Standard name
Human Ortholog
Description Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.37 0.31 0.43 0.4 0.33 0.46 0.34 0.39 0.45 0.42 0.43 0.51 0.25 0.13 0.27 0.33 0.22 0.19 0.62 0.51 0.61 0.16 0.1 0.05
Bud 0.13 0.11 0.11 0.08 0.11 0.13 0.13 0.08 0.13 0.1 0.13 0.13 0 0 0.08 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.14 0.12 0.13 0.14 0.07 0.1 0.07 0.1 0.06 0.08 0.13 0.1 0.19 0.11 0.14 0.15 0.28 0.17 0 0 0 0 0 0
Cytoplasm 0.38 0.42 0.33 0.32 0.34 0.26 0.27 0.16 0.19 0.16 0.16 0.13 0.55 0.71 0.52 0.47 0.61 0.39 0.2 0.24 0.2 0.61 0.73 0.82
Endoplasmic Reticulum 0.16 0.18 0.18 0.24 0.2 0.26 0.2 0.18 0.2 0.18 0.2 0.13 0.21 0.15 0.21 0.05 0.06 0.11 0 0.05 0.06 0.05 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Golgi 0.1 0.05 0.25 0.21 0.27 0.21 0.11 0.41 0.21 0.36 0.29 0.29 0.07 0.05 0.15 0.2 0.17 0.42 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.2 0 0.25 0.12 0.23 0.21 0 0 0 0 0.11 0.08 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.06 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 58 46 147 119 120 158 92 161 171 168 138 193 24 25 67 37 4 7 121 96 242 16 17 9
Bud 20 16 37 24 41 46 34 33 50 40 40 50 3 6 19 3 0 1 6 5 7 2 2 2
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 5 5 1 1 0
Bud Site 0 0 0 1 1 1 0 1 2 1 3 7 0 0 0 0 0 0 – – – – – –
Cell Periphery 22 18 46 41 25 36 18 41 23 34 43 39 18 21 35 17 5 6 7 2 10 1 2 0
Cytoplasm 60 63 114 97 122 91 74 64 74 65 51 48 53 136 132 52 11 14 38 44 81 62 124 144
Endoplasmic Reticulum 25 27 62 72 73 91 54 75 77 72 65 49 20 28 53 5 1 4 4 9 22 5 7 3
Endosome 0 1 1 0 3 3 4 4 3 7 3 13 0 0 3 0 1 0 4 6 11 1 1 1
Golgi 16 7 87 64 97 72 30 166 82 145 93 112 7 10 39 22 3 15 2 5 6 2 2 1
Mitochondria 2 3 0 1 2 8 55 13 96 48 74 80 0 0 0 2 2 3 3 2 1 1 0 0
Nucleus 0 1 2 1 0 0 3 1 1 1 0 1 1 0 0 0 0 0 1 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 2 0 0 0 4 0 0 0 0 0 0 0 0 2 0 0 3
Nucleolus 2 0 0 3 4 2 1 7 3 9 1 7 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 0 1 1 0 2 1 1 0 2 0 5 0 0 0 0 0 0 0 0 2 0 0 0
SpindlePole 0 0 9 0 2 2 1 4 0 0 3 5 0 1 1 1 0 1 0 0 1 0 1 0
Vac/Vac Membrane 1 3 1 1 6 13 17 25 9 18 13 8 2 0 0 0 0 0 3 7 1 2 2 3
Unique Cell Count 157 150 343 301 361 346 271 409 383 402 319 381 97 192 252 111 18 36 197 190 400 102 170 176
Labelled Cell Count 206 185 507 425 496 525 384 598 591 610 527 622 128 227 349 140 27 51 197 190 400 102 170 176


Actin, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 23.1 19.1 21.3 20.1 20.2 18.4 11.9 17.6 15.7 16.7 15.7 15.6 21.1 20.6 21.2 20.0 25.8 27.0 27.3 34.6 39.0
Std Deviation (1e-4) 5.5 4.5 3.3 3.5 3.7 3.6 3.8 3.6 3.6 4.1 3.6 3.7 4.2 4.7 4.5 4.9 6.3 7.0 7.8 9.8 13.6
Intensity Change (Log2) – – – -0.08 -0.07 -0.21 -0.84 -0.27 -0.43 -0.35 -0.44 -0.45 -0.01 -0.04 -0.0 -0.09 0.28 0.34 0.36 0.7 0.87

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002040WT3HU80HU120HU16002040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302040WT1AF100AF140AF18002040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -0.9 -2.6 0.7 -2.2 -1.0 0.5 -0.3 0.1 2.1 -3.2 -7.1 -4.1 -1.8 -1.7 -2.7
Bud -1.2 0.2 1.0 0.7 -1.3 0.9 -0.4 0.7 1.0 -2.3 -3.1 -1.3 -2.6 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.1 -2.9 -1.2 -2.7 -1.4 -3.4 -2.2 0 -1.3 1.3 -0.8 0.2 0.5 0 0
Cytoplasm -0.3 0.2 -2.0 -1.6 -5.7 -4.3 -5.4 -5.1 -6.7 3.8 8.4 4.7 2.6 2.4 0.7
Endoplasmic Reticulum 1.8 0.7 2.6 0.6 0.1 0.7 -0.1 0.8 -1.9 0.6 -1.0 0.9 -3.5 0 -1.0
Endosome 0 0 0 0 0 0 0 0 3.0 0 0 0 0 0 0
Golgi -1.2 0.5 -1.4 -4.5 4.4 -1.3 3.1 1.1 1.2 -3.9 -5.8 -2.9 -1.2 0 2.1
Mitochondria 0 0 0 8.7 3.3 10.0 6.6 9.5 9.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 -2.2 -2.1 0 -1.7 0 0 -1.6 -1.3 0 0 0 0 0 0
Vacuole 0 0 3.2 4.4 4.4 0 3.6 3.4 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 17.6395 18.2186 16.8556 18.8189 14.1649 17.9445 22.7912 22.2907 21.8385 21.0018 20.0175 21.819 16.969 20.0368 18.2771 17.9978 16.4228 19.6176
Actin 0.8095 0.7601 0.816 0.952 0.7621 0.8817 0.8158 0.8563 0.9213 0.7339 0.8714 0.9502 0.6694 0.6957 0.7678 0.7883 0.7196 0.8705
Bud 0.0045 0.0066 0.0076 0.0129 0.0045 0.0011 0.0009 0.0008 0.018 0.0475 0.0044 0.0005 0.0024 0.0037 0.025 0.0236 0.0042 0.001
Bud Neck 0.0055 0.003 0.0149 0.0031 0.0017 0.0065 0.001 0.0009 0.0045 0.0101 0.0005 0.0256 0.0068 0.0022 0.0045 0.0046 0.0034 0.0372
Bud Periphery 0.0034 0.0038 0.0087 0.0212 0.0098 0.0011 0.0005 0.0004 0.0187 0.0677 0.0035 0.0004 0.0021 0.0017 0.0142 0.0482 0.005 0.0011
Bud Site 0.0112 0.0825 0.0088 0.0014 0.0151 0.002 0.0149 0.0391 0.0042 0.0029 0.002 0.0006 0.0202 0.0798 0.0174 0.0109 0.0038 0.0014
Cell Periphery 0.0033 0.0016 0.0007 0.0004 0.0035 0.0002 0.0005 0.0004 0.0004 0.001 0.0002 0.0001 0.0006 0.0006 0.0014 0.0036 0.0004 0.0002
Cytoplasm 0.0228 0.0945 0.0443 0.0009 0.0046 0.029 0.0681 0.0737 0.0215 0.1007 0.0134 0.0103 0.0812 0.1386 0.0665 0.0182 0.0792 0.0301
Cytoplasmic Foci 0.0267 0.0204 0.0206 0.0005 0.0173 0.0071 0.0253 0.0119 0.003 0.0057 0.0113 0.0046 0.0502 0.041 0.0186 0.0146 0.0225 0.0154
Eisosomes 0.0024 0.0007 0.0005 0.0043 0.0013 0.001 0.0011 0.0002 0.0002 0.0002 0.0004 0.0005 0.0007 0.0003 0.0015 0.0005 0.0006 0.0005
Endoplasmic Reticulum 0.0046 0.0006 0.0019 0.0001 0.0075 0.0031 0.0056 0.0005 0.0002 0.003 0.0005 0.0001 0.0036 0.002 0.0058 0.0091 0.0125 0.001
Endosome 0.024 0.0024 0.0145 0.0002 0.0398 0.0133 0.028 0.0012 0.0005 0.0059 0.0242 0.0004 0.0345 0.0034 0.0246 0.0144 0.0353 0.0052
Golgi 0.0335 0.0121 0.0268 0.0023 0.0569 0.0446 0.0267 0.0086 0.0056 0.0147 0.0573 0.0044 0.0342 0.0147 0.0259 0.02 0.0404 0.0246
Lipid Particles 0.0117 0.0013 0.0096 0.0001 0.0353 0.0013 0.0014 0.0009 0.0001 0.0002 0.0003 0.0001 0.0138 0.0044 0.0071 0.0086 0.0312 0.0007
Mitochondria 0.0074 0.0005 0.0116 0.0002 0.0236 0.0053 0.0018 0.0004 0.0001 0.0027 0.0075 0.0002 0.0086 0.0005 0.0016 0.02 0.0139 0.0073
None 0.0031 0.0001 0.0006 0 0.0012 0.0001 0.0003 0.0002 0 0.0004 0.0002 0 0.0019 0.0004 0.0073 0.0018 0.0013 0.0001
Nuclear Periphery 0.0031 0.0001 0.0019 0 0.0028 0.0005 0.0012 0.0001 0 0.0006 0.0001 0 0.0143 0.0002 0.0016 0.0018 0.0097 0.0001
Nucleolus 0.0016 0 0.0001 0 0.0003 0 0 0 0 0 0 0 0.0021 0 0.0002 0.0005 0.0004 0
Nucleus 0.0018 0.0001 0.0005 0 0.0009 0.0001 0.0005 0.0001 0 0.0003 0 0 0.0302 0.0002 0.0007 0.0008 0.0008 0.0001
Peroxisomes 0.007 0.0092 0.0072 0.0003 0.0045 0.0012 0.004 0.004 0.0016 0.001 0.0019 0.002 0.017 0.01 0.0029 0.0039 0.0077 0.0031
Punctate Nuclear 0.0095 0.0001 0.0009 0 0.0004 0.0001 0.0002 0.0001 0 0.0002 0.0001 0.0001 0.0026 0.0005 0.0028 0.0006 0.0063 0.0001
Vacuole 0.0023 0.0003 0.0014 0.0001 0.0046 0.0003 0.0015 0.0001 0.0001 0.0009 0.0003 0 0.0025 0.0001 0.0022 0.0046 0.0008 0.0002
Vacuole Periphery 0.0013 0 0.0008 0 0.0019 0.0004 0.0009 0 0 0.0004 0.0004 0 0.0011 0 0.0004 0.0014 0.0009 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 90.5677 48.2064 42.1917 69.7521 74.399 96.7363 71.5499 66.2161 73.5316 81.6717
Translational Efficiency 1.4972 2.0847 2.0865 1.4184 1.4928 1.5154 1.5397 1.7642 1.7373 1.6839

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
29 645 365 1109 1589 2179 1330 1482 1618 2824 1695 2591

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1685.67 1506.55 2046.65 2082.40 1529.06 1764.48 2104.85 2344.81 1531.87 1705.57 2092.32 2232.49
Standard Deviation 687.96 305.42 349.53 510.03 291.22 298.78 415.93 477.60 303.65 319.23 403.27 508.59
Intensity Change Log 2 — -0.162074 0.279942 0.304925 — 0.206598 0.461072 0.616826 — 0.025047 0.368935 0.461700

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.046133 0.727798 0.643661 0.613230 0.836065 0.810809 0.656165 0.598678 0.821907 0.791849 0.653472 0.604906
Bud Neck 0.010480 0.006651 0.032822 0.012873 0.007534 0.003474 0.015215 0.015545 0.007587 0.004200 0.019006 0.014401
Bud Site 0.108242 0.061788 0.165666 0.156877 0.071928 0.097196 0.124802 0.208942 0.072579 0.089108 0.133602 0.186657
Cell Periphery 0.079783 0.001282 0.020389 0.042036 0.003173 0.001611 0.016043 0.036281 0.004546 0.001536 0.016979 0.038744
Cytoplasm 0.143796 0.022460 0.009956 0.034157 0.013717 0.028251 0.022287 0.049191 0.016049 0.026928 0.019631 0.042756
Cytoplasmic Foci 0.031722 0.031024 0.010349 0.007628 0.012538 0.019038 0.015337 0.006077 0.012882 0.021776 0.014263 0.006741
Eisosomes 0.000678 0.001859 0.010492 0.019932 0.004312 0.001169 0.008916 0.012249 0.004247 0.001327 0.009255 0.015537
Endoplasmic Reticulum 0.027605 0.002755 0.010027 0.003568 0.004841 0.000820 0.005714 0.002960 0.005249 0.001262 0.006643 0.003220
Endosome 0.025083 0.042527 0.019183 0.011990 0.011792 0.006281 0.026296 0.005111 0.012031 0.014559 0.024764 0.008055
Golgi 0.125547 0.032127 0.013619 0.017149 0.015019 0.010400 0.026466 0.011694 0.017000 0.015363 0.023699 0.014029
Lipid Particles 0.025092 0.046488 0.049779 0.044548 0.011634 0.003932 0.065880 0.038969 0.011876 0.013651 0.062413 0.041357
Mitochondria 0.017511 0.000372 0.000190 0.006564 0.000625 0.000543 0.000322 0.001036 0.000928 0.000504 0.000293 0.003402
Mitotic Spindle 0.011016 0.001897 0.000909 0.004433 0.000602 0.001049 0.001101 0.000938 0.000789 0.001243 0.001060 0.002434
None 0.002491 0.000054 0.000041 0.000144 0.000056 0.000082 0.000079 0.000214 0.000099 0.000076 0.000070 0.000184
Nuclear Periphery 0.001412 0.000017 0.000098 0.000270 0.000009 0.000003 0.000070 0.000093 0.000035 0.000006 0.000076 0.000169
Nuclear Periphery Foci 0.049760 0.000319 0.000551 0.001148 0.000173 0.000044 0.000574 0.000322 0.001062 0.000106 0.000569 0.000675
Nucleolus 0.036380 0.000014 0.000007 0.000413 0.000005 0.000004 0.000006 0.000018 0.000657 0.000006 0.000006 0.000187
Nucleus 0.185652 0.000140 0.000289 0.000872 0.000152 0.000089 0.000396 0.000731 0.003477 0.000101 0.000373 0.000791
Peroxisomes 0.005652 0.016846 0.001617 0.002976 0.005002 0.014443 0.004312 0.003095 0.005014 0.014992 0.003732 0.003044
Vacuole 0.045979 0.002240 0.009871 0.014896 0.000608 0.000534 0.009559 0.006682 0.001421 0.000924 0.009626 0.010198
Vacuole Periphery 0.019986 0.001342 0.000485 0.004297 0.000212 0.000228 0.000463 0.001174 0.000566 0.000482 0.000467 0.002511

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -25.62 -20.09 -22.19 6.86 1.25 2.68 16.05 20.75 19.00 3.81 3.23 15.92 21.79 20.73 3.87
Bud Neck 0.95 -4.19 -0.48 -5.47 6.17 4.44 -6.14 -6.51 -12.54 -0.22 3.79 -8.75 -6.57 -14.59 3.93
Bud Site 1.59 -2.23 -2.01 -11.32 0.73 -4.23 -8.26 -17.61 -14.24 -9.51 -3.08 -10.02 -18.36 -16.61 -7.41
Cell Periphery 2.20 1.64 1.02 -12.57 -4.94 3.17 -7.74 -12.92 -13.62 -6.83 3.73 -7.75 -15.97 -18.45 -8.94
Cytoplasm 2.61 2.88 2.33 -2.60 -5.90 -5.04 -3.72 -8.99 -5.19 -5.27 -3.94 -2.27 -8.68 -5.39 -6.23
Cytoplasmic Foci -0.04 2.05 2.60 7.12 1.47 -3.07 -1.56 4.41 7.50 5.94 -4.55 -1.04 4.38 9.87 5.80
Eisosomes -2.06 -4.75 -9.08 -8.45 -3.26 4.89 -3.23 -4.89 -7.44 -1.79 4.59 -3.97 -8.11 -11.43 -3.92
Endoplasmic Reticulum 3.48 2.37 3.37 -1.15 3.06 5.45 -0.91 2.45 -7.30 4.19 5.33 -1.40 2.64 -6.78 4.95
Endosome -2.67 0.82 2.26 6.91 1.88 4.10 -6.50 5.16 1.27 10.60 -1.57 -6.28 2.96 4.92 9.20
Golgi 2.52 3.05 2.95 3.57 -1.01 2.47 -4.14 1.45 -0.60 5.10 0.77 -2.70 1.34 0.74 4.11
Lipid Particles -2.55 -2.82 -2.60 0.27 0.83 5.09 -12.61 -8.40 -11.65 5.46 -0.95 -13.61 -11.13 -10.57 5.19
Mitochondria 1.17 1.18 0.73 -4.60 -4.75 0.44 2.08 -1.44 -1.75 -2.77 1.35 2.15 -3.76 -4.81 -5.23
Mitotic Spindle 1.35 1.42 0.98 -2.01 -2.40 -1.05 -1.53 -0.89 0.32 0.56 -1.03 -0.99 -2.95 -2.10 -2.46
None 3.86 3.88 3.71 -3.66 -4.32 -0.43 -0.79 -3.32 -1.98 -2.64 0.64 1.20 -2.48 -2.30 -3.38
Nuclear Periphery 2.59 2.44 2.12 -4.03 -2.64 3.14 -10.62 -9.89 -11.18 -2.26 2.69 -3.42 -4.51 -5.97 -3.28
Nuclear Periphery Foci 2.00 1.98 1.97 -2.13 -1.10 2.23 -3.57 -1.11 -5.28 3.08 2.11 1.00 0.90 -3.40 -0.18
Nucleolus 2.59 2.59 2.56 -1.26 -1.29 0.63 -0.09 -1.90 -2.58 -2.20 2.37 2.37 1.63 -1.34 -1.34
Nucleus 3.58 3.57 3.56 -2.61 -1.92 0.99 -2.67 -5.32 -8.74 -1.73 3.08 2.71 2.41 -5.56 -2.06
Peroxisomes -3.08 1.48 0.99 6.06 -3.84 -7.83 0.99 2.77 9.69 1.76 -8.96 1.99 3.33 11.67 1.36
Vacuole 3.22 2.62 2.28 -6.44 -1.87 0.43 -8.86 -8.12 -8.21 2.77 1.52 -9.13 -9.09 -10.00 0.18
Vacuole Periphery 4.14 4.43 3.50 -2.43 -4.92 -0.23 -4.20 -3.50 -3.40 -2.54 0.32 0.70 -5.15 -4.78 -5.54
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Amphiphysin-like lipid raft protein; N-BAR domain protein that interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
Localization
Cell Percentages actin (76%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Rvs161

Rvs161


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rvs161-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available