Standard name
Human Ortholog
Description Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.1 0.06 0 0 0 0 0 0 0
Bud 0 0 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0.1 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0.07 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0.1 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0.09 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.07 0 – 0 0 0 0 0 0 0 0 0.05 0.1 0.07 0.05 0 0.06 0.05 0.06 0.06
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0.08 0.15 0.19 0.25 0.26 0.05 0.08 0 0.07 0.1 0.1
Mitochondria 0.91 0.89 0.96 0.96 0.9 0.92 – 0.9 0.94 0.93 0.93 0.97 0.88 0.88 0.82 0 0.12 0.07 0.79 0.79 0.84 0.67 0.66 0.62
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.1 0.08 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.11 – 0.13 0.14 0.09 0.13 0.08 0 0 0 0.14 0.1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.09 – 0.11 0.1 0.11 0.09 0.08 0 0 0 0.05 0.06 0.1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0 0.1 0 0.1 0 0 0 0.05 0.05 0.05
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0
Vac/Vac Membrane 0.17 0.2 0.05 0 0.07 0.07 – 0 0 0 0 0 0.14 0.1 0.12 0.19 0.27 0.19 0 0 0 0.05 0.05 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 5 0 0 0 1 0 – 0 0 0 0 0 3 5 5 2 3 2 5 2 0 6 17 25
Bud 3 4 9 5 8 4 – 15 7 17 9 15 3 2 3 2 1 1 1 1 0 1 5 7
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 5 4
Bud Site 2 0 2 1 0 1 – 4 10 4 3 6 0 0 1 0 1 1 – – – – – –
Cell Periphery 7 11 6 7 2 1 – 5 1 3 3 4 13 17 31 1 2 7 0 0 0 0 1 0
Cytoplasm 3 0 4 3 12 9 – 10 3 4 5 3 14 17 25 1 2 6 0 0 1 1 1 2
Endoplasmic Reticulum 3 0 3 0 0 4 – 1 3 0 2 0 4 8 6 1 2 2 0 0 0 1 2 4
Endosome 11 0 0 5 27 2 – 8 1 2 1 0 18 29 35 1 5 5 20 4 8 12 35 49
Golgi 8 6 0 0 3 0 – 0 0 1 1 0 29 67 136 4 12 18 22 13 2 15 62 76
Mitochondria 386 144 135 246 353 328 – 499 426 578 325 457 512 740 756 0 6 5 350 134 117 153 425 478
Nucleus 3 1 0 0 2 3 – 3 3 2 3 1 3 2 5 2 4 3 1 0 0 0 2 3
Nuclear Periphery 17 3 3 8 12 38 – 70 62 55 45 40 19 30 30 3 5 3 5 0 1 2 4 5
Nucleolus 11 5 3 9 16 33 – 59 45 66 31 37 16 25 17 1 3 7 0 0 0 0 3 3
Peroxisomes 6 1 0 5 16 0 – 17 4 9 0 2 12 39 37 2 0 7 12 5 4 11 32 35
SpindlePole 2 0 0 2 2 0 – 8 5 15 4 6 7 7 5 0 2 5 1 0 0 3 2 7
Vac/Vac Membrane 74 33 7 4 28 25 – 20 13 14 8 12 84 86 109 4 13 13 18 4 0 11 34 60
Unique Cell Count 424 161 141 255 392 357 554 454 619 350 473 580 838 925 21 48 70 443 170 139 229 642 770
Labelled Cell Count 541 208 172 295 482 448 719 583 770 440 583 737 1074 1201 24 61 85 443 170 139 229 642 770


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.6 8.1 4.7 5.8 6.9 6.4 – 7.4 6.8 7.2 7.1 7.4 7.6 8.4 9.1 9.0 9.0 10.0 7.4 7.9 7.8
Std Deviation (1e-4) 1.1 1.3 1.0 2.3 1.7 1.8 – 2.1 2.4 2.2 2.6 2.6 1.3 1.6 1.6 2.1 2.3 2.9 3.2 2.4 2.4
Intensity Change (Log2) – – – 0.3 0.56 0.45 – 0.65 0.53 0.61 0.59 0.65 0.68 0.83 0.95 0.94 0.94 1.09 0.64 0.74 0.73


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 – 0 0 0 -2.0 -1.7 0 0 0 0 0 0
Bud Neck 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 3.2 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 – 0 0 0 0 0 2.7 3.5 4.9 0 0 6.3
Mitochondria 0.4 -2.1 -1.5 – -2.1 -0.9 -1.1 -1.2 0.5 -2.6 -2.7 -4.2 -11.0 -11.4 -12.8
Nucleus 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 3.1 – 3.6 3.8 2.7 3.6 2.6 0 0 0 0 0 0
Nucleolus 0 1.1 2.8 – 3.2 3.0 3.2 2.7 2.4 0 0 0 0 0 0
Peroxisomes 0 0 0 – 0 0 0 0 0 0 2.6 0 0 0 0
SpindlePole 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0.9 0.8 – -0.7 0 0 0 0 3.1 2.0 2.4 0 4.3 3.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 4.8229 4.9839 4.9988 4.4987 4.0947 4.9248 3.3928 3.9224 3.636 3.2116 3.0831 4.1086 5.7465 5.9869 6.0353 5.799 5.538 6.3184
Actin 0.0118 0.0043 0.0013 0.0005 0.0245 0.0014 0.0302 0.0109 0.0044 0.0102 0.0132 0.0107 0.0059 0.0025 0.0078 0.0003 0.0063 0.0013
Bud 0.0002 0.0009 0.0003 0.0004 0.0002 0.0001 0.0008 0.0032 0.0005 0.0006 0.0038 0.0004 0.0003 0.0005 0.0003 0.0001 0.0002 0.0001
Bud Neck 0.0003 0.0004 0.0001 0.0001 0.0004 0.0001 0.0076 0.0009 0.0008 0.0003 0.0003 0.0005 0.0003 0.0004 0.0001 0 0.0003 0.0001
Bud Periphery 0.0004 0.0013 0.0011 0.0014 0.0005 0.0002 0.0015 0.0077 0.0012 0.0018 0.0143 0.0012 0.0008 0.0011 0.0006 0.0003 0.0003 0.0002
Bud Site 0.0006 0.0052 0.0002 0.0007 0.0004 0.0001 0.0098 0.0117 0.0062 0.0019 0.0011 0.0004 0.0041 0.0029 0.0006 0.0001 0.0002 0.0001
Cell Periphery 0.001 0.0005 0.0002 0.0004 0.0001 0.0001 0.001 0.0022 0.0004 0.0004 0.0004 0.0003 0.0005 0.0007 0.0002 0.0001 0.0001 0.0001
Cytoplasm 0.0009 0.0013 0.0001 0.0001 0.001 0.0001 0.0011 0.0008 0.0007 0.0003 0.0105 0.0003 0.0011 0.0003 0.0002 0 0.0001 0.0001
Cytoplasmic Foci 0.0063 0.0209 0.0027 0.003 0.021 0.0047 0.0209 0.0176 0.0059 0.0128 0.0166 0.0089 0.0044 0.0078 0.0053 0.0009 0.0061 0.0021
Eisosomes 0.0032 0.0002 0.0003 0.0001 0.0002 0.0001 0.0007 0.0006 0.0002 0.0004 0.0005 0.0005 0.0004 0.0001 0.0002 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0008 0.0003 0.0004 0.0002 0.0005 0.0002 0.0011 0.0006 0.0009 0.0003 0.0024 0.0009 0.0013 0.0002 0.0001 0.0001 0.0001 0.0001
Endosome 0.0202 0.0334 0.0142 0.0228 0.025 0.0087 0.0454 0.0357 0.0245 0.0219 0.0616 0.0135 0.0188 0.0296 0.0119 0.0041 0.0511 0.0094
Golgi 0.0159 0.0314 0.021 0.0222 0.0468 0.0137 0.0392 0.0413 0.0207 0.0306 0.0321 0.0228 0.02 0.033 0.0207 0.0046 0.0337 0.0115
Lipid Particles 0.0217 0.0057 0.0055 0.0129 0.0252 0.0039 0.023 0.0067 0.006 0.0209 0.0288 0.0129 0.0311 0.0086 0.0056 0.0011 0.0037 0.0042
Mitochondria 0.8904 0.8339 0.9339 0.9227 0.8347 0.9564 0.7655 0.8045 0.9051 0.8461 0.7558 0.9041 0.8887 0.8652 0.9229 0.9786 0.8725 0.9606
None 0.0033 0.0001 0.0001 0.0001 0.0014 0 0.0012 0.0002 0.0006 0.0004 0.0027 0.0003 0.0015 0.0001 0.0001 0 0.0001 0
Nuclear Periphery 0.001 0.0004 0.0003 0.0001 0.0007 0.0001 0.0024 0.0004 0.0011 0.0006 0.0108 0.0012 0.003 0.0002 0 0 0.0002 0.0001
Nucleolus 0.001 0.0003 0.0001 0.0002 0.0002 0.0001 0.0028 0.0008 0.0004 0.0005 0.0007 0.0002 0.0005 0.0005 0.0001 0.0001 0.0001 0.0001
Nucleus 0.0005 0.0002 0.0001 0.0001 0.0002 0.0001 0.0011 0.0005 0.0004 0.0003 0.0015 0.0003 0.0008 0.0003 0.0001 0 0.0001 0.0001
Peroxisomes 0.0137 0.0362 0.0127 0.004 0.009 0.0045 0.0305 0.0196 0.0097 0.0422 0.0194 0.0135 0.009 0.02 0.0177 0.0079 0.0106 0.005
Punctate Nuclear 0.0012 0.0001 0 0 0.0049 0 0.0056 0.0001 0.0013 0.0036 0.0086 0.0003 0.0005 0 0 0 0 0
Vacuole 0.0022 0.0086 0.0021 0.0027 0.0012 0.0012 0.0045 0.0201 0.0046 0.0016 0.008 0.0024 0.0025 0.0146 0.0022 0.0005 0.005 0.0011
Vacuole Periphery 0.0035 0.0145 0.0035 0.0053 0.0019 0.0043 0.0039 0.0139 0.0042 0.0022 0.0068 0.0044 0.0044 0.0114 0.0036 0.001 0.0093 0.0035

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 51.598 26.0195 28.0838 43.5036 18.869 63.4701 50.2249 68.604 65.3019 43.3286
Translational Efficiency 1.2602 2.4551 2.499 2.0294 3.0691 1.9299 1.8865 1.9224 2.0416 1.8458

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1834 1886 733 232 1649 1786 1829 768 3483 3672 2562 1000

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 782.89 906.04 1142.09 1331.68 847.10 906.84 1019.74 1141.32 813.29 906.43 1054.74 1185.48
Standard Deviation 136.82 139.82 145.16 227.03 124.19 117.78 130.82 221.60 134.86 129.57 145.96 236.91
Intensity Change Log 2 — 0.210765 0.544795 0.766366 — 0.098316 0.267597 0.430099 — 0.153420 0.407390 0.601399

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000853 0.001637 0.006114 0.014261 0.000458 0.000640 0.002287 0.013269 0.000666 0.001152 0.003381 0.013499
Bud Neck 0.003215 0.000517 0.005316 0.002861 0.000474 0.000857 0.003879 0.002730 0.001917 0.000682 0.004290 0.002760
Bud Site 0.009930 0.002047 0.020610 0.011050 0.001385 0.001960 0.020452 0.011708 0.005885 0.002005 0.020497 0.011556
Cell Periphery 0.000499 0.000214 0.000415 0.000449 0.000387 0.000273 0.000236 0.001373 0.000446 0.000243 0.000287 0.001158
Cytoplasm 0.004238 0.000633 0.003762 0.001742 0.000735 0.000485 0.003577 0.001191 0.002580 0.000561 0.003630 0.001319
Cytoplasmic Foci 0.027605 0.020338 0.085890 0.021377 0.004343 0.016609 0.029833 0.015224 0.016592 0.018524 0.045871 0.016651
Eisosomes 0.000061 0.000049 0.000074 0.000428 0.000021 0.000035 0.000053 0.000930 0.000042 0.000042 0.000059 0.000814
Endoplasmic Reticulum 0.000529 0.000144 0.001453 0.001982 0.000163 0.000201 0.000382 0.000531 0.000356 0.000172 0.000688 0.000867
Endosome 0.060048 0.031089 0.135852 0.024569 0.010343 0.050159 0.053750 0.022059 0.036516 0.040364 0.077240 0.022642
Golgi 0.060044 0.032348 0.142922* 0.081033 0.007681 0.033085 0.041149 0.041090 0.035253 0.032707 0.070267 0.050357
Lipid Particles 0.005431 0.001793 0.002403 0.006599 0.001463 0.003994 0.001045 0.001332 0.003553 0.002864 0.001434 0.002554
Mitochondria 0.768321* 0.872061* 0.367767* 0.750555* 0.955136* 0.858243* 0.709564* 0.845121* 0.856767* 0.865340* 0.611774* 0.823182*
Mitotic Spindle 0.004656 0.003713 0.076200 0.025707 0.001540 0.002053 0.053925 0.007756 0.003181 0.002906 0.060298 0.011921
None 0.000708 0.000148 0.000324 0.001282 0.000383 0.000196 0.000313 0.000366 0.000554 0.000171 0.000316 0.000579
Nuclear Periphery 0.000115 0.000072 0.001754 0.001314 0.000046 0.000095 0.000422 0.000080 0.000082 0.000083 0.000803 0.000366
Nuclear Periphery Foci 0.000293 0.000110 0.002022 0.000894 0.000073 0.000144 0.000426 0.000099 0.000189 0.000127 0.000883 0.000283
Nucleolus 0.000770 0.000070 0.000643 0.000115 0.000131 0.000103 0.000243 0.000057 0.000467 0.000086 0.000358 0.000071
Nucleus 0.001821 0.000052 0.001247 0.000115 0.000124 0.000089 0.000783 0.000079 0.001017 0.000070 0.000916 0.000087
Peroxisomes 0.023143 0.023941 0.025402 0.012192 0.007015 0.012289 0.032830 0.026064 0.015508 0.018274 0.030705 0.022846
Vacuole 0.011449 0.004115 0.062127 0.018236 0.003071 0.009057 0.023676 0.003900 0.007482 0.006519 0.034677 0.007226
Vacuole Periphery 0.016271 0.004910 0.057703 0.023238 0.005027 0.009431 0.021175 0.005040 0.010948 0.007109 0.031626 0.009262

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.54 -4.28 -3.31 -3.11 -1.92 -0.89 -5.66 -5.79 -5.71 -4.93 -2.60 -6.42 -6.61 -6.35 -5.11
Bud Neck 5.59 -2.49 0.47 -4.10 2.73 -1.51 -7.34 -3.62 -3.13 1.62 4.38 -5.32 -1.57 -4.39 2.64
Bud Site 6.39 -4.33 -0.26 -1.98 1.91 -1.18 -10.96 -4.99 -4.74 3.37 5.63 -9.69 -2.84 -5.04 3.91
Cell Periphery 3.44 0.51 0.37 -1.82 -0.17 0.79 1.23 -2.57 -2.96 -3.13 2.51 1.92 -2.46 -3.23 -3.07
Cytoplasm 4.45 0.20 1.27 -1.42 1.09 0.78 -6.16 -1.26 -3.80 6.48 4.44 -2.05 2.07 -2.85 4.93
Cytoplasmic Foci 3.51 -12.56 1.26 -0.46 10.74 -9.01 -14.66 -5.79 0.63 6.02 -1.49 -14.76 -0.14 0.86 11.88
Eisosomes 2.16 -1.98 -2.20 -2.28 -2.12 -6.60 -13.27 -1.43 -1.40 -1.38 -0.00 -4.96 -1.57 -1.57 -1.54
Endoplasmic Reticulum 5.65 -4.92 -1.46 -1.85 -0.50 -0.56 -5.01 -4.16 -3.28 -1.47 3.85 -5.06 -2.11 -2.89 -0.64
Endosome 8.78 -11.48 7.16 1.45 15.31 -13.48 -16.33 -4.41 7.81 9.45 -1.68 -13.61 5.30 6.77 16.79
Golgi 8.28 -11.16 -1.83 -4.34 4.76 -11.70 -14.76 -8.21 -1.81 -0.00 1.22 -11.37 -3.49 -4.16 4.13
Lipid Particles 3.59 2.95 -0.48 -2.14 -1.85 -3.12 1.07 0.29 3.22 -0.67 1.05 3.77 1.28 0.44 -1.80
Mitochondria -11.48 27.11 0.88 5.55 -15.13 14.28 28.08 10.76 1.18 -10.94 -1.47 28.32 3.40 4.34 -18.12
Mitotic Spindle 1.22 -11.86 -3.32 -3.46 5.82 -0.99 -16.22 -4.18 -3.92 13.17 0.59 -19.80 -4.67 -4.80 14.21
None 3.75 2.58 -1.27 -2.75 -2.32 0.98 0.39 0.11 -3.80 -1.88 3.19 2.03 -0.09 -4.08 -2.66
Nuclear Periphery 2.15 -5.08 -4.86 -5.03 1.08 -3.82 -3.51 -2.18 0.78 3.16 -0.09 -5.98 -4.67 -4.62 3.24
Nuclear Periphery Foci 3.53 -6.80 -2.97 -3.95 3.60 -2.45 -5.82 -0.95 1.76 5.53 2.08 -7.96 -1.69 -3.07 6.28
Nucleolus 2.08 0.19 1.96 -0.90 2.63 0.30 -1.15 0.81 1.36 4.04 2.09 0.50 2.19 0.55 4.22
Nucleus 2.69 0.39 2.46 -1.24 2.59 0.53 -1.57 0.63 0.26 1.67 2.72 -0.14 2.62 -0.97 2.53
Peroxisomes -0.27 -0.65 2.55 2.72 2.76 -2.86 -9.59 -4.98 -3.56 1.59 -1.59 -6.77 -2.31 -1.44 2.29
Vacuole 7.12 -13.71 -1.50 -2.93 6.86 -5.75 -12.64 -0.99 5.25 12.41 1.31 -16.82 0.00 -0.70 13.79
Vacuole Periphery 10.48 -10.50 -1.66 -4.47 6.17 -4.90 -10.17 -0.02 4.61 9.97 5.33 -12.47 1.35 -1.82 11.75
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein required for assembly of succinate dehydrogenase; interacts with flavinylated Sdh1p and may function as a chaperone for free Sdh1p, protecting its FAD cofactor from redox reactions before assembly of the complex; soluble protein of the mitochondrial matrix; respiratory defect of null mutant is functionally complemented by Drosophila and human orthologs
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Sdh8

Sdh8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sdh8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available