Standard name
Human Ortholog
Description Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.73 0.75 0.62 0.32 0.24 0.35 0.38 – 0.29 0.32 0.32 0.28 0.74 0.65 0.44 0.48 0.6 0.59 0.66 0.49 0.49 0.82 0.79 0.81
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0.05 0 – 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.34 0.07 – 0.41 0.43 0.49 0.57 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0.14 0.15 0.17 0.2 0.26 – 0.29 0.24 0.21 0.23 0 0.07 0.15 0.08 0.08 0.07 0.2 0.3 0.3 0.09 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.39 0.41 0.56 0.58 0.65 0.32 0.38 – 0.15 0.18 0.14 0.14 0.43 0.51 0.54 0.58 0.49 0.45 0.05 0.13 0.1 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 1 0 0 0 0 3 1 – 2 5 1 2 0 0 0 0 0 0 1 10 2 0 3 4
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 2 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 1 0 3 0 3 – 0 0 0 0 0 2 0 0 1 0 0 0 0 0 0 0
Cytoplasm 258 452 77 45 42 41 93 – 47 65 30 39 237 313 205 96 80 89 247 333 72 247 460 408
Endoplasmic Reticulum 3 6 2 3 0 0 0 – 1 0 0 0 3 4 1 5 4 4 3 4 3 4 16 7
Endosome 6 0 0 3 9 6 10 – 2 5 5 1 1 1 5 5 1 1 10 19 3 2 29 22
Golgi 1 1 0 0 0 0 0 – 0 0 0 0 3 0 14 6 0 6 2 1 1 0 4 7
Mitochondria 0 1 0 1 2 39 18 – 67 88 47 79 0 0 0 0 2 1 0 0 0 1 0 2
Nucleus 5 26 17 22 29 23 63 – 47 50 20 32 6 32 68 16 11 11 74 206 44 26 21 13
Nuclear Periphery 0 0 0 0 0 0 0 – 1 0 0 2 0 0 0 0 0 0 5 7 1 3 7 3
Nucleolus 0 0 1 0 0 0 0 – 0 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 1 – 0 1 0 1 0 0 0 0 0 0 2 6 1 0 6 8
Vac/Vac Membrane 139 245 70 83 114 37 95 – 25 37 13 19 138 245 255 116 66 67 18 87 14 12 20 17
Unique Cell Count 355 603 124 142 175 116 247 164 206 95 138 321 478 468 200 134 150 374 685 149 303 585 501
Labelled Cell Count 414 731 168 157 199 149 284 192 254 117 176 388 597 549 244 165 179 374 685 149 303 585 501


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.8 12.0 10.5 10.3 9.9 5.9 6.8 – 5.7 5.7 5.5 5.3 13.8 11.7 13.0 14.3 13.6 13.2 11.5 12.9 13.1
Std Deviation (1e-4) 1.7 1.6 1.5 1.3 1.7 1.8 1.6 – 1.9 1.6 1.9 1.8 2.1 1.8 2.1 2.6 3.0 2.3 1.8 1.8 2.2
Intensity Change (Log2) – – – -0.04 -0.09 -0.83 -0.63 – -0.89 -0.88 -0.95 -0.99 0.39 0.15 0.3 0.43 0.37 0.32 0.13 0.29 0.31

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -5.0 -6.6 -4.1 -4.5 – -5.7 -5.4 -4.5 -5.5 2.4 0.7 -3.6 -2.5 -0.4 -0.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 7.1 3.1 – 8.1 8.5 8.8 10.1 0 0 0 0 0 0
Nucleus 0.4 0.7 1.3 2.6 – 3.0 2.3 1.4 2.0 -5.1 -2.5 0.2 -1.7 -1.4 -1.7
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0.3 1.5 -3.8 -3.3 – -7.4 -7.2 -6.5 -7.3 -2.6 -1.0 -0.4 0.3 -1.2 -1.9

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.5615 6.7627 6.0202 5.4444 5.4483 6.0134 6.9495 8.172 7.8002 7.2438 6.7866 7.7314 10.113 11.7591 10.421 10.5743 10.5836 10.8587
Actin 0.029 0.0062 0.0145 0.0034 0.0017 0.0006 0.0189 0.0006 0.0128 0.0003 0.0145 0.0001 0.0006 0.0004 0.0004 0.0001 0.0001 0.0002
Bud 0.0005 0.0002 0.0005 0.0002 0.0004 0.0002 0.0004 0.0003 0.0002 0.0001 0.0003 0.0001 0.0002 0.0006 0.0001 0.0001 0.0001 0.0001
Bud Neck 0.0019 0.0008 0.0044 0.001 0.0014 0.0029 0.0025 0.0027 0.0014 0.0009 0.0013 0.0017 0.0005 0.0008 0.0004 0.0006 0.0006 0.0015
Bud Periphery 0.0005 0.0001 0.0004 0.0001 0.0002 0.0001 0.0004 0.0002 0.0001 0 0.0003 0 0.0001 0.0001 0 0 0 0
Bud Site 0.0009 0.0025 0.0024 0.0005 0.0008 0.0002 0.0014 0.0022 0.0008 0.0002 0.0004 0.0001 0.0003 0.0011 0.0002 0.0001 0.0001 0.0001
Cell Periphery 0.0001 0 0.0001 0.0001 0 0 0.0002 0 0 0 0.0001 0 0 0 0 0 0 0
Cytoplasm 0.4365 0.4374 0.4335 0.2505 0.5276 0.3555 0.4068 0.387 0.3549 0.3066 0.4493 0.2784 0.6196 0.5571 0.5177 0.5642 0.5449 0.4797
Cytoplasmic Foci 0.0095 0.0043 0.0111 0.0266 0.0093 0.0021 0.0066 0.0018 0.0018 0.0016 0.0065 0.0013 0.0022 0.0012 0.0014 0.0011 0.0009 0.0012
Eisosomes 0.0002 0 0 0.0001 0 0 0.0007 0 0.0001 0 0.0002 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0106 0.0022 0.0029 0.0183 0.005 0.0038 0.007 0.0015 0.0034 0.0032 0.0064 0.0018 0.0062 0.0027 0.0023 0.001 0.0064 0.0033
Endosome 0.026 0.0032 0.0122 0.0129 0.0269 0.0066 0.0104 0.0018 0.0059 0.0032 0.0224 0.0017 0.0036 0.0009 0.0009 0.0008 0.0021 0.0022
Golgi 0.0063 0.0002 0.003 0.0016 0.0047 0.0005 0.0034 0.0002 0.001 0.0001 0.0032 0 0.0001 0.0001 0.0001 0 0 0
Lipid Particles 0.0094 0.0001 0.0025 0.0042 0.0033 0.0005 0.0034 0 0.0003 0 0.0051 0 0.0001 0 0 0 0 0
Mitochondria 0.0108 0.0003 0.0045 0.0016 0.0023 0.005 0.0034 0.0003 0.0008 0.0004 0.0064 0.0002 0.0005 0.0005 0.0003 0.0002 0.0002 0.0004
None 0.0047 0.0011 0.0023 0.0061 0.002 0.0012 0.0046 0.0014 0.0015 0.0027 0.0037 0.0009 0.0032 0.0021 0.0038 0.0007 0.0009 0.0008
Nuclear Periphery 0.0317 0.016 0.0171 0.0135 0.0205 0.02 0.0291 0.0142 0.019 0.0192 0.0421 0.0136 0.0222 0.0161 0.0111 0.0082 0.0211 0.0167
Nucleolus 0.0007 0.0004 0.0013 0.0007 0.0005 0.0005 0.001 0.0004 0.0006 0.0004 0.0008 0.0005 0.0002 0.0003 0.0002 0.0001 0.0002 0.0002
Nucleus 0.3987 0.5174 0.4724 0.6151 0.3799 0.5921 0.485 0.5802 0.5883 0.6521 0.4148 0.693 0.3358 0.4109 0.4578 0.419 0.4178 0.488
Peroxisomes 0.0108 0.0003 0.0028 0.0019 0.0021 0.0002 0.0055 0.0002 0.0003 0.0001 0.005 0 0.0001 0.0001 0.0001 0 0 0
Punctate Nuclear 0.0065 0.0054 0.0078 0.0403 0.0068 0.0052 0.0067 0.0034 0.005 0.0078 0.0142 0.0052 0.0028 0.0035 0.0024 0.0013 0.0032 0.0037
Vacuole 0.0033 0.0015 0.0037 0.0011 0.0036 0.0021 0.0021 0.0013 0.0014 0.0009 0.0019 0.0011 0.0013 0.0013 0.0006 0.002 0.0011 0.0012
Vacuole Periphery 0.0015 0.0003 0.0005 0.0004 0.0008 0.0006 0.0007 0.0002 0.0005 0.0002 0.0012 0.0002 0.0003 0.0002 0.0001 0.0004 0.0003 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 61.3002 56.5664 40.663 61.5572 42.303 51.3846 55.4069 55.4907 62.3392 67.5985
Translational Efficiency 1.7563 1.7621 2.2205 1.4121 2.481 2.3019 1.3767 2.0051 1.5861 1.47

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2222 1553 2194 112 1861 1899 322 1350 4083 3452 2516 1462

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1006.30 1214.00 1454.34 1439.20 1033.57 1155.07 1381.35 1379.31 1018.73 1181.58 1445.00 1383.90
Standard Deviation 132.36 176.29 194.11 196.43 145.46 175.03 186.01 211.30 139.15 178.03 194.62 210.80
Intensity Change Log 2 — 0.270708 0.531304 0.516207 — 0.160344 0.418443 0.416311 — 0.215844 0.475223 0.466455

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000236 0.000616 0.000164 0.003099 0.000405 0.000519 0.001581 0.000963 0.000313 0.000562 0.000346 0.001126
Bud Neck 0.003868 0.012303 0.002236 0.010392 0.002959 0.005525 0.006066 0.007765 0.003453 0.008575 0.002727 0.007966
Bud Site 0.002192 0.008117 0.002226 0.021289 0.001901 0.003030 0.003302 0.005307 0.002059 0.005319 0.002364 0.006532
Cell Periphery 0.000096 0.000196 0.000054 0.000543 0.000097 0.000106 0.000288 0.000183 0.000097 0.000146 0.000084 0.000211
Cytoplasm 0.296360 0.207632 0.378540 0.158677 0.260388 0.280342 0.104196 0.198915 0.279964 0.247631 0.343429 0.195832
Cytoplasmic Foci 0.007091 0.008178 0.001367 0.003123 0.004708 0.007411 0.001766 0.003823 0.006005 0.007756 0.001418 0.003769
Eisosomes 0.000010 0.000015 0.000003 0.000041 0.000009 0.000013 0.000023 0.000012 0.000010 0.000014 0.000005 0.000014
Endoplasmic Reticulum 0.004862 0.006167 0.000664 0.004224 0.004434 0.004589 0.006342 0.002310 0.004667 0.005299 0.001391 0.002456
Endosome 0.000507 0.001337 0.000268 0.008001 0.000728 0.001828 0.001023 0.002076 0.000608 0.001607 0.000365 0.002530
Golgi 0.000123 0.000272 0.000077 0.001741 0.000216 0.001701 0.000203 0.006835 0.000166 0.001058 0.000093 0.006445
Lipid Particles 0.000437 0.000450 0.000240 0.000790 0.000409 0.000616 0.000936 0.000542 0.000424 0.000541 0.000329 0.000561
Mitochondria 0.001038 0.001522 0.000813 0.017982 0.000530 0.001430 0.001362 0.002868 0.000806 0.001471 0.000883 0.004026
Mitotic Spindle 0.001974 0.004067 0.003813 0.011453 0.002653 0.011153 0.001656 0.022537 0.002284 0.007965 0.003537 0.021688
None 0.003254 0.004786 0.006943 0.008977 0.004736 0.008656 0.003685 0.008953 0.003930 0.006915 0.006526 0.008955
Nuclear Periphery 0.001854 0.001788 0.001221 0.002137 0.001359 0.001783 0.001470 0.002013 0.001628 0.001785 0.001253 0.002022
Nuclear Periphery Foci 0.001450 0.001978 0.000519 0.000944 0.002270 0.001485 0.002900 0.001302 0.001823 0.001707 0.000823 0.001274
Nucleolus 0.000734 0.001326 0.000140 0.000430 0.000488 0.001228 0.000391 0.000571 0.000622 0.001272 0.000172 0.000560
Nucleus 0.666649 0.728602 0.593171 0.707545 0.702512 0.652864 0.832100 0.712828 0.682995 0.686937 0.623749 0.712423
Peroxisomes 0.000278 0.000338 0.000084 0.000348 0.000150 0.000402 0.000134 0.000127 0.000220 0.000374 0.000090 0.000144
Vacuole 0.006813 0.009441 0.007393 0.035338 0.008828 0.014945 0.030408 0.017064 0.007731 0.012469 0.010339 0.018464
Vacuole Periphery 0.000174 0.000869 0.000064 0.002926 0.000220 0.000375 0.000168 0.003009 0.000195 0.000597 0.000078 0.003003

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.36 -0.65 -5.05 -3.40 -4.99 -1.15 -7.99 -3.65 -2.82 4.19 -3.85 -2.86 -5.61 -3.01 -4.60
Bud Neck -7.18 1.47 -4.25 -1.11 -4.54 -3.99 -5.17 -8.69 -5.55 -2.95 -8.08 -0.29 -9.55 -2.57 -9.36
Bud Site -5.20 -0.27 -2.86 -1.43 -2.81 -2.17 -3.89 -5.15 -3.61 -1.63 -5.54 -0.91 -5.89 -0.99 -4.52
Cell Periphery -7.39 2.62 -6.95 -4.65 -7.31 -0.88 -8.47 -10.31 -9.82 4.67 -6.85 -2.46 -12.58 -6.58 -10.32
Cytoplasm 12.40 -7.09 15.04 8.19 18.92 -1.30 18.92 14.38 14.99 -7.10 6.91 -5.71 21.78 14.67 25.27
Cytoplasmic Foci -1.01 8.57 2.65 2.82 -1.43 -2.42 4.58 3.90 5.23 -0.69 -2.11 10.04 6.63 6.40 -1.85
Eisosomes -4.04 7.52 -7.04 -5.61 -8.17 -4.71 -8.25 -10.92 -6.21 3.34 -5.91 3.65 -12.86 -6.58 -15.57
Endoplasmic Reticulum -3.86 15.90 -1.78 0.41 -7.21 -1.49 -3.67 4.52 4.91 5.75 -3.59 15.89 5.04 7.53 -9.73
Endosome -3.87 1.88 -1.83 -1.03 -1.93 -3.90 -2.66 -1.56 2.25 0.32 -5.55 2.07 -2.80 1.57 -3.45
Golgi -2.88 1.20 -1.79 -1.13 -1.88 -2.27 -0.41 -2.04 -0.53 -2.01 -2.53 1.17 -2.14 -1.13 -2.20
Lipid Particles -2.01 -0.30 -5.72 -5.18 -5.65 -2.60 -6.08 -5.99 -3.05 2.33 -3.37 -2.55 -8.54 -5.31 -6.56
Mitochondria -2.31 0.04 -1.49 -1.29 -1.50 -3.62 -11.59 -6.14 -2.58 -2.60 -3.89 -3.18 -5.14 -3.02 -4.37
Mitotic Spindle -2.39 -3.91 -3.11 -2.89 -2.78 -4.37 -0.50 -6.30 -2.69 -4.35 -5.06 -3.62 -7.24 -4.66 -5.89
None -5.34 -15.09 -2.78 -1.45 0.44 -3.98 2.52 -4.87 0.16 -7.60 -5.62 -8.76 -7.49 -2.00 -3.07
Nuclear Periphery 0.04 0.60 -5.70 -5.72 -5.98 -4.63 -4.26 -9.25 -5.07 -5.80 -3.01 -1.85 -9.23 -7.06 -8.48
Nuclear Periphery Foci -2.70 3.29 -1.62 -0.04 -2.90 2.76 -0.59 2.56 0.16 2.27 0.24 4.50 1.14 0.95 -1.85
Nucleolus -2.62 3.43 -0.54 2.24 -4.51 -2.99 1.10 -0.87 2.45 -1.99 -3.81 4.45 -0.34 3.47 -4.52
Nucleus -7.08 7.40 -0.66 1.58 -2.74 4.92 -9.91 -3.25 -7.71 7.13 -0.82 7.01 -5.69 -4.80 -10.81
Peroxisomes -0.97 2.26 0.24 1.38 -2.76 -1.96 -0.23 1.07 2.26 1.98 -2.02 2.44 1.89 3.24 -1.17
Vacuole -4.28 -8.03 -6.57 -6.28 -5.96 -5.92 -7.77 -13.20 -9.13 -0.81 -7.59 -9.93 -15.35 -12.34 -10.72
Vacuole Periphery -2.06 2.25 -1.05 0.32 -1.26 -1.36 0.39 -1.25 -1.00 -1.32 -2.49 2.28 -1.36 -0.65 -1.55
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Pbp1p binding protein; interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay; relative distribution to the nucleus increases upon DNA replication stress
Localization
Cell Percentages cytoplasm (69%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-6

Pbp4

Pbp4


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pbp4-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available