Standard name
Human Ortholog
Description Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.05 0.05 0.06 – 0.08 0.07 0 0 0 0 0.06 0.06 0 0 0 0 0 0
Cytoplasm 0.95 0.95 0.94 0.96 0.88 0.84 0.75 0.67 0.64 – 0.64 0.6 0.95 0.98 0.96 0.91 0.9 0.92 0.94 0.95 0.88 0.89 0.83 0.83
Endoplasmic Reticulum 0.05 0.05 0.06 0 0.1 0.1 0.12 0.12 0.14 – 0.14 0.12 0 0 0 0 0 0 0 0 0.06 0.07 0.12 0.13
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.13 0.12 0.21 0.3 – 0.32 0.38 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 1 1 2 12 14 26 11 – 12 11 1 0 2 2 0 0 0 0 0 0 0 0
Bud 0 0 6 1 1 1 3 1 3 – 2 4 0 0 1 0 0 0 0 1 2 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 13 11 8 7 12 11 26 28 24 – 26 28 7 7 8 6 10 9 0 0 2 0 0 0
Cytoplasm 322 521 426 347 379 395 370 367 267 – 207 225 289 278 264 189 155 144 326 520 429 153 238 247
Endoplasmic Reticulum 17 26 25 13 45 46 61 68 57 – 46 44 9 5 7 8 6 6 10 13 30 12 34 38
Endosome 1 0 0 0 0 0 0 1 0 – 0 0 0 0 1 2 2 0 0 0 0 0 1 0
Golgi 3 0 1 0 0 3 5 4 1 – 0 1 0 0 1 4 2 1 0 0 2 0 1 0
Mitochondria 0 0 3 11 11 59 61 116 126 – 104 142 3 0 3 5 1 0 2 0 2 1 0 0
Nucleus 0 0 1 0 0 0 0 2 2 – 0 0 1 1 0 4 3 5 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 1 0 – 1 3 1 0 1 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 3 1 3 5 1 9 19 4 – 2 11 2 0 3 9 11 5 0 7 16 2 4 2
Unique Cell Count 338 546 453 363 431 470 493 544 418 321 378 304 285 276 207 173 156 349 548 490 172 287 297
Labelled Cell Count 357 564 472 383 455 528 549 633 495 400 469 313 291 291 229 190 170 349 548 490 172 287 297


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 18.3 15.1 11.0 11.2 11.9 11.2 10.9 10.8 9.7 – 9.5 9.7 13.9 14.0 11.8 15.4 16.6 16.1 14.9 15.3 16.2
Std Deviation (1e-4) 3.0 2.6 1.7 1.8 1.8 1.7 1.8 2.1 1.9 – 2.0 2.2 2.4 2.1 2.0 3.9 3.5 3.6 2.5 2.9 2.6
Intensity Change (Log2) – – – 0.03 0.12 0.03 -0.01 -0.02 -0.18 – -0.21 -0.17 0.35 0.36 0.11 0.49 0.6 0.56 0.45 0.49 0.56

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 3.0 3.2 4.4 3.0 – 3.8 3.2 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0.2 1.0 0.6 2.9 2.8 3.1 – 4.2 4.0 0.5 0.6 1.0 0 0 0
Cytoplasm 1.0 -3.2 -4.8 -8.0 -10.4 -11.0 – -10.5 -12.0 0.6 2.2 0.9 -1.3 -1.9 -0.8
Endoplasmic Reticulum -1.3 2.7 2.4 3.7 3.8 4.1 – 4.2 3.2 -1.7 -2.5 -1.9 -0.9 -1.1 -0.8
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 2.6 2.2 7.2 7.2 10.0 12.2 – 12.6 14.0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 3.7 0 – 0 3.2 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.9218 17.9635 16.1546 16.2597 13.3707 16.1898 9.7447 14.1975 12.7141 13.095 12.1504 12.7498 15.2456 18.5806 16.8596 17.03 16.0514 17.4245
Actin 0.0492 0.0006 0.0127 0.0015 0.014 0.0145 0.0421 0.0023 0.0086 0.0007 0.0083 0.0031 0.0175 0.0011 0.0063 0.0003 0.0129 0.0033
Bud 0.0015 0.0006 0.0011 0.0013 0.0017 0.0006 0.0009 0.0047 0.0007 0.0006 0.0005 0.0002 0.0011 0.0002 0.0007 0.0006 0.0006 0.0003
Bud Neck 0.0077 0.0009 0.0031 0.0016 0.0029 0.003 0.0041 0.0003 0.0008 0.0008 0.006 0.0008 0.0013 0.0003 0.0008 0.0006 0.0009 0.0014
Bud Periphery 0.0024 0.0003 0.0013 0.0009 0.0024 0.0007 0.0009 0.0007 0.0005 0.0002 0.0007 0.0001 0.0007 0.0001 0.0005 0.0002 0.0007 0.0002
Bud Site 0.0117 0.0016 0.003 0.0005 0.0034 0.0004 0.0028 0.0051 0.0006 0.0001 0.0005 0.0002 0.0055 0.0004 0.0057 0.0002 0.0004 0.0002
Cell Periphery 0.0026 0.0014 0.0045 0.0008 0.0013 0.0014 0.0006 0.0004 0.0005 0.0002 0.0002 0.0001 0.0008 0.0002 0.0003 0.0001 0.0002 0.0001
Cytoplasm 0.4387 0.929 0.7867 0.7712 0.5706 0.6696 0.6372 0.9286 0.8482 0.7559 0.7438 0.8473 0.7481 0.9554 0.8627 0.8387 0.8622 0.8584
Cytoplasmic Foci 0.0223 0.0034 0.0135 0.0064 0.0182 0.0116 0.0195 0.0086 0.016 0.024 0.0099 0.0149 0.0284 0.0071 0.0136 0.0087 0.0221 0.016
Eisosomes 0.0009 0 0.0004 0 0.0008 0.0001 0.0003 0 0.0001 0 0.0001 0 0.0003 0 0.0001 0 0 0
Endoplasmic Reticulum 0.1774 0.034 0.0728 0.0646 0.1236 0.1787 0.0768 0.0184 0.0404 0.0476 0.1027 0.0444 0.0782 0.0075 0.044 0.066 0.0248 0.0531
Endosome 0.0723 0.0086 0.0265 0.0458 0.0785 0.0662 0.0892 0.0145 0.0465 0.0848 0.0677 0.0442 0.0505 0.0125 0.0304 0.0436 0.0418 0.0457
Golgi 0.0182 0.0009 0.0042 0.0037 0.0217 0.0078 0.0156 0.0031 0.0064 0.0022 0.0059 0.0102 0.0146 0.01 0.0091 0.0019 0.0083 0.0087
Lipid Particles 0.028 0.0003 0.0063 0.0002 0.0515 0.0007 0.0088 0.0005 0.0013 0.02 0.0021 0.0135 0.0061 0.0001 0.0017 0.0002 0.0023 0.0003
Mitochondria 0.054 0.0006 0.0085 0.0025 0.0417 0.0092 0.0159 0.0014 0.0041 0.0014 0.0021 0.0054 0.0116 0.0015 0.0051 0.0012 0.0055 0.0046
None 0.0072 0.0003 0.0006 0.0004 0.0051 0.0009 0.0046 0.001 0.001 0.0011 0.0009 0.0005 0.0092 0.0003 0.0009 0.0005 0.001 0.0006
Nuclear Periphery 0.0217 0.0023 0.008 0.0171 0.0101 0.0115 0.0229 0.0012 0.0034 0.0072 0.0067 0.0027 0.0046 0.0004 0.0025 0.0039 0.0039 0.0013
Nucleolus 0.0015 0 0.0003 0 0.0008 0.0001 0.0068 0.0001 0.0001 0.0002 0.0003 0.0001 0.0005 0 0.0002 0 0 0
Nucleus 0.0171 0.0017 0.003 0.004 0.0033 0.0031 0.0118 0.0012 0.002 0.0021 0.0019 0.001 0.0018 0.0005 0.0016 0.0015 0.0017 0.0008
Peroxisomes 0.0113 0 0.0026 0.0001 0.0102 0.0002 0.0036 0.0009 0.0003 0.001 0.0005 0.0029 0.0065 0.0001 0.0051 0 0.0004 0.0002
Punctate Nuclear 0.0042 0.0001 0.0003 0.0001 0.0007 0.0003 0.0048 0.0002 0.0006 0.0015 0.0032 0.0005 0.0009 0 0.0006 0.0001 0.0003 0.0001
Vacuole 0.0405 0.0117 0.0356 0.06 0.0256 0.0138 0.0242 0.0058 0.0152 0.0326 0.0278 0.0046 0.0096 0.002 0.0068 0.0243 0.0073 0.0032
Vacuole Periphery 0.0096 0.0019 0.0049 0.0171 0.0121 0.0057 0.0067 0.001 0.0027 0.0157 0.0084 0.0031 0.0022 0.0003 0.0015 0.0075 0.0025 0.0015

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 83.0126 53.6294 49.6285 77.8384 59.4675 59.2619 65.4952 66.1211 58.1168 84.2248
Translational Efficiency 0.7109 0.7239 0.7866 0.4692 0.6446 0.8464 0.5961 0.4147 0.573 0.4964

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2404 287 1627 1143 1310 2018 117 1449 3714 2305 1744 2592

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1124.97 1404.94 1718.21 1612.27 1128.53 1319.63 1699.96 1699.73 1126.23 1330.25 1716.99 1661.16
Standard Deviation 155.16 214.31 247.22 258.73 175.31 206.10 192.10 266.73 162.56 209.04 243.96 266.79
Intensity Change Log 2 — 0.320622 0.611020 0.519207 — 0.225689 0.591056 0.590861 — 0.273861 0.601057 0.555535

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000124 0.000507 0.000249 0.000397 0.000288 0.000165 0.000971 0.000949 0.000182 0.000208 0.000298 0.000706
Bud Neck 0.000238 0.000728 0.000828 0.001875 0.000318 0.000345 0.004797 0.001229 0.000266 0.000393 0.001094 0.001514
Bud Site 0.015891 0.043285 0.012285 0.023258 0.017810 0.017520 0.040502 0.028446 0.016568 0.020728 0.014178 0.026158
Cell Periphery 0.000471 0.000830 0.001468 0.000983 0.000585 0.000248 0.000879 0.005347 0.000511 0.000321 0.001429 0.003423
Cytoplasm 0.700188 0.573291 0.862785 0.670627 0.722545 0.699757 0.417631 0.812804 0.708074 0.684010 0.832921 0.750108
Cytoplasmic Foci 0.171105 0.227062 0.023901 0.049426 0.148920 0.170483 0.136090 0.026711 0.163280 0.177528 0.031427 0.036728
Eisosomes 0.000006 0.000007 0.000002 0.000005 0.000006 0.000004 0.000013 0.000008 0.000006 0.000005 0.000003 0.000007
Endoplasmic Reticulum 0.016693 0.010279 0.002448 0.001355 0.019415 0.008642 0.009002 0.001821 0.017653 0.008846 0.002888 0.001616
Endosome 0.004279 0.019359 0.003467 0.014742 0.008780 0.009915 0.044022 0.004341 0.005867 0.011091 0.006188 0.008928
Golgi 0.018415 0.041087 0.026721 0.024449 0.022860 0.028095 0.022806 0.021427 0.019983 0.029713 0.026458 0.022759
Lipid Particles 0.000614 0.003177 0.004824 0.008486 0.002538 0.001181 0.010609 0.015705 0.001293 0.001430 0.005212 0.012522
Mitochondria 0.002311 0.001078 0.000123 0.001582 0.000951 0.001347 0.000023 0.000417 0.001831 0.001313 0.000116 0.000931
Mitotic Spindle 0.000430 0.005866 0.004333 0.005533 0.000670 0.001625 0.011770 0.001526 0.000515 0.002153 0.004832 0.003293
None 0.001220 0.000111 0.000479 0.000165 0.000453 0.000725 0.000048 0.000287 0.000950 0.000648 0.000450 0.000233
Nuclear Periphery 0.000050 0.000142 0.000137 0.000154 0.000074 0.000030 0.000264 0.000032 0.000059 0.000044 0.000145 0.000086
Nuclear Periphery Foci 0.000693 0.001580 0.007587 0.003114 0.002050 0.000519 0.009845 0.002681 0.001171 0.000651 0.007738 0.002872
Nucleolus 0.000055 0.000053 0.000030 0.000312 0.000072 0.000046 0.000051 0.000067 0.000061 0.000047 0.000032 0.000175
Nucleus 0.002003 0.001169 0.002996 0.004010 0.002003 0.001345 0.003206 0.001838 0.002003 0.001323 0.003010 0.002796
Peroxisomes 0.000171 0.000454 0.000078 0.001127 0.000305 0.000324 0.000811 0.000423 0.000219 0.000340 0.000127 0.000734
Vacuole 0.013127 0.037588 0.029671 0.166487 0.024469 0.029221 0.273616 0.063070 0.017128 0.030263 0.046037 0.108674
Vacuole Periphery 0.051915 0.032347 0.015588 0.021913 0.024885 0.028461 0.013045 0.010871 0.042381 0.028945 0.015418 0.015740

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -5.06 -4.78 -7.05 1.22 -3.03 2.74 -3.90 -3.07 -3.69 0.12 -1.15 -3.98 -4.34 -4.14 -3.24
Bud Neck -6.38 -7.38 -12.20 -7.94 -6.65 -0.78 -7.37 -9.21 -8.76 5.80 -4.15 -9.43 -15.38 -13.39 -3.39
Bud Site -5.91 2.95 -4.30 4.13 -5.77 0.23 -4.47 -5.72 -5.99 2.19 -3.94 1.99 -7.60 -3.75 -7.82
Cell Periphery -2.82 -8.06 -4.75 -0.58 3.85 3.73 -1.35 -8.98 -9.77 -8.07 4.28 -7.80 -9.61 -10.33 -6.08
Cytoplasm 6.59 -20.85 3.02 -4.62 18.37 2.31 10.71 -8.69 -12.13 -13.88 3.19 -16.55 -5.41 -7.64 10.46
Cytoplasmic Foci -4.61 36.03 27.58 15.30 -9.52 -3.37 1.08 24.29 32.13 8.93 -2.84 38.59 38.51 33.79 -2.21
Eisosomes -0.90 9.31 1.64 1.98 -6.70 2.80 -4.53 -0.89 -1.87 2.36 3.58 9.04 -0.36 -1.84 -3.84
Endoplasmic Reticulum 2.58 12.04 13.52 4.05 3.25 5.13 4.41 9.15 6.94 4.18 6.75 14.13 15.89 8.30 3.30
Endosome -6.87 2.51 -8.97 2.26 -9.49 -1.48 -8.66 6.42 8.48 9.83 -8.96 -0.67 -4.76 3.36 -3.55
Golgi -7.63 -5.49 -1.80 5.34 1.90 -3.52 0.32 1.04 3.75 0.11 -8.11 -4.49 -1.23 5.01 2.70
Lipid Particles -2.88 -9.88 -9.65 -4.41 -3.82 3.33 -6.01 -11.94 -13.55 -2.85 -0.54 -9.28 -15.98 -15.28 -8.88
Mitochondria 1.89 14.52 1.46 -0.36 -2.09 -1.05 2.83 1.50 4.02 -2.58 2.25 11.26 3.09 1.42 -2.59
Mitotic Spindle -2.14 -6.05 -3.90 0.12 -0.68 -3.78 -4.32 -2.06 0.12 3.91 -4.31 -6.85 -4.48 -1.58 1.85
None 3.89 2.59 3.71 -1.50 7.31 -0.66 4.88 1.34 1.06 -2.50 0.75 2.65 3.70 1.17 3.51
Nuclear Periphery -1.04 -3.87 -3.64 -0.19 -0.51 2.60 -4.33 2.46 -0.63 5.63 0.98 -4.18 -1.97 -2.63 2.58
Nuclear Periphery Foci -2.53 -11.62 -6.77 -4.32 7.10 5.90 -6.59 -2.24 -12.27 6.09 2.81 -12.08 -7.45 -13.55 8.93
Nucleolus 0.15 2.17 -2.10 -2.10 -2.35 1.39 0.92 0.18 -2.54 -1.59 1.25 3.03 -2.09 -2.41 -2.73
Nucleus 1.70 -2.64 -5.95 -7.79 -4.81 1.50 -2.43 0.00 -3.83 3.34 2.36 -3.38 -3.94 -9.90 -0.57
Peroxisomes -4.93 7.84 -3.30 -2.22 -3.64 -0.22 -3.01 -1.33 -1.77 2.56 -2.56 2.73 -3.91 -2.89 -4.72
Vacuole -4.35 -8.15 -24.67 -15.93 -21.17 -1.94 -9.64 -10.75 -9.69 7.96 -7.31 -9.77 -26.17 -21.15 -14.41
Vacuole Periphery 4.51 15.23 12.10 3.02 -2.21 -1.68 4.38 7.70 10.62 0.64 6.79 14.79 15.97 9.00 0.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the CCR4-NOT1 core complex; this complex has multiple roles in the regulation of mRNA levels including regulation of transcription and destabilization of mRNA by deadenylation; basal transcription factor that increases initiation and elongation; activates the ATPase activity of Dhh1p, resulting in processing body disassembly
Localization
Cell Percentages cytoplasm (98%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-5

Cdc39

Cdc39


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc39-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available