Standard name
Human Ortholog
Description Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.13 0.29 0.38 0.16 0.44 0.37 0.53 – 0.58 0.58 0.62 0.67 0.52 0.75 0.89 0.22 0.18 0.18 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0.05 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.08 0.14 0 0.05 0 0.14 0 – 0 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.14 0.1 0.33 0.16 0.07 0.19 0.15 – 0.11 0.1 0.07 0.06 0 0 0 0.3 0.23 0.28 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.77 0.71 0.57 0.82 0.64 0.56 0.53 – 0.5 0.49 0.41 0.41 0.58 0.34 0.16 0.6 0.66 0.72 0.88 0.86 0.92 0.91 0.87 0.83
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 2
Bud 0 1 0 0 0 0 1 – 1 2 1 5 1 0 0 0 0 0 0 2 1 2 3 5
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 31 45 32 6 72 50 117 – 110 125 124 156 150 366 417 34 23 12 0 6 0 2 5 16
Endoplasmic Reticulum 1 0 0 0 1 0 1 – 0 2 0 1 4 1 0 8 3 1 0 0 0 0 2 3
Endosome 8 2 2 1 8 3 4 – 3 2 4 4 15 12 9 3 2 3 14 4 2 5 19 19
Golgi 0 0 1 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 4 0 0 0 2 0
Mitochondria 20 22 2 2 1 19 5 – 5 11 9 14 1 0 1 0 4 3 6 3 0 3 5 12
Nucleus 35 15 28 6 11 25 34 – 20 21 15 14 7 3 0 47 30 19 2 1 0 4 7 2
Nuclear Periphery 0 1 0 0 1 0 1 – 1 1 0 3 0 0 0 1 0 0 1 1 0 3 1 6
Nucleolus 1 0 0 0 0 1 0 – 1 1 1 0 0 0 1 0 2 0 0 0 0 0 0 1
Peroxisomes 0 0 0 0 1 0 1 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
SpindlePole 0 0 0 0 1 0 1 – 0 0 0 1 1 2 0 0 0 0 0 1 1 1 2 3
Vac/Vac Membrane 187 110 48 31 105 75 118 – 95 105 83 96 168 168 73 93 85 49 234 144 89 253 410 389
Unique Cell Count 243 154 84 38 164 134 222 189 214 200 234 288 489 467 156 129 68 268 168 97 280 469 469
Labelled Cell Count 283 196 113 46 202 173 283 236 270 237 297 347 552 501 186 149 87 268 168 97 280 469 469


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.2 5.2 5.9 5.5 8.1 5.9 7.0 – 6.2 6.6 6.3 7.9 5.7 5.4 5.2 10.0 9.7 9.9 5.4 5.4 5.5
Std Deviation (1e-4) 1.2 1.2 1.4 1.1 1.6 1.7 1.7 – 1.7 1.8 1.6 22.5 1.4 1.4 1.5 3.0 2.6 2.5 1.5 1.9 1.8
Intensity Change (Log2) – – – -0.1 0.45 0.0 0.25 – 0.08 0.16 0.08 0.42 -0.06 -0.14 -0.17 0.76 0.72 0.75 -0.14 -0.12 -0.11


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -2.5 0.9 -0.1 2.3 – 3.1 3.2 3.7 4.6 2.3 6.8 11.1 -2.7 -3.3 -2.8
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 2.9 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus -2.0 -5.5 -2.5 -3.5 – -4.6 -4.9 -5.5 -6.4 -8.5 0 0 -0.5 -1.6 -0.7
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 2.6 1.1 -0.2 -0.6 – -1.1 -1.3 -2.4 -2.5 0.2 -4.0 -8.5 0.4 1.3 1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.6271 1.4993 0.966 0.3006 0.2599 0.8418 0.8552 2.7486 2.4571 2.051 2.0049 2.4009 2.9592 5.636 4.9729 4.8356 4.751 5.0207
Actin 0.0035 0 0.0017 0 0.004 0 0.0025 0.0001 0.0025 0.0007 0.0002 0.0003 0.0006 0 0.0005 0 0.0024 0
Bud 0.0003 0.0002 0.0003 0.0002 0.0005 0.0003 0.0011 0.0016 0.0014 0.0011 0.0003 0.0009 0.0002 0.0002 0.0003 0.0002 0.0002 0.0003
Bud Neck 0.0005 0.0005 0.0008 0.001 0.0013 0.001 0.0012 0.0012 0.0009 0.0018 0.0012 0.0016 0.001 0.0006 0.0007 0.0005 0.0011 0.0011
Bud Periphery 0.0006 0.0005 0.0007 0.0006 0.0012 0.0009 0.0022 0.0009 0.0017 0.0017 0.0004 0.0012 0.0006 0.0005 0.0008 0.0004 0.0006 0.0008
Bud Site 0.0007 0.0005 0.0014 0.0005 0.0012 0.0005 0.0015 0.01 0.0037 0.0059 0.001 0.0011 0.0012 0.0005 0.0008 0.0003 0.0006 0.0006
Cell Periphery 0.001 0.002 0.0014 0.0023 0.0025 0.0025 0.0011 0.0014 0.0017 0.0016 0.0008 0.0018 0.0013 0.0017 0.0016 0.0008 0.0024 0.002
Cytoplasm 0.0035 0.0081 0.003 0.0018 0.0049 0.002 0.0032 0.0101 0.0126 0.0027 0.0041 0.0046 0.0082 0.0023 0.0031 0.0015 0.0016 0.0035
Cytoplasmic Foci 0.0191 0.0092 0.0084 0.002 0.0065 0.0028 0.0173 0.0188 0.0089 0.0077 0.0218 0.0188 0.009 0.0048 0.0043 0.0031 0.0026 0.0033
Eisosomes 0 0 0 0 0.0001 0 0.0001 0 0.0001 0 0 0 0.0001 0 0.0001 0 0.0013 0
Endoplasmic Reticulum 0.002 0.0027 0.002 0.0039 0.0011 0.0011 0.003 0.0033 0.005 0.0008 0.0009 0.0015 0.0032 0.0037 0.0028 0.0007 0.0012 0.002
Endosome 0.3197 0.1303 0.2384 0.1384 0.1087 0.1111 0.3318 0.2 0.2425 0.2416 0.3112 0.166 0.2719 0.1187 0.2265 0.1747 0.1299 0.13
Golgi 0.0097 0.0024 0.0105 0.002 0.0049 0.0027 0.0167 0.0067 0.0099 0.0145 0.0444 0.0064 0.0084 0.0036 0.0071 0.0033 0.0038 0.0029
Lipid Particles 0.0261 0.0052 0.0169 0.0056 0.0095 0.0122 0.0459 0.0124 0.0086 0.005 0.0056 0.0152 0.0175 0.0079 0.0063 0.0041 0.01 0.0089
Mitochondria 0.0171 0.0071 0.0452 0.0056 0.0032 0.0173 0.048 0.0211 0.0674 0.0048 0.0034 0.005 0.0256 0.0017 0.0351 0.0334 0.0047 0.0082
None 0.0036 0.0014 0.0005 0.0002 0.0144 0.0012 0.0006 0.0009 0.0041 0.0001 0.0002 0.0003 0.0122 0.0004 0.005 0.0002 0.0046 0.0005
Nuclear Periphery 0.0093 0.0068 0.009 0.0103 0.0035 0.0029 0.0036 0.0131 0.0107 0.0023 0.0017 0.0029 0.0058 0.006 0.0079 0.0013 0.0037 0.0078
Nucleolus 0.007 0.0044 0.0044 0.0045 0.003 0.0049 0.0015 0.0076 0.0037 0.0033 0.0025 0.0048 0.0035 0.001 0.0016 0.0011 0.0035 0.0022
Nucleus 0.007 0.0034 0.0072 0.0027 0.0043 0.0043 0.0016 0.0138 0.0035 0.0279 0.003 0.0042 0.0042 0.002 0.0025 0.0014 0.0023 0.0027
Peroxisomes 0.0048 0.0007 0.0039 0.0005 0.0018 0.007 0.0053 0.001 0.0023 0.0017 0.0011 0.0009 0.0026 0.0003 0.0006 0.0005 0.0013 0.0004
Punctate Nuclear 0.0018 0.0002 0.0003 0.0001 0.0177 0.0002 0.0027 0.0051 0.0002 0.0001 0.0002 0.0001 0.0006 0.0001 0.0001 0 0.0011 0.0001
Vacuole 0.4174 0.6184 0.4689 0.6505 0.6822 0.6295 0.3841 0.5322 0.4555 0.5613 0.4965 0.6418 0.461 0.6301 0.5242 0.6365 0.6898 0.6351
Vacuole Periphery 0.1452 0.1961 0.175 0.1672 0.1235 0.1955 0.1251 0.1387 0.1534 0.1131 0.0994 0.1205 0.1613 0.214 0.1683 0.136 0.1313 0.1878

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 34.0851 7.086 10.5163 19.2992 27.7489 22.1826 16.4788 24.1784 18.1741 34.6412
Translational Efficiency 2.2616 4.5265 1.9389 1.8152 1.9582 3.8262 1.8349 1.2134 1.8962 1.6457

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1168 1420 1757 1190 1996 2188 490 1475 3164 3608 2247 2665

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 706.67 842.42 912.21 864.12 757.83 859.23 809.81 899.53 738.94 852.61 889.88 883.72
Standard Deviation 130.56 125.64 111.04 128.92 92.62 112.96 115.90 118.52 110.97 118.40 119.83 124.53
Intensity Change Log 2 — 0.253503 0.368329 0.290195 — 0.181170 0.095709 0.247297 — 0.216526 0.233694 0.268156

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000051 0.000075 0.000331 0.000470 0.000011 0.000050 0.000554 0.001258 0.000026 0.000060 0.000379 0.000906
Bud Neck 0.020248 0.009143 0.019525 0.013968 0.010803 0.008831 0.009924 0.018013 0.014290 0.008954 0.017432 0.016206
Bud Site 0.011253 0.015743 0.018594 0.027572 0.004730 0.010515 0.010026 0.045699 0.007138 0.012573 0.016726 0.037605
Cell Periphery 0.000985 0.000530 0.000065 0.000080 0.000210 0.000698 0.000117 0.000090 0.000496 0.000632 0.000076 0.000085
Cytoplasm 0.036026 0.030340 0.351948* 0.287937* 0.028598 0.018264 0.338859* 0.309383* 0.031340 0.023017 0.349093* 0.299807*
Cytoplasmic Foci 0.021348 0.033332 0.029658 0.056933 0.015917 0.011800 0.101013 0.103171 0.017922 0.020274 0.045218 0.082524
Eisosomes 0.000024 0.000018 0.000024 0.000035 0.000013 0.000014 0.000066 0.000037 0.000017 0.000015 0.000033 0.000036
Endoplasmic Reticulum 0.002436 0.002720 0.003396 0.001706 0.001799 0.003299 0.003734 0.001426 0.002034 0.003071 0.003470 0.001551
Endosome 0.093214 0.101287 0.035299 0.065799 0.057726 0.062104 0.067311 0.080924 0.070826 0.077525 0.042280 0.074170
Golgi 0.001926 0.005925 0.001297 0.004289 0.000960 0.002791 0.001686 0.004520 0.001316 0.004025 0.001382 0.004417
Lipid Particles 0.002084 0.001257 0.002178 0.002963 0.001081 0.000832 0.010023 0.003995 0.001451 0.000999 0.003888 0.003534
Mitochondria 0.003229 0.003359 0.001340 0.003112 0.001291 0.005226 0.000846 0.003006 0.002006 0.004491 0.001232 0.003053
Mitotic Spindle 0.000123 0.000267 0.013697 0.047506 0.000221 0.001430 0.022790 0.036375 0.000185 0.000973 0.015680 0.041345
None 0.001155 0.000188 0.002509 0.001814 0.000114 0.000747 0.005114 0.000956 0.000498 0.000527 0.003077 0.001339
Nuclear Periphery 0.000321 0.000128 0.004522 0.001866 0.000187 0.000223 0.002477 0.001244 0.000237 0.000186 0.004076 0.001522
Nuclear Periphery Foci 0.000327 0.000201 0.002775 0.002451 0.000092 0.000096 0.009381 0.001616 0.000179 0.000137 0.004216 0.001989
Nucleolus 0.003070 0.000565 0.003326 0.002126 0.000417 0.000525 0.003097 0.001164 0.001396 0.000541 0.003276 0.001594
Nucleus 0.012647 0.003362 0.212381* 0.063943 0.006478 0.006371 0.143875* 0.051167 0.008755 0.005187 0.197442* 0.056872
Peroxisomes 0.001304 0.001461 0.002164 0.004197 0.000860 0.000931 0.009357 0.011930 0.001024 0.001140 0.003733 0.008477
Vacuole 0.745713* 0.735250* 0.290961* 0.403800* 0.846649* 0.828535* 0.258408* 0.320484* 0.809388* 0.791821* 0.283862* 0.357687*
Vacuole Periphery 0.042517 0.054849 0.004009 0.007433 0.021843 0.036718 0.001341 0.003542 0.029475 0.043853 0.003427 0.005279

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.84 -3.21 -3.57 -3.15 -0.09 -3.33 -9.02 -2.12 -2.01 -0.61 -2.61 -5.40 -2.67 -2.50 -1.01
Bud Neck 4.58 -0.21 3.32 -2.45 5.15 1.67 -0.48 -3.92 -5.71 -2.51 4.59 -2.95 -0.01 -5.99 3.36
Bud Site -2.85 -1.94 -2.78 -0.62 -0.83 -4.96 -4.22 -9.96 -7.39 -7.48 -5.79 -4.75 -10.19 -6.67 -5.14
Cell Periphery 3.27 7.47 7.48 7.39 0.25 -4.81 6.61 9.47 6.21 3.92 -1.68 9.04 9.13 8.56 0.95
Cytoplasm 1.44 -41.73 -29.81 -31.15 4.40 3.89 -22.46 -37.73 -39.55 -0.18 3.71 -49.91 -48.22 -50.42 3.09
Cytoplasmic Foci -3.85 -1.83 -7.73 -3.30 -7.20 2.67 -12.45 -17.10 -19.00 1.72 -1.42 -10.52 -18.67 -17.66 -8.47
Eisosomes 2.74 -1.15 -5.38 -9.68 -5.50 -0.39 -14.63 -11.88 -10.95 8.81 1.52 -11.89 -13.21 -14.84 0.63
Endoplasmic Reticulum -0.77 -4.37 3.01 3.66 11.18 -6.14 -7.79 2.90 7.78 9.04 -5.05 -10.09 4.07 8.36 14.76
Endosome -1.28 13.03 10.16 12.89 -3.30 -1.19 1.32 1.55 2.56 -0.21 -2.02 13.07 8.11 10.29 -4.86
Golgi -4.45 3.22 0.05 4.03 -1.88 -3.58 -0.40 -2.89 0.60 -2.01 -5.75 1.50 -2.32 3.31 -3.19
Lipid Particles 2.51 -0.07 -1.70 -5.78 -2.45 1.75 -6.39 -6.71 -7.69 4.38 2.96 -6.66 -6.80 -9.78 1.51
Mitochondria -0.17 3.39 2.17 2.61 -1.22 -5.44 1.71 -1.69 4.12 -2.92 -4.74 3.14 0.32 4.89 -2.54
Mitotic Spindle -2.35 -9.06 -9.51 -9.47 -5.12 -2.73 -5.51 -10.35 -9.81 -0.65 -2.92 -10.50 -13.98 -13.56 -5.28
None 3.71 -2.90 -1.79 -7.68 1.30 -1.94 -4.18 -10.06 -1.55 2.97 -0.10 -7.33 -6.73 -4.28 3.79
Nuclear Periphery 2.23 -21.03 -12.56 -14.66 8.53 -0.60 -10.46 -14.30 -14.27 3.92 1.01 -24.21 -18.90 -20.23 11.61
Nuclear Periphery Foci 1.60 -6.95 -5.18 -5.43 0.19 -0.11 -6.03 -8.60 -8.59 4.86 1.28 -9.35 -8.41 -8.59 4.04
Nucleolus 3.88 -1.45 1.49 -6.05 4.94 -1.48 -6.60 -7.29 -6.55 4.30 3.46 -6.90 -1.41 -8.95 7.01
Nucleus 4.60 -36.16 -16.32 -20.05 20.43 -0.04 -16.10 -20.52 -20.00 9.33 3.25 -41.05 -26.14 -28.08 25.04
Peroxisomes -0.52 -1.28 -3.72 -3.00 -1.65 -0.25 -4.32 -7.88 -7.89 -0.21 -0.57 -4.29 -8.68 -8.48 -3.59
Vacuole 0.87 41.58* 24.15 24.63 -13.63 2.57 43.67* 51.73* 48.91* -6.60 2.78 70.64* 54.36* 52.44* -14.05
Vacuole Periphery -4.02 18.75 17.79 22.04 -0.68 -8.60 19.06 17.63 25.17 -3.60 -8.99 25.27 24.36 32.80* -0.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
Localization
Cell Percentages vacuole (91%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Grx6

Grx6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Grx6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available