Standard name
Human Ortholog
Description Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0.07 0 0 0 0
Bud 0 0.05 0 0.05 0 0 0 0 0 0 0.05 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – – – –
Cell Periphery 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0.15 – – 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.13 0.15 0 – – 0.06 0 0 0 0.07 0.09
Golgi 0 0 0 0.1 0.16 0 0 0 0 0 0 0 0.07 0.07 0.05 0.25 – – 0 0.06 0 0.06 0.05 0.06
Mitochondria 0.89 0.86 0.79 0.79 0.79 0.77 0.82 0.79 0.88 0.84 0.89 0.86 0.77 0.32 0.21 0.15 – – 0.73 0.7 0.7 0.68 0.59 0.49
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0.07 0 0 0.05 0 0.07 0 0 0 0 0.05 – – 0 0 0 0 0 0
Nucleolus 0.08 0 0.06 0 0 0.09 0.12 0.13 0.07 0.08 0.07 0.05 0 0 0.06 0.15 – – 0 0 0 0 0 0
Peroxisomes 0.12 0.13 0 0.12 0.06 0 0.05 0.05 0 0 0 0 0.18 0.46 0.46 0.25 – – 0.06 0 0.11 0.09 0.11 0.16
SpindlePole 0.05 0 0.11 0.06 0 0 0 0 0 0 0 0 0.08 0.38 0.47 0.1 – – 0 0 0 0 0.06 0.09
Vac/Vac Membrane 0.07 0.12 0.09 0 0.1 0.11 0.06 0.07 0.06 0.08 0.06 0.1 0.12 0.06 0.06 0.15 – – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 1 8 12 0 0 4 0 1 3 2 5 7 0 0 – – 3 7 1 4 11 16
Bud 5 4 1 16 19 11 15 14 19 16 28 18 14 19 14 0 – – 0 1 2 3 10 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 – – 0 0 0 0 2 4
Bud Site 1 1 0 1 1 0 4 2 3 1 7 3 0 4 1 0 – – – – – – – –
Cell Periphery 0 4 0 4 12 4 2 3 3 5 6 10 11 4 9 3 – – 0 0 0 0 0 0
Cytoplasm 2 0 1 8 12 12 11 12 18 16 10 11 3 7 9 1 – – 0 0 0 0 0 0
Endoplasmic Reticulum 0 1 0 0 0 1 0 0 3 0 1 0 1 1 1 0 – – 0 0 0 0 0 1
Endosome 2 2 1 8 20 8 11 23 5 4 0 11 21 58 77 0 – – 7 3 3 10 30 53
Golgi 0 1 0 29 89 7 3 10 1 8 2 10 23 31 28 5 – – 5 6 1 15 24 36
Mitochondria 108 72 42 236 444 251 481 526 425 506 462 551 244 138 112 3 – – 93 77 58 174 264 274
Nucleus 1 0 1 1 2 2 7 5 4 5 3 6 0 0 1 0 – – 0 0 0 0 2 0
Nuclear Periphery 5 1 1 7 10 24 25 18 26 27 37 26 5 2 1 1 – – 0 1 0 1 4 3
Nucleolus 10 2 3 9 19 29 71 86 34 50 37 35 5 19 30 3 – – 1 0 1 3 5 3
Peroxisomes 15 11 2 37 32 9 28 31 13 16 8 17 57 199 245 5 – – 8 3 9 22 48 91
SpindlePole 6 1 6 17 19 4 15 21 12 12 14 20 27 165 247 2 – – 4 3 1 9 27 52
Vac/Vac Membrane 8 10 5 13 59 37 33 49 31 49 29 63 39 24 30 3 – – 1 3 1 6 12 8
Unique Cell Count 122 84 53 297 565 328 585 667 482 602 518 639 318 433 528 20 128 111 83 258 451 564
Labelled Cell Count 163 111 64 394 750 399 706 804 597 716 647 783 455 678 808 26 128 111 83 258 451 564


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.3 11.6 8.8 11.2 14.7 13.7 12.8 12.7 11.0 11.2 9.9 10.2 11.4 10.9 10.1 22.4 – – 9.3 9.6 9.4
Std Deviation (1e-4) 1.7 3.8 2.2 2.5 3.9 4.3 4.5 4.3 4.0 4.5 4.1 4.0 3.7 2.9 3.0 7.2 – – 2.9 3.0 2.2
Intensity Change (Log2) – – – 0.34 0.74 0.63 0.54 0.52 0.32 0.34 0.16 0.21 0.38 0.31 0.2 1.34 – – 0.08 0.13 0.1

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_101020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Endosome 0 0 0 0 0 0 0 0 0 0 2.4 2.6 0 – –
Golgi 0 3.1 0 0 0 0 0 0 0 0 0 0 0 – –
Mitochondria 0 -0.1 -0.4 0.5 -0.1 1.9 0.9 2.1 1.4 -0.4 -6.7 -9.1 -5.0 – –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 – –
Nucleolus 0 0 0 1.4 1.5 0 0 0 0 0 0 0 0 – –
Peroxisomes 1.9 0 0 0 0 0 0 0 0 2.6 5.9 6.0 0 – –
SpindlePole 0 0 0 0 0 0 0 0 0 0 3.9 5.0 0 – –
Vacuole 0 0.2 0.4 0 0 0 0 0 0.1 0.6 0 0 0 – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.3673 7.5069 5.146 4.0106 4.1606 6.4347 3.0975 5.1471 3.5916 2.5155 3.6972 3.0264 1.9466 3.0031 2.241 2.4868 2.6309 2.6449
Actin 0.0144 0.0179 0.0099 0.0374 0.0312 0.0071 0.0071 0.0056 0.0079 0.002 0.0006 0.0031 0.0176 0.0183 0.0335 0.0199 0.0222 0.0089
Bud 0.0006 0.0004 0.0047 0.0021 0.0056 0.0002 0.0011 0.0044 0.0013 0.0007 0.0002 0.0035 0.0018 0.0053 0.0076 0.0048 0.0015 0.0029
Bud Neck 0.0007 0.0003 0.0003 0.0002 0.0007 0.0002 0.0032 0.0005 0.0006 0.0002 0.0001 0.0006 0.0009 0.0011 0.0025 0.0018 0.0005 0.0012
Bud Periphery 0.0013 0.0007 0.0103 0.0058 0.0067 0.0004 0.0024 0.0081 0.0024 0.0033 0.0003 0.0028 0.0037 0.0089 0.0189 0.0145 0.0031 0.0176
Bud Site 0.0019 0.0017 0.0048 0.0012 0.003 0.0002 0.011 0.0077 0.0095 0.001 0.0011 0.0012 0.0051 0.0437 0.0219 0.0072 0.0022 0.0005
Cell Periphery 0.0009 0.0001 0.0005 0.0004 0.0002 0.0001 0.0007 0.0006 0.0005 0.0003 0.0001 0.0002 0.002 0.0036 0.0027 0.0045 0.0004 0.0004
Cytoplasm 0.0018 0.0002 0.0008 0.0004 0.006 0.0003 0.0051 0.0019 0.0028 0.0015 0.0008 0.0092 0.0111 0.0385 0.0133 0.0724 0.0115 0.0064
Cytoplasmic Foci 0.0246 0.0218 0.0286 0.0159 0.0257 0.0177 0.0293 0.0242 0.0161 0.0172 0.0049 0.0256 0.032 0.0328 0.0269 0.0436 0.026 0.0224
Eisosomes 0.0013 0.0003 0.0003 0.0005 0.0003 0.0002 0.0005 0.0003 0.0002 0.0001 0.0001 0.0001 0.0009 0.0007 0.0007 0.0007 0.0002 0.0002
Endoplasmic Reticulum 0.0026 0.0001 0.0004 0.0017 0.0012 0.0002 0.001 0.0002 0.0004 0.0002 0.0011 0.0006 0.004 0.0028 0.0025 0.0013 0.0012 0.0006
Endosome 0.023 0.0121 0.0187 0.0092 0.0276 0.0077 0.0448 0.02 0.0374 0.0349 0.0464 0.026 0.0895 0.0561 0.0608 0.1598 0.2044 0.0566
Golgi 0.0246 0.0294 0.0282 0.0053 0.0167 0.0133 0.0264 0.0115 0.0258 0.0103 0.0151 0.0217 0.0852 0.0348 0.0474 0.0293 0.0661 0.0604
Lipid Particles 0.014 0.0184 0.0125 0.0206 0.0381 0.0145 0.0765 0.0125 0.0101 0.0022 0.0046 0.0263 0.0457 0.0301 0.0164 0.0236 0.0577 0.0149
Mitochondria 0.8317 0.8203 0.8264 0.8212 0.7369 0.9037 0.7068 0.8618 0.8119 0.8876 0.8994 0.8356 0.6144 0.6102 0.6754 0.5117 0.5271 0.7453
None 0.002 0.0112 0.0014 0.0008 0.0109 0.0002 0.0174 0.0042 0.012 0.0008 0.0003 0.0071 0.0192 0.0424 0.0151 0.0081 0.0012 0.0263
Nuclear Periphery 0.0036 0 0.0007 0.0023 0.0025 0.0014 0.0047 0.0001 0.0006 0.0001 0.0008 0.0004 0.0054 0.0011 0.0022 0.0008 0.0019 0.0002
Nucleolus 0.001 0.0003 0.0004 0.0006 0.0005 0.0001 0.0008 0.0014 0.0006 0.0002 0.0001 0.0004 0.002 0.0012 0.0015 0.0005 0.0003 0.0002
Nucleus 0.0007 0.0001 0.0004 0.0005 0.0015 0.0002 0.0009 0.0003 0.0006 0.0003 0.0003 0.0007 0.0013 0.0014 0.0009 0.0014 0.0005 0.0003
Peroxisomes 0.0428 0.0628 0.0438 0.0702 0.0703 0.0301 0.0454 0.0248 0.0447 0.0192 0.0174 0.0281 0.0422 0.0256 0.0189 0.0201 0.0238 0.0238
Punctate Nuclear 0.0012 0.0004 0.0004 0.0013 0.0102 0.0006 0.0016 0.0017 0.0003 0.0001 0.0001 0.0016 0.001 0.0005 0.0004 0.0005 0.0001 0.0001
Vacuole 0.0027 0.0005 0.0039 0.0011 0.002 0.0004 0.0075 0.0061 0.0084 0.0142 0.0043 0.0024 0.0085 0.0254 0.0226 0.0458 0.0212 0.0045
Vacuole Periphery 0.0028 0.001 0.0027 0.0012 0.0021 0.001 0.0056 0.0022 0.0057 0.0035 0.002 0.0028 0.0066 0.0155 0.0079 0.0277 0.0269 0.0061

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 63.1681 83.7919 114.2168 148.0102 136.7205 107.9373 234.3665 239.6032 243.4908 209.5166
Translational Efficiency 2.6331 2.4309 2.2733 1.6701 1.5694 2.6911 2.0954 1.8828 1.8175 1.7877

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
15 906 2229 1303 1606 1781 253 1108 1621 2687 2482 2411

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1330.92 1066.77 2486.12 3643.29 940.96 1260.39 2566.38 3905.71 944.57 1195.11 2494.30 3763.89
Standard Deviation 382.99 303.84 792.55 1066.76 216.09 272.11 622.39 1130.98 221.39 297.63 777.29 1104.51
Intensity Change Log 2 — -0.319175 0.901472 1.452818 — 0.421665 1.447530 2.053380 — 0.034684 1.153111 1.732399

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.035326 0.012314 0.005629 0.009363 0.004830 0.002550 0.015496 0.010945 0.005112 0.005842 0.006634 0.010090
Bud Neck 0.003128 0.003679 0.001637 0.003406 0.002752 0.001248 0.015594 0.003445 0.002755 0.002068 0.003060 0.003424
Bud Site 0.003892 0.005921 0.002490 0.007071 0.005871 0.003261 0.007247 0.004048 0.005853 0.004158 0.002975 0.005682
Cell Periphery 0.000246 0.000580 0.000088 0.000722 0.000779 0.000115 0.000225 0.001045 0.000774 0.000271 0.000102 0.000870
Cytoplasm 0.013335 0.000926 0.000489 0.001488 0.001055 0.000869 0.000599 0.000481 0.001169 0.000888 0.000500 0.001025
Cytoplasmic Foci 0.015646 0.026377 0.014253 0.020359 0.021297 0.021081 0.070239 0.020950 0.021245 0.022867 0.019960 0.020631
Eisosomes 0.000673 0.001448 0.001510 0.003426 0.000308 0.000211 0.003298 0.002632 0.000311 0.000628 0.001692 0.003061
Endoplasmic Reticulum 0.027465 0.000346 0.000063 0.000155 0.000254 0.000181 0.000517 0.000357 0.000506 0.000237 0.000109 0.000248
Endosome 0.009632 0.011483 0.000607 0.001128 0.010912 0.007256 0.004242 0.001560 0.010900 0.008681 0.000978 0.001326
Golgi 0.050818 0.032169 0.012851 0.013027 0.018001 0.038894 0.025843 0.015648 0.018304 0.036626 0.014175 0.014232
Lipid Particles 0.002885 0.013004 0.005814 0.005463 0.007847 0.007072 0.013063 0.005296 0.007801 0.009072 0.006553 0.005386
Mitochondria 0.688636 0.830671 0.927068 0.882221 0.879718 0.889980 0.744109 0.882310 0.877949 0.869983 0.908418 0.882262
Mitotic Spindle 0.000744 0.002201 0.001954 0.002476 0.001856 0.002447 0.016541 0.003308 0.001845 0.002364 0.003441 0.002858
None 0.001169 0.001443 0.003228 0.004249 0.000684 0.000852 0.003883 0.004163 0.000689 0.001051 0.003295 0.004209
Nuclear Periphery 0.024146 0.000159 0.000541 0.000806 0.000113 0.000276 0.003788 0.000873 0.000336 0.000237 0.000872 0.000837
Nuclear Periphery Foci 0.005332 0.000973 0.000159 0.000253 0.000267 0.000338 0.002132 0.000302 0.000314 0.000552 0.000360 0.000275
Nucleolus 0.001280 0.001503 0.000734 0.002087 0.000388 0.000331 0.002388 0.001544 0.000396 0.000726 0.000903 0.001837
Nucleus 0.057319 0.000841 0.000059 0.000494 0.000133 0.000086 0.000210 0.000132 0.000662 0.000341 0.000074 0.000327
Peroxisomes 0.027816 0.047044 0.009692 0.010138 0.036764 0.014380 0.043446 0.014302 0.036681 0.025394 0.013133 0.012052
Vacuole 0.024054 0.004322 0.003307 0.008941 0.003362 0.003702 0.013711 0.008960 0.003553 0.003911 0.004368 0.008950
Vacuole Periphery 0.006458 0.002597 0.007829 0.022725 0.002811 0.004869 0.013429 0.017700 0.002844 0.004103 0.008400 0.020416

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.90 1.18 1.02 1.21 -2.58 2.37 -3.71 -3.46 -5.23 1.43 -0.65 -1.41 -3.76 -3.42 -2.93
Bud Neck -0.21 1.09 -0.08 0.31 -3.53 3.80 -3.99 -1.14 -4.14 3.74 1.64 -0.56 -1.45 -3.52 -0.73
Bud Site -0.67 0.58 -1.17 -0.82 -3.12 1.99 -0.69 1.40 -0.79 1.68 1.38 2.40 -0.05 -1.63 -2.82
Cell Periphery -1.70 2.10 -2.13 -0.58 -2.96 2.15 1.78 -0.45 -1.83 -1.61 1.61 2.20 -0.27 -2.27 -2.97
Cytoplasm 1.37 1.41 1.32 -1.24 -1.99 0.59 2.43 2.96 1.56 1.09 1.21 3.04 0.31 -0.61 -1.87
Cytoplasmic Foci -1.24 0.17 -0.59 1.93 -2.89 0.09 -5.52 0.11 0.03 5.55 -0.70 0.53 0.17 1.06 -0.44
Eisosomes -2.36 -2.98 -5.06 -3.73 -3.84 3.11 -6.29 -7.83 -8.18 1.19 -3.99 -11.00 -9.31 -8.01 -4.29
Endoplasmic Reticulum 1.12 1.13 1.13 4.27 -5.58 1.03 -1.01 -0.78 -1.37 0.57 1.14 1.71 1.07 -0.17 -2.26
Endosome -0.48 2.52 2.37 6.16 -2.62 3.03 4.50 9.13 7.03 2.26 1.84 10.35 9.85 9.58 -1.55
Golgi 0.71 1.57 1.57 5.45 -0.10 -6.97 -2.01 1.03 7.34 2.52 -7.34 2.26 2.20 9.54 -0.04
Lipid Particles -4.51 -1.78 -1.45 3.91 0.32 0.58 -1.89 2.11 1.50 2.87 -1.00 1.08 2.18 3.60 1.33
Mitochondria -1.63 -2.55 -2.11 -4.43 6.44 -1.25 6.66 -0.26 0.93 -6.74 0.99 -4.21 -0.49 -1.74 4.52
Mitotic Spindle -1.73 -2.24 -2.23 -0.30 -0.68 -0.93 -3.58 -1.71 -1.02 3.20 -0.87 -2.23 -1.53 -0.81 0.75
None -0.61 -4.78 -6.81 -11.44 -4.27 -3.04 -7.55 -15.46 -14.71 -0.59 -5.38 -19.16 -23.03 -19.99 -4.67
Nuclear Periphery 1.01 0.99 0.98 -2.83 -1.12 -2.54 -2.78 -5.50 -3.94 2.20 0.41 -2.13 -2.03 -4.14 0.17
Nuclear Periphery Foci 1.28 1.51 1.48 1.27 -2.36 -0.69 -1.68 -0.64 0.34 1.64 -1.12 -0.31 0.76 1.36 0.70
Nucleolus 0.18 0.78 -0.26 -1.33 -4.46 0.28 -5.10 -5.69 -4.95 1.95 -1.99 -3.22 -7.86 -4.83 -4.30
Nucleus 1.58 1.60 1.59 0.56 -4.13 1.36 -2.10 0.03 -1.47 2.30 1.02 1.64 1.06 -0.03 -4.36
Peroxisomes -1.07 0.92 0.89 8.36 -0.25 6.74 -0.90 6.59 0.03 4.05 3.33 7.53 8.06 6.25 0.64
Vacuole 1.43 1.48 1.19 -4.14 -5.76 -0.56 -4.13 -4.70 -4.34 1.74 -0.47 -1.14 -6.40 -6.32 -5.52
Vacuole Periphery 1.62 -0.67 -5.25 -9.12 -6.56 -3.08 -5.27 -8.28 -6.97 -1.62 -2.35 -7.96 -11.86 -11.01 -7.77
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Catabolic L-serine (L-threonine) deaminase; catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Cha1

Cha1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cha1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available