Standard name
Human Ortholog
Description Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 – – 0 0 0 0 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0.14 0.14 0.13 0 0 0 0 0 0
Cytoplasm 0.98 0.98 – – 1.0 0.88 0.91 0.93 0.76 0.86 0.71 0.67 1.0 0.99 0.99 0.92 0.96 0.97 0.88 0.92 0.72 0.89 0.86 0.88
Endoplasmic Reticulum 0 0 – – 0 0 0 0 0 0 0 0.05 0 0 0 0 0.07 0 0 0 0 0 0 0
Endosome 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.06 0 – – 0 0.29 0.19 0.11 0.39 0.18 0.54 0.38 0 0 0 0 0 0 0 0 0.14 0 0.06 0
Nucleus 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 2 0 – – 0 0 0 1 0 0 0 0 1 0 0 3 0 0 1 0 0 1 1 6
Bud 1 2 – – 0 1 4 1 4 2 5 2 2 0 0 0 0 1 0 0 0 0 2 4
Bud Neck 0 0 – – 0 0 0 1 0 2 0 0 0 0 1 0 0 0 3 1 0 1 2 2
Bud Site 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 – – 1 0 2 5 0 4 2 1 4 6 3 30 23 20 0 0 0 0 1 1
Cytoplasm 276 140 – – 37 43 145 145 90 124 45 44 222 186 248 197 155 146 258 135 13 125 208 277
Endoplasmic Reticulum 3 3 – – 0 0 0 2 2 4 1 3 2 1 0 8 11 4 5 1 0 2 3 5
Endosome 0 0 – – 0 0 1 1 0 0 1 0 0 0 1 7 0 0 3 0 0 0 2 0
Golgi 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 2 1 0 2 0 0 0 0 0
Mitochondria 16 1 – – 0 14 31 17 46 26 34 25 0 0 0 1 5 0 9 2 2 6 13 3
Nucleus 1 0 – – 0 2 0 1 0 1 0 1 0 0 0 0 1 1 0 0 0 0 0 0
Nuclear Periphery 0 0 – – 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 – – 0 1 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 – – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 – – 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2
Vac/Vac Membrane 0 1 – – 0 1 1 0 0 2 0 0 0 1 0 11 2 0 6 4 0 1 3 3
Unique Cell Count 283 143 37 49 159 156 118 144 63 66 222 188 251 214 161 151 294 147 19 142 243 317
Labelled Cell Count 300 148 38 63 185 174 143 165 88 76 231 194 255 259 198 172 294 147 19 142 243 317


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 6.1 – – 5.8 4.4 4.2 4.8 4.0 4.2 4.1 4.1 6.1 6.3 6.4 8.9 8.2 8.4 5.6 6.1 6.4
Std Deviation (1e-4) 0.5 0.8 – – 0.8 0.7 0.5 0.6 0.5 0.6 0.5 0.5 0.8 0.9 1.3 1.6 1.2 1.3 1.1 1.3 1.7
Intensity Change (Log2) – – – – – – – – – – – – – – – – – – – – –


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – – –
Bud Neck – – – – – – – – – – – – – – –
Bud Site – – – – – – – – – – – – – – –
Cell Periphery – – – – – – – – – – – – – – –
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – – –
Endosome – – – – – – – – – – – – – – –
Golgi – – – – – – – – – – – – – – –
Mitochondria – – – – – – – – – – – – – – –
Nuclear Periphery – – – – – – – – – – – – – – –
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – – –
Peroxisomes – – – – – – – – – – – – – – –
SpindlePole – – – – – – – – – – – – – – –
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – – –
Cytoplasm – – – – – – – – – – – – – – –
Nucleus – – – – – – – – – – – – – – –
Vacuole – – – – – – – – – – – – – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.4851 2.251 1.8969 1.8014 1.7859 2.0127 1.242 1.8875 1.6699 1.7823 1.8098 1.7434 2.5521 1.1839 1.3838 0.4533 0.2904 0.5885
Actin 0.0068 0.0204 0.0098 0.0043 0.0272 0.0124 0.0271 0.0004 0.0142 0.0319 0.0169 0.0066 0.0376 0.0006 0.0137 0.1467 0.0046 0.013
Bud 0.0033 0.0006 0.0012 0.0015 0.0017 0.0008 0.0046 0.0086 0.0025 0.0016 0.0072 0.0066 0.0014 0.0001 0.0006 0.0018 0.0001 0.0002
Bud Neck 0.0025 0.0006 0.0022 0.0008 0.0007 0.0118 0.0022 0.0004 0.0019 0.0024 0.002 0.0049 0.0019 0.0001 0.0003 0.0073 0.0002 0.0011
Bud Periphery 0.0052 0.0007 0.0019 0.0022 0.0035 0.0026 0.0054 0.0015 0.0019 0.002 0.0095 0.0083 0.0027 0.0001 0.0004 0.0024 0 0.0004
Bud Site 0.01 0.0068 0.0067 0.0011 0.0023 0.0005 0.0062 0.0312 0.0098 0.0106 0.0093 0.0015 0.0062 0.0018 0.0022 0.0066 0.0001 0.0004
Cell Periphery 0.0015 0.0008 0.0005 0.0003 0.0002 0.0002 0.0009 0.0004 0.0005 0.0005 0.0007 0.0005 0.0019 0.0003 0.0006 0.0008 0.0001 0.0002
Cytoplasm 0.6327 0.7963 0.7196 0.616 0.5709 0.7762 0.5524 0.7 0.6955 0.6474 0.6545 0.7381 0.6226 0.8266 0.7729 0.4157 0.7573 0.7935
Cytoplasmic Foci 0.0319 0.0137 0.0266 0.0118 0.0523 0.0162 0.0308 0.026 0.0245 0.0438 0.028 0.0256 0.0358 0.0165 0.0155 0.052 0.056 0.0275
Eisosomes 0.0021 0.0005 0.0003 0.0001 0.0003 0.0001 0.0005 0 0.0001 0.0003 0.0003 0.0002 0.0007 0.0001 0.0011 0.0007 0 0
Endoplasmic Reticulum 0.0051 0.002 0.0024 0.0032 0.0014 0.0025 0.0111 0.0019 0.0038 0.0051 0.0043 0.0032 0.0117 0.0046 0.0056 0.0127 0.0074 0.0087
Endosome 0.0307 0.0105 0.0205 0.0183 0.0575 0.0138 0.0456 0.0175 0.0249 0.0473 0.0622 0.0165 0.0297 0.0076 0.0147 0.132 0.0068 0.0386
Golgi 0.0085 0.0047 0.0055 0.004 0.0378 0.0034 0.0067 0.0014 0.0038 0.0053 0.0097 0.0026 0.0108 0.001 0.0022 0.0668 0.0016 0.0229
Lipid Particles 0.0089 0.0003 0.0015 0.0004 0.0147 0.0007 0.009 0.0031 0.0039 0.0175 0.0164 0.0024 0.0153 0.0004 0.0095 0.0149 0.0083 0.0026
Mitochondria 0.0164 0.0046 0.0079 0.0302 0.0489 0.0027 0.007 0.0004 0.0039 0.0041 0.0085 0.0062 0.051 0.0001 0.0314 0.0358 0.0003 0.0302
None 0.2029 0.1327 0.173 0.2856 0.1053 0.1507 0.2545 0.1919 0.1837 0.0955 0.0738 0.1615 0.0935 0.1358 0.1129 0.0485 0.0939 0.0461
Nuclear Periphery 0.0033 0.0003 0.0006 0.0016 0.0006 0.0003 0.0067 0.0007 0.0025 0.0083 0.0253 0.0011 0.0196 0.0006 0.0008 0.0034 0.001 0.0007
Nucleolus 0.0012 0.0001 0.0003 0.0002 0.0003 0 0.0015 0.0003 0.0008 0.0021 0.0017 0.0015 0.0022 0.0001 0.0002 0.0003 0 0.0001
Nucleus 0.0027 0.0009 0.0013 0.0016 0.0007 0.0005 0.0064 0.0023 0.0031 0.006 0.0363 0.0022 0.0043 0.0008 0.0009 0.001 0.0013 0.0006
Peroxisomes 0.0124 0.0015 0.0107 0.0007 0.0642 0.0024 0.0045 0.0048 0.0069 0.0447 0.0053 0.0051 0.0141 0.0002 0.0087 0.0378 0.058 0.0082
Punctate Nuclear 0.0045 0.0003 0.0008 0.0009 0.0008 0.0003 0.0078 0.0034 0.0027 0.0098 0.0178 0.0024 0.0055 0.0006 0.0004 0.0013 0.0009 0.0005
Vacuole 0.0062 0.0016 0.0058 0.0097 0.0064 0.0013 0.0077 0.0032 0.008 0.0118 0.0078 0.0025 0.0164 0.0019 0.0047 0.0086 0.0019 0.0031
Vacuole Periphery 0.001 0.0003 0.0009 0.0054 0.0022 0.0003 0.0015 0.0004 0.0011 0.0017 0.0024 0.0006 0.0152 0.0002 0.0006 0.0026 0.0003 0.0012

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 11.6594 1.8951 10.5466 11.1892 13.0555 14.831 14.8497 16.812 13.1636 12.5102
Translational Efficiency – – – – – – – – – –

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency –

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2264 344 1837 1614 1165 1640 711 1340 3429 1984 2548 2954

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 794.10 858.72 908.72 903.17 750.46 798.79 1008.83 958.56 779.27 809.18 936.65 928.30
Standard Deviation 92.31 109.61 114.51 123.95 90.31 109.31 109.44 129.37 93.94 111.69 121.70 129.41
Intensity Change Log 2 — 0.112867 0.194515 0.185677 — 0.090041 0.426836 0.353094 — 0.101822 0.312068 0.269448

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000384 0.000932 0.000399 0.002799 0.000246 0.001109 0.000219 0.000527 0.000338 0.001079 0.000349 0.001768
Bud Neck 0.016677 0.023864 0.002432 0.005085 0.013109 0.017253 0.003051 0.004548 0.015464 0.018399 0.002604 0.004842
Bud Site 0.017713 0.066549 0.011251 0.051444 0.016612 0.044232 0.012945 0.039790 0.017339 0.048102 0.011723 0.046158
Cell Periphery 0.000187 0.000206 0.000084 0.000139 0.000224 0.000249 0.000135 0.000095 0.000199 0.000241 0.000098 0.000119
Cytoplasm 0.517069* 0.427137* 0.714641* 0.563196* 0.534184* 0.497354* 0.537409* 0.536176* 0.522884* 0.485179* 0.665186* 0.550939*
Cytoplasmic Foci 0.272480* 0.312525* 0.026909 0.045045 0.250827* 0.261692* 0.074190 0.050199 0.265124* 0.270506* 0.040103 0.047383
Eisosomes 0.000295 0.000218 0.000022 0.000034 0.000231 0.000276 0.000075 0.000028 0.000273 0.000266 0.000037 0.000032
Endoplasmic Reticulum 0.001979 0.000865 0.001070 0.000888 0.002852 0.000903 0.001075 0.001011 0.002275 0.000897 0.001071 0.000944
Endosome 0.023784 0.043078 0.002181 0.014189 0.025763 0.036120 0.007811 0.015796 0.024457 0.037327 0.003752 0.014918
Golgi 0.016729 0.012329 0.000135 0.008713 0.009235 0.019458 0.000379 0.005345 0.014183 0.018222 0.000203 0.007185
Lipid Particles 0.005018 0.002739 0.000714 0.000749 0.006205 0.002997 0.001899 0.001232 0.005422 0.002953 0.001044 0.000968
Mitochondria 0.004676 0.001226 0.000244 0.005749 0.003241 0.006484 0.000505 0.004837 0.004188 0.005573 0.000317 0.005335
Mitotic Spindle 0.000758 0.001428 0.003024 0.051122 0.003568 0.002159 0.004733 0.046676 0.001713 0.002033 0.003501 0.049105
None 0.001504 0.000245 0.002701 0.002455 0.002267 0.000577 0.001440 0.001394 0.001763 0.000520 0.002349 0.001974
Nuclear Periphery 0.000065 0.000086 0.000521 0.000573 0.000139 0.000080 0.000481 0.000962 0.000090 0.000081 0.000510 0.000749
Nuclear Periphery Foci 0.000234 0.000515 0.001522 0.001240 0.000449 0.000323 0.003985 0.002730 0.000307 0.000357 0.002210 0.001915
Nucleolus 0.000346 0.000304 0.000179 0.000265 0.000347 0.000258 0.000251 0.000673 0.000346 0.000266 0.000199 0.000450
Nucleus 0.024327 0.006583 0.133942* 0.019983 0.028217 0.010391 0.082131 0.023561 0.025649 0.009731 0.119484 0.021606
Peroxisomes 0.003480 0.006768 0.000409 0.001712 0.003093 0.006610 0.000986 0.002408 0.003348 0.006638 0.000570 0.002028
Vacuole 0.089180 0.089136 0.097395 0.216577* 0.096574 0.087425 0.266050* 0.255839* 0.091692 0.087722 0.144457 0.234387*
Vacuole Periphery 0.003114 0.003266 0.000225 0.008044 0.002617 0.004047 0.000251 0.006173 0.002945 0.003911 0.000232 0.007195

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.06 0.09 -2.72 -0.88 -2.56 -4.19 0.22 -1.50 3.77 -1.63 -4.17 0.02 -2.78 0.86 -2.48
Bud Neck -2.12 14.78 14.40 6.33 -1.27 -3.22 10.10 9.93 15.13 -0.81 -2.56 17.76 17.44 16.19 -1.45
Bud Site -8.18 5.67 -2.96 6.62 -6.26 -10.44 2.41 -1.81 7.70 -4.00 -14.50 5.97 -3.40 9.91 -7.53
Cell Periphery -0.70 10.84 8.81 4.88 0.20 -0.43 7.16 11.29 3.40 7.99 -0.89 13.19 14.25 3.71 3.40
Cytoplasm 5.90 -16.48 -1.15 -6.20 12.38 3.71 3.16 2.97 -0.32 -0.54 5.13 -11.87 1.05 -3.69 11.40
Cytoplasmic Foci -3.12 58.41 54.52 22.36 -6.14 -1.48 31.20 37.48 43.22 5.91 -0.94 66.32 66.07 49.56 -1.60
Eisosomes 0.93 15.20 15.02 2.30 -1.56 -1.03 12.70 16.21 5.97 10.70 0.19 18.91 19.73 6.36 5.93
Endoplasmic Reticulum 3.09 2.24 4.96 1.36 7.62 3.66 2.94 4.21 1.60 4.42 4.95 3.63 6.43 2.42 8.09
Endosome -5.68 22.01 13.81 10.92 -5.52 -4.60 12.46 10.43 14.91 -1.51 -7.51 25.35 17.29 18.74 -6.30
Golgi 3.09 23.76 13.19 6.14 -4.41 -8.25 14.27 7.83 13.80 -2.71 -3.82 27.40 15.90 14.85 -5.20
Lipid Particles 3.85 14.33 14.63 3.81 1.71 5.33 7.66 9.00 7.74 3.84 7.40 15.69 16.30 10.02 3.09
Mitochondria 5.67 8.20 2.85 -1.56 -3.24 -2.51 3.63 1.26 3.71 -2.21 -1.44 8.74 3.18 3.59 -3.93
Mitotic Spindle -0.76 -3.36 -7.81 -7.34 -6.96 0.99 0.22 -6.00 -7.00 -6.16 -0.46 -1.71 -10.12 -10.06 -9.47
None 3.53 -2.65 -0.47 -3.02 1.34 2.16 1.24 1.24 -3.22 -0.06 3.41 -1.03 0.45 -3.39 1.88
Nuclear Periphery -0.82 -25.54 -5.68 -5.15 3.10 1.90 -11.02 -3.51 -3.89 0.01 0.42 -26.73 -6.08 -6.05 1.84
Nuclear Periphery Foci -1.93 -13.06 -9.56 -2.32 5.76 1.83 -13.40 -3.80 -4.17 7.27 -1.27 -18.18 -6.69 -5.92 7.21
Nucleolus 0.33 3.52 2.57 0.79 -0.52 1.74 3.19 -0.08 -0.66 -1.02 1.88 4.60 0.85 -0.19 -1.14
Nucleus 17.35 -34.10 -5.74 -18.15 30.86 13.17 -11.83 -2.98 -14.20 9.95 20.96 -34.97 -6.50 -21.98 31.44
Peroxisomes -5.35 14.01 11.35 9.74 -3.10 -6.13 5.01 3.85 12.17 -1.68 -8.70 13.22 10.01 15.94 -3.59
Vacuole -0.04 -11.10 -32.60 -24.29 -21.81 1.83 -22.37 -29.47 -31.71 -1.49 1.06 -21.26 -44.39 -42.89 -20.14
Vacuole Periphery -0.35 15.14 0.02 0.21 -4.30 -3.76 11.07 0.32 2.59 -4.18 -3.18 18.62 0.32 2.14 -5.89
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Adaptor protein for various signaling pathways; involved in mating response, invasive/filamentous growth, osmotolerance; acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
Localization
Cell Percentages cytoplasm (94%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Ste50

Ste50


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ste50-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available