Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.19 0.05 0 0 0 0 0 0.06 0.08
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.14 0.06 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.19 0.19 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.15 0 0 0.06 0 0 0 0 0 0 0.06 0.09 0.12 0.38 0.62 0.55 0.09 0.14 0.06 0.13 0.16 0.16
Mitochondria 0.87 0.84 0.94 0.96 0.89 0.88 0.85 0.91 0.91 0.93 0.93 0.95 0.93 0.88 0 0 0.06 0.78 0.71 0.79 0.66 0.6 0.6
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0 0 0.1 0.09 0.11 0.06 0.08 0.12 0 0.05 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0 0 0.05 0.05 0.13 0.11 0.12 0.09 0.08 0.09 0 0 0 0.06 0.05 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.08 0.05
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.24 0.17 0.08 0 0.1 0.05 0.05 0.06 0 0 0 0.1 0.08 0.11 0.25 0.05 0.26 0.06 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 8 1 2 0 0 0 0 0 1 0 1 2 1 3 1 1 4 8 4 3 20 32
Bud 2 1 8 6 2 3 8 14 13 13 15 0 5 5 0 0 1 1 1 0 0 2 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 1 0 1 0 0 1 5 5 2 7 7 1 0 1 0 0 0
Cell Periphery 5 11 3 5 1 0 1 2 3 3 5 11 3 2 0 3 3 1 0 0 0 0 1
Cytoplasm 0 2 4 4 11 3 10 5 7 5 5 3 3 4 3 4 4 0 1 1 0 0 0
Endoplasmic Reticulum 5 5 10 1 3 5 2 2 2 3 4 3 7 1 1 0 0 3 1 1 0 1 3
Endosome 3 0 0 0 6 3 10 2 5 0 0 1 5 4 0 0 0 9 3 7 6 10 9
Golgi 20 39 2 0 18 1 1 0 1 2 1 17 38 58 6 13 26 43 39 11 22 52 69
Mitochondria 404 223 187 264 252 301 565 353 553 432 577 281 403 410 0 0 3 393 202 158 110 197 256
Nucleus 0 1 2 1 1 3 6 1 3 3 3 0 0 2 0 1 1 0 1 1 0 1 0
Nuclear Periphery 18 6 11 12 10 34 59 42 37 36 77 11 23 14 0 0 1 3 3 0 1 1 4
Nucleolus 22 6 7 13 14 44 75 48 52 39 53 10 17 9 1 1 0 0 1 0 1 2 2
Peroxisomes 0 4 0 3 2 1 11 1 12 2 3 1 6 13 0 0 0 3 4 9 10 26 21
SpindlePole 0 1 0 0 0 0 8 4 5 8 3 0 0 1 0 0 0 1 0 0 1 1 1
Vac/Vac Membrane 112 45 16 5 27 17 35 23 18 14 12 30 36 50 4 1 12 31 14 2 5 11 15
Unique Cell Count 465 266 199 275 284 344 668 387 608 463 622 297 432 466 16 21 47 502 286 202 166 330 426
Labelled Cell Count 594 352 252 316 347 416 796 502 713 568 765 370 548 575 18 24 52 502 286 202 166 330 426


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.5 13.1 8.1 10.5 11.5 9.0 8.8 7.7 8.1 7.8 7.9 12.0 12.3 11.9 16.2 16.2 17.2 10.9 12.3 12.6
Std Deviation (1e-4) 2.1 2.0 2.1 2.2 2.8 2.1 2.4 2.0 2.3 2.3 2.2 2.1 2.4 2.3 4.5 4.1 4.0 2.4 2.5 2.6
Intensity Change (Log2) 0.37 0.5 0.15 0.11 -0.07 -0.0 -0.06 -0.05 0.57 0.59 0.55 1.0 1.0 1.08 0.43 0.6 0.63


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud -1.2 0 0 0 -0.2 -1.4 -0.8 -1.2 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 1.4 0 0 0 0 0
Cytoplasm 0 1.2 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 -2.7 -2.4 0 0 0 0 0 -2.7 -2.5 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 2.9 0 0 0 0 0 0 2.7 3.7 4.7 0 0 10.5
Mitochondria 1.0 -2.0 -2.4 -3.4 -1.2 -1.3 -0.3 -0.6 0.3 -0.3 -2.3 -10.7 -11.5 -12.9
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -0.6 -1.1 1.8 1.5 2.1 0.3 1.0 2.7 -1.0 -0.1 -1.6 0 0 0
Nucleolus 0.6 0.7 3.6 3.3 3.5 2.4 2.3 2.4 -0.1 0.3 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -3.2 0.6 -1.5 -1.5 -1.0 -3.1 -2.8 -4.1 0.8 0.1 1.1 0 0 3.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.9986 10.516 9.831 8.9474 8.9329 10.4524 8.9652 9.6335 9.5781 8.7963 8.1559 9.583 11.7312 11.8607 11.9867 12.307 10.6915 11.6734
Actin 0.011 0.0011 0.0112 0.0108 0.003 0.0029 0.0192 0.0136 0.0055 0.0015 0.0111 0.0118 0.006 0.002 0.0147 0.0005 0.0006 0.0061
Bud 0.0002 0.0003 0.0002 0.0054 0.0002 0.0001 0.0006 0.0002 0.0011 0.0003 0.0003 0.0001 0.0002 0.0005 0.0004 0 0.0001 0
Bud Neck 0.0006 0 0.0002 0.0003 0.0001 0 0.0003 0.0001 0.0001 0.0001 0.0023 0.0001 0.0005 0.0001 0.0001 0 0 0.0001
Bud Periphery 0.0006 0.001 0.0006 0.0084 0.0003 0.0002 0.0013 0.0003 0.0029 0.0004 0.0012 0.0002 0.0004 0.0008 0.0006 0.0002 0.0002 0.0001
Bud Site 0.0006 0.0003 0.0003 0.0045 0.0014 0 0.002 0.0021 0.0023 0.0005 0.0005 0.0001 0.0012 0.0004 0.004 0.0001 0 0
Cell Periphery 0.0007 0.0004 0.0003 0.0003 0.0001 0.0001 0.0003 0.0002 0.0019 0.0001 0.0009 0.0001 0.0003 0.0003 0.0001 0.0002 0 0.0001
Cytoplasm 0.0006 0 0.0002 0.0008 0.0016 0 0.0029 0 0.0003 0 0.0003 0.0001 0.0004 0.0001 0.0005 0 0 0
Cytoplasmic Foci 0.0051 0.0007 0.0006 0.0052 0.0045 0.0021 0.0095 0.0009 0.006 0.012 0.0005 0.0007 0.0125 0.0016 0.0044 0.0007 0.0004 0.0009
Eisosomes 0.0003 0.0002 0.0002 0.0006 0.0003 0.0001 0.0008 0.0006 0.0017 0.0001 0.0005 0.0003 0.0002 0.0002 0.0003 0.0002 0.0001 0.0002
Endoplasmic Reticulum 0.0015 0.0001 0.0003 0.0006 0.0012 0.0001 0.0043 0.0001 0.0002 0 0.0036 0.0004 0.0003 0.0001 0.0004 0 0 0.0001
Endosome 0.0126 0.0046 0.0032 0.0026 0.0032 0.0018 0.0169 0.0062 0.0059 0.0072 0.0105 0.0053 0.0177 0.0147 0.0084 0.0013 0.0045 0.0029
Golgi 0.0123 0.0191 0.0077 0.0018 0.005 0.0099 0.0135 0.0168 0.0096 0.0181 0.0103 0.0181 0.0275 0.0301 0.0125 0.0102 0.0296 0.0174
Lipid Particles 0.0077 0.0068 0.0008 0.0062 0.0108 0.0031 0.0163 0.0032 0.0025 0.0053 0.0014 0.0103 0.0289 0.0036 0.0139 0.0106 0.0029 0.0065
Mitochondria 0.9145 0.9305 0.9634 0.9194 0.9428 0.9758 0.8644 0.9417 0.9445 0.9307 0.9455 0.9423 0.8486 0.9202 0.9207 0.9635 0.9588 0.9537
None 0.0004 0 0.0004 0.0025 0.0027 0 0.0015 0 0.0002 0 0.0001 0.0001 0.0006 0 0.0004 0.0004 0 0
Nuclear Periphery 0.0017 0.0002 0.0007 0.005 0.0051 0 0.013 0.0001 0.0018 0 0.0042 0.002 0.0008 0.0002 0.0009 0.0006 0 0.0005
Nucleolus 0.0015 0.0003 0.0001 0.0055 0.0023 0 0.0007 0.0001 0.0001 0.0001 0.0002 0.0001 0.0006 0.0005 0.0002 0.0051 0.0001 0.0001
Nucleus 0.0006 0.0001 0.0002 0.0033 0.0035 0 0.0013 0.0001 0.0001 0.0001 0.0007 0.0001 0.0002 0.0002 0.0003 0.0012 0 0.0001
Peroxisomes 0.0062 0.0021 0.0015 0.0034 0.0014 0.0015 0.0086 0.0025 0.0018 0.0215 0.0012 0.0027 0.0284 0.0021 0.0054 0.0021 0.0008 0.0045
Punctate Nuclear 0.001 0 0.0006 0.0113 0.0059 0.0001 0.0011 0 0.0005 0.0001 0.0002 0.0003 0.0012 0 0.0012 0.0007 0 0
Vacuole 0.009 0.0046 0.0046 0.0009 0.001 0.0004 0.0051 0.0021 0.0034 0.0006 0.0029 0.001 0.0059 0.0066 0.0021 0.0005 0.0003 0.0009
Vacuole Periphery 0.0113 0.0276 0.0029 0.0012 0.0036 0.0018 0.0166 0.0092 0.0077 0.0012 0.0017 0.0039 0.0177 0.0158 0.0084 0.0017 0.0015 0.0057

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 34.374 36.8739 27.362 33.6614 35.6539 54.9679 43.497 47.1818 55.8246 52.2663
Translational Efficiency 1.3589 1.2924 1.4334 1.7657 1.2453 1.276 1.6622 1.9168 1.3865 1.286

Hit Data

Dataset Hit
Protein Concentration
Protein Localization
Gene Expression
Translational Efficiency

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
202 1437 123 619 1702 2107 1977 1748 1904 3544 2100 2367

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 967.49 1155.77 1498.21 1345.79 904.09 1162.51 1277.13 1274.90 910.82 1159.78 1290.08 1293.44
Standard Deviation 150.15 213.50 216.48 214.14 174.62 206.63 193.34 191.50 173.29 209.47 201.57 200.11
Intensity Change Log 2 0.256536 0.630921 0.476135 0.362705 0.498367 0.495846 0.308798 0.568408 0.485690

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003050 0.008655 0.005083 0.007463 0.005574 0.001888 0.001103 0.005768 0.005307 0.004632 0.001336 0.006211
Bud Neck 0.004071 0.000890 0.012142 0.001430 0.001855 0.000573 0.002225 0.000747 0.002090 0.000702 0.002806 0.000926
Bud Site 0.005692 0.001750 0.005787 0.005951 0.004009 0.001095 0.007698 0.004273 0.004188 0.001360 0.007586 0.004712
Cell Periphery 0.000540 0.000182 0.000228 0.000542 0.000701 0.000115 0.000490 0.000846 0.000684 0.000142 0.000475 0.000766
Cytoplasm 0.000295 0.000380 0.000565 0.000356 0.000755 0.000166 0.001419 0.000570 0.000706 0.000253 0.001369 0.000514
Cytoplasmic Foci 0.020202 0.012214 0.062934 0.011085 0.006070 0.008567 0.006407 0.007311 0.007569 0.010046 0.009718 0.008298
Eisosomes 0.000115 0.000247 0.000204 0.000216 0.000167 0.000101 0.000079 0.000111 0.000161 0.000160 0.000086 0.000138
Endoplasmic Reticulum 0.000429 0.000294 0.000895 0.001054 0.000343 0.000150 0.000124 0.000508 0.000352 0.000208 0.000169 0.000651
Endosome 0.028153 0.009974 0.027764 0.008597 0.011469 0.007189 0.009206 0.007992 0.013239 0.008318 0.010293 0.008150
Golgi 0.037587 0.036502 0.060342 0.066640 0.014553 0.026408 0.013564 0.045595 0.016997 0.030501 0.016303 0.051098
Lipid Particles 0.006115 0.003329 0.005387 0.001323 0.006298 0.002234 0.001508 0.000802 0.006279 0.002678 0.001735 0.000938
Mitochondria 0.853416* 0.901983* 0.677983* 0.857513* 0.924191* 0.935745* 0.902925* 0.897406* 0.916683* 0.922056* 0.889750* 0.886974*
Mitotic Spindle 0.002368 0.001416 0.036517 0.002760 0.000345 0.000458 0.004584 0.002568 0.000560 0.000846 0.006454 0.002618
None 0.000414 0.000686 0.001524 0.000932 0.000578 0.000548 0.000922 0.000518 0.000560 0.000604 0.000957 0.000626
Nuclear Periphery 0.000570 0.000184 0.005382 0.000588 0.000060 0.000102 0.000446 0.000216 0.000114 0.000135 0.000735 0.000313
Nuclear Periphery Foci 0.001202 0.000195 0.003422 0.000350 0.000212 0.000098 0.000381 0.000161 0.000317 0.000137 0.000559 0.000210
Nucleolus 0.003344 0.000166 0.002827 0.000094 0.000177 0.000245 0.000371 0.000324 0.000513 0.000213 0.000515 0.000264
Nucleus 0.001381 0.000459 0.000683 0.000037 0.000108 0.000158 0.000167 0.000077 0.000243 0.000280 0.000197 0.000067
Peroxisomes 0.015645 0.008237 0.021337 0.008700 0.017581 0.004283 0.004970 0.003740 0.017375 0.005886 0.005929 0.005037
Vacuole 0.007707 0.005307 0.027791 0.007567 0.002222 0.004187 0.017874 0.006459 0.002804 0.004641 0.018455 0.006749
Vacuole Periphery 0.007705 0.006951 0.041203 0.016802 0.002733 0.005690 0.023537 0.014009 0.003260 0.006201 0.024572 0.014740

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.24 -1.23 -2.09 0.52 -1.06 3.56 4.47 -0.14 -3.54 -4.39 0.64 4.38 -0.72 -1.46 -5.21
Bud Neck 2.14 -2.71 1.75 -1.70 4.05 3.97 -0.92 3.40 -1.07 4.70 4.29 -1.66 3.48 -1.56 5.57
Bud Site 1.10 -0.06 -0.07 -2.10 -0.02 3.74 -2.78 -0.29 -3.44 2.37 3.60 -2.64 -0.52 -3.90 2.12
Cell Periphery 1.44 1.26 -0.01 -3.63 -3.15 4.55 1.15 -0.47 -2.58 -1.14 4.59 1.22 -0.34 -2.96 -1.19
Cytoplasm -1.20 -3.06 -0.91 0.33 2.29 1.75 -1.41 0.49 -2.75 2.21 1.50 -1.52 0.59 -2.35 2.42
Cytoplasmic Foci 2.00 -3.92 2.18 0.59 5.01 -2.65 -0.43 -1.35 1.22 -0.97 -2.74 -1.99 -0.77 1.92 1.31
Eisosomes -3.44 -2.51 -2.36 0.62 -0.24 3.74 5.29 3.12 -0.77 -2.87 0.04 4.92 1.24 1.18 -3.85
Endoplasmic Reticulum 1.31 -2.62 -1.67 -2.08 -0.39 2.04 2.34 -0.97 -2.50 -2.70 1.68 2.15 -1.82 -3.10 -3.38
Endosome 3.94 0.05 4.24 0.87 3.48 3.15 1.57 2.58 -0.84 1.17 3.77 2.05 3.94 0.20 2.13
Golgi 0.14 -2.01 -3.04 -4.27 -0.59 -5.00 0.55 -9.73 -5.52 -10.33 -6.25 0.37 -11.06 -6.49 -11.66
Lipid Particles 1.32 0.31 2.29 3.24 3.70 3.48 4.00 4.69 2.66 1.31 3.41 4.12 5.05 4.10 1.67
Mitochondria -2.64 5.11 -0.20 3.83 -5.73 -1.94 3.29 3.93 6.16 0.76 -0.96 4.10 4.60 6.32 0.35
Mitotic Spindle 1.36 -3.29 -0.47 -1.77 3.25 -1.14 -6.72 -5.94 -5.50 2.79 -1.57 -6.80 -6.28 -4.84 4.20
None -3.15 -5.15 -4.73 -2.73 2.72 0.66 -6.22 1.35 1.01 9.53 -1.02 -7.51 -1.48 -0.68 7.28
Nuclear Periphery 1.42 -2.08 -0.05 -1.56 2.07 -2.56 -5.49 -2.82 -2.02 2.59 -0.60 -4.02 -2.38 -2.21 2.47
Nuclear Periphery Foci 2.19 -2.20 1.83 -1.43 3.37 1.40 -1.48 0.57 -1.48 2.41 2.00 -1.90 1.12 -1.62 3.42
Nucleolus 1.30 0.13 1.33 1.04 2.04 -0.36 -2.52 -0.56 -0.27 0.12 1.05 -0.04 0.71 -0.25 1.08
Nucleus 0.82 0.62 1.27 1.12 2.59 -0.40 -1.44 0.52 0.60 1.52 -0.19 0.36 1.45 1.22 2.65
Peroxisomes 1.75 -0.82 1.49 -0.17 1.93 6.34 5.85 6.48 0.54 1.11 5.90 5.63 6.12 0.79 0.78
Vacuole 0.99 -3.48 0.04 -1.40 3.67 -3.10 -12.12 -4.61 -2.27 7.56 -3.01 -12.28 -4.79 -2.45 8.27
Vacuole Periphery 0.38 -3.39 -3.27 -4.22 2.45 -4.92 -12.46 -9.03 -6.31 4.67 -5.14 -12.67 -10.35 -7.38 5.01
Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; forms a subcomplex with Mic10p and Mic27p whose assembly and stability requires cardiolipin
Localization
Cell Percentages mitochondrion (96%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mic12

Mic12


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)

Molecular Function (Gene Ontology)

Cellular Component (Gene Ontology)


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mic12-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available