.020484 0.040309 0.144941
Vacuole Periphery 0.243006 0.022305 0.003758 0.012223 0.024528 0.011497 0.011140 0.001582 0.045147 0.012511 0.007639 0.005659

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.03 -0.42 -2.20 -0.70 -2.07 -3.67 -8.89 -4.45 -2.33 0.18 -5.20 -5.11 -3.38 -2.51 -1.94
Bud Neck 0.16 -2.17 -5.43 -6.34 -4.74 -2.79 -12.43 -8.30 -8.01 -6.15 -2.25 -13.56 -10.91 -10.56 -7.60
Bud Site -3.55 1.08 -1.46 2.48 -3.27 -5.93 -13.04 -8.09 -6.19 -2.57 -6.69 -11.87 -9.68 -6.44 -4.17
Cell Periphery 7.74 9.06 9.17 5.98 11.22 8.10 5.31 11.29 11.88 11.62 9.27 9.83 11.61 10.99 14.51
Cytoplasm -15.19 -24.16 -5.10 15.66 44.26 -3.74 5.88 41.32 50.07 38.87 -8.14 -3.51 38.74 60.16 58.36
Cytoplasmic Foci -5.02 -0.96 -1.48 4.62 -1.07 -5.10 -7.05 -9.24 -4.58 -2.72 -6.90 -9.05 -9.98 -2.65 -2.24
Eisosomes 2.00 3.16 -16.53 -20.10 -20.98 1.16 -8.24 -33.42 -33.70 -31.45 2.18 -4.28 -37.21 -37.95 -36.01
Endoplasmic Reticulum 1.26 2.76 1.54 0.41 -6.59 2.11 3.02 -2.67 -8.96 -15.12 2.42 4.12 -1.84 -6.94 -11.92
Endosome -3.18 3.97 -3.82 -0.39 -5.77 -4.23 -5.50 -6.13 -4.41 -4.31 -5.19 -4.22 -8.30 -5.92 -7.25
Golgi 7.00 12.16 12.47 7.80 5.17 4.37 10.61 15.67 13.46 10.90 7.01 15.19 18.15 15.34 11.85
Lipid Particles 2.25 7.00 7.01 4.26 0.41 5.97 2.49 8.96 6.99 8.69 6.14 6.90 10.36 6.36 7.46
Mitochondria 4.06 -0.45 -3.05 -3.26 -3.03 -0.73 -2.31 -8.06 -7.70 -4.32 0.02 -3.37 -4.32 -4.31 -3.85
Mitotic Spindle -2.98 -9.22 -8.20 -7.77 -6.08 -2.51 -6.37 -7.93 -7.21 -4.65 -2.76 -10.03 -11.32 -10.58 -7.54
None 2.78 -8.72 -8.72 -9.67 -5.65 -0.79 -0.45 -5.65 -3.49 -4.66 -0.71 -2.11 -8.37 -4.91 -6.84
Nuclear Periphery 2.94 3.64 -7.03 -10.00 -13.81 2.78 -0.57 -18.84 -20.03 -19.11 3.92 0.20 -22.38 -24.47 -23.28
Nuclear Periphery Foci 1.90 6.13 8.56 6.12 6.07 2.90 5.03 11.88 9.22 7.48 3.23 6.99 13.25 10.22 9.71
Nucleolus 4.11 0.71 -4.66 -5.51 -4.87 -1.72 -8.72 -5.09 -4.80 -4.52 -1.20 -8.94 -7.04 -6.73 -6.34
Nucleus 0.10 -15.28 -24.35 -25.43 -18.76 -4.41 -17.10 -35.25 -34.68 -30.97 -4.17 -26.63 -43.16 -42.54 -35.45
Peroxisomes -1.81 0.85 -4.30 -4.04 -4.41 -3.38 -6.62 -5.82 -5.43 -4.91 -3.75 -6.54 -5.97 -5.75 -5.62
Vacuole 7.96 8.48 -9.80 -27.04 -29.27 3.17 -10.56 -31.05 -33.12 -23.72 6.47 -2.63 -37.88 -43.61 -37.83
Vacuole Periphery 11.10 12.35 12.31 4.00 -0.21 6.32 6.92 12.80 11.45 8.91 10.57 12.73 14.46 9.89 6.46
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Urea amidolyase; contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Dur1,2

Dur1,2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dur1,2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available