Standard name
Human Ortholog
Description 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
DOWNLOAD

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 1.0 0.97 0.97 0.92 0.89 0.79 0.59 0.37 0.39 0.3 0.37 0.17 0.61 0.96 0.99 0.98 0.99 0.55 0.49 0.71 0.51 0.65 0.72
Endoplasmic Reticulum 0 0 0 0 0 0.05 0.06 0.07 0.08 0 0.07 0 0 0 0 0 0.06 0 0.05 0.05 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0.07 0.09 0.18 0.18 0.12 0.14 0.81 0.2 0 0 0 0 0.24 0.31 0.14 0.33 0.17 0.11
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0.07 0.06 0.09 0.06 0.05 0.09 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.09 0.19 0.28 0.3 0.43 0.39 0 0.07 0 0 0 0 0 0.07 0 0.08 0.06 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 1 2 3 1 3 0 0 0 0 0 0 0 0 1 0 0 1
Bud 0 0 0 0 0 0 1 0 1 2 1 0 0 0 1 0 1 0 1 2 0 1 6 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 3 1 1 2 2 0 0 0 0 0 1 0 2 0 0 0 0 1 0
Cytoplasm 109 17 88 125 128 139 142 86 66 56 27 37 25 69 135 229 162 202 51 46 108 65 160 180
Endoplasmic Reticulum 0 0 1 0 6 8 11 10 15 5 6 3 0 2 3 8 10 9 4 4 5 1 4 5
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 1 0 0 2 0 6 4 4 0 3 0 2 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 2 1 2 2 0 4 0 0 1 0 0 0 0 0 0 0 0
Nucleus 1 0 1 2 1 1 13 13 32 26 11 14 118 23 0 0 0 0 22 29 21 41 42 27
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 0
Nucleolus 2 0 0 1 0 1 1 5 12 9 8 6 8 10 1 0 0 0 0 0 0 0 2 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0
Vac/Vac Membrane 0 0 1 2 5 6 16 28 49 42 39 39 2 8 2 0 0 0 2 7 5 10 15 15
Unique Cell Count 111 17 91 129 139 156 179 147 178 142 91 99 146 113 140 231 165 204 95 95 152 128 247 250
Labelled Cell Count 112 17 92 130 140 160 185 152 184 151 95 105 157 114 142 239 173 213 95 95 152 128 247 250


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 152.3 198.7 136.6 130.0 104.8 78.9 58.9 54.3 47.3 44.3 38.3 41.7 152.8 146.1 146.9 211.8 227.9 219.0 137.8 145.8 150.7
Std Deviation (1e-4) 39.8 57.6 30.3 32.0 26.8 19.0 14.8 14.8 10.6 11.8 12.5 13.2 48.8 46.5 45.2 58.8 71.7 68.3 43.4 40.5 42.6
Intensity Change (Log2) – – – -0.07 -0.38 -0.79 -1.21 -1.33 -1.53 -1.62 -1.83 -1.71 0.16 0.1 0.1 0.63 0.74 0.68 0.01 0.09 0.14


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.1 -1.4 -2.1 -3.8 -6.5 -9.4 -8.8 -9.4 -8.6 -11.9 -6.0 -0.1 1.6 0.7 1.4
Endoplasmic Reticulum 0 0 0 0 0 2.4 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 2.5 4.0 4.0 3.0 3.3 11.9 4.2 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.5 4.1 5.3 5.5 6.8 6.5 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 60.873 209.0777 205.8403 166.4663 115.1939 103.7642 135.3797 174.5884 167.2258 149.1026 121.9713 150.5156 127.3028 173.0921 157.8855 140.165 109.1312 148.7444
Actin 0.0211 0.0026 0.009 0.0044 0.0244 0.048 0.0003 0.0002 0.0002 0.0002 0.001 0.0001 0.0101 0.0002 0.0001 0.0532 0.0049 0.0002
Bud 0.0124 0.0009 0.0001 0.004 0.0008 0.0055 0.0007 0.0005 0.0002 0.0002 0.0028 0.0001 0.0017 0.0008 0.0002 0.001 0.005 0.0003
Bud Neck 0.0012 0.0003 0.0008 0.0004 0.0004 0.0018 0 0.0001 0.0002 0.0001 0.0004 0.0004 0.0002 0.0001 0.0001 0.0011 0.0004 0.0005
Bud Periphery 0.006 0.0003 0 0.006 0.0005 0.005 0.0001 0.0001 0 0 0.0009 0 0.0007 0.0002 0.0001 0.0006 0.0017 0.0001
Bud Site 0.0082 0.0006 0.0001 0.0037 0.0003 0.0093 0 0.0001 0 0 0.001 0 0.0008 0.0002 0.0001 0.0044 0.0009 0
Cell Periphery 0.0068 0.0001 0 0.0004 0.0006 0.0009 0 0.0001 0 0 0.0019 0 0.0008 0.0006 0.0001 0.0001 0.001 0.0001
Cytoplasm 0.2752 0.794 0.6386 0.5533 0.4622 0.4255 0.222 0.6145 0.5401 0.6438 0.3945 0.2951 0.3451 0.6196 0.4687 0.447 0.3872 0.6784
Cytoplasmic Foci 0.1261 0.001 0.002 0.0021 0.0453 0.0402 0 0.0001 0.0003 0.0009 0.0567 0 0.0314 0.0034 0.0108 0.0195 0.0109 0.0003
Eisosomes 0.0012 0 0 0.0001 0.001 0.0002 0 0 0 0 0.0003 0 0.0002 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.0045 0.0001 0.0001 0.0035 0.0041 0.0141 0.0001 0.0001 0.0001 0.0006 0.0013 0.0002 0.0009 0.0001 0.0001 0.0003 0.0011 0.0006
Endosome 0.0507 0.0001 0.0008 0.0076 0.0161 0.1228 0 0 0.0001 0.0022 0.0015 0 0.0035 0.0012 0.0001 0.0031 0.0571 0.0003
Golgi 0.0233 0.0003 0.0026 0.0024 0.0184 0.0356 0 0 0 0.0001 0.0003 0 0.0015 0.0012 0 0.0094 0.0453 0
Lipid Particles 0.0319 0.0002 0.0003 0.0003 0.0106 0.0104 0 0 0 0 0.0067 0 0.0079 0.0002 0.0011 0.0005 0.0048 0
Mitochondria 0.0268 0.0011 0.0005 0.0548 0.0553 0.0205 0.0045 0.0006 0.0005 0.0006 0.0099 0.0002 0.0092 0.0006 0.0024 0.0014 0.0967 0.0003
None 0.0326 0.0012 0.0003 0.0019 0.0405 0.0176 0.0002 0.0002 0.0004 0.0002 0.0391 0 0.0118 0.0012 0.0036 0.0002 0.0093 0.0003
Nuclear Periphery 0.0166 0.0104 0.0212 0.0161 0.0358 0.0445 0.0219 0.0155 0.0186 0.0137 0.0445 0.0403 0.0491 0.0214 0.0326 0.032 0.0347 0.0427
Nucleolus 0.1003 0.0034 0.0006 0.0004 0.0192 0.0117 0.0005 0.0007 0.0024 0.0001 0.0385 0.0001 0.0233 0.0016 0.0069 0.0002 0.0021 0.0015
Nucleus 0.1836 0.1806 0.3187 0.3331 0.2522 0.1619 0.7483 0.3659 0.4341 0.3353 0.3713 0.6625 0.4851 0.3445 0.4684 0.417 0.3245 0.2687
Peroxisomes 0.0161 0.0004 0.0012 0.0006 0.0023 0.0039 0 0 0 0 0.0008 0 0.001 0.0003 0.0002 0.008 0.0022 0
Punctate Nuclear 0.0254 0.0005 0.0028 0.0005 0.0017 0.0074 0.0002 0.0003 0.0014 0.0002 0.0056 0.0003 0.007 0.001 0.0016 0.0007 0.0006 0.0006
Vacuole 0.0223 0.0014 0.0002 0.003 0.0031 0.0082 0.0003 0.0007 0.0007 0.0009 0.0135 0.0004 0.0047 0.0013 0.0013 0.0002 0.007 0.0031
Vacuole Periphery 0.0077 0.0007 0.0002 0.0015 0.0052 0.0049 0.0007 0.0003 0.0006 0.0009 0.0074 0.0004 0.0041 0.0003 0.0014 0.0002 0.0025 0.0017

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 436.2066 410.3254 372.8719 333.0201 335.4805 457.7634 413.5355 358.6379 344.4213 356.2968
Translational Efficiency 1.7295 1.8796 1.8095 1.8158 2.1107 2.0059 1.815 1.9773 1.8784 1.9757

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
57 273 142 1320 1793 1352 184 1117 1850 1625 326 2437

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 10537.16 12689.92 6740.52 5327.89 11322.13 11544.80 6240.82 4391.99 11297.94 11737.18 6458.48 4898.92
Standard Deviation 3707.40 3347.65 1558.65 1642.68 2670.02 2715.93 1323.39 1534.72 2711.32 2864.11 1451.93 1660.91
Intensity Change Log 2 — 0.268197 -0.644554 -0.983850 — 0.028098 -0.859338 -1.366199 — 0.148829 -0.751807 -1.169236

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001024 0.000148 0.000254 0.002369 0.000072 0.000071 0.000353 0.002263 0.000101 0.000084 0.000310 0.002321
Bud Neck 0.007898 0.004509 0.012120 0.012532 0.003047 0.001271 0.012413 0.020285 0.003196 0.001815 0.012285 0.016086
Bud Site 0.006524 0.002147 0.001282 0.018499 0.000434 0.000458 0.002697 0.038588 0.000621 0.000742 0.002080 0.027707
Cell Periphery 0.004698 0.000990 0.001431 0.001063 0.000203 0.000254 0.001262 0.000915 0.000342 0.000377 0.001336 0.000995
Cytoplasm 0.182341* 0.212605* 0.098856 0.266742* 0.192018* 0.211342* 0.081549 0.251868* 0.191720* 0.211554* 0.089088 0.259925*
Cytoplasmic Foci 0.036199 0.011603 0.010677 0.019090 0.001092 0.002687 0.012921 0.043482 0.002174 0.004185 0.011944 0.030270
Eisosomes 0.000037 0.000003 0.000006 0.000011 0.000002 0.000001 0.000010 0.000021 0.000003 0.000002 0.000008 0.000016
Endoplasmic Reticulum 0.002888 0.000074 0.000141 0.000578 0.000100 0.000052 0.000231 0.001234 0.000186 0.000056 0.000192 0.000879
Endosome 0.005533 0.000086 0.000275 0.006847 0.000026 0.000047 0.012362 0.026722 0.000196 0.000053 0.007097 0.015957
Golgi 0.007003 0.000594 0.000478 0.007827 0.000060 0.000177 0.003191 0.024460 0.000274 0.000247 0.002009 0.015451
Lipid Particles 0.002777 0.000335 0.002545 0.001965 0.000037 0.000073 0.001729 0.013364 0.000121 0.000117 0.002084 0.007190
Mitochondria 0.001413 0.000917 0.001519 0.003579 0.000535 0.000509 0.003211 0.004166 0.000562 0.000578 0.002474 0.003848
Mitotic Spindle 0.000574 0.001973 0.022590 0.102424* 0.000821 0.000537 0.043630 0.150036* 0.000814 0.000778 0.034466 0.124247*
None 0.003379 0.007488 0.007007 0.029379 0.007275 0.009436 0.007297 0.040742 0.007155 0.009109 0.007171 0.034587
Nuclear Periphery 0.002061 0.001539 0.007749 0.004775 0.000335 0.000366 0.010468 0.002434 0.000388 0.000563 0.009284 0.003702
Nuclear Periphery Foci 0.007670 0.001852 0.006081 0.008153 0.000142 0.000290 0.005403 0.008749 0.000374 0.000553 0.005698 0.008426
Nucleolus 0.003345 0.000348 0.000443 0.001306 0.000164 0.000121 0.000479 0.001818 0.000262 0.000159 0.000463 0.001541
Nucleus 0.677704* 0.749885* 0.817614* 0.491512* 0.792332* 0.769667* 0.788813* 0.344049* 0.788800* 0.766343* 0.801358* 0.423922*
Peroxisomes 0.000743 0.000019 0.000034 0.000290 0.000003 0.000004 0.000707 0.001428 0.000026 0.000007 0.000414 0.000812
Vacuole 0.045257 0.002309 0.008716 0.015166 0.000685 0.001446 0.009803 0.018367 0.002058 0.001591 0.009329 0.016633
Vacuole Periphery 0.000934 0.000574 0.000182 0.005891 0.000614 0.001190 0.001470 0.005008 0.000624 0.001087 0.000909 0.005486

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.77 1.86 0.34 -2.51 -1.53 -0.80 -7.48 -4.43 -4.38 -0.14 -0.24 -8.94 -4.78 -4.76 -1.06
Bud Neck 1.61 -2.90 0.07 -3.58 3.72 2.94 -7.21 -11.61 -13.06 4.36 1.33 -9.30 -14.95 -15.87 5.79
Bud Site 1.19 -0.10 -1.24 -4.37 -1.88 -0.74 -6.22 -8.98 -8.88 -2.81 -1.41 -7.63 -11.56 -11.06 -3.09
Cell Periphery 3.20 1.99 3.40 1.34 4.77 -3.42 -8.99 -11.46 -7.79 6.59 -2.25 -10.61 -9.12 -7.20 8.08
Cytoplasm -0.67 4.90 -2.42 -2.86 -17.22 -2.05 20.36 -6.58 -4.66 -24.56 -1.95 20.49 -7.09 -5.15 -29.69
Cytoplasmic Foci 1.95 -0.38 2.40 1.21 3.64 -5.73 -6.19 -10.81 -8.69 2.17 -5.99 -7.96 -12.75 -8.15 4.32
Eisosomes 2.94 1.93 2.48 -4.08 2.56 1.48 -8.77 -11.16 -11.89 5.63 1.64 -10.00 -12.17 -15.49 6.17
Endoplasmic Reticulum 1.73 1.59 1.50 -8.65 -2.91 4.28 -7.93 -5.63 -6.50 0.50 2.75 -4.32 -4.70 -10.75 -0.58
Endosome 1.58 1.34 0.88 -4.91 -3.02 -1.47 -1.57 -4.93 -4.90 -1.53 1.06 -1.78 -6.20 -6.44 -1.76
Golgi 1.10 0.99 0.79 -2.03 -1.33 -1.52 -3.44 -3.98 -3.86 -2.72 -0.26 -3.90 -4.71 -4.72 -2.94
Lipid Particles 2.90 -1.19 -0.22 -10.93 1.39 -2.05 -5.42 -7.96 -7.57 -0.37 -1.53 -7.13 -12.24 -11.53 0.78
Mitochondria 1.60 -1.43 -1.14 -3.74 0.33 -0.05 -8.52 -5.49 -5.38 2.89 -1.24 -11.33 -8.74 -8.06 2.36
Mitotic Spindle -1.63 -4.32 -15.21 -14.28 -2.99 -0.25 -4.22 -14.51 -14.49 -3.25 -0.61 -5.95 -20.75 -20.70 -4.40
None -5.38 -6.14 -13.74 -10.46 -6.94 -1.97 -1.15 -8.84 -8.51 -7.47 -1.80 -1.92 -11.43 -12.40 -10.20
Nuclear Periphery 0.97 -4.83 -3.31 -5.75 3.47 -2.97 -5.86 -18.87 -17.45 3.80 -2.35 -8.59 -21.31 -17.83 4.96
Nuclear Periphery Foci 1.40 -0.91 -0.33 -3.82 1.01 -2.60 -4.11 -9.73 -8.64 1.82 -1.68 -5.70 -10.89 -9.51 1.99
Nucleolus 1.61 0.95 0.99 -5.47 0.27 0.28 -4.10 -7.85 -8.04 -0.09 0.57 -5.69 -10.79 -12.33 0.19
Nucleus -2.47 -0.45 4.62 15.78 6.25 3.02 4.61 33.69 31.03 9.63 3.06 5.82 38.61 35.93 10.99
Peroxisomes 2.06 1.62 1.72 -4.30 0.82 -1.80 -3.21 -4.23 -4.21 -0.66 1.24 -3.96 -5.16 -5.51 -0.15
Vacuole 2.89 0.90 -0.67 -16.25 -3.71 -2.73 -7.22 -18.14 -17.81 -4.72 -0.56 -8.71 -24.07 -24.03 -5.33
Vacuole Periphery 0.76 1.66 -0.82 -1.44 -2.09 -0.61 0.32 -0.62 0.15 -1.52 -0.55 0.42 -0.91 -0.23 -2.53
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Aro4

Aro4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Aro4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available