Standard name
Human Ortholog
Description Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.08 0.07 0 0 0 0 0 0
Cytoplasm 0 0 0.73 0.7 0.66 0.57 0.59 0.53 0.44 0.4 0.41 0.49 0.93 0.84 0.9 0.11 0.05 0.13 0 0 0.53 0.75 0.75 0.67
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.06 0.08 0.06 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.22 0.44 0.31 0.07 0.08 0 0 0 0
Mitochondria 0.93 0.81 0.21 0.3 0.33 0.57 0.49 0.49 0.66 0.69 0.74 0.66 0.05 0.13 0.07 0.12 0.14 0.09 0.72 0.66 0.25 0.1 0.11 0.11
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Peroxisomes 0.05 0.21 0.09 0.06 0 0 0 0 0 0 0 0 0 0 0 0.29 0.17 0.19 0.07 0.08 0.05 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.14 0.11 0 0 0 0 0 0
Vac/Vac Membrane 0 0.1 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.15 0.13 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 5 0 0 0 0 0 0 0 0 2 0 0 1 1 5 0 3 19 21 7 1 2 4
Bud 17 4 3 3 7 6 6 11 13 12 10 12 0 0 0 14 4 6 0 2 12 1 6 2
Bud Neck 0 0 0 0 1 0 0 3 0 1 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Bud Site 3 1 0 0 1 1 2 3 1 4 1 1 0 0 0 1 0 2 – – – – – –
Cell Periphery 2 13 3 1 0 1 1 2 5 1 2 4 1 1 1 32 35 13 0 0 0 0 0 0
Cytoplasm 4 3 249 149 238 208 253 301 182 209 144 234 238 140 235 48 21 24 0 1 187 80 174 105
Endoplasmic Reticulum 0 1 1 0 0 0 0 2 1 0 0 1 1 0 0 3 12 7 0 1 2 0 0 1
Endosome 6 14 4 2 11 4 6 13 0 3 2 0 0 2 5 41 25 15 35 12 7 0 4 4
Golgi 1 5 1 0 0 0 0 0 0 0 1 0 5 3 0 100 190 59 43 32 5 4 3 4
Mitochondria 573 282 73 64 118 206 208 277 271 360 261 313 14 21 19 56 60 17 455 253 88 10 25 16
Nucleus 2 0 0 1 0 1 5 8 5 3 4 4 2 0 0 8 3 2 0 0 0 0 0 0
Nuclear Periphery 15 12 3 2 7 16 15 22 18 19 8 9 1 1 2 9 4 5 3 2 1 0 0 0
Nucleolus 57 12 6 0 8 13 14 20 17 18 13 11 0 2 1 14 11 10 1 2 0 0 0 0
Peroxisomes 31 73 30 13 12 1 4 5 1 3 1 3 0 2 8 133 71 36 46 30 19 2 4 6
SpindlePole 9 4 5 4 7 2 3 4 3 7 6 3 0 0 4 48 62 20 6 4 9 0 2 1
Vac/Vac Membrane 27 34 1 2 5 6 7 13 18 25 11 10 1 1 1 68 57 17 7 8 4 2 2 4
Unique Cell Count 616 348 343 214 362 363 427 565 412 519 352 474 256 167 262 456 430 188 628 381 358 107 233 158
Labelled Cell Count 749 463 379 241 415 465 524 684 535 665 466 605 263 174 277 580 555 236 628 381 358 107 233 158


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.6 11.9 5.3 5.5 5.3 5.2 4.6 5.2 4.8 4.9 4.8 4.4 5.5 5.9 5.9 10.1 11.4 11.0 5.0 5.0 6.3
Std Deviation (1e-4) 1.8 2.8 2.7 3.1 3.1 3.1 2.7 2.9 2.8 2.8 2.6 2.4 2.6 2.9 2.9 2.6 2.9 3.0 2.7 2.3 2.6
Intensity Change (Log2) – – – 0.05 0.01 -0.04 -0.21 -0.04 -0.14 -0.11 -0.16 -0.28 0.04 0.16 0.15 0.92 1.1 1.05 -0.08 -0.08 0.25

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 1.3 0 1.6 0 0 0 0 0 2.1 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 4.2 4.6 3.9
Cytoplasm -0.8 -2.0 -4.3 -3.9 -5.8 -7.9 -9.3 -8.4 -6.7 6.3 2.8 5.2 -18.0 -19.6 -13.2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 2.7 0
Endosome 0 1.7 0 0 1.2 0 0 0 0 0 0 0 4.7 3.4 4.0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 9.1 14.1 10.8
Mitochondria 2.3 3.4 9.6 0 8.3 0 13.8 0 0 -5.4 -2.4 -4.8 -3.4 -2.7 -3.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 2.9 0 2.7 0 2.5 0 0 0 0 0 1.3 0 0
Nucleolus 0 0.4 1.5 0 1.6 0 1.5 0 0 0 0 0 1.2 0.8 2.3
Peroxisomes -1.1 -3.0 -5.5 0 -6.0 0 -6.1 0 0 -4.9 -3.3 -2.9 7.1 3.2 3.5
SpindlePole 0 0.5 0 0 0 0 0 0 0 0 0 0 5.1 6.4 4.8
Vacuole 0 0 0 0 2.4 3.6 3.8 2.9 0 0 0 0 7.3 6.8 5.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.6577 6.9971 6.1662 5.9998 4.5467 5.752 11.3295 10.8286 11.4659 11.3152 10.3182 11.4103 10.8627 11.9202 11.8596 10.7869 11.7651 11.6857
Actin 0.0187 0.0114 0.0093 0.008 0.0004 0.0014 0.0028 0.0015 0.0041 0 0.0033 0.0004 0.0074 0.0063 0.0056 0.0017 0.0002 0.0032
Bud 0.0004 0.0002 0.0003 0.0001 0 0.0001 0.0001 0.0002 0.0003 0 0.0004 0 0.0002 0.0003 0.0002 0.0002 0 0
Bud Neck 0.0004 0.0002 0.0002 0.0001 0 0.0001 0.0001 0.0001 0.0001 0 0.0001 0 0.0003 0.0001 0 0 0 0
Bud Periphery 0.0005 0.0004 0.0012 0.0002 0.0001 0.0002 0.0002 0.0005 0.0007 0 0.0009 0.0002 0.0009 0.0006 0.0005 0.0006 0.0001 0.0001
Bud Site 0.0018 0.0005 0.0008 0.0003 0 0.0001 0.0006 0.0003 0.0003 0 0.0004 0.0001 0.0002 0.0008 0.0001 0.0001 0 0
Cell Periphery 0.0002 0.0003 0.0004 0.0001 0 0.0001 0.0002 0.0003 0.0002 0 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0
Cytoplasm 0.004 0.0001 0.0003 0.0024 0 0 0.0002 0.0001 0.0001 0 0.0002 0 0.0011 0.0001 0.0002 0 0 0
Cytoplasmic Foci 0.0165 0.0081 0.008 0.0015 0.0002 0.0004 0.0026 0.0028 0.0013 0 0.0018 0.0005 0.0114 0.0022 0.0024 0.0017 0.0002 0.0012
Eisosomes 0.0012 0.0003 0.0004 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0004 0.0002 0.0001 0.0002 0.0001 0.0001
Endoplasmic Reticulum 0.0027 0.0001 0.0003 0.0027 0 0.0001 0.0003 0.0002 0.0001 0 0.0004 0.0005 0.0008 0.0001 0.0001 0 0 0
Endosome 0.0252 0.0079 0.016 0.0078 0.0008 0.003 0.0068 0.0084 0.0071 0.0007 0.0216 0.007 0.0187 0.0069 0.0089 0.0038 0.0021 0.0068
Golgi 0.0164 0.0366 0.0161 0.024 0.0025 0.0069 0.02 0.0342 0.0221 0.0031 0.0348 0.0209 0.03 0.0281 0.019 0.0229 0.006 0.0177
Lipid Particles 0.0465 0.0212 0.0125 0.015 0.005 0.0051 0.0092 0.0074 0.0053 0.0001 0.0213 0.0013 0.0298 0.0068 0.0029 0.0012 0.0005 0.0049
Mitochondria 0.7651 0.8946 0.9032 0.9134 0.9882 0.975 0.9413 0.9334 0.9491 0.9949 0.9031 0.963 0.8615 0.9214 0.9541 0.9642 0.983 0.9583
None 0.0247 0 0.0004 0.0008 0 0 0.0006 0 0.0001 0 0.0001 0.0001 0.0038 0 0.0001 0 0 0
Nuclear Periphery 0.0115 0.0002 0.0006 0.0115 0 0.0001 0.0025 0 0.0001 0 0.0005 0.0005 0.0027 0.0001 0 0 0 0
Nucleolus 0.0029 0.0019 0.0021 0.0002 0 0.0001 0.0005 0.0001 0.0001 0 0.0001 0.0014 0.0013 0.0003 0 0 0 0
Nucleus 0.0096 0.0003 0.0003 0.0034 0 0.0001 0.0003 0 0.0001 0 0.0003 0.0007 0.0009 0.0001 0 0 0 0
Peroxisomes 0.0348 0.009 0.0107 0.0033 0.0015 0.0015 0.0048 0.0072 0.0051 0.0001 0.0027 0.0007 0.0131 0.0126 0.0028 0.002 0.0006 0.0059
Punctate Nuclear 0.0113 0.0001 0.0003 0.0012 0 0 0.002 0 0 0 0.0001 0.0001 0.0087 0 0.0001 0 0 0
Vacuole 0.0019 0.0026 0.0051 0.001 0.0002 0.0008 0.0013 0.0009 0.001 0.0001 0.0041 0.0007 0.0021 0.0037 0.0008 0.0003 0.0009 0.0003
Vacuole Periphery 0.0038 0.0039 0.0114 0.0026 0.0009 0.0048 0.0035 0.0023 0.0027 0.0008 0.0039 0.0018 0.0045 0.009 0.0019 0.0009 0.0061 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 19.0607 13.2527 18.7315 21.5006 17.8483 15.5224 17.5473 24.3325 18.9958 19.8919
Translational Efficiency 1.5648 1.7298 1.3634 1.3435 1.1861 1.502 1.1732 0.8302 1.1623 1.0829

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1732 2795 1729 1307 2192 975 1850 2037 3924 3770 3579 3344

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 868.15 1133.33 1103.97 1201.19 1036.83 1055.65 1157.12 1437.60 962.38 1113.24 1131.44 1345.20
Standard Deviation 157.58 230.05 176.97 208.44 182.07 215.68 175.96 242.28 191.03 228.96 178.44 256.99
Intensity Change Log 2 — 0.384552 0.346685 0.468448 — 0.025952 0.158359 0.471483 — 0.200483 0.247243 0.470101

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003715 0.001830 0.001716 0.009178 0.001338 0.004974 0.004174 0.005675 0.002387 0.002643 0.002986 0.007044
Bud Neck 0.000843 0.000645 0.002772 0.001266 0.000179 0.002301 0.001561 0.000366 0.000472 0.001073 0.002146 0.000718
Bud Site 0.002967 0.001628 0.004501 0.004228 0.000248 0.003067 0.003323 0.003721 0.001448 0.002000 0.003892 0.003919
Cell Periphery 0.000210 0.000111 0.000122 0.000366 0.000058 0.000387 0.000143 0.001971 0.000125 0.000183 0.000133 0.001344
Cytoplasm 0.000604 0.000582 0.000814 0.000950 0.000189 0.000735 0.000712 0.000789 0.000372 0.000622 0.000761 0.000852
Cytoplasmic Foci 0.014150 0.007705 0.025184 0.012777 0.007878 0.037539 0.023566 0.001606 0.010646 0.015421 0.024348 0.005972
Eisosomes 0.000125 0.000138 0.000069 0.000214 0.000146 0.000349 0.000097 0.000156 0.000137 0.000193 0.000084 0.000179
Endoplasmic Reticulum 0.000289 0.000088 0.000216 0.000550 0.000054 0.000281 0.000284 0.000560 0.000158 0.000138 0.000251 0.000556
Endosome 0.017307 0.007623 0.028345 0.013589 0.003987 0.021192 0.019895 0.003484 0.009866 0.011132 0.023977 0.007433
Golgi 0.027814 0.015234 0.031012 0.064716 0.019497 0.060295 0.056683 0.014794 0.023168 0.026887 0.044282 0.034306
Lipid Particles 0.008903 0.005152 0.005578 0.001972 0.003533 0.016057 0.008066 0.001134 0.005903 0.007973 0.006864 0.001462
Mitochondria 0.898520 0.937110 0.828368 0.849637 0.951424 0.807093 0.834344 0.941223 0.928073 0.903485 0.831457 0.905426
Mitotic Spindle 0.000899 0.001281 0.017840 0.006104 0.000416 0.002419 0.007794 0.000711 0.000630 0.001575 0.012647 0.002819
None 0.000606 0.000541 0.000619 0.000663 0.000595 0.000733 0.000598 0.001145 0.000600 0.000591 0.000608 0.000957
Nuclear Periphery 0.000263 0.000103 0.001677 0.000433 0.000124 0.000298 0.001272 0.000119 0.000186 0.000153 0.001468 0.000242
Nuclear Periphery Foci 0.000279 0.000156 0.001189 0.000397 0.000064 0.000452 0.000684 0.000064 0.000159 0.000232 0.000928 0.000194
Nucleolus 0.000530 0.000262 0.000762 0.000253 0.000035 0.000974 0.000113 0.000139 0.000254 0.000446 0.000426 0.000184
Nucleus 0.000123 0.000133 0.000316 0.000156 0.000012 0.000671 0.000055 0.000094 0.000061 0.000272 0.000181 0.000118
Peroxisomes 0.012136 0.013705 0.014897 0.009588 0.007816 0.026075 0.011718 0.001709 0.009722 0.016904 0.013254 0.004788
Vacuole 0.003639 0.003053 0.016605 0.009928 0.000730 0.008022 0.009292 0.007028 0.002014 0.004338 0.012825 0.008162
Vacuole Periphery 0.006078 0.002920 0.017397 0.013035 0.001678 0.006086 0.015626 0.013513 0.003620 0.003739 0.016482 0.013326

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.92 3.20 -3.59 -5.05 -5.16 -4.41 -3.38 -4.67 -0.58 -1.23 -0.62 -1.17 -5.62 -5.20 -4.50
Bud Neck 1.21 -6.23 -2.32 -4.00 4.68 -5.07 -7.27 -2.84 4.60 6.13 -4.31 -9.43 -2.83 2.39 7.92
Bud Site 1.38 -1.41 -1.27 -3.26 0.12 -4.45 -5.34 -5.91 -0.78 -0.42 -1.07 -4.21 -4.27 -3.45 -0.09
Cell Periphery 3.68 3.82 -1.48 -2.43 -2.35 -3.43 -3.96 -5.76 -4.59 -5.50 -1.90 -0.52 -5.89 -5.57 -5.86
Cytoplasm 0.06 -0.96 -1.48 -1.59 -0.68 -2.99 -3.08 -3.31 -0.22 -0.25 -1.51 -2.88 -3.23 -1.27 -0.51
Cytoplasmic Foci 4.94 -5.43 0.82 -4.09 6.19 -10.53 -9.95 9.07 13.10 15.24 -4.48 -10.85 5.93 9.73 15.51
Eisosomes -0.70 3.13 -2.03 -1.80 -3.45 -2.16 3.17 -0.44 2.04 -3.15 -2.05 4.54 -1.92 0.43 -4.75
Endoplasmic Reticulum 6.33 2.19 -1.83 -3.27 -2.37 -5.58 -8.56 -5.28 -2.69 -2.79 0.99 -4.57 -4.92 -5.14 -3.75
Endosome 6.31 -4.58 2.00 -4.54 6.45 -9.74 -12.03 0.83 10.21 12.84 -1.35 -10.60 2.82 4.51 13.21
Golgi 5.47 -1.11 -7.77 -11.07 -7.02 -8.85 -10.57 2.31 9.95 12.09 -1.96 -9.22 -4.90 -3.08 3.65
Lipid Particles 2.84 2.45 5.74 4.63 4.86 -5.67 -4.08 4.44 6.91 6.87 -2.22 -1.15 7.25 8.78 8.58
Mitochondria -6.49 8.43 5.61 11.09 -2.08 14.57 16.79 2.27 -13.31 -14.83 5.49 18.01 5.03 -0.30 -12.59
Mitotic Spindle -1.28 -8.99 -4.85 -4.48 5.35 -3.32 -6.82 -1.49 2.92 6.61 -3.66 -11.21 -4.99 -2.67 8.52
None 1.11 -0.21 -0.93 -2.58 -0.86 -1.57 -0.07 -5.50 -3.35 -5.64 0.21 -0.23 -5.42 -5.52 -5.55
Nuclear Periphery 3.01 -5.10 -1.66 -3.69 4.33 -2.20 -4.97 0.08 3.02 5.13 0.75 -7.14 -1.06 -2.19 6.84
Nuclear Periphery Foci 2.30 -5.66 -1.02 -2.11 4.10 -3.53 -6.04 -0.06 3.53 6.03 -1.78 -8.21 -0.77 0.62 7.20
Nucleolus 0.64 -0.51 0.18 -0.52 0.81 -2.17 -6.62 -3.85 1.94 -0.91 -0.86 -0.81 -0.00 1.04 0.99
Nucleus -0.15 -2.43 -0.70 -0.62 0.24 -1.42 -6.87 -2.08 1.25 -0.97 -1.60 -3.20 -1.18 0.77 0.24
Peroxisomes -0.87 -1.37 1.36 2.25 2.58 -6.36 -2.31 5.67 8.92 6.88 -5.11 -2.71 4.98 9.32 7.06
Vacuole 0.97 -9.94 -4.85 -5.33 3.71 -5.37 -10.65 -7.03 0.59 1.87 -4.59 -14.36 -8.18 -4.50 4.44
Vacuole Periphery 4.80 -8.87 -5.60 -8.55 2.69 -5.37 -11.56 -9.97 -5.27 1.24 -0.28 -14.74 -11.07 -10.60 2.64
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Non-proteolytic ATPase of the AAA family; stimulates incorporation of the pyridoxal phosphate cofactor into Hem1p (5-aminolevulinic acid synthase); localized to the mitochondrial matrix; ortholog of vertebrate CLPX, which promotes erythropoiesis
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mcx1

Mcx1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mcx1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available