Standard name
Human Ortholog
Description Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.06 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.06 0 0 0 0 – 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0.05 0 – 0.05 0 0.07 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0.06 0.07 0.14 0.08 0.1 0.05 – 0 0.05 0 0.06 0.09 0.13 0.2 0.08 0 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.17 0.13 0.1 0.19 0.16 0 0.17 – 0 0.06 0.05 0.06 0.35 0.2 0.25 0.16 0.2 0.08 0.11 0.24 0.19 0.21 0.3 0.26
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.17 0.36 0 0.1 0.05 0.48 0.11 – 0.34 0.21 0.33 0.2 0.06 0 0 0.12 0.08 0.07 0.09 0.09 0.07 0.06 0 0
Nucleus 0.17 0.12 0.21 0.24 0.17 0.17 0.15 – 0.14 0.14 0.1 0.11 0.15 0.14 0.1 0.15 0.19 0.19 0.06 0.07 0.06 0.05 0 0
Nuclear Periphery 0.05 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0.26 0.16 0.25 0.16 0.11 0
Nucleolus 0.25 0.23 0.07 0.1 0.16 0.3 0.21 – 0.39 0.34 0.33 0.37 0.3 0.35 0.35 0.6 0.61 0.62 0.15 0.13 0.13 0.13 0.08 0.11
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0 0 0
SpindlePole 0.07 0 0.42 0.27 0.55 0.3 0.62 – 0.51 0.54 0.49 0.61 0.33 0.5 0.5 0.36 0.22 0.24 0.18 0.16 0.17 0.26 0.31 0.41
Vac/Vac Membrane 0.32 0.34 0.24 0.15 0.12 0 0 – 0 0 0 0 0.14 0 0 0 0.09 0.07 0.08 0.08 0.05 0.07 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 2 2
Bud 0 0 1 1 1 8 1 – 6 10 8 5 0 1 0 1 0 3 1 0 0 3 5 7
Bud Neck 0 0 4 6 10 3 14 – 7 20 14 7 6 8 13 4 2 6 0 0 1 1 5 5
Bud Site 0 1 0 2 2 7 6 – 13 11 18 20 1 1 2 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 5 5 22 27 14 19 – 11 18 12 22 25 50 115 19 6 12 1 1 1 3 6 8
Endoplasmic Reticulum 0 3 0 0 0 1 0 – 0 0 0 1 1 0 0 1 5 0 0 0 1 2 2 3
Endosome 18 11 7 31 54 1 61 – 5 24 14 22 104 77 147 39 28 13 15 27 23 56 133 143
Golgi 0 0 0 0 0 0 0 – 0 0 0 1 0 0 1 0 0 0 0 0 0 1 2 2
Mitochondria 18 31 2 17 18 70 40 – 87 82 90 76 18 11 4 29 12 12 11 10 8 15 15 20
Nucleus 18 10 15 39 57 24 54 – 36 55 28 43 43 55 56 37 27 33 8 7 7 12 12 8
Nuclear Periphery 5 3 1 3 2 0 0 – 2 2 0 2 3 1 2 4 4 2 35 18 31 42 48 19
Nucleolus 26 20 5 17 56 43 75 – 101 134 90 140 89 138 204 147 87 106 19 14 16 35 36 61
Peroxisomes 0 1 0 0 1 0 6 – 2 2 2 4 10 7 42 5 2 4 0 0 0 0 4 3
SpindlePole 7 2 30 43 188 44 218 – 130 213 132 233 98 193 287 87 32 41 23 18 21 69 137 225
Vac/Vac Membrane 33 29 17 24 41 5 14 – 5 7 6 5 40 9 18 11 13 12 10 9 6 18 17 16
Unique Cell Count 104 86 71 162 343 145 352 256 391 269 380 293 389 578 245 143 171 134 114 126 271 442 548
Labelled Cell Count 131 116 88 205 458 220 508 405 578 414 581 438 551 891 384 218 244 134 114 126 271 442 548


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.0 4.7 5.8 5.5 6.0 3.8 5.2 – 4.4 4.7 4.4 4.5 5.6 5.4 5.7 7.7 8.0 8.5 5.0 5.1 5.1
Std Deviation (1e-4) 1.1 0.8 1.9 1.5 1.3 0.9 1.3 – 1.1 1.2 1.0 1.1 1.3 1.5 1.7 2.0 1.6 1.8 1.4 1.3 1.5
Intensity Change (Log2) – – – -0.08 0.05 -0.6 -0.17 – -0.42 -0.31 -0.41 -0.37 -0.07 -0.1 -0.04 0.4 0.45 0.54 -0.23 -0.19 -0.19

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – -5.1 -2.9 -3.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.4007 0.2985 0.3226 0.5985 0.0562 0.3406 0.6881 0.8872 0.6992 0.5263 0.3792 0.6778 1.2974 2.0835 1.819 1.9042 1.6236 2.328
Actin 0.0215 0.0002 0.0207 0.0006 0.0002 0.0008 0.0359 0.0007 0.0082 0.0001 0.0001 0.0036 0.0581 0.0007 0.0043 0 0.0039 0.0019
Bud 0.0004 0.0001 0.0004 0.0001 0.0001 0.0001 0.0004 0.0003 0.0002 0.0001 0 0.0001 0.0003 0.0005 0.0001 0.0001 0.0003 0.0001
Bud Neck 0.0075 0.0026 0.0021 0.0158 0.0035 0.0026 0.0026 0.0103 0.0107 0.0455 0.0027 0.005 0.0017 0.0036 0.0046 0.008 0.0075 0.0037
Bud Periphery 0.0009 0.0002 0.0008 0.0002 0.0003 0.0004 0.0013 0.0008 0.0003 0.0003 0.0001 0.0004 0.0007 0.0013 0.0003 0.0001 0.0005 0.0004
Bud Site 0.0035 0.0026 0.0037 0.0005 0.0009 0.0004 0.0027 0.0036 0.0049 0.0027 0.0005 0.0003 0.0016 0.01 0.0051 0.0008 0.0021 0.0008
Cell Periphery 0.0013 0.0004 0.0004 0.0002 0.0001 0.0004 0.0005 0.0006 0.0004 0.0004 0 0.0001 0.0002 0.001 0.0008 0.0001 0.0002 0.0003
Cytoplasm 0.0069 0.0056 0.0017 0.0006 0.0007 0.0157 0.0085 0.0143 0.0007 0.0002 0.0001 0.007 0.0074 0.0088 0.0054 0 0.0014 0.0181
Cytoplasmic Foci 0.0261 0.0295 0.031 0.0161 0.0174 0.0045 0.0204 0.0164 0.0266 0.0289 0.0284 0.0047 0.0382 0.0274 0.035 0.044 0.0841 0.01
Eisosomes 0.0005 0 0.0002 0 0 0.0001 0.0008 0.0001 0.0001 0 0 0.0001 0.0005 0.0002 0.0002 0 0.0002 0.0001
Endoplasmic Reticulum 0.0099 0.0048 0.0006 0.0043 0.0003 0.0044 0.023 0.0121 0.0208 0.0001 0 0.0123 0.0135 0.0023 0.0024 0 0.0004 0.0178
Endosome 0.0292 0.0113 0.0108 0.034 0.0091 0.0065 0.0251 0.0296 0.0095 0.0039 0.0024 0.01 0.0294 0.0126 0.0087 0.0036 0.0114 0.0127
Golgi 0.0088 0.0022 0.0048 0.0106 0.0024 0.0015 0.0083 0.0082 0.0041 0.002 0.0024 0.0023 0.0061 0.0045 0.003 0.0023 0.0068 0.0021
Lipid Particles 0.094 0.0731 0.1194 0.1257 0.1186 0.053 0.0962 0.0849 0.1 0.1097 0.1213 0.0489 0.0689 0.0943 0.1321 0.1301 0.0857 0.0494
Mitochondria 0.0279 0.0005 0.0024 0.0007 0.0012 0.0013 0.0102 0.0019 0.0008 0.0007 0.0001 0.0028 0.0027 0.0022 0.0009 0.0001 0.0045 0.0077
None 0.0138 0.0086 0.0043 0.0003 0.0007 0.017 0.0128 0.0137 0.0012 0.0001 0.0001 0.0025 0.0071 0.0698 0.0017 0.0001 0.0061 0.0616
Nuclear Periphery 0.2387 0.1393 0.0401 0.0134 0.0124 0.3857 0.193 0.1996 0.016 0.0175 0.002 0.5194 0.2932 0.0443 0.0216 0.0001 0.1377 0.3108
Nucleolus 0.1993 0.3729 0.4377 0.5407 0.3468 0.1692 0.2077 0.32 0.5112 0.5473 0.2172 0.1215 0.0821 0.2794 0.4119 0.5952 0.0799 0.1542
Nucleus 0.0524 0.0866 0.045 0.0291 0.0681 0.1212 0.1162 0.1135 0.0659 0.0374 0.0116 0.1164 0.1074 0.0833 0.072 0.0576 0.0212 0.0744
Peroxisomes 0.0085 0.0024 0.0047 0.0023 0.0026 0.0007 0.0122 0.0016 0.0071 0.0035 0.0027 0.002 0.0268 0.0059 0.005 0.0034 0.0113 0.0018
Punctate Nuclear 0.2376 0.2488 0.267 0.1973 0.4119 0.2052 0.2087 0.1549 0.2048 0.197 0.6078 0.1269 0.2454 0.3334 0.2806 0.1538 0.5322 0.2562
Vacuole 0.006 0.0057 0.0014 0.005 0.0015 0.0029 0.0057 0.007 0.0054 0.0021 0.0003 0.0031 0.0028 0.0127 0.0024 0.0006 0.0012 0.0055
Vacuole Periphery 0.0054 0.0025 0.0008 0.0023 0.001 0.0065 0.0078 0.0058 0.0011 0.0004 0.0001 0.0106 0.0062 0.0018 0.0017 0 0.0013 0.0103

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 25.9964 18.9357 7.6642 7.6987 19.9736 9.623 28.2836 14.0969 12.5707 15.1519
Translational Efficiency 1.5598 2.8986 1.8572 2.0941 1.6147 3.6 1.5656 2.4483 1.8829 1.818

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
471 969 1026 1894 1232 1201 1149 1436 1703 2170 2175 3330

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 713.31 781.66 875.47 834.65 618.22 781.99 849.47 865.53 644.52 781.84 861.73 847.97
Standard Deviation 212.39 96.07 107.60 115.77 73.73 95.20 159.84 126.82 134.97 95.59 138.30 121.62
Intensity Change Log 2 — 0.132012 0.295529 0.226642 — 0.339030 0.458443 0.485463 — 0.231833 0.373461 0.352603

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000302 0.000650 0.000898 0.000636 0.000241 0.000291 0.000818 0.000571 0.000258 0.000451 0.000856 0.000608
Bud Neck 0.004194 0.009261 0.015441 0.018904 0.005294 0.008395 0.018469 0.018556 0.004990 0.008782 0.017040 0.018754
Bud Site 0.001147 0.002381 0.005064 0.010856 0.001344 0.003309 0.007861 0.008704 0.001290 0.002895 0.006542 0.009928
Cell Periphery 0.000158 0.000138 0.000120 0.000111 0.000151 0.000111 0.000166 0.000108 0.000153 0.000123 0.000144 0.000110
Cytoplasm 0.039038 0.039217 0.029444 0.025432 0.105646 0.060505 0.037039 0.051321 0.087225 0.050999 0.033456 0.036597
Cytoplasmic Foci 0.029577 0.025263 0.001514 0.003844 0.062459 0.034425 0.002426 0.008436 0.053365 0.030334 0.001996 0.005824
Eisosomes 0.000091 0.000081 0.000059 0.000039 0.000095 0.000075 0.000054 0.000045 0.000094 0.000077 0.000056 0.000042
Endoplasmic Reticulum 0.012515 0.013296 0.006292 0.006733 0.005705 0.010022 0.005894 0.005260 0.007589 0.011484 0.006082 0.006098
Endosome 0.008037 0.014068 0.004158 0.007231 0.014087 0.021097 0.006862 0.014250 0.012414 0.017958 0.005586 0.010257
Golgi 0.004207 0.004399 0.000707 0.002043 0.002696 0.003312 0.001314 0.003916 0.003114 0.003798 0.001027 0.002850
Lipid Particles 0.113643 0.039849 0.001588 0.002796 0.086689 0.062659 0.001644 0.004084 0.094144 0.052473 0.001618 0.003351
Mitochondria 0.015445 0.010001 0.002314 0.004428 0.013274 0.022248 0.003185 0.004195 0.013874 0.016779 0.002774 0.004328
Mitotic Spindle 0.035807 0.120242 0.293468 0.402908 0.029494 0.079169 0.232260 0.439061 0.031240 0.097510 0.261133 0.418498
None 0.008336 0.007410 0.005300 0.004097 0.027694 0.009549 0.010264 0.004968 0.022340 0.008594 0.007922 0.004473
Nuclear Periphery 0.081894 0.070523 0.015217 0.048176 0.049126 0.102280 0.032506 0.023175 0.058189 0.088099 0.024351 0.037395
Nuclear Periphery Foci 0.234089 0.284305 0.121496 0.127465 0.236320 0.216270 0.103076 0.105156 0.235703 0.246650 0.111765 0.117845
Nucleolus 0.217892 0.178030 0.232719 0.195832 0.186338 0.170932 0.289300 0.155622 0.195065 0.174101 0.262609 0.178492
Nucleus 0.182367 0.168852 0.254509 0.127858 0.161891 0.178192 0.236227 0.123044 0.167554 0.174021 0.244851 0.125782
Peroxisomes 0.004997 0.005380 0.002089 0.001554 0.006315 0.005178 0.002024 0.002112 0.005951 0.005268 0.002055 0.001795
Vacuole 0.004006 0.004750 0.006986 0.007541 0.003905 0.008859 0.006723 0.022688 0.003933 0.007024 0.006847 0.014073
Vacuole Periphery 0.002259 0.001906 0.000617 0.001516 0.001234 0.003120 0.001889 0.004727 0.001517 0.002578 0.001289 0.002901

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.80 -11.34 -6.71 -0.36 5.75 -1.55 -11.62 -6.72 -5.81 4.78 -4.25 -16.41 -9.94 -3.87 7.34
Bud Neck -5.19 -14.17 -15.94 -12.41 -2.69 -3.35 -16.05 -14.46 -11.31 1.09 -5.63 -21.15 -21.37 -16.76 -0.93
Bud Site -3.28 -7.79 -8.86 -7.86 -2.46 -2.71 -7.08 -10.98 -7.45 -0.49 -3.82 -10.14 -13.19 -10.30 -1.95
Cell Periphery 0.89 1.45 2.40 3.11 2.32 3.85 0.69 5.05 0.87 2.73 3.02 1.80 5.33 2.73 3.52
Cytoplasm -0.25 3.08 1.26 1.99 -3.03 5.91 11.57 7.52 1.80 -4.51 6.33 12.49 9.23 3.38 -5.01
Cytoplasmic Foci 0.90 7.57 7.02 9.53 -2.95 7.47 17.81 16.09 12.01 -4.73 7.80 19.24 17.95 15.72 -5.32
Eisosomes 1.73 3.78 9.37 9.00 7.10 4.72 9.65 9.83 5.26 0.47 4.84 9.56 14.70 10.57 5.75
Endoplasmic Reticulum -0.64 2.83 3.26 6.43 1.15 -4.80 -2.16 -0.66 4.41 1.47 -5.09 0.57 1.66 7.28 1.56
Endosome -4.15 2.83 1.16 6.27 -2.98 -3.45 6.63 1.45 4.68 -6.00 -4.06 7.56 3.50 7.58 -6.30
Golgi -0.17 2.07 1.69 2.92 -1.37 -0.55 6.12 0.96 1.23 -2.18 -0.73 4.75 2.57 3.27 -2.46
Lipid Particles 7.35 11.90 11.83 11.84 -1.90 4.16 20.31 19.80 16.67 -4.38 8.68 23.13 22.81 20.42 -4.52
Mitochondria 2.06 5.31 4.64 7.14 -3.77 -4.12 8.44 7.81 9.55 -0.45 -2.02 10.08 8.98 11.30 -2.79
Mitotic Spindle -8.48 -20.59 -31.88 -22.36 -6.26 -8.46 -22.08 -34.97 -27.83 -10.31 -12.67 -31.18 -49.97 -36.24 -11.81
None 0.66 4.03 4.11 2.70 -0.10 9.18 10.00 11.76 5.25 3.06 9.15 11.17 12.48 5.79 2.88
Nuclear Periphery 1.24 8.92 5.54 6.05 -8.77 -8.67 4.75 6.87 14.13 1.80 -6.45 10.18 7.17 14.11 -4.76
Nuclear Periphery Foci -2.61 8.31 9.28 15.94 1.18 1.40 14.55 14.47 13.18 -0.35 -1.20 16.27 17.09 20.28 0.33
Nucleolus 3.24 -1.52 1.75 -2.44 4.69 2.36 -6.89 3.24 0.82 10.36 3.74 -6.41 2.70 -1.44 10.52
Nucleus 0.76 -3.29 3.00 3.06 8.43 -2.18 -7.63 1.63 3.80 9.36 -1.49 -8.37 2.93 4.91 12.69
Peroxisomes -0.82 2.12 3.23 5.93 3.92 1.48 6.23 6.18 5.44 -0.11 0.84 6.47 7.59 8.38 2.61
Vacuole -1.00 -4.72 -7.27 -7.84 -2.12 -5.70 -5.70 -10.04 -7.73 -6.74 -5.34 -7.69 -13.04 -10.42 -6.51
Vacuole Periphery 0.47 2.33 1.47 2.89 -3.99 -4.26 -0.68 -2.81 0.17 -2.07 -3.34 1.23 -1.49 1.55 -2.60
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Nucleolar protein that mediates homolog segregation during meiosis I; forms a complex with Lrs4p and then Mam1p at kinetochores; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
Localization
Cell Percentages nuclear periphery (21%), nucleolus (18%), mixed (22%)
Cell Cycle Regulation Yes
nucleolus - S/G2 (3.4e-05)
nuclear periphery - T/G1 (8e-05)
Subcompartmental Group N/A

Csm1

Csm1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Csm1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available