Standard name
Human Ortholog
Description Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0
Cytoplasm 0.96 0.96 0.94 1.0 0.94 0.92 0.93 0.92 0.83 – 0.73 0.77 0.99 0.99 0.99 0.9 0.89 0.88 0.9 0.95 0.82 0.82 0.74 0.67
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.06 0.08 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0 0.09 0.14 0.08 0.33 – 0.47 0.31 0 0 0 0 0 0 0 0 0 0.06 0.09 0.09
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 0 0 – 1 1 0 0 0 0 0 1 0 0 1 2 5 10
Bud 0 1 1 1 0 1 1 2 5 – 7 7 1 1 1 0 0 0 0 0 2 2 10 22
Bud Neck 0 0 1 1 0 1 1 2 0 – 0 3 0 0 0 0 0 0 0 0 1 0 2 2
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 3 1 1 0 2 2 4 – 0 2 1 1 1 8 3 0 0 0 0 0 2 2
Cytoplasm 105 110 195 133 179 194 297 317 222 – 146 191 379 352 448 100 98 59 115 119 179 171 347 261
Endoplasmic Reticulum 0 2 3 0 1 1 1 1 2 – 1 2 0 0 1 7 9 2 0 0 2 5 6 5
Endosome 1 0 5 0 4 5 3 4 0 – 0 0 0 4 0 2 4 3 2 2 6 0 12 14
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 2 1 3 1 0 0 0 5 3
Mitochondria 2 2 1 6 4 19 46 26 89 – 94 76 3 0 2 4 2 2 2 1 9 13 41 35
Nucleus 1 0 2 1 2 2 3 3 1 – 0 8 1 0 1 1 2 1 0 0 2 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 1 – 0 1 0 0 0 0 0 1 0 0 0 0 1 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 3 1 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 2
SpindlePole 0 0 3 0 2 1 3 0 2 – 0 1 0 0 0 1 1 1 0 0 3 0 9 8
Vac/Vac Membrane 1 2 4 1 1 4 1 6 5 – 4 3 2 1 2 6 4 3 2 0 3 9 18 16
Unique Cell Count 109 114 207 133 191 210 321 343 269 200 249 381 356 453 111 110 67 129 126 218 210 470 390
Labelled Cell Count 110 117 218 145 194 228 359 363 331 253 295 387 359 456 134 125 76 129 126 218 210 470 390


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 5.0 5.7 5.1 5.5 4.5 4.6 5.0 4.2 – 3.8 4.1 5.4 5.4 5.4 9.1 9.9 8.5 5.2 4.9 5.3
Std Deviation (1e-4) 1.0 0.8 1.1 1.6 1.2 1.0 1.3 1.6 1.7 – 1.0 1.3 0.9 1.3 1.5 2.3 2.7 1.9 1.8 1.5 2.1
Intensity Change (Log2) – – – -0.17 -0.06 -0.35 -0.33 -0.2 -0.44 – -0.6 -0.47 -0.1 -0.09 -0.09 0.66 0.79 0.56 -0.15 -0.23 -0.1


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm 2.8 -0.2 -0.7 -0.7 -0.8 -3.8 – -5.8 -5.2 4.0 3.2 3.5 -1.3 -1.6 -1.7
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 3.7 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9153 2.9425 2.6653 2.1506 1.8444 2.7591 0.1786 1.3754 1.0833 0.9818 0.5236 0.9422 1.4052 2.2476 1.7737 1.8513 1.8882 1.6853
Actin 0.0275 0.0013 0.0112 0.0013 0.0003 0.0021 0.0085 0.0007 0.0091 0.04 0.0008 0.0009 0.0301 0.0071 0.0118 0.0114 0.0216 0.0108
Bud 0.001 0.0007 0.0014 0.0001 0.0001 0.0015 0.0014 0.0039 0.0007 0.026 0.0001 0.0028 0.0145 0.0264 0.0273 0.0115 0.024 0.0148
Bud Neck 0.0009 0.0004 0.0005 0.0011 0.0002 0.0039 0.0019 0.0003 0.0005 0.001 0.0002 0.0033 0.0015 0.0011 0.0013 0.0039 0.0012 0.0037
Bud Periphery 0.0049 0.0005 0.0015 0.0001 0.0001 0.0064 0.0014 0.0048 0.0006 0.0142 0.0001 0.0021 0.0097 0.0123 0.0156 0.0097 0.0192 0.0119
Bud Site 0.0017 0.0069 0.0016 0.0002 0.0001 0.0013 0.0091 0.0136 0.0045 0.0036 0 0.0004 0.0284 0.0914 0.0346 0.0091 0.003 0.0019
Cell Periphery 0.0003 0.0003 0.0002 0.0002 0.0004 0.0003 0.0003 0.0002 0.0001 0.0004 0 0.0001 0.0016 0.0016 0.0014 0.0008 0.0006 0.0005
Cytoplasm 0.286 0.4727 0.451 0.5474 0.4671 0.5841 0.4622 0.76 0.6819 0.5955 0.7108 0.7835 0.344 0.4931 0.4397 0.4254 0.5146 0.5548
Cytoplasmic Foci 0.0209 0.0119 0.0099 0.0117 0.0085 0.0067 0.0461 0.0113 0.0218 0.0347 0.0136 0.0152 0.0518 0.0182 0.0275 0.0206 0.0211 0.0297
Eisosomes 0.0008 0.0002 0.0002 0.0003 0.0003 0.0001 0.0002 0 0.0002 0.0001 0 0 0.0007 0.0003 0.0003 0.0002 0.0002 0.0002
Endoplasmic Reticulum 0.011 0.0045 0.0051 0.0046 0.0014 0.0034 0.0035 0.0022 0.0032 0.0023 0.0054 0.0021 0.0127 0.0025 0.0059 0.0066 0.0076 0.0055
Endosome 0.0095 0.0063 0.0051 0.0079 0.0015 0.0045 0.049 0.0038 0.016 0.0526 0.0101 0.0087 0.0245 0.0024 0.0082 0.0312 0.0114 0.0188
Golgi 0.003 0.0006 0.0007 0.0005 0.0001 0.0006 0.0168 0.0003 0.0106 0.0391 0.0004 0.0003 0.0117 0.0014 0.003 0.0122 0.0056 0.0054
Lipid Particles 0.0064 0.0005 0.0019 0.0023 0.0009 0.0003 0.0263 0.0001 0.0027 0.0047 0.0001 0.0001 0.0103 0.0008 0.005 0.0132 0.0094 0.0092
Mitochondria 0.0027 0.0006 0.0006 0.0008 0.0005 0.0013 0.0126 0.0003 0.0092 0.0052 0.0003 0.0003 0.0129 0.0016 0.0101 0.0096 0.0297 0.0052
None 0.5921 0.4773 0.4953 0.409 0.5149 0.377 0.3167 0.192 0.2284 0.1575 0.2524 0.1744 0.3987 0.3042 0.3536 0.3953 0.2789 0.2759
Nuclear Periphery 0.0035 0.0021 0.0016 0.0022 0.0004 0.0011 0.0034 0.0006 0.0011 0.0017 0.0012 0.0008 0.0069 0.0021 0.006 0.005 0.0153 0.0069
Nucleolus 0.0004 0.0004 0.0005 0.0002 0.0002 0.0002 0.0025 0.0001 0.0001 0.0002 0 0.0001 0.0033 0.0025 0.0024 0.0011 0.0012 0.0015
Nucleus 0.0022 0.0048 0.003 0.0068 0.0011 0.0025 0.0027 0.0026 0.0021 0.0067 0.0011 0.0021 0.0076 0.0096 0.0151 0.0138 0.016 0.0173
Peroxisomes 0.007 0.0005 0.0045 0.0003 0.0002 0.0003 0.0215 0.0004 0.0041 0.0066 0.0001 0.0002 0.0092 0.0014 0.0065 0.0015 0.002 0.0011
Punctate Nuclear 0.0156 0.0039 0.0015 0.0013 0.0006 0.0006 0.0075 0.0011 0.0009 0.0016 0.0004 0.0009 0.0134 0.017 0.0198 0.011 0.0113 0.021
Vacuole 0.0019 0.0031 0.0024 0.0015 0.001 0.0016 0.0044 0.0015 0.0016 0.0046 0.0023 0.0015 0.0052 0.0025 0.0041 0.0055 0.0038 0.0026
Vacuole Periphery 0.0006 0.0004 0.0003 0.0004 0.0001 0.0004 0.0016 0.0002 0.0004 0.0018 0.0005 0.0003 0.0013 0.0003 0.0009 0.0015 0.0022 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.9179 17.9545 19.4294 26.6718 21.1581 28.8558 19.0993 22.9736 22.052 25.0711
Translational Efficiency 0.9694 1.0177 0.907 0.7102 0.7471 0.8527 0.8209 0.5992 0.6984 0.6232

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1941 195 1225 1677 1660 1431 1789 204 3601 1626 3014 1881

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 687.10 852.93 1030.22 1033.49 683.40 808.46 999.27 1011.15 685.39 813.79 1011.85 1031.07
Standard Deviation 75.78 125.11 127.90 137.85 97.81 105.42 130.27 148.54 86.66 108.93 130.20 139.22
Intensity Change Log 2 — 0.311907 0.584360 0.588932 — 0.242446 0.548144 0.565195 — 0.277688 0.566415 0.577145

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000081 0.000763 0.001783 0.001725 0.000138 0.000929 0.000341 0.002988 0.000107 0.000909 0.000927 0.001862
Bud Neck 0.010526 0.014718 0.006288 0.012410 0.006862 0.023772 0.003099 0.006512 0.008837 0.022686 0.004395 0.011770
Bud Site 0.004666 0.019911 0.014827 0.050961 0.003596 0.018008 0.006163 0.091634 0.004173 0.018236 0.009685 0.055372
Cell Periphery 0.000101 0.000160 0.000133 0.000153 0.000097 0.000155 0.000107 0.000115 0.000099 0.000156 0.000118 0.000149
Cytoplasm 0.602520* 0.454589* 0.431213* 0.433214* 0.580454* 0.447657* 0.530836* 0.183645* 0.592348* 0.448488* 0.490346* 0.406148*
Cytoplasmic Foci 0.173957 0.268608* 0.008143 0.019071 0.186614* 0.253384* 0.007164 0.041742 0.179792 0.255210* 0.007562 0.021529
Eisosomes 0.000109 0.000131 0.000028 0.000030 0.000083 0.000123 0.000021 0.000041 0.000097 0.000124 0.000024 0.000031
Endoplasmic Reticulum 0.000640 0.000772 0.004486 0.002206 0.000913 0.000803 0.002673 0.001294 0.000766 0.000800 0.003410 0.002107
Endosome 0.008355 0.035173 0.002358 0.009119 0.010163 0.035712 0.001363 0.007704 0.009188 0.035647 0.001768 0.008965
Golgi 0.001532 0.002664 0.000110 0.006233 0.001392 0.007977 0.000082 0.000947 0.001468 0.007340 0.000094 0.005660
Lipid Particles 0.004223 0.003436 0.001387 0.001151 0.006232 0.006020 0.000772 0.001752 0.005149 0.005710 0.001022 0.001216
Mitochondria 0.004226 0.001616 0.000684 0.005751 0.002707 0.007493 0.000741 0.000157 0.003526 0.006788 0.000717 0.005144
Mitotic Spindle 0.000560 0.008983 0.004583 0.191878* 0.002456 0.010141 0.024256 0.491301* 0.001434 0.010002 0.016260 0.224352*
None 0.004906 0.003179 0.005161 0.006570 0.005999 0.002617 0.005772 0.004517 0.005410 0.002685 0.005524 0.006347
Nuclear Periphery 0.000241 0.000242 0.002470 0.002327 0.000402 0.000330 0.001712 0.000741 0.000315 0.000319 0.002020 0.002155
Nuclear Periphery Foci 0.000362 0.001395 0.002806 0.004160 0.000820 0.000502 0.002044 0.007840 0.000574 0.000609 0.002354 0.004559
Nucleolus 0.000906 0.000576 0.000297 0.000805 0.001384 0.001358 0.000304 0.001235 0.001126 0.001265 0.000301 0.000851
Nucleus 0.112427 0.052392 0.444027* 0.157766* 0.132346* 0.052702 0.354733* 0.029146 0.121609 0.052665 0.391026* 0.143817*
Peroxisomes 0.001941 0.010526 0.000294 0.003327 0.002063 0.010773 0.000392 0.015928 0.001997 0.010743 0.000352 0.004693
Vacuole 0.066854 0.118101 0.068729 0.085604 0.054368 0.116226 0.057307 0.110596 0.061098 0.116451 0.061949 0.088315
Vacuole Periphery 0.000864 0.002063 0.000192 0.005539 0.000912 0.003318 0.000118 0.000165 0.000886 0.003167 0.000148 0.004957

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.29 -1.81 -6.05 -0.51 0.44 -1.72 -5.48 -1.77 -0.53 -1.40 -1.97 -2.45 -5.92 -0.14 -0.85
Bud Neck -1.07 3.15 -2.30 0.26 -5.07 -10.03 2.03 -2.33 6.72 -3.64 -9.12 4.34 -4.41 6.14 -7.95
Bud Site -4.47 -3.82 -11.16 -1.80 -5.33 -9.53 -3.75 -5.76 -4.28 -5.39 -10.28 -5.16 -12.69 -4.96 -9.44
Cell Periphery -2.08 -5.77 -2.09 1.10 1.36 -3.91 -2.05 -0.93 2.75 0.36 -4.34 -5.16 -2.30 1.94 0.09
Cytoplasm 7.46 29.10 29.79 5.06 -0.53 13.02 17.60 26.18 17.57 16.37 17.32 32.04 35.16 13.02 7.85
Cytoplasmic Foci -5.68 41.55 37.34 16.33 -10.19 -8.90 38.02 19.65 26.16 -4.34 -12.07 56.24 48.40 43.43 -11.20
Eisosomes -0.65 9.76 10.25 2.94 1.29 -3.92 6.13 2.44 7.63 -4.30 -3.14 11.46 10.53 12.61 -2.00
Endoplasmic Reticulum -1.49 -21.10 -11.15 -7.80 14.44 0.88 -12.22 -4.99 -5.42 3.39 -0.47 -23.06 -11.53 -10.64 12.85
Endosome -5.45 8.92 4.73 6.26 -3.97 -13.91 11.42 -0.15 12.12 -7.14 -16.03 14.71 6.03 18.57 -7.01
Golgi -1.54 10.06 0.17 1.36 -2.76 -7.14 9.26 3.25 7.82 -5.64 -7.20 13.67 0.20 6.48 -2.95
Lipid Particles 1.06 7.32 6.11 1.96 -3.15 0.32 8.24 3.27 3.40 -4.72 -1.03 11.12 8.25 7.93 -7.75
Mitochondria 1.78 3.16 1.89 -0.35 -2.08 -4.26 2.84 3.59 8.01 7.48 -3.10 4.12 2.16 5.34 -1.95
Mitotic Spindle -2.01 -5.63 -24.05 -19.78 -23.20* -3.78 -8.96 -12.46 -12.17 -11.36 -4.96 -10.07 -26.58 -24.91 -23.28
None 0.99 1.32 -6.17 -3.41 -9.71 3.12 0.02 0.52 -1.36 0.56 3.48 0.35 -5.17 -8.05 -7.23
Nuclear Periphery -0.55 -27.44 -14.32 -14.21 -0.24 1.14 -23.23 -9.08 -9.45 1.97 -0.35 -35.85 -14.98 -14.85 -1.37
Nuclear Periphery Foci -3.80 -13.09 -11.02 -8.54 -6.05 2.45 -5.74 -5.25 -5.33 -4.33 -0.45 -9.23 -11.69 -11.64 -6.48
Nucleolus 1.56 2.81 -5.89 -6.66 -7.09 0.20 1.30 -1.61 -1.83 -2.50 -0.45 2.02 -5.78 -5.59 -6.58
Nucleus 9.49 -43.33 -13.37 -17.95 29.60 18.20 -34.46 8.22 -0.63 31.65 22.35 -54.71 -10.22 -23.20 35.01
Peroxisomes -3.71 10.19 0.37 3.73 -4.30 -8.80 9.39 -2.18 0.38 -2.70 -9.59 13.62 -1.23 7.83 -4.79
Vacuole -5.52 -11.24 -18.28 -3.51 -5.63 -13.13 -13.29 -9.52 -6.50 -6.44 -13.66 -17.04 -21.66 -9.62 -9.37
Vacuole Periphery -1.10 5.92 -0.82 0.74 -2.68 -8.31 6.88 6.06 11.68 -4.59 -8.28 9.10 -0.55 4.97 -2.82
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)
Localization
Cell Percentages cytoplasm (80%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Dug2

Dug2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Dug2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available