Standard name
Human Ortholog
Description Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.44 0.49 0.66 0.52 0.5 0.34 0.35 0.36 0.26 0.31 0.19 0.21 0.38 0.41 0.42 0.65 0.56 0.51 0.29 0.26 0.35 0.21 0.14 0.07
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.08 0.06 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.06 0.08 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.32 0.05 0.27 0.41 0.49 0.71 0.74 0.64 0.78 0.75 0.85 0.78 0 0 0 0.08 0.05 0.06 0 0 0.08 0 0 0
Nucleus 0.1 0.24 0.05 0.1 0.1 0.17 0.1 0.16 0.2 0.17 0.22 0.19 0.38 0.2 0.18 0.06 0.09 0.07 0.23 0.34 0.12 0.41 0.38 0.38
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.09 0.07
Vac/Vac Membrane 0.27 0.38 0.13 0.14 0.08 0 0 0 0 0 0.08 0 0.28 0.39 0.43 0.24 0.33 0.38 0.3 0.3 0.31 0.21 0.23 0.3
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 6 1 1 4
Bud 1 0 1 3 3 3 5 10 3 10 2 6 0 0 0 0 0 0 2 4 4 11 10 17
Bud Neck 0 0 0 0 1 2 1 4 0 1 0 0 0 0 0 0 1 0 0 2 3 2 3 7
Bud Site 0 0 0 1 0 3 5 8 4 12 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1 0 0 0 0 0 0 0
Cytoplasm 56 163 178 113 117 112 150 184 83 118 25 26 199 297 279 195 161 117 56 110 123 92 72 33
Endoplasmic Reticulum 0 2 1 0 0 0 0 0 0 0 0 0 1 5 0 17 22 14 1 0 4 1 1 5
Endosome 2 4 2 0 1 0 0 1 0 0 0 0 4 24 38 11 16 19 4 4 3 4 10 12
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 2 1 1 0 2 1 3 1
Mitochondria 41 16 73 89 114 232 315 331 253 287 115 96 15 29 14 23 14 14 8 9 26 20 19 10
Nucleus 13 80 13 22 23 57 42 82 65 65 30 23 200 144 119 17 26 17 45 146 42 182 189 177
Nuclear Periphery 2 2 1 0 1 0 1 1 1 2 1 1 2 0 0 0 0 0 1 0 0 1 0 1
Nucleolus 0 1 1 0 0 0 0 1 1 0 0 0 1 2 0 1 0 0 0 0 0 4 6 5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 1 0 0 1
SpindlePole 0 1 2 1 2 0 2 2 2 3 1 0 0 0 1 0 2 1 5 10 10 22 46 34
Vac/Vac Membrane 34 125 36 30 19 11 13 21 9 10 11 3 147 284 283 71 94 86 57 126 107 94 116 139
Unique Cell Count 128 332 271 216 232 327 427 515 324 382 135 123 523 726 664 301 287 229 194 428 352 449 500 469
Labelled Cell Count 149 394 308 259 281 420 534 645 421 508 186 155 570 785 738 338 339 269 194 428 352 449 500 469


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.8 4.3 3.5 3.2 3.5 3.0 2.6 2.9 2.8 2.6 2.7 2.7 4.5 4.4 4.5 5.1 6.4 5.7 4.1 4.3 5.1
Std Deviation (1e-4) 1.0 0.7 0.7 0.6 1.3 0.9 0.9 1.0 1.1 0.9 0.6 1.1 1.0 1.3 1.3 1.9 2.4 1.7 1.2 1.7 1.3
Intensity Change (Log2) – – – -0.12 -0.01 -0.23 -0.42 -0.27 -0.29 -0.42 -0.35 -0.35 0.36 0.35 0.36 0.56 0.88 0.7 0.23 0.3 0.56


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 3.2 5.4 6.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.8797 2.532 2.6713 2.7305 2.3306 2.4958 2.3028 1.6176 1.948 1.955 1.4932 1.7819 2.7657 2.6211 2.9292 2.0457 2.4336 2.7095
Actin 0.006 0.0097 0.0021 0.0008 0.0249 0.0016 0.0349 0.0008 0.0038 0.0224 0.0003 0.0062 0.0574 0.0087 0.026 0.0005 0.0315 0.0031
Bud 0.0003 0.0033 0.0011 0.0001 0.0004 0.0003 0.0012 0.0011 0.0006 0.0003 0.0001 0.0002 0.0006 0.0002 0.0006 0.0001 0.0002 0.0003
Bud Neck 0.0017 0.0008 0.0057 0.0008 0.0059 0.0027 0.0027 0.0005 0.0014 0.0006 0.0006 0.0029 0.0021 0.0005 0.004 0.0003 0.0009 0.0113
Bud Periphery 0.0003 0.0089 0.0016 0.0001 0.0007 0.0004 0.0015 0.0021 0.0007 0.0004 0 0.0002 0.001 0.0002 0.0013 0.0001 0.0003 0.0007
Bud Site 0.0021 0.0054 0.0029 0.0003 0.0038 0.0003 0.0069 0.0013 0.0097 0.0006 0.0001 0.0012 0.0017 0.0017 0.0151 0.0002 0.0003 0.0003
Cell Periphery 0.0003 0.0004 0.0003 0.0001 0.0003 0.0001 0.0003 0.0001 0.0002 0.0001 0 0 0.0002 0.0001 0.0004 0 0.0001 0.0001
Cytoplasm 0.1293 0.2368 0.1235 0.1498 0.1954 0.1442 0.1051 0.1929 0.1342 0.1125 0.124 0.1555 0.1138 0.2129 0.1118 0.2439 0.115 0.1501
Cytoplasmic Foci 0.0215 0.0088 0.0191 0.0064 0.0117 0.0096 0.0371 0.0059 0.0126 0.0088 0.0087 0.0149 0.0152 0.0037 0.0178 0.0034 0.0109 0.0107
Eisosomes 0.0002 0.0002 0.0002 0.0001 0.0005 0.0001 0.0004 0.0001 0.0002 0.0001 0.0001 0.0001 0.0005 0.0002 0.0004 0 0.0004 0.0001
Endoplasmic Reticulum 0.0061 0.0078 0.0024 0.0037 0.0031 0.0035 0.0075 0.0036 0.0026 0.002 0.002 0.0026 0.0078 0.0023 0.0041 0.0059 0.0044 0.0031
Endosome 0.0224 0.0073 0.0094 0.0113 0.006 0.0074 0.0633 0.0046 0.0121 0.0126 0.0111 0.0091 0.0274 0.0031 0.0097 0.0053 0.015 0.0038
Golgi 0.0034 0.0015 0.0017 0.0002 0.0032 0.0027 0.0248 0.0004 0.0049 0.0177 0.0078 0.0038 0.0142 0.0018 0.0056 0.0001 0.008 0.0003
Lipid Particles 0.0137 0.0018 0.004 0.0006 0.0174 0.0016 0.0238 0.0006 0.0134 0.0044 0.0195 0.0039 0.0151 0.0015 0.0095 0.0002 0.0184 0.0005
Mitochondria 0.0017 0.0081 0.0119 0.001 0.0067 0.0074 0.0114 0.0018 0.0264 0.0162 0.0032 0.0104 0.0035 0.0013 0.0057 0.0009 0.0029 0.0007
None 0.392 0.3121 0.4584 0.4158 0.418 0.2674 0.3316 0.3914 0.3712 0.3379 0.3901 0.2906 0.4396 0.4497 0.4453 0.3551 0.3939 0.2971
Nuclear Periphery 0.0268 0.019 0.01 0.0251 0.0091 0.019 0.0167 0.0116 0.0117 0.01 0.0125 0.0089 0.0353 0.0068 0.0148 0.0222 0.014 0.0129
Nucleolus 0.0107 0.0039 0.0043 0.0026 0.0056 0.0058 0.0025 0.0035 0.0044 0.0026 0.003 0.0046 0.0033 0.0024 0.0035 0.0014 0.0021 0.0041
Nucleus 0.2989 0.3118 0.2937 0.3355 0.2488 0.4468 0.2434 0.3447 0.3291 0.3803 0.3899 0.4292 0.2177 0.2863 0.2717 0.3474 0.3419 0.4555
Peroxisomes 0.0037 0.0008 0.0044 0.0002 0.0219 0.0009 0.0294 0.0011 0.0111 0.021 0.0057 0.0114 0.0071 0.0008 0.0143 0.0001 0.0185 0.0003
Punctate Nuclear 0.0551 0.0443 0.0385 0.0316 0.0139 0.0742 0.0473 0.0289 0.0468 0.0472 0.0198 0.0426 0.0304 0.0135 0.0355 0.0094 0.0196 0.043
Vacuole 0.003 0.006 0.004 0.0125 0.0022 0.0024 0.0051 0.0026 0.0023 0.0015 0.0011 0.0013 0.0047 0.002 0.0021 0.0028 0.0006 0.0017
Vacuole Periphery 0.0009 0.0011 0.0008 0.0012 0.0005 0.0017 0.0032 0.0005 0.0007 0.0009 0.0004 0.0003 0.0015 0.0003 0.0007 0.0006 0.0009 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.0738 4.223 3.5813 7.6698 5.6874 4.0469 7.4723 6.5872 8.2738 8.1087
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
215 2066 627 1853 721 1550 191 1017 936 3616 818 2870

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 637.54 677.55 810.28 839.24 702.07 718.71 845.26 959.56 687.25 695.19 818.45 881.88
Standard Deviation 65.80 86.16 97.16 108.67 76.67 91.36 99.30 179.80 79.12 90.75 98.78 149.64
Intensity Change Log 2 — 0.087812 0.345905 0.396568 — 0.033795 0.267780 0.450758 — 0.059755 0.305489 0.425222

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000025 0.000135 0.000217 0.002652 0.000446 0.000135 0.000517 0.000651 0.000349 0.000135 0.000288 0.001943
Bud Neck 0.001253 0.017551 0.003549 0.021340 0.003216 0.016951 0.002094 0.029571 0.002765 0.017294 0.003209 0.024257
Bud Site 0.001015 0.004744 0.002658 0.028630 0.002085 0.008025 0.001217 0.027960 0.001839 0.006150 0.002321 0.028393
Cell Periphery 0.000117 0.000113 0.000079 0.000248 0.000187 0.000141 0.000121 0.014636 0.000171 0.000125 0.000089 0.005346
Cytoplasm 0.198537* 0.319619* 0.027700 0.173205* 0.274277* 0.315812* 0.074123 0.334555* 0.256880* 0.317987* 0.038539 0.230380*
Cytoplasmic Foci 0.030421 0.065627 0.000672 0.002350 0.085207 0.060758 0.004564 0.010236 0.072623 0.063540 0.001581 0.005144
Eisosomes 0.000046 0.000045 0.000023 0.000028 0.000082 0.000044 0.000041 0.005368 0.000074 0.000045 0.000027 0.001921
Endoplasmic Reticulum 0.000260 0.001352 0.003845 0.004440 0.000830 0.001075 0.007253 0.001843 0.000699 0.001233 0.004641 0.003519
Endosome 0.001562 0.004190 0.000501 0.003350 0.002312 0.004771 0.001607 0.000807 0.002140 0.004439 0.000759 0.002449
Golgi 0.000157 0.001255 0.000032 0.002230 0.001253 0.001055 0.000663 0.000230 0.001001 0.001169 0.000179 0.001521
Lipid Particles 0.002199 0.004348 0.000488 0.000668 0.007460 0.004434 0.005176 0.001292 0.006251 0.004385 0.001582 0.000889
Mitochondria 0.000611 0.007190 0.000466 0.006144 0.005403 0.007495 0.000674 0.002605 0.004302 0.007321 0.000514 0.004890
Mitotic Spindle 0.001897 0.004392 0.002882 0.037853 0.003518 0.008523 0.000263 0.003673 0.003146 0.006163 0.002271 0.025741
None 0.008305 0.010289 0.003886 0.009017 0.005127 0.011043 0.005121 0.040078 0.005857 0.010612 0.004174 0.020024
Nuclear Periphery 0.000598 0.001381 0.001134 0.003268 0.001021 0.002038 0.001229 0.000691 0.000923 0.001663 0.001157 0.002355
Nuclear Periphery Foci 0.000183 0.000533 0.000194 0.000604 0.000498 0.000319 0.000521 0.000477 0.000425 0.000441 0.000270 0.000559
Nucleolus 0.002047 0.005158 0.001039 0.001561 0.001460 0.004249 0.000810 0.001287 0.001595 0.004768 0.000985 0.001464
Nucleus 0.746223* 0.526712* 0.943824* 0.673518* 0.592864* 0.525990* 0.869686* 0.509144* 0.628091* 0.526403* 0.926513* 0.615271*
Peroxisomes 0.000955 0.004192 0.000260 0.000566 0.002471 0.004809 0.000130 0.000570 0.002123 0.004457 0.000229 0.000567
Vacuole 0.003404 0.020232 0.006458 0.027182 0.010040 0.020965 0.024073 0.013935 0.008515 0.020546 0.010571 0.022488
Vacuole Periphery 0.000185 0.000942 0.000094 0.001144 0.000243 0.001369 0.000117 0.000391 0.000230 0.001125 0.000100 0.000877

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.53 -7.21 -3.68 -3.34 -2.88 0.96 -0.80 -0.17 -1.03 0.48 0.83 -0.22 -1.93 -3.41 -2.40
Bud Neck -10.70 -2.91 -12.66 -0.76 -10.50 -8.51 0.58 -10.27 -3.62 -11.05 -12.51 -1.27 -15.05 -2.86 -14.56
Bud Site -3.93 -1.47 -8.85 -7.16 -7.35 -3.59 -0.16 -6.45 -4.40 -6.60 -4.19 -0.84 -10.16 -8.03 -9.54
Cell Periphery 0.25 2.11 -4.01 -4.83 -5.89 0.96 0.99 -9.03 -9.08 -9.09 1.23 1.96 -8.82 -8.97 -9.04
Cytoplasm -7.17 10.93 3.74 24.55 -21.18 -3.68 15.14 -3.07 0.56 -18.84 -6.68 26.21 6.64 19.42 -30.38
Cytoplasmic Foci -7.98 8.72 8.38 22.96 -4.76 4.28 15.04 15.02 18.03 -1.86 2.00 17.33 16.79 29.51 -4.34
Eisosomes 0.18 3.63 1.47 2.67 -4.19 5.71 2.07 -4.91 -4.97 -4.94 5.51 6.59 -4.80 -4.92 -4.95
Endoplasmic Reticulum -10.86 -12.87 -23.89 -19.16 -3.64 -0.95 -9.56 -2.63 -2.43 8.67 -2.81 -13.45 -15.53 -17.74 3.21
Endosome -2.87 1.17 -0.35 4.95 -5.05 -3.23 0.84 3.00 8.49 1.97 -4.04 2.76 1.51 8.60 -2.70
Golgi -3.67 1.60 -1.46 1.06 -1.81 0.29 1.22 1.80 3.07 0.66 -0.39 1.90 0.84 1.90 -1.60
Lipid Particles -5.09 4.86 3.96 11.34 -3.64 2.64 1.60 5.89 6.79 1.09 2.11 4.98 6.26 12.59 0.63
Mitochondria -8.56 0.40 -6.01 3.88 -6.88 -1.00 2.29 1.33 4.79 -2.61 -1.84 2.36 0.57 5.99 -7.07
Mitotic Spindle -1.08 -0.36 -8.30 -8.70 -8.41 -2.16 1.71 -2.60 -0.72 -4.81 -1.87 0.34 -8.58 -8.08 -8.91
None -1.11 2.59 0.29 2.54 -3.78 -3.51 0.70 -8.36 -6.49 -9.06 -3.99 1.79 -7.15 -4.37 -9.12
Nuclear Periphery -9.17 -6.96 -22.24 -18.07 -17.66 -2.52 -3.78 -3.05 1.48 0.92 -3.95 -4.52 -19.00 -10.06 -15.82
Nuclear Periphery Foci -3.31 -0.60 -4.17 -2.46 -3.99 1.10 -1.72 0.30 -1.32 1.96 -0.29 -0.39 -2.45 -2.88 -2.27
Nucleolus -3.48 1.89 1.08 6.79 -2.50 -4.47 2.98 -1.07 2.95 -2.42 -7.17 3.15 -0.14 7.07 -3.34
Nucleus 11.36 -10.32 2.92 -16.76 28.62 4.72 -13.59 2.70 -2.15 16.49 9.14 -26.24 -1.29 -14.94 34.91
Peroxisomes -5.77 1.61 1.64 10.23 -0.03 -2.97 6.25 5.60 7.15 -1.96 -4.94 6.08 6.04 12.15 -0.61
Vacuole -10.14 -3.41 -18.37 -13.46 -16.04 -6.68 -4.35 -4.78 1.41 3.38 -10.61 -4.14 -17.79 -12.15 -9.65
Vacuole Periphery -5.53 1.11 -2.48 2.87 -3.91 -4.62 2.82 -0.62 3.80 -1.58 -7.05 3.42 -2.39 4.68 -4.13
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topo I and topo II; mutations in the human homolog, TDP1, result in the a neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy (SCAN1); yeast cells and human rhabdomyosarcoma lines that overexpress TDP1 both exhibit elevated dosage chromosomal instability (dCIN)
Localization
Cell Percentages nucleus (38%), cytoplasm (1%), mixed (45%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Tdp1

Tdp1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tdp1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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