Standard name
Human Ortholog
Description Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.96 0.99 0.99 0.94 0.88 0.81 0.76 0.81 0.66 0.8 0.99 0.99 1.0 0.98 0.99 0.97 0.94 0.98 0.95 0.96 0.91 0.91
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0 0.05 0.16 0.19 0.33 0.23 0.39 0.18 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.06 0 0.08 0.08 0.07 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud 3 1 2 0 0 0 2 2 2 4 6 0 0 0 0 0 0 0 2 1 0 0 6 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 3 6 2 2 1 5 4 6 1 0 2 0 7 4 0 0 0 0 0 0
Cytoplasm 327 245 80 79 295 253 345 224 127 180 132 172 246 365 369 41 136 111 322 238 113 109 270 270
Endoplasmic Reticulum 1 0 0 0 0 1 4 4 2 1 3 2 1 3 1 1 9 4 0 0 0 0 2 2
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 2 0 0 0 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 1 1
Mitochondria 12 1 0 4 2 14 64 51 55 51 77 39 0 0 0 0 0 0 3 0 1 1 2 2
Nucleus 1 2 1 1 1 4 5 0 3 7 2 3 2 0 0 0 3 3 0 0 0 0 0 0
Nuclear Periphery 0 0 1 0 0 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 1 0 0 0 2 2
Vac/Vac Membrane 2 1 0 0 1 5 15 17 7 17 16 16 0 0 1 1 0 2 0 0 2 0 1 1
Unique Cell Count 337 247 83 80 297 270 393 275 168 223 200 215 248 368 370 42 137 114 342 244 119 114 296 296
Labelled Cell Count 346 250 85 84 302 283 437 302 200 266 242 238 250 369 374 43 155 124 342 244 119 114 296 296


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 6.7 5.9 5.2 6.3 5.9 5.8 6.4 5.7 5.9 5.6 6.4 6.1 6.8 6.8 16.6 16.6 16.5 6.0 7.1 7.1
Std Deviation (1e-4) 1.1 1.4 1.2 0.9 1.7 1.4 1.2 1.3 1.2 1.2 1.2 1.2 1.1 1.2 1.2 4.9 3.8 4.2 1.2 1.6 1.6
Intensity Change (Log2) – – – -0.17 0.09 0.01 -0.03 0.11 -0.05 0.01 -0.07 0.11 0.06 0.2 0.2 1.5 1.49 1.48 0.03 0.27 0.27


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 2.1 -0.9 -2.3 -3.3 -4.1 -3.4 -5.4 -3.5 1.8 2.0 2.9 0.4 1.6 0.4
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 4.0 4.2 5.9 4.8 6.6 4.2 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8938 0.8781 0.4985 0.5834 -0.244 0.6105 1.3969 1.5612 1.3999 1.4233 1.3327 1.2534 2.3199 2.1021 2.3115 2.2532 2.2712 1.7509
Actin 0.0336 0.0025 0.0047 0.0152 0.0045 0.0091 0.0461 0.0043 0.0155 0.0602 0.0258 0.0096 0.0348 0.0015 0.0212 0.0459 0.0503 0.0083
Bud 0.002 0.0095 0.0086 0.0004 0.0031 0.0015 0.0005 0.0038 0.0008 0.002 0.0024 0.0002 0.0008 0.0005 0.0247 0.0165 0.01 0.0006
Bud Neck 0.0057 0.0004 0.0006 0.0005 0.001 0.0011 0.0015 0.0005 0.0044 0.0015 0.0007 0.0005 0.0005 0.0002 0.0008 0.0009 0.0007 0.0008
Bud Periphery 0.0036 0.0025 0.0038 0.0005 0.0043 0.0017 0.0007 0.0029 0.0014 0.0067 0.0028 0.0002 0.0007 0.0002 0.0086 0.0129 0.0205 0.0002
Bud Site 0.0114 0.0124 0.0068 0.0003 0.0012 0.0007 0.0028 0.0138 0.0044 0.0037 0.0037 0.0002 0.0028 0.0016 0.0187 0.0106 0.0122 0.0001
Cell Periphery 0.0005 0.0002 0.0002 0.0001 0.0001 0.0001 0.0003 0.0002 0.0004 0.0006 0.0002 0 0.0003 0.0002 0.0007 0.0005 0.0008 0.0001
Cytoplasm 0.3542 0.5605 0.401 0.4049 0.3911 0.5466 0.3839 0.5489 0.4637 0.4433 0.4614 0.5587 0.7433 0.8834 0.7674 0.7161 0.6164 0.8183
Cytoplasmic Foci 0.0348 0.0179 0.0208 0.013 0.0435 0.0124 0.0322 0.0093 0.0126 0.0152 0.0151 0.0139 0.0274 0.0044 0.0114 0.0382 0.0105 0.0227
Eisosomes 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0006 0.0001 0.0002 0.0006 0.0002 0 0.0003 0 0.0002 0.0003 0.0003 0
Endoplasmic Reticulum 0.0041 0.0015 0.0023 0.0038 0.0045 0.0018 0.0077 0.0016 0.0028 0.0066 0.0041 0.0018 0.0063 0.0033 0.0079 0.0044 0.0092 0.003
Endosome 0.034 0.0027 0.0135 0.0282 0.0271 0.0143 0.0305 0.0022 0.007 0.0402 0.0288 0.0078 0.0092 0.0019 0.0088 0.0128 0.024 0.0077
Golgi 0.0093 0.0009 0.0069 0.0088 0.0053 0.0038 0.0121 0.0005 0.0039 0.0119 0.0076 0.0023 0.0034 0.0002 0.0023 0.0058 0.005 0.0027
Lipid Particles 0.0249 0.0009 0.0023 0.0044 0.0027 0.0035 0.0328 0.0002 0.0017 0.0122 0.0075 0.0016 0.0047 0.0004 0.0019 0.0025 0.0045 0.0014
Mitochondria 0.0095 0.0037 0.006 0.0028 0.0585 0.0026 0.0076 0.0007 0.0024 0.0312 0.0067 0.0011 0.0019 0.0002 0.0049 0.006 0.0057 0.0008
None 0.4005 0.3693 0.5006 0.4763 0.4113 0.3831 0.3779 0.3959 0.4609 0.2498 0.3964 0.392 0.1324 0.0964 0.1013 0.0809 0.1452 0.1219
Nuclear Periphery 0.0099 0.0011 0.0022 0.0048 0.0053 0.0019 0.0046 0.0008 0.0016 0.0368 0.0139 0.0013 0.0154 0.0011 0.0035 0.0061 0.0359 0.0025
Nucleolus 0.0039 0.0006 0.0007 0.0002 0.0007 0.0007 0.0008 0.0004 0.0006 0.0012 0.0009 0.0001 0.0005 0.0001 0.0014 0.0027 0.0026 0.0002
Nucleus 0.0065 0.0035 0.005 0.0032 0.0058 0.0045 0.0042 0.006 0.0041 0.0175 0.0053 0.0027 0.0056 0.0024 0.0074 0.0151 0.0126 0.0035
Peroxisomes 0.0279 0.0052 0.0049 0.0276 0.0134 0.0047 0.0467 0.0052 0.0069 0.041 0.0041 0.0032 0.0032 0.0001 0.001 0.0036 0.0097 0.0005
Punctate Nuclear 0.0171 0.0032 0.0067 0.0017 0.0116 0.004 0.0041 0.0018 0.0031 0.0096 0.0077 0.002 0.0043 0.0009 0.0034 0.0148 0.0014 0.0037
Vacuole 0.0047 0.0012 0.0019 0.002 0.0033 0.0015 0.002 0.0009 0.0013 0.0049 0.0023 0.0005 0.0013 0.0009 0.002 0.0023 0.0161 0.0007
Vacuole Periphery 0.0015 0.0002 0.0005 0.0012 0.0015 0.0004 0.0008 0.0001 0.0002 0.0033 0.0023 0.0002 0.0008 0.0001 0.0005 0.001 0.0062 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 33.172 19.7691 27.0229 32.3117 39.2362 39.5517 28.9308 35.5024 43.9208 30.1976
Translational Efficiency 1.4351 1.7704 1.7267 2.0559 1.3073 1.2745 1.3637 1.3866 1.4648 1.5398

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (43%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Sol2

Sol2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sol2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available