Standard name
Human Ortholog
Description Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.18 0.39 0.25 0.45 0.37 0.45 0.43 0.51 0.59 0.58 0.55 0.56 0.17 0.13 0.14 0.25 0.26 0.28 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0
Endosome 0 0.06 0.14 0.18 0.13 0 0 0.05 0 0 0 0 0 0.06 0 0.05 0 0.07 0.05 0.07 0.1 0.11 0.1 0.13
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.05 0.1 0.15 0.25 0.19 0.4 0.52 0.33 0.43 0.39 0.45 0.38 0.07 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.08 0 0 0 0 0 0 0 0 0 0 0 0.09 0.05 0.07 0.05 0.05 0.06 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.81 0.59 0.66 0.46 0.56 0.37 0.25 0.29 0.24 0.27 0.24 0.29 0.68 0.83 0.77 0.74 0.75 0.73 0.87 0.81 0.76 0.77 0.75 0.75
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 1 0 0 0 1 1 0 0 0
Bud 0 0 1 4 5 6 18 30 29 16 33 26 0 0 0 0 1 0 1 1 3 0 1 3
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 2 0 0 0 0 0 3 4 5 2 2 0 0 1 3 0 1 0 0 0 0 0 0
Cytoplasm 51 191 153 233 215 390 465 541 463 451 447 559 13 24 30 60 58 69 5 18 9 3 7 10
Endoplasmic Reticulum 6 10 5 1 8 11 19 20 4 4 7 6 4 9 9 5 3 4 0 3 8 1 3 1
Endosome 10 30 86 95 75 37 36 52 15 25 20 26 3 11 7 11 6 17 14 37 63 16 29 42
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 1 2 0 1 0
Mitochondria 14 50 90 126 113 346 556 357 336 308 366 373 5 0 0 7 8 2 7 20 20 4 11 8
Nucleus 23 14 4 1 8 10 19 16 6 3 4 4 7 10 15 11 12 15 5 5 1 3 5 3
Nuclear Periphery 1 6 3 0 1 1 21 13 0 5 1 5 1 4 4 7 0 3 4 6 43 3 5 8
Nucleolus 0 0 1 1 1 0 4 4 2 0 2 1 1 0 0 0 0 0 0 1 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 1 0 1 2 3 1 1 1 1 0 0 1 0 0 0 1 1 0 1 2
Vac/Vac Membrane 231 289 401 234 325 323 269 310 190 211 197 289 51 156 164 177 167 182 266 442 504 118 223 247
Unique Cell Count 284 493 605 514 582 874 1075 1067 780 780 817 992 75 187 212 240 223 250 308 549 665 153 298 331
Labelled Cell Count 336 593 744 696 752 1124 1408 1349 1052 1030 1080 1293 86 214 233 283 255 293 308 549 665 153 298 331


Ambiguous

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.4 4.9 5.0 5.0 5.2 4.6 4.3 4.8 4.6 4.6 4.6 4.4 6.0 6.2 6.5 7.0 6.7 6.7 5.7 5.9 6.2
Std Deviation (1e-4) 0.7 1.1 1.2 1.4 1.0 1.5 0.9 1.1 1.0 0.9 0.9 0.8 1.1 0.8 0.8 1.3 1.3 1.4 0.8 1.2 1.4
Intensity Change (Log2) – – – -0.0 0.06 -0.11 -0.2 -0.05 -0.12 -0.12 -0.12 -0.17 0.27 0.32 0.39 0.49 0.43 0.43 0.2 0.25 0.32

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 7.0 4.3 7.6 7.3 10.1 12.7 12.1 11.1 12.1 -1.5 -3.6 -3.3 -0.1 0.2 0.7
Endoplasmic Reticulum 0 0.9 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 1.9 -0.7 0 0 0 0 0 0 0 -2.5 -3.0 -4.3 -4.0 -4.7 -3.0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.1 2.1 0 0 0 0 0 0 0 -1.9 -5.6 -6.0 -4.9 -4.5 -6.0
Nucleus 0 1.2 0.9 1.9 1.5 0 0 0 0 0 0 0 0 0 4.8
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -7.0 -3.7 -11.1 -16.6 -14.8 -15.6 -14.6 -15.9 -14.5 0.3 4.5 3.0 2.1 2.4 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.5486 0.9932 0.9532 0.9094 0.2312 0.9505 2.476 3.1245 2.8752 2.9287 2.6411 2.9634 0.9174 1.8203 1.3578 0.7687 1.1823 1.3626
Actin 0.0003 0.0011 0 0.0001 0 0.0001 0.0025 0 0.0011 0 0 0 0.0937 0.0002 0.0002 0 0 0
Bud 0.0003 0.0011 0.0004 0.0005 0.0004 0.0004 0.0004 0.001 0.0016 0.0012 0.0002 0.0003 0.0002 0.0005 0.0003 0.0001 0.0005 0.0003
Bud Neck 0.0005 0.0002 0.0002 0.0004 0.0003 0.0005 0.0006 0.0009 0.0005 0.0077 0.0004 0.0007 0.0004 0.0071 0.0002 0.0001 0.0001 0.0001
Bud Periphery 0.0005 0.0012 0.0013 0.0007 0.0005 0.0008 0.0009 0.0024 0.0017 0.0019 0.0005 0.0009 0.0003 0.0006 0.0003 0.0002 0.0009 0.0007
Bud Site 0.0026 0.0016 0.0004 0.0005 0.0007 0.0003 0.0015 0.0023 0.0039 0.0009 0.0003 0.0003 0.0009 0.0083 0.0007 0.0001 0.0004 0.0001
Cell Periphery 0.0005 0.0003 0.0003 0.0003 0.0001 0.0002 0.0005 0.0004 0.0005 0.0002 0.0002 0.0003 0.0002 0.0014 0.0004 0.0002 0.0004 0.0002
Cytoplasm 0.02 0.0558 0.0498 0.044 0.0122 0.046 0.0289 0.0482 0.0393 0.021 0.0137 0.037 0.016 0.054 0.0984 0.0012 0.055 0.0219
Cytoplasmic Foci 0.0177 0.0203 0.0185 0.0312 0.0241 0.0325 0.0165 0.0143 0.0201 0.016 0.0087 0.0193 0.0255 0.017 0.0307 0.0007 0.0082 0.0092
Eisosomes 0 0 0 0 0 0 0 0 0 0 0 0 0.0003 0.0001 0 0 0 0
Endoplasmic Reticulum 0.0065 0.0078 0.0031 0.0036 0.0024 0.0058 0.0061 0.0141 0.0083 0.0023 0.0027 0.0049 0.0025 0.0093 0.0032 0.0007 0.0084 0.0019
Endosome 0.3036 0.2641 0.2956 0.2853 0.2756 0.3144 0.2785 0.2087 0.2868 0.3173 0.227 0.257 0.2213 0.2214 0.2174 0.1373 0.1832 0.2238
Golgi 0.0048 0.0035 0.0047 0.006 0.0038 0.0041 0.0073 0.0028 0.0067 0.0045 0.002 0.0034 0.005 0.0093 0.0209 0.0011 0.0013 0.0017
Lipid Particles 0.0098 0.009 0.0044 0.0072 0.0048 0.0042 0.0064 0.0047 0.005 0.0007 0.0035 0.0048 0.0489 0.0157 0.0012 0.0009 0.0026 0.0006
Mitochondria 0.0077 0.0109 0.0133 0.0137 0.0039 0.0103 0.0079 0.0083 0.0232 0.002 0.0029 0.0108 0.0048 0.0166 0.0008 0.0007 0.0045 0.0015
None 0.0297 0.0208 0.0276 0.0913 0.0431 0.0304 0.0352 0.0226 0.0285 0.0024 0.0653 0.0184 0.077 0.0692 0.0244 0.0001 0.1478 0.0036
Nuclear Periphery 0.0332 0.036 0.0128 0.0098 0.0089 0.0205 0.0151 0.0258 0.019 0.0059 0.0081 0.0197 0.0042 0.0215 0.0071 0.0052 0.017 0.0116
Nucleolus 0.0017 0.0009 0.0016 0.0009 0.0014 0.0012 0.0025 0.0015 0.0028 0.0008 0.0005 0.0011 0.0006 0.0052 0.0014 0.0003 0.0021 0.0005
Nucleus 0.0087 0.0048 0.0046 0.0033 0.0034 0.0063 0.0077 0.0047 0.0071 0.0051 0.0015 0.0062 0.0019 0.0048 0.0328 0.0007 0.0135 0.0039
Peroxisomes 0.0012 0.0024 0.0007 0.0014 0.0006 0.0013 0.0065 0.0005 0.0012 0.0005 0.0003 0.0008 0.01 0.001 0.0017 0.0001 0.0003 0.0002
Punctate Nuclear 0.0022 0.0009 0.0006 0.0011 0.0013 0.0021 0.0026 0.0006 0.0012 0.0003 0.0002 0.0012 0.0015 0.0014 0.0002 0 0.001 0.0001
Vacuole 0.3821 0.3146 0.3492 0.2859 0.3305 0.3038 0.4028 0.3829 0.3368 0.4366 0.3818 0.3437 0.3812 0.4169 0.4265 0.4929 0.2434 0.4078
Vacuole Periphery 0.1663 0.2425 0.2108 0.2127 0.2819 0.2148 0.1695 0.2531 0.2045 0.1729 0.2801 0.2693 0.1036 0.1183 0.1312 0.3575 0.3094 0.3104

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.7332 12.3187 15.6703 16.1829 15.7397 16.0681 18.3124 19.6153 18.0751 18.6471
Translational Efficiency 0.56 0.5329 0.4564 0.4042 0.3828 0.5462 0.3792 0.3476 0.3911 0.3573

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1661 1843 2493 109 1620 1386 1958 1891 3281 3229 4451 2000

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 677.83 834.40 957.01 1127.75 614.41 743.14 964.46 962.22 646.52 795.23 960.29 971.24
Standard Deviation 81.18 116.23 119.07 139.09 96.54 93.88 124.65 147.06 94.57 116.34 121.62 151.38
Intensity Change Log 2 — 0.299816 0.497611 0.734452 — 0.274432 0.650520 0.647165 — 0.287803 0.572336 0.693608

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000053 0.000115 0.000012 0.000178 0.000068 0.000050 0.000015 0.000036 0.000060 0.000087 0.000013 0.000044
Bud Neck 0.011529 0.003993 0.008177 0.014241 0.014465 0.004136 0.006297 0.004739 0.012979 0.004054 0.007350 0.005257
Bud Site 0.004213 0.005842 0.003443 0.011304 0.010157 0.005716 0.005831 0.009898 0.007148 0.005788 0.004494 0.009975
Cell Periphery 0.000076 0.000083 0.000082 0.000051 0.000171 0.000170 0.000042 0.000144 0.000123 0.000120 0.000064 0.000139
Cytoplasm 0.329246 0.031088 0.006407 0.004852 0.150926 0.015619 0.022721 0.009410 0.241200 0.024448 0.013583 0.009161
Cytoplasmic Foci 0.199030 0.046980 0.001028 0.007633 0.121355 0.024975 0.004710 0.006797 0.160678 0.037535 0.002648 0.006843
Eisosomes 0.000074 0.000017 0.000009 0.000011 0.000061 0.000019 0.000006 0.000008 0.000067 0.000018 0.000008 0.000008
Endoplasmic Reticulum 0.003862 0.005797 0.003794 0.001973 0.006984 0.013610 0.001761 0.001959 0.005404 0.009150 0.002900 0.001960
Endosome 0.065271 0.086316 0.015465 0.052208 0.120546 0.068559 0.025995 0.055832 0.092563 0.078694 0.020097 0.055634
Golgi 0.002116 0.003165 0.000467 0.003060 0.004577 0.003814 0.001433 0.004760 0.003331 0.003444 0.000892 0.004667
Lipid Particles 0.011834 0.002753 0.000326 0.000486 0.013615 0.005515 0.000313 0.000441 0.012713 0.003938 0.000320 0.000443
Mitochondria 0.004270 0.007236 0.001287 0.000437 0.009106 0.013912 0.001188 0.002505 0.006657 0.010102 0.001243 0.002392
Mitotic Spindle 0.002055 0.000984 0.000432 0.012745 0.000551 0.000860 0.001471 0.000944 0.001312 0.000931 0.000889 0.001588
None 0.001261 0.000165 0.000160 0.000077 0.004416 0.000829 0.000199 0.000463 0.002819 0.000450 0.000177 0.000442
Nuclear Periphery 0.001065 0.000862 0.002010 0.003731 0.001655 0.002097 0.001079 0.000968 0.001356 0.001392 0.001601 0.001118
Nuclear Periphery Foci 0.000597 0.000311 0.000261 0.002162 0.001023 0.000705 0.000287 0.000387 0.000807 0.000480 0.000272 0.000483
Nucleolus 0.001435 0.000641 0.005648 0.005768 0.004073 0.001434 0.003943 0.002541 0.002738 0.000981 0.004898 0.002717
Nucleus 0.061048 0.004715 0.025780 0.006757 0.037989 0.011066 0.014445 0.005351 0.049663 0.007441 0.020794 0.005427
Peroxisomes 0.002595 0.000799 0.000147 0.000814 0.002401 0.000863 0.000340 0.000462 0.002500 0.000827 0.000232 0.000481
Vacuole 0.290057 0.626245 0.733254 0.698529 0.416162 0.603623 0.725814 0.669090 0.352322 0.616535 0.729981 0.670694
Vacuole Periphery 0.008314 0.171895 0.191811 0.172984 0.079698 0.222427 0.182110 0.223267 0.043560 0.193585 0.187543 0.220526

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.34 6.12 -1.32 -0.71 -1.68 0.80 2.68 1.50 0.85 -2.09 -0.92 4.57 1.03 1.44 -2.91
Bud Neck 7.80 2.84 -0.76 -2.23 -1.33 9.52 7.28 8.99 -0.91 2.51 12.34 6.97 8.83 -2.00 3.29
Bud Site -2.24 1.05 -1.92 -1.54 -2.07 3.59 4.63 0.06 -3.21 -3.86 1.92 4.70 -3.01 -4.16 -5.79
Cell Periphery -0.91 -0.31 1.81 2.12 1.31 0.03 8.37 0.99 0.95 -4.54 0.21 4.58 -0.73 -0.83 -3.19
Cytoplasm 45.91 51.38 48.12 7.77 -0.03 26.58 23.44 27.98 2.41 6.15 48.91 51.51 52.15 7.89 3.08
Cytoplasmic Foci 33.56 48.71 35.08 9.48 -1.87 26.61 35.67 34.73 10.71 -3.12 40.89 58.53 55.89 21.11 -7.19
Eisosomes 15.03 20.11 14.66 1.37 -1.02 10.10 14.03 13.46 7.22 -3.26 17.48 23.56 23.09 6.75 -0.63
Endoplasmic Reticulum -3.81 -0.04 1.81 3.91 1.95 -5.41 8.73 8.28 10.64 -0.87 -6.11 6.82 9.06 13.31 5.22
Endosome -5.98 20.10 1.34 3.61 -4.11 11.66 27.45 16.14 3.44 -11.72 4.69 33.52 12.06 7.75 -15.32
Golgi -1.85 3.58 -0.57 0.05 -1.59 0.87 5.86 -0.22 -1.01 -5.39 -0.26 6.91 -1.96 -1.77 -6.44
Lipid Particles 12.00 16.21 15.58 7.54 -1.92 6.75 13.07 12.90 7.94 -1.34 12.66 20.04 19.65 10.88 -1.48
Mitochondria -2.68 3.23 4.25 9.01 2.32 -3.31 11.12 8.78 8.62 -4.05 -3.93 9.22 6.87 10.36 -3.51
Mitotic Spindle 1.15 1.82 -1.79 -1.92 -1.97 -0.93 -2.11 -1.59 -0.34 1.07 0.75 0.67 -0.90 -1.64 -1.59
None 2.99 3.02 3.20 1.23 1.69 3.39 4.12 3.81 1.14 -1.39 4.30 4.90 4.21 0.05 -1.52
Nuclear Periphery 0.86 -3.70 -1.27 -1.35 -0.83 -1.03 1.86 1.84 2.39 0.57 -0.17 -1.74 0.58 0.64 1.66
Nuclear Periphery Foci 3.93 3.92 -1.41 -1.54 -1.55 1.47 5.67 4.30 1.52 -1.23 3.13 6.83 1.39 -0.69 -2.06
Nucleolus 4.10 -11.09 -1.58 -1.82 -0.29 5.49 -0.08 2.43 -2.35 2.60 6.97 -6.73 -0.17 -3.95 4.22
Nucleus 25.05 12.05 17.03 -1.36 6.76 9.38 8.15 12.88 3.22 7.44 23.41 13.75 25.05 1.72 12.73
Peroxisomes 5.51 7.86 3.79 -0.14 -2.06 5.64 8.32 7.88 2.95 -1.68 7.88 11.38 9.95 3.73 -4.50
Vacuole -42.27 -62.99 -15.79 -2.47 1.73 -19.47 -38.32 -29.97 -7.48 7.88 -42.15 -69.29 -46.60 -7.96 9.75
Vacuole Periphery -39.25 -49.80 -8.06 0.17 1.09 -22.25 -20.22 -25.24 0.09 -7.04 -39.64 -45.62 -35.51 -4.38 -6.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar membrane cation-chloride cotransporter (CCC); likely mediates K+ and Cl- cotransport into the vacuole; has a role in potassium homeostasis and salt tolerance; localizes to sites of contact between the vacuole and mitochondria (vCLAMPs); similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family
Localization
Cell Percentages vacuolar membrane (24%), cytoplasm (19%), mixed (18%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Vhc1

Vhc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vhc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available