Standard name
Human Ortholog
Description Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.07 0 0 0 0 0 0.08 – 0.09 0.14 0.09 0.16 0 0 0 0.2 0.13 0.2 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.98 0.99 0.99 0.99 0.93 – 0.89 0.82 0.87 0.78 0.99 0.99 1.0 0.91 0.94 0.91 0.96 0.93 0.97 0.88 0.89 0.85
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0.05 0.1 0.08 0.12 0 0 0 0 0.06 0.07 0 0 0 0 0 0.06
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 2 2 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 2 2 0 1 1 1 – 0 1 5 2 0 1 0 0 1 0 0 0 1 0 2 1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 14 2 9 4 4 5 31 – 25 46 20 40 1 3 0 114 50 89 0 0 0 1 0 0
Cytoplasm 207 268 306 161 268 279 346 – 249 266 196 201 193 237 255 532 351 406 215 292 367 141 235 228
Endoplasmic Reticulum 0 0 1 0 2 2 8 – 15 34 17 30 0 0 0 25 21 32 2 0 0 5 10 17
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Golgi 0 0 1 0 0 0 0 – 2 0 0 0 0 0 0 1 1 0 0 0 0 0 1 6
Mitochondria 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Nucleus 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 4 0 1 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 1 0 0 0 0 – 0 2 0 1 0 0 0 1 0 0 0 7 1 1 4 5
Unique Cell Count 212 271 312 162 270 283 372 281 324 226 257 194 240 255 583 373 448 225 316 380 161 264 268
Labelled Cell Count 223 272 320 165 275 287 386 291 351 240 276 195 241 255 673 424 527 225 316 380 161 264 268


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 428.5 320.4 299.1 294.5 269.1 217.6 184.0 – 135.0 110.4 104.4 103.1 359.1 345.3 330.7 498.2 473.0 507.1 324.9 331.6 325.9
Std Deviation (1e-4) 76.3 77.5 73.4 76.3 60.5 51.3 44.9 – 37.7 35.0 37.5 32.9 76.8 70.8 73.6 121.9 112.5 103.9 57.5 69.0 72.4
Intensity Change (Log2) – – – -0.02 -0.15 -0.46 -0.7 – -1.15 -1.44 -1.52 -1.54 0.26 0.21 0.14 0.74 0.66 0.76 0.12 0.15 0.12

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000200400600WT3HU80HU120HU1600200400600WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30200400600WT1AF100AF140AF1800200400600
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 -1.1 -0.9 3.0 – 3.1 5.1 3.0 5.4 0 -1.3 0 6.9 4.9 6.9
Cytoplasm 1.1 1.2 0.5 -3.1 – -4.7 -6.7 -5.2 -7.6 1.3 0.6 2.2 -4.0 -2.6 -4.2
Endoplasmic Reticulum 0 0 0 0 – 3.8 5.6 4.6 5.9 0 0 0 3.4 3.9 4.5
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 455.1469 611.9749 469.8879 389.9071 490.1023 527.7218 553.1044 727.1972 593.3145 413.3512 537.3315 628.2797 470.9727 704.0134 548.9541 488.3047 635.5526 581.5817
Actin 0.013 0.0004 0.0144 0.0015 0.0011 0.0017 0.0008 0.0002 0.0056 0.0004 0.0005 0.001 0.0107 0.0005 0.0049 0.0006 0.0024 0.0024
Bud 0.0031 0.0014 0.0024 0.013 0.0029 0.0033 0.0016 0.0016 0.0017 0.0094 0.0012 0.0014 0.0033 0.002 0.0026 0.007 0.0027 0.004
Bud Neck 0.0016 0.0008 0.0016 0.0051 0.0014 0.004 0.0007 0.0004 0.0014 0.001 0.0012 0.0022 0.0006 0.0003 0.0006 0.0006 0.0009 0.0013
Bud Periphery 0.0017 0.0004 0.0024 0.0104 0.0005 0.002 0.0013 0.0005 0.001 0.0043 0.0005 0.0005 0.0019 0.0006 0.0015 0.003 0.0008 0.0045
Bud Site 0.0021 0.0007 0.0019 0.0061 0.0003 0.0004 0.0009 0.0007 0.0037 0.0004 0.0003 0.0002 0.0014 0.0013 0.0021 0.0005 0.0002 0.0004
Cell Periphery 0.0277 0.0078 0.0129 0.0484 0.0049 0.0114 0.0274 0.0094 0.0182 0.005 0.0132 0.0039 0.0119 0.008 0.0041 0.0029 0.001 0.0139
Cytoplasm 0.6568 0.9167 0.7717 0.4347 0.7995 0.7557 0.801 0.9508 0.8469 0.7136 0.6941 0.8922 0.6986 0.9213 0.8116 0.6977 0.9104 0.7836
Cytoplasmic Foci 0.0148 0.0003 0.0113 0.0045 0.0473 0.0011 0.0076 0.0002 0.0084 0.0224 0.0292 0.0025 0.0134 0.0008 0.016 0.0071 0.0009 0.0017
Eisosomes 0.0016 0 0.0006 0.0007 0.0005 0.0001 0.0011 0 0.0004 0.001 0.002 0.0002 0.0022 0 0.0005 0.0002 0.0001 0.0013
Endoplasmic Reticulum 0.0098 0.0009 0.0021 0.0007 0.0004 0.0015 0.0061 0.0006 0.0013 0.0078 0.0017 0.0023 0.0038 0.0002 0.0026 0.0003 0.0011 0.0036
Endosome 0.01 0.0002 0.0097 0.0008 0.0011 0.001 0.0005 0.0001 0.0007 0.0382 0.0166 0.0007 0.0048 0.0001 0.0139 0.0003 0.0007 0.0017
Golgi 0.0034 0 0.0055 0.0002 0.0004 0.0002 0.0001 0 0.0005 0.002 0.0017 0.0002 0.0006 0 0.007 0.0001 0.0001 0.0008
Lipid Particles 0.005 0.0001 0.0024 0.0031 0.0134 0.0004 0.0021 0.0002 0.0012 0.0034 0.0073 0.0009 0.0026 0.0002 0.005 0.0009 0.0001 0.0005
Mitochondria 0.0223 0.0045 0.0289 0.0285 0.019 0.0173 0.0116 0.0009 0.0095 0.0215 0.0152 0.0069 0.0336 0.0022 0.0215 0.0443 0.0044 0.0221
None 0.0127 0.0011 0.0079 0.0106 0.0122 0.002 0.0087 0.0006 0.012 0.0119 0.0316 0.0101 0.0288 0.0021 0.0104 0.0082 0.0032 0.0023
Nuclear Periphery 0.0435 0.0071 0.0178 0.0328 0.0092 0.0311 0.0361 0.0044 0.0135 0.0084 0.024 0.018 0.0418 0.0043 0.0101 0.0137 0.0212 0.0322
Nucleolus 0.0437 0.0086 0.0302 0.1107 0.0157 0.0123 0.0183 0.0008 0.0201 0.0698 0.0569 0.0031 0.0345 0.0025 0.0269 0.0806 0.0011 0.0057
Nucleus 0.0705 0.0283 0.0333 0.0875 0.0405 0.0802 0.0344 0.0128 0.0225 0.036 0.0479 0.0314 0.073 0.04 0.031 0.0974 0.0335 0.0567
Peroxisomes 0.0034 0.0001 0.0067 0.0013 0.0032 0.0004 0.0007 0 0.0012 0.0012 0.0009 0.0004 0.0013 0.0001 0.0079 0.0011 0.0001 0.0004
Punctate Nuclear 0.0028 0.0001 0.001 0.0004 0.0013 0.0002 0.0011 0 0.0004 0.0007 0.0019 0.0008 0.0015 0.0001 0.0015 0.0002 0.0004 0.0005
Vacuole 0.0367 0.0169 0.0228 0.1086 0.0122 0.0441 0.0301 0.0132 0.0244 0.0301 0.0348 0.0155 0.0174 0.0111 0.0102 0.0172 0.0082 0.0336
Vacuole Periphery 0.014 0.0035 0.0126 0.0902 0.0129 0.0297 0.0077 0.0024 0.0054 0.0115 0.0172 0.0056 0.0124 0.0023 0.0081 0.0161 0.0065 0.0268

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 125.972 115.4882 117.7193 121.6628 132.9277 219.1802 182.7388 167.7207 192.666 156.6044
Translational Efficiency 1.3275 1.3366 1.28 1.5763 1.3071 1.1785 1.2336 1.3395 1.2085 1.1963

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2159 1761 1263 186 1344 1634 1962 2101 3503 3395 3225 2287

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 24446.48 30356.60 18448.47 8172.64 23929.10 27627.54 20212.00 8309.67 24247.98 29043.11 19521.35 8298.53
Standard Deviation 6111.25 6852.85 4996.95 3065.25 5190.94 6916.95 5458.28 3376.05 5781.00 7017.53 5352.09 3352.06
Intensity Change Log 2 — 0.312383 -0.406126 -1.580753 — 0.207341 -0.243554 -1.525903 — 0.261379 -0.323420 -1.553361

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000034 0.000069 0.000117 0.000280 0.000057 0.000077 0.000070 0.000122 0.000043 0.000073 0.000088 0.000135
Bud Neck 0.000152 0.000355 0.001493 0.003803 0.000442 0.000356 0.000949 0.001308 0.000263 0.000356 0.001162 0.001511
Bud Site 0.002190 0.001679 0.002317 0.012072 0.003274 0.001529 0.004043 0.007465 0.002606 0.001607 0.003367 0.007839
Cell Periphery 0.009083 0.019371 0.027469 0.060251 0.022746 0.012756 0.010954 0.006083 0.014325 0.016187 0.017422 0.010488
Cytoplasm 0.895965 0.845266 0.710120 0.559550 0.766905 0.861287 0.777396 0.828176 0.846448 0.852977 0.751049 0.806329
Cytoplasmic Foci 0.005758 0.006200 0.007675 0.015085 0.010638 0.007326 0.005247 0.005376 0.007630 0.006742 0.006198 0.006166
Eisosomes 0.000001 0.000002 0.000004 0.000009 0.000002 0.000002 0.000002 0.000002 0.000001 0.000002 0.000002 0.000003
Endoplasmic Reticulum 0.000182 0.000330 0.000154 0.000077 0.000257 0.000128 0.000161 0.000097 0.000210 0.000233 0.000158 0.000096
Endosome 0.000155 0.000185 0.000166 0.000370 0.000293 0.000153 0.000283 0.000510 0.000208 0.000170 0.000237 0.000499
Golgi 0.014524 0.018200 0.015261 0.009695 0.034124 0.016148 0.009168 0.004272 0.022044 0.017212 0.011554 0.004713
Lipid Particles 0.002838 0.010317 0.009055 0.038047 0.008098 0.005263 0.009195 0.005725 0.004856 0.007884 0.009140 0.008354
Mitochondria 0.000179 0.000181 0.000256 0.000072 0.000173 0.000284 0.000142 0.000263 0.000177 0.000231 0.000187 0.000248
Mitotic Spindle 0.000355 0.000531 0.000410 0.000457 0.000885 0.000404 0.000540 0.001126 0.000558 0.000470 0.000489 0.001072
None 0.003576 0.002926 0.003730 0.001067 0.003136 0.004806 0.002398 0.002978 0.003407 0.003831 0.002919 0.002822
Nuclear Periphery 0.000246 0.000585 0.001401 0.001114 0.000805 0.000529 0.000566 0.000178 0.000460 0.000558 0.000893 0.000254
Nuclear Periphery Foci 0.002680 0.006006 0.005802 0.006084 0.006387 0.004708 0.005023 0.002031 0.004102 0.005381 0.005328 0.002361
Nucleolus 0.000040 0.000050 0.000131 0.000120 0.000065 0.000096 0.000098 0.000193 0.000050 0.000072 0.000111 0.000187
Nucleus 0.015714 0.019016 0.060842 0.038399 0.017629 0.029645 0.025024 0.029532 0.016449 0.024132 0.039052 0.030253
Peroxisomes 0.000022 0.000027 0.000012 0.000057 0.000020 0.000028 0.000028 0.000053 0.000021 0.000027 0.000021 0.000054
Vacuole 0.020054 0.050697 0.122832 0.242349 0.065052 0.037141 0.130650 0.097675 0.037319 0.044172 0.127588 0.109442
Vacuole Periphery 0.026253 0.018009 0.030753 0.011043 0.059012 0.017334 0.018064 0.006834 0.038822 0.017684 0.023033 0.007176

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.00 -9.28 -7.23 -5.87 -4.14 -1.13 -4.19 -5.60 -2.07 -3.28 -2.69 -10.41 -8.18 -4.08 -2.98
Bud Neck -3.76 -11.10 -8.14 -7.58 -4.61 0.93 -9.31 -7.53 -7.78 -1.52 -2.95 -15.22 -10.26 -9.30 -2.02
Bud Site 1.34 -1.18 -3.79 -3.98 -3.51 2.49 -2.28 -6.02 -8.16 -3.89 2.62 -3.34 -8.36 -9.64 -5.87
Cell Periphery -7.00 -10.42 -7.07 -5.08 -3.63 5.34 7.19 10.80 6.91 6.29 -1.86 -2.70 5.32 7.07 8.23
Cytoplasm 7.88 22.06 15.39 12.62 5.72 -9.31 2.10 -3.33 7.82 -6.42 -0.31 18.62 10.26 10.61 -7.47
Cytoplasmic Foci -1.21 -4.06 -4.23 -3.97 -3.33 2.88 4.07 3.01 0.28 -1.01 0.99 0.38 -1.05 -1.83 -1.38
Eisosomes -5.50 -9.92 -8.77 -7.42 -4.96 1.21 0.06 -0.69 -2.59 -1.35 -2.12 -7.56 -6.96 -4.88 -0.36
Endoplasmic Reticulum -2.38 1.08 4.54 4.38 5.68 4.00 3.62 5.81 1.43 3.06 -0.64 2.86 5.52 4.09 3.80
Endosome -1.57 -1.25 -2.91 -2.37 -2.64 2.65 -0.87 -2.36 -3.45 -2.11 1.01 -3.11 -3.44 -3.66 -2.81
Golgi -2.88 -0.40 4.77 7.03 5.11 8.88 14.39 17.54 11.07 10.19 4.21 11.35 19.99 16.59 14.18
Lipid Particles -8.66 -8.99 -6.26 -4.69 -4.87 3.17 -1.31 2.93 -0.64 4.20 -5.25 -7.58 -4.97 -0.22 1.69
Mitochondria -0.26 -4.15 3.96 2.80 7.54 -1.19 -0.18 -2.38 -0.13 -2.39 -1.20 -2.90 -2.25 -0.75 -1.35
Mitotic Spindle -1.93 -1.09 -1.25 0.33 -0.57 1.56 0.10 -1.29 -2.82 -1.61 0.57 -0.92 -2.37 -2.68 -2.05
None 1.20 -0.00 5.72 4.20 3.33 -2.19 1.12 0.35 2.77 -0.87 -0.96 1.18 1.31 2.12 0.16
Nuclear Periphery -7.51 -11.09 -4.19 -2.26 2.19 2.55 1.29 6.71 6.26 6.92 -2.45 -7.87 4.10 7.52 11.45
Nuclear Periphery Foci -7.11 -6.34 -4.18 0.67 0.47 2.13 1.90 9.39 5.11 8.28 -3.50 -3.99 6.48 8.69 10.08
Nucleolus -1.61 -8.97 -6.83 -5.64 1.61 -1.34 -8.15 -5.03 -2.48 -3.41 -1.79 -12.78 -5.70 -4.08 -3.02
Nucleus -2.82 -15.83 -6.66 -5.71 3.19 -6.46 -8.00 -11.44 -4.61 -3.26 -6.99 -17.46 -14.57 -8.90 2.32
Peroxisomes -0.52 1.54 -2.28 -1.94 -3.50 -0.40 -1.44 -4.83 -1.19 -4.02 -0.55 0.00 -4.75 -2.23 -5.60
Vacuole -10.56 -19.59 -13.31 -11.23 -6.36 6.21 -13.65 -8.62 -15.21 5.95 -3.49 -25.57 -19.70 -17.15 3.74
Vacuole Periphery 3.67 -1.53 7.53 5.03 9.41 10.70 11.15 14.51 7.84 11.00 10.31 8.09 17.46 11.45 16.09
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase; phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
Localization
Cell Percentages cytoplasm (96%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

His4

His4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (His4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available