Standard name
Human Ortholog
Description Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.6 – 0.58 0.51 0.46 0.34 0.39 0.43 0.37 0.4 0.42 0.39 0.64 0.59 0.51 0.37 0.44 0.43 0.79 0.77 0.84 0.67 0.71 0.8
Bud 0.18 – 0.18 0.14 0.28 0.16 0.2 0.14 0.14 0.18 0.18 0.13 0.14 0.11 0 0 0.06 0 0 0.05 0 0.07 0.05 0.05
Bud Neck 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0.05 0.07 0 0 0.05 0 0.05 0 0 0.06 0.1 0.1 0.12 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 – 0.08 0.08 0.06 0 0 0 0 0 0.05 0 0.05 0 0 0.22 0.06 0.11 0 0 0 0 0 0
Endoplasmic Reticulum 0.07 – 0 0 0 0 0 0 0.09 0.05 0.06 0.05 0 0.06 0.07 0.05 0 0.07 0 0 0 0 0 0
Endosome 0.08 – 0.05 0 0.09 0.06 0 0 0 0 0 0 0.12 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.15 – 0.27 0.25 0.16 0.12 0.13 0.29 0.34 0.2 0.18 0.24 0.47 0.7 0.71 0.44 0.5 0.54 0.07 0.08 0 0.1 0.07 0.07
Mitochondria 0.37 – 0.18 0.35 0.3 0.56 0.55 0.41 0.5 0.52 0.5 0.51 0.21 0 0 0.12 0.25 0.15 0 0 0 0 0 0
Nucleus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.05 – 0.25 0.27 0.26 0.23 0.14 0.22 0.1 0.14 0.05 0.12 0.14 0.06 0.05 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0 0 0 0 0 0 0
Vac/Vac Membrane 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 71 – 141 123 145 111 216 162 130 146 137 167 51 146 124 37 7 20 112 45 244 129 173 224
Bud 21 – 45 34 87 51 111 54 50 65 59 55 11 27 8 4 1 2 6 3 11 13 11 13
Bud Neck 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 1 0 0 1 5 2
Bud Site 3 – 1 6 9 5 6 6 1 6 5 7 0 0 0 1 0 1 – – – – – –
Cell Periphery 4 – 13 16 10 11 25 17 19 9 14 25 8 24 28 4 0 2 0 0 0 1 1 2
Cytoplasm 15 – 20 20 18 13 18 11 9 6 15 6 4 9 10 22 1 5 1 1 4 0 5 0
Endoplasmic Reticulum 8 – 9 5 5 4 17 17 30 20 21 21 3 15 16 5 0 3 1 0 0 2 4 1
Endosome 10 – 11 5 29 20 24 13 9 11 9 13 10 5 7 1 0 1 3 0 2 6 9 4
Golgi 18 – 67 60 49 38 69 112 119 73 58 102 38 174 171 44 8 25 9 4 12 18 16 19
Mitochondria 44 – 44 85 95 184 301 157 174 191 163 219 17 10 4 12 4 7 1 1 0 5 3 1
Nucleus 1 – 1 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1
Nuclear Periphery 0 – 0 1 0 0 2 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 – 1 5 14 10 14 4 6 9 9 11 1 1 0 2 0 0 0 0 0 0 0 1
Peroxisomes 6 – 61 64 80 75 77 83 35 50 18 53 11 14 12 2 0 0 2 0 12 3 3 4
SpindlePole 1 – 10 13 13 9 9 13 5 11 4 5 2 4 2 5 1 2 1 0 1 1 1 0
Vac/Vac Membrane 0 – 0 1 1 1 2 3 1 3 2 3 1 1 1 2 0 1 0 0 0 3 2 1
Unique Cell Count 119 244 241 312 327 550 381 347 366 329 428 80 248 242 101 16 46 142 59 293 192 244 280
Labelled Cell Count 202 424 438 555 532 891 653 589 601 515 688 157 430 383 141 22 69 142 59 293 192 244 280


Actin

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.5 – 22.9 18.9 19.7 20.9 19.6 22.4 23.2 20.9 21.9 21.6 22.5 23.0 24.4 32.9 34.7 33.6 24.0 22.1 23.6
Std Deviation (1e-4) 8.8 – 11.6 10.8 10.4 12.0 11.1 12.8 14.0 12.3 13.5 14.4 12.8 11.3 11.6 18.2 17.5 12.3 12.4 10.7 10.3
Intensity Change (Log2) – – – -0.28 -0.22 -0.13 -0.23 -0.03 0.02 -0.13 -0.06 -0.09 -0.03 0.01 0.09 0.52 0.6 0.55 0.07 -0.05 0.04

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -1.5 -2.6 -5.7 -4.8 -3.7 -4.9 -4.3 -3.8 -4.7 0.9 0.2 -1.4 -3.6 -1.1 -1.8
Bud -1.3 2.6 -0.9 0.6 -1.4 -1.3 -0.2 -0.2 -2.0 -1.0 -2.4 -5.4 -3.5 0 -2.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.6 -1.2 -1.2 -0.5 -0.5 0.1 -1.9 -0.6 0.3 1.5 1.8 2.5 0 0 0
Cytoplasm 0 -1.1 -2.1 -3.0 -3.0 -3.1 -3.9 -1.8 -4.4 -0.9 -2.2 -1.9 3.5 0 0
Endoplasmic Reticulum -1.1 -1.6 -2.0 -0.4 0.5 2.4 1.0 1.4 0.7 0 1.2 1.5 0 0 0
Endosome -1.5 2.2 0.8 -0.1 -0.7 -1.3 -1.0 -1.1 -1.0 2.5 -1.6 -0.9 0 0 0
Golgi -0.6 -3.4 -4.8 -5.1 0.5 1.8 -2.2 -2.8 -1.0 3.3 9.5 9.5 2.9 0 3.6
Mitochondria 4.3 3.4 9.2 9.6 6.1 8.0 8.5 7.8 8.5 0.6 -5.0 -6.1 -1.4 0 -0.5
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 2.9 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0.4 0.2 -0.6 -3.8 -0.9 -4.8 -3.6 -6.7 -4.2 -2.1 -6.0 -6.2 -5.0 0 -3.8
SpindlePole 0.7 0 -0.9 -2.1 -0.4 -2.0 -0.7 -2.2 -2.5 0 -1.7 -2.3 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.331 15.6772 13.1406 8.8616 12.8136 14.8597 14.9453 19.2954 18.6879 16.0004 17.6392 19.3751 9.8207 10.9428 11.3192 11.7204 9.2811 11.473
Actin 0.6639 0.8586 0.8484 0.9724 0.682 0.9357 0.7484 0.7902 0.8498 0.7608 0.8256 0.9125 0.7547 0.8861 0.893 0.7091 0.8241 0.9156
Bud 0.0011 0.0045 0.0051 0.0055 0.0036 0.0005 0.0021 0.003 0.0136 0.0059 0.0038 0.0002 0.002 0.0034 0.017 0.0035 0.0005 0.0003
Bud Neck 0.0022 0.0009 0.002 0.0002 0.0005 0.0075 0.0021 0.0032 0.0044 0.01 0.0041 0.0185 0.0036 0.001 0.0013 0.0014 0.0011 0.0118
Bud Periphery 0.0009 0.0024 0.0077 0.0043 0.0222 0.0007 0.0023 0.002 0.0088 0.0087 0.0056 0.0003 0.0017 0.0022 0.0207 0.0041 0.0004 0.0004
Bud Site 0.0209 0.033 0.0163 0.0133 0.0015 0.0011 0.0067 0.0692 0.021 0.0078 0.0101 0.0003 0.0197 0.0593 0.0132 0.0052 0.0008 0.0006
Cell Periphery 0.0003 0.0004 0.0005 0.0001 0.0011 0.0001 0.0005 0.0007 0.0004 0.0017 0.0003 0.0003 0.0005 0.0002 0.0001 0.0002 0.0001 0.0002
Cytoplasm 0.0187 0.016 0.0064 0.0002 0.0008 0.0016 0.006 0.0018 0.0072 0.0037 0.0026 0.0001 0.0304 0.0024 0.0122 0.0023 0.0023 0.0004
Cytoplasmic Foci 0.0592 0.0251 0.0187 0.0006 0.0225 0.0046 0.0223 0.0335 0.0089 0.0486 0.0318 0.0011 0.0305 0.0111 0.0093 0.0202 0.0194 0.0183
Eisosomes 0.0054 0.0068 0.0188 0.0004 0.1022 0.0012 0.0323 0.0534 0.0179 0.0013 0.0007 0.0399 0.0017 0.0003 0.0009 0.0291 0.0005 0.0019
Endoplasmic Reticulum 0.0019 0 0.003 0 0.0024 0.0017 0.0077 0.0002 0.0009 0.0008 0.0056 0 0.0141 0.0001 0.0001 0.0025 0.0023 0.0005
Endosome 0.0423 0.0004 0.0118 0 0.0508 0.0106 0.0575 0.0016 0.0148 0.0456 0.0343 0.0008 0.043 0.0043 0.0018 0.0781 0.0475 0.0056
Golgi 0.0392 0.0039 0.0122 0.0009 0.0618 0.0082 0.0335 0.0062 0.024 0.0465 0.0194 0.0203 0.0233 0.0185 0.0158 0.0608 0.0669 0.0141
Lipid Particles 0.0198 0.0004 0.0025 0 0.0309 0.0035 0.0174 0.0007 0.0044 0.0196 0.0245 0.0003 0.0073 0.0005 0.0002 0.0306 0.0199 0.0062
Mitochondria 0.0165 0.0008 0.0181 0.0005 0.0048 0.0019 0.0125 0.0063 0.0136 0.0125 0.0075 0.0005 0.0054 0.0006 0.0008 0.0077 0.0063 0.0069
None 0.0304 0.0011 0.0063 0 0.0005 0.0002 0.0078 0.0001 0.0003 0.0001 0.0021 0 0.0032 0 0.0044 0.0004 0.0005 0.0005
Nuclear Periphery 0.0037 0 0.0039 0 0.0018 0.0076 0.0148 0.0001 0.0004 0.0007 0.0071 0 0.0238 0 0.0001 0.0036 0.0012 0.0089
Nucleolus 0.0109 0.0002 0.0008 0 0.0001 0.0001 0.0007 0 0.0001 0.0005 0.0006 0 0.0018 0 0 0.0003 0.0001 0.0003
Nucleus 0.0115 0.0001 0.0035 0 0.0002 0.0007 0.0022 0.0001 0.0002 0.0007 0.0015 0 0.0103 0 0.0005 0.0006 0.0001 0.0005
Peroxisomes 0.0388 0.045 0.0066 0.0012 0.0072 0.0099 0.0062 0.0272 0.0064 0.0142 0.0052 0.005 0.0134 0.0098 0.0084 0.0273 0.0028 0.0048
Punctate Nuclear 0.0092 0.0003 0.0055 0 0.0018 0.0013 0.0057 0.0002 0.0005 0.001 0.0025 0 0.0028 0.0001 0.0001 0.0008 0.0006 0.0006
Vacuole 0.0023 0.0001 0.001 0 0.0005 0.0004 0.0084 0.0001 0.0016 0.0076 0.0031 0 0.0044 0.0001 0.0001 0.0075 0.0011 0.0003
Vacuole Periphery 0.001 0 0.0008 0 0.0007 0.0007 0.003 0 0.0006 0.0016 0.0019 0 0.0023 0.0001 0 0.0048 0.0015 0.0013

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 100.3095 78.5685 96.9574 109.9455 98.4707 104.0732 104.9133 104.0286 114.08 109.9096
Translational Efficiency 1.2324 1.2318 1.1019 1.0311 1.1 1.4452 1.1841 1.1198 1.1536 1.0291

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1498 857 211 227 1608 1739 398 190 3106 2596 609 417

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1300.54 1841.10 1812.10 2083.73 1474.53 1590.40 1967.44 2280.34 1390.62 1673.16 1913.62 2173.31
Standard Deviation 451.60 667.34 702.45 812.57 536.89 603.15 737.73 825.49 505.12 636.09 729.45 824.32
Intensity Change Log 2 — 0.501457 0.478552 0.680058 — 0.109134 0.416064 0.628994 — 0.306315 0.445686 0.653150

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.806854 0.840153 0.690633 0.656051 0.693140 0.794247 0.607330 0.718769 0.747984 0.809402 0.636192 0.684627
Bud Neck 0.005939 0.005684 0.020682 0.022804 0.013779 0.005493 0.020667 0.017445 0.009998 0.005556 0.020672 0.020362
Bud Site 0.059124 0.034923 0.122337 0.077423 0.141395 0.042719 0.149980 0.056912 0.101716 0.040145 0.140403 0.068077
Cell Periphery 0.000887 0.000818 0.001225 0.002357 0.018782 0.000736 0.001885 0.004623 0.010151 0.000763 0.001657 0.003389
Cytoplasm 0.006833 0.002908 0.016652 0.011111 0.014665 0.005034 0.023384 0.001746 0.010888 0.004332 0.021052 0.006844
Cytoplasmic Foci 0.017698 0.008794 0.030161 0.045989 0.015094 0.020632 0.056000 0.016867 0.016350 0.016724 0.047048 0.032720
Eisosomes 0.006768 0.045710 0.018717 0.010002 0.015364 0.006926 0.006937 0.024200 0.011218 0.019730 0.011018 0.016471
Endoplasmic Reticulum 0.000788 0.001570 0.001970 0.006407 0.009407 0.001536 0.002184 0.010292 0.005250 0.001547 0.002110 0.008177
Endosome 0.016397 0.013346 0.033215 0.054138 0.016332 0.024615 0.036534 0.049685 0.016364 0.020895 0.035384 0.052109
Golgi 0.017618 0.012127 0.014339 0.050411 0.015198 0.028293 0.025144 0.048406 0.016365 0.022956 0.021401 0.049498
Lipid Particles 0.014353 0.007249 0.014347 0.038698 0.011046 0.033256 0.023301 0.032662 0.012641 0.024670 0.020198 0.035947
Mitochondria 0.004607 0.004962 0.007140 0.001696 0.013750 0.004169 0.002730 0.001159 0.009340 0.004431 0.004258 0.001451
Mitotic Spindle 0.000673 0.000428 0.002779 0.001703 0.000592 0.000938 0.003951 0.000613 0.000631 0.000770 0.003545 0.001207
None 0.000095 0.000079 0.000056 0.000038 0.000249 0.000112 0.000048 0.000047 0.000175 0.000102 0.000051 0.000042
Nuclear Periphery 0.000012 0.000066 0.000077 0.000181 0.000120 0.000025 0.000093 0.000111 0.000068 0.000039 0.000087 0.000149
Nuclear Periphery Foci 0.000051 0.000427 0.000294 0.000713 0.000243 0.000121 0.000506 0.000288 0.000150 0.000222 0.000433 0.000519
Nucleolus 0.000011 0.000011 0.000023 0.000016 0.000046 0.000028 0.000018 0.000008 0.000029 0.000022 0.000020 0.000012
Nucleus 0.000091 0.000073 0.000171 0.000286 0.000317 0.000100 0.000282 0.000091 0.000208 0.000091 0.000244 0.000197
Peroxisomes 0.040643 0.019398 0.012004 0.010720 0.016345 0.029930 0.025424 0.009815 0.028064 0.026453 0.020775 0.010307
Vacuole 0.000437 0.000892 0.012849 0.008433 0.002457 0.000875 0.013239 0.005634 0.001483 0.000881 0.013104 0.007158
Vacuole Periphery 0.000121 0.000379 0.000327 0.000825 0.001678 0.000216 0.000363 0.000625 0.000927 0.000270 0.000351 0.000734

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.95 4.82 6.33 7.52 1.11 -8.68 4.57 -0.96 3.22 -4.05 -7.47 7.43 3.85 7.33 -2.32
Bud Neck 0.26 -4.81 -5.72 -5.77 -0.57 7.88 -2.86 -1.37 -4.62 0.98 6.31 -5.65 -5.13 -7.42 0.10
Bud Site 4.48 -4.21 -1.71 -3.94 2.55 14.06 -0.88 7.44 -1.58 6.39 13.57 -4.14 4.08 -3.88 6.40
Cell Periphery 0.43 -1.70 -2.62 -2.74 -1.91 9.17 8.35 5.94 -2.86 -1.88 9.08 7.85 5.44 -3.81 -2.26
Cytoplasm 3.55 -1.94 -1.29 -2.09 0.56 5.34 -2.13 6.90 2.97 4.58 5.97 -3.08 0.97 -1.34 3.19
Cytoplasmic Foci 3.94 -2.28 -3.36 -4.29 -1.68 -2.58 -6.45 -0.48 0.80 5.32 -0.37 -6.71 -3.31 -3.19 1.97
Eisosomes -7.31 -2.45 -0.97 6.01 1.58 3.97 3.48 -1.21 -2.43 -2.41 -3.86 0.16 -1.37 0.84 -1.35
Endoplasmic Reticulum -1.81 -3.32 -3.50 -2.91 -2.70 5.92 5.36 -0.34 -4.35 -4.01 5.15 4.33 -2.00 -5.16 -4.71
Endosome 1.28 -2.67 -5.12 -5.46 -2.17 -3.65 -4.93 -4.80 -3.58 -1.74 -2.70 -5.52 -7.00 -6.03 -2.81
Golgi 2.20 0.96 -3.86 -4.49 -4.06 -5.38 -2.19 -4.42 -2.65 -2.83 -3.63 -1.53 -5.77 -4.56 -4.50
Lipid Particles 3.04 -0.02 -3.43 -4.49 -3.06 -6.85 -2.71 -3.20 0.06 -1.18 -5.19 -2.28 -4.73 -2.20 -2.74
Mitochondria -0.29 -1.02 3.65 2.84 2.23 5.74 6.64 8.19 3.71 1.88 4.75 4.00 8.85 4.44 2.76
Mitotic Spindle 1.64 -2.02 -1.73 -2.08 0.76 -1.99 -4.85 -0.14 1.30 4.68 -1.12 -5.03 -1.73 -1.33 3.30
None 0.35 1.51 2.21 1.37 1.18 2.64 4.96 5.06 1.95 0.27 2.14 5.06 5.49 2.38 0.92
Nuclear Periphery -1.10 -4.28 -3.83 -1.88 -2.32 1.38 0.35 0.13 -3.45 -0.51 0.75 -0.56 -1.93 -3.60 -2.15
Nuclear Periphery Foci -0.99 -2.86 -2.05 -0.63 -1.27 0.99 -1.99 -0.38 -2.06 1.94 -0.52 -3.19 -1.98 -1.41 -0.29
Nucleolus -0.12 -2.09 -1.37 -1.22 0.46 1.54 3.79 5.30 2.02 2.56 0.87 1.88 2.74 1.04 1.17
Nucleus 0.25 -1.42 -1.64 -1.67 -1.11 3.31 0.13 3.78 0.36 3.23 2.83 -1.04 -0.62 -1.56 -0.13
Peroxisomes 5.45 8.00 8.88 2.58 0.43 -4.63 -2.22 1.19 3.51 2.43 0.66 2.49 5.77 5.09 2.88
Vacuole -1.13 -2.38 -3.51 -3.28 0.68 3.87 -3.88 -1.99 -3.00 2.53 2.34 -4.60 -3.94 -4.35 2.11
Vacuole Periphery -1.26 -2.23 -3.15 -1.49 -2.06 4.79 4.21 3.00 -2.38 -1.42 3.79 3.41 0.86 -2.91 -2.48
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches
Localization
Cell Percentages actin (76%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Arc40

Arc40


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Arc40-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available