Standard name
Human Ortholog
Description Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0
Bud 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0
Cytoplasm 0.74 0.74 0.8 0.74 0.74 0.62 0.6 0.59 – 0.5 0.53 0.42 0.81 0.93 0.98 – 0.92 0.86 0.3 0.33 0.14 0.26 0.33 0.42
Endoplasmic Reticulum 0.19 0.17 0.07 0.12 0 0 0 0 – 0 0 0 0.15 0.07 0 – 0 0 0.37 0.22 0.57 0.32 0.23 0.2
Endosome 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0.08 0.08 0.18 0.18 0.5 0.51 0.56 – 0.67 0.64 0.7 0 0 0 – 0 0 0.13 0.13 0.14 0.24 0.24 0.16
Nucleus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.08 0 0.05 0 – 0 0 0 0 0 0 – 0 0.05 0.05 0.14 0 0.05 0.05 0.07
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 3 0 0 0 0 1 – 0 0 0 1 0 1 – 2 3 12 12 16 12 16 16
Bud 3 2 4 6 2 4 11 8 – 6 18 22 3 0 0 – 0 1 5 2 4 2 6 5
Bud Neck 0 0 1 0 0 0 0 0 – 2 0 0 8 4 4 – 0 2 8 7 4 3 8 10
Bud Site 0 0 0 0 0 2 0 1 – 5 1 1 0 0 0 – 0 0 – – – – – –
Cell Periphery 5 2 7 7 9 7 3 5 – 3 5 10 16 11 12 – 2 11 2 5 4 7 13 13
Cytoplasm 197 185 208 159 224 201 217 342 – 193 264 233 720 864 876 – 210 159 118 106 46 88 134 171
Endoplasmic Reticulum 50 42 19 25 7 5 3 8 – 3 2 6 133 63 14 – 8 7 145 71 186 109 92 81
Endosome 2 0 6 3 13 3 1 2 – 0 1 3 6 3 1 – 4 2 10 7 5 6 4 5
Golgi 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – 0 0 6 2 1 3 0 0
Mitochondria 10 21 22 38 56 163 185 326 – 258 315 387 2 0 0 – 9 8 50 42 45 82 97 65
Nucleus 0 1 0 0 0 4 1 2 – 0 2 3 2 0 2 – 2 1 0 0 0 0 0 0
Nuclear Periphery 1 0 0 0 0 0 0 1 – 1 1 8 0 0 0 – 0 0 0 2 0 0 1 0
Nucleolus 1 0 1 1 1 0 2 3 – 0 2 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 2 0 0 1 – 0 0 0 0 0 0 – 0 0 2 0 1 0 0 0
SpindlePole 0 0 0 0 0 1 1 5 – 4 3 5 3 3 0 – 0 0 3 2 0 0 2 4
Vac/Vac Membrane 10 4 11 9 25 14 17 20 – 13 16 20 39 16 13 – 9 10 20 46 8 17 21 29
Unique Cell Count 267 249 259 215 304 326 361 580 385 495 554 889 933 898 229 185 393 321 330 339 404 407
Labelled Cell Count 281 260 282 248 339 404 441 725 488 630 698 933 964 923 246 204 393 321 330 339 404 407


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.9 4.8 4.5 4.7 4.6 3.6 3.4 3.6 – 3.0 3.3 3.2 6.3 6.1 6.3 4.6 5.6 5.6 6.2 5.9 6.0
Std Deviation (1e-4) 0.7 0.7 1.2 1.4 1.9 1.2 1.1 1.0 – 0.7 1.0 0.7 0.8 0.7 1.0 0.9 0.9 0.9 1.3 1.3 1.4
Intensity Change (Log2) – – – 0.07 0.02 -0.33 -0.41 -0.33 – -0.6 -0.46 -0.5 0.48 0.43 0.48 0.03 0.31 0.31 0.46 0.4 0.42

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – – 0 0
Bud Neck – – – – – – – – – – – – – 0 0
Bud Site – – – – – – – – – – – – – 0 0
Cell Periphery – – – – – – – – – – – – – 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – – 0 0
Endosome – – – – – – – – – – – – – 0 0
Golgi – – – – – – – – – – – – – 0 0
Mitochondria – – – – – – – – – – – – – 0 0
Nuclear Periphery – – – – – – – – – – – – – 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – – 0 0
Peroxisomes – – – – – – – – – – – – – 0 0
SpindlePole – – – – – – – – – – – – – 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – – 0 0
Cytoplasm – – – – – – – – – – – – – 0 0
Nucleus – – – – – – – – – – – – – 0 0
Vacuole – – – – – – – – – – – – – -0.2 0.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.4981 2.1092 2.2744 1.954 1.954 2.134 3.7044 4.0179 3.8354 3.7977 3.0923 3.5524 3.0917 3.6712 3.7116 3.3898 3.2886 3.4842
Actin 0.0284 0.0074 0.0113 0.0235 0.0062 0.0036 0.0657 0.0037 0.0069 0.0004 0.0102 0.0009 0.0033 0.0011 0.0017 0.0067 0.0013 0.0018
Bud 0.0064 0.0113 0.0192 0.0238 0.004 0.0044 0.001 0.001 0.0005 0.0016 0.0001 0.0001 0.0006 0.0078 0.0006 0.0078 0.0002 0.0001
Bud Neck 0.0035 0.0017 0.0034 0.003 0.0156 0.0166 0.031 0.0006 0.0005 0.0002 0.0022 0.0009 0.0015 0.0007 0.0021 0.0288 0.0012 0.004
Bud Periphery 0.0058 0.0048 0.0096 0.0066 0.0039 0.003 0.002 0.0016 0.0011 0.0026 0.0002 0.0002 0.0018 0.0027 0.0015 0.0335 0.0002 0.0002
Bud Site 0.0056 0.0539 0.0418 0.0294 0.0425 0.0036 0.0097 0.0143 0.009 0.0004 0.0009 0.0002 0.0026 0.0095 0.0021 0.0051 0.0002 0.0003
Cell Periphery 0.0012 0.0026 0.0025 0.0011 0.0015 0.0009 0.0014 0.0016 0.0018 0.0003 0.0008 0.0006 0.0036 0.0016 0.0079 0.004 0.0003 0.0004
Cytoplasm 0.1606 0.3557 0.2879 0.2249 0.3841 0.3028 0.2871 0.3631 0.4113 0.362 0.4009 0.4668 0.4158 0.4221 0.4313 0.3227 0.4164 0.437
Cytoplasmic Foci 0.0272 0.0218 0.0164 0.0342 0.0226 0.0329 0.0248 0.0216 0.0175 0.0135 0.0407 0.0229 0.0212 0.0196 0.0179 0.017 0.02 0.0243
Eisosomes 0.0007 0.0006 0.0005 0.0006 0.0003 0.0002 0.0008 0.0003 0.0002 0.0003 0.0003 0.0001 0.0008 0.0002 0.0002 0.0006 0.0001 0.0001
Endoplasmic Reticulum 0.0877 0.0893 0.1015 0.1005 0.0181 0.0815 0.1351 0.1846 0.2095 0.0704 0.1319 0.183 0.2516 0.1644 0.2092 0.2535 0.2356 0.2383
Endosome 0.0219 0.0243 0.0156 0.0383 0.0326 0.0158 0.0612 0.0322 0.0265 0.0169 0.0913 0.0461 0.039 0.0377 0.0394 0.0219 0.0484 0.0383
Golgi 0.0113 0.0038 0.0037 0.0073 0.0182 0.001 0.0099 0.0019 0.003 0.0009 0.0025 0.0014 0.003 0.0021 0.0017 0.0014 0.0009 0.0012
Lipid Particles 0.0176 0.0046 0.0074 0.0358 0.0056 0.0038 0.0192 0.0069 0.0078 0.0015 0.0073 0.0054 0.007 0.0059 0.0044 0.0021 0.0019 0.0037
Mitochondria 0.0151 0.0043 0.0028 0.0046 0.028 0.0053 0.0066 0.0016 0.0031 0.0065 0.002 0.0009 0.0024 0.0024 0.0018 0.0026 0.0011 0.0014
None 0.5211 0.3277 0.4067 0.3805 0.3782 0.4035 0.2793 0.3136 0.2618 0.4996 0.2619 0.22 0.2077 0.2695 0.2321 0.2553 0.2004 0.1905
Nuclear Periphery 0.0121 0.015 0.0168 0.0242 0.0039 0.0164 0.0186 0.0122 0.0162 0.0028 0.0072 0.0114 0.0113 0.0103 0.0091 0.007 0.0048 0.0104
Nucleolus 0.0161 0.0053 0.0031 0.0024 0.0048 0.0024 0.001 0.0008 0.0003 0.0004 0.0006 0.0004 0.0004 0.0007 0.0005 0.0007 0.0002 0.0004
Nucleus 0.01 0.0332 0.0182 0.0186 0.0116 0.0242 0.0053 0.005 0.0035 0.0022 0.004 0.0048 0.0052 0.0081 0.0055 0.0068 0.0028 0.0132
Peroxisomes 0.0198 0.0035 0.0029 0.0096 0.0024 0.0008 0.0075 0.0004 0.0039 0.0002 0.0024 0.0004 0.0007 0.0004 0.0005 0.0018 0.0007 0.0004
Punctate Nuclear 0.0217 0.0194 0.0222 0.023 0.0101 0.0702 0.012 0.0024 0.002 0.0013 0.0073 0.0019 0.0031 0.0026 0.0022 0.0028 0.0009 0.0014
Vacuole 0.005 0.0084 0.0058 0.0059 0.005 0.0057 0.0171 0.028 0.0123 0.0102 0.0215 0.029 0.0156 0.0282 0.0253 0.0163 0.0568 0.03
Vacuole Periphery 0.0014 0.0014 0.001 0.0021 0.001 0.0015 0.004 0.0026 0.0013 0.0057 0.0039 0.0027 0.0017 0.0025 0.0029 0.0016 0.0056 0.0025

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 52.973 51.1215 48.7157 41.7779 45.6578 53.5454 52.9131 47.7395 54.7273 64.4231
Translational Efficiency 0.6457 0.7084 0.6184 0.892 0.8933 0.6138 0.5671 0.752 0.6054 0.6062

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
83 1799 1767 118 1639 2061 2425 1062 1722 3860 4192 1180

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 892.82 795.06 890.71 1058.44 711.44 773.22 921.72 932.93 720.18 783.40 908.65 945.48
Standard Deviation 122.97 103.77 106.25 130.90 81.86 89.97 123.35 132.28 92.82 97.26 117.45 137.40
Intensity Change Log 2 — -0.167306 -0.003414 0.245498 — 0.120137 0.373586 0.391027 — -0.032725 0.176017 0.311853

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000305 0.000549 0.000458 0.018460 0.000244 0.000454 0.003489 0.005973 0.000247 0.000498 0.002212 0.007222
Bud Neck 0.003523 0.008899 0.002840 0.006820 0.007960 0.015750 0.012144 0.011001 0.007746 0.012557 0.008222 0.010583
Bud Site 0.051225 0.004936 0.006472 0.030251 0.001403 0.006055 0.017017 0.035973 0.003804 0.005534 0.012572 0.035401
Cell Periphery 0.000452 0.000308 0.000302 0.002701 0.000693 0.000427 0.002863 0.003073 0.000681 0.000372 0.001784 0.003036
Cytoplasm 0.219919 0.421079 0.509867 0.166742 0.359753 0.366746 0.292253 0.307987 0.353013 0.392069 0.383981 0.293863
Cytoplasmic Foci 0.097161 0.207339 0.037385 0.071107 0.150250 0.210517 0.019397 0.063318 0.147691 0.209036 0.026979 0.064097
Eisosomes 0.000226 0.000516 0.000084 0.001636 0.001306 0.000947 0.001425 0.001758 0.001254 0.000746 0.000860 0.001746
Endoplasmic Reticulum 0.005660 0.048018 0.074027 0.220382 0.142912 0.062328 0.401470 0.282210 0.136297 0.055659 0.263447 0.276027
Endosome 0.019969 0.014013 0.005564 0.016335 0.013497 0.018478 0.006757 0.011630 0.013809 0.016397 0.006254 0.012100
Golgi 0.012180 0.007502 0.000366 0.009673 0.016439 0.012521 0.003462 0.006311 0.016233 0.010182 0.002157 0.006647
Lipid Particles 0.011511 0.050422 0.007945 0.038485 0.140905 0.087396 0.023150 0.041812 0.134668 0.070164 0.016741 0.041479
Mitochondria 0.000899 0.005448 0.000473 0.002507 0.009967 0.011440 0.002696 0.001751 0.009530 0.008647 0.001759 0.001827
Mitotic Spindle 0.006153 0.000862 0.001305 0.001176 0.000111 0.000843 0.001181 0.003495 0.000402 0.000852 0.001233 0.003263
None 0.000469 0.003116 0.001618 0.000154 0.003415 0.001790 0.002030 0.000900 0.003273 0.002408 0.001856 0.000826
Nuclear Periphery 0.001388 0.003068 0.010595 0.004693 0.005335 0.003231 0.003118 0.001120 0.005145 0.003155 0.006270 0.001477
Nuclear Periphery Foci 0.005081 0.005005 0.038714 0.051142 0.002691 0.002745 0.016306 0.024116 0.002807 0.003798 0.025751 0.026818
Nucleolus 0.000308 0.001318 0.000289 0.000100 0.000689 0.000792 0.000305 0.000266 0.000671 0.001037 0.000298 0.000250
Nucleus 0.216547 0.137051 0.230780 0.048801 0.094063 0.130658 0.135365 0.067250 0.099967 0.133638 0.175584 0.065405
Peroxisomes 0.001584 0.004607 0.000372 0.001170 0.006346 0.007894 0.001471 0.002595 0.006117 0.006362 0.001007 0.002453
Vacuole 0.337647 0.074414 0.070288 0.304281 0.040331 0.056921 0.053681 0.126322 0.054662 0.065074 0.060681 0.144118
Vacuole Periphery 0.007793 0.001529 0.000258 0.003384 0.001689 0.002065 0.000419 0.001137 0.001983 0.001815 0.000351 0.001362

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.13 -1.61 -2.38 -2.35 -2.36 -2.84 -7.23 -8.76 -8.41 -3.07 -2.52 -7.48 -7.48 -7.17 -5.08
Bud Neck -4.99 0.69 -2.71 1.97 -4.38 -5.73 -3.66 -2.31 3.15 0.97 -4.72 -0.69 -2.33 1.73 -2.06
Bud Site 2.11 2.03 0.50 -3.32 -3.14 -5.95 -11.24 -10.69 -9.06 -5.27 -2.06 -7.34 -10.24 -9.85 -7.25
Cell Periphery 0.96 0.98 -4.23 -4.39 -4.40 2.80 -9.16 -9.34 -11.25 -0.41 3.42 -7.09 -9.86 -12.18 -4.66
Cytoplasm -8.11 -11.23 1.34 13.51 17.81 -0.93 9.51 5.75 6.67 -1.64 -5.91 -4.13 6.72 12.30 10.77
Cytoplasmic Foci -9.27 3.54 1.03 16.31 -4.01 -10.90 33.20 18.27 30.03 -14.58 -13.09 31.62 18.27 36.58 -13.12
Eisosomes -4.15 2.18 -2.52 -1.85 -2.77 2.38 -0.57 -1.68 -3.90 -1.29 3.68 2.70 -1.90 -5.26 -4.42
Endoplasmic Reticulum -14.75 -17.91 -6.52 -4.79 -3.86 12.46 -27.85 -10.71 -19.56 10.64 13.83 -16.47 -11.07 -21.01 0.22
Endosome 0.41 2.95 0.33 -0.05 -4.46 -4.39 8.41 1.97 5.86 -5.00 -3.15 9.91 1.90 5.01 -6.56
Golgi 0.09 1.08 0.12 0.09 -1.51 3.70 14.95 9.80 6.74 -3.18 6.19 16.08 8.74 4.65 -4.84
Lipid Particles -11.92 0.45 -4.87 3.57 -6.09 11.12 28.46 21.36 12.91 -6.67 15.18 30.00 21.13 10.56 -10.09
Mitochondria -5.53 0.56 -0.90 2.41 -1.10 -1.20 8.95 9.39 9.53 2.05 0.94 10.32 9.31 9.40 0.17
Mitotic Spindle 1.28 1.23 1.13 -1.19 -0.75 -1.62 -2.27 -3.33 -2.41 -2.09 -0.22 -0.88 -2.57 -2.63 -2.19
None -3.37 -2.08 1.37 4.80 7.31 2.18 1.90 3.50 2.95 3.33 1.21 2.13 3.59 4.54 4.12
Nuclear Periphery -4.54 -10.30 -1.65 -0.56 3.67 3.46 4.50 8.99 5.27 10.63 3.92 -1.71 7.94 5.82 11.68
Nuclear Periphery Foci -0.54 -16.11 -7.45 -7.44 -1.10 -0.22 -16.43 -14.73 -14.63 -4.48 -3.66 -24.01 -16.41 -15.62 -0.17
Nucleolus -2.49 0.47 1.80 3.03 2.98 -1.38 6.78 7.23 9.78 1.63 -2.01 6.84 7.51 4.23 2.13
Nucleus 2.05 -0.98 4.72 9.42 18.49 -8.97 -9.71 5.92 13.77 14.20 -9.17 -18.70 7.50 17.58 26.19
Peroxisomes -6.51 2.30 0.26 9.41 -4.58 -2.70 13.16 9.66 10.87 -4.41 -0.60 15.03 9.93 11.81 -7.06
Vacuole 8.74 8.62 0.39 -11.20 -11.02 -6.34 -6.98 -17.17 -14.33 -13.91 -2.57 -3.18 -16.04 -15.94 -15.54
Vacuole Periphery 0.83 1.11 0.57 -0.54 -1.27 -1.77 9.48 1.97 2.96 -2.18 0.19 6.10 1.64 1.81 -2.70
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen; ARE1 has a paralog, ARE2, that arose from the whole genome duplication
Localization
Cell Percentages ER (80%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Are1

Are1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Are1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available