ORF
Human Ortholog
Description NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Cytoplasm 0.97 0.99 0.97 0.97 0.94 0.84 0.78 0.76 0.67 0.73 0.69 0.63 0.99 0.98 0.99 0.93 0.9 0.97 0.94 0.96 0.9 0.96 0.95 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.08 0.05 0.13 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.13 0.16 0.17 0.22 0.19 0.21 0.31 0 0 0 0.06 0.1 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 1 1 5 0 0 0 0 0 0 0 0 0 0 0 0 2 2
Bud 0 0 1 0 0 2 0 2 3 2 1 5 0 0 1 0 2 0 0 0 0 1 4 7
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 1
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 3 4 9 11 7 11 4 4 1 3 3 5 9 0 0 0 0 0 0 0
Cytoplasm 118 195 101 139 264 242 263 247 177 252 130 121 399 556 660 145 180 144 109 188 104 203 418 472
Endoplasmic Reticulum 0 1 1 0 2 9 7 16 7 5 2 2 3 2 1 4 2 2 0 0 0 0 0 1
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 1 3
Golgi 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Mitochondria 3 0 0 0 1 6 15 4 20 17 24 10 0 2 0 0 2 0 0 0 1 3 1 2
Nucleus 3 0 1 2 2 4 10 5 5 8 7 7 1 0 0 1 2 0 0 3 3 0 0 2
Nuclear Periphery 0 0 0 0 0 0 2 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 3
Vac/Vac Membrane 0 0 3 3 10 37 54 54 58 65 40 60 3 10 15 10 20 3 1 0 4 2 1 1
Unique Cell Count 122 197 104 143 280 288 339 325 263 344 188 191 403 566 670 156 199 148 116 196 116 213 439 505
Labelled Cell Count 126 197 107 144 283 305 360 340 278 365 208 210 407 573 680 165 218 151 116 196 116 213 439 505


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.9 14.6 11.0 11.4 13.4 13.1 13.2 13.7 12.5 13.1 11.7 12.6 17.9 27.3 31.2 27.0 26.8 23.2 8.7 9.4 10.3
Std Deviation (1e-4) 2.0 3.4 2.6 2.3 3.3 3.9 4.1 3.6 4.3 4.5 4.3 5.5 6.6 9.2 10.6 18.5 15.1 10.1 1.7 2.0 2.3
Intensity Change (Log2) – – – 0.05 0.28 0.25 0.26 0.31 0.18 0.25 0.08 0.2 0.7 1.31 1.5 1.29 1.28 1.08 -0.35 -0.23 -0.11

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700010203040WT3HU80HU120HU160010203040WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3010203040WT1AF100AF140AF180010203040
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 -1.1 -3.5 -4.6 -4.8 -6.0 -5.2 -5.6 -6.4 1.5 0.8 1.0 -1.5 -2.1 0.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 2.9 0 3.8 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 2.9 3.5 3.6 4.4 4.0 4.2 5.7 0 0 0 1.3 2.2 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 8.5491 12.1502 9.9434 8.2878 8.8936 11.2853 8.9237 13.398 11.1246 11.6685 10.6051 11.6674 13.5418 16.8423 14.8014 13.7681 16.0883 15.1603
Actin 0.0193 0.0025 0.0078 0.0261 0.0079 0.0012 0.0236 0.0004 0.0058 0.0074 0.0072 0.0019 0.0095 0.003 0.0044 0.001 0.0005 0.0003
Bud 0.001 0.0011 0.0052 0.0004 0.0012 0.0002 0.0036 0.0009 0.0007 0.0003 0.0002 0.0008 0.0007 0.0029 0.0017 0.0004 0.0002 0.0002
Bud Neck 0.0032 0.0003 0.0007 0.0006 0.0014 0.001 0.0039 0.0002 0.0015 0.0008 0.0012 0.0013 0.0011 0.0002 0.0006 0.0005 0.0007 0.0007
Bud Periphery 0.0021 0.0003 0.0033 0.0003 0.001 0.0001 0.0017 0.0002 0.0021 0.0002 0.0001 0.0005 0.0005 0.0007 0.0012 0.0001 0 0.0001
Bud Site 0.0041 0.0012 0.0044 0.0006 0.0071 0.0001 0.0034 0.0011 0.0012 0.0003 0.0003 0.0006 0.004 0.0063 0.0018 0.0001 0.0001 0.0001
Cell Periphery 0.0007 0.0001 0.0002 0.0001 0.0003 0 0.0002 0 0.0003 0.0001 0 0.0001 0.0002 0.0001 0.0002 0 0 0
Cytoplasm 0.7517 0.955 0.8501 0.7579 0.7601 0.9287 0.7608 0.981 0.9003 0.8738 0.8226 0.9242 0.8604 0.9712 0.9104 0.8976 0.959 0.9263
Cytoplasmic Foci 0.0449 0.0049 0.0197 0.0139 0.0456 0.0048 0.0323 0.0028 0.0072 0.0468 0.0263 0.0084 0.019 0.0014 0.0109 0.0147 0.0027 0.0061
Eisosomes 0.0004 0 0 0.0003 0.0001 0 0.0002 0 0.0002 0.0001 0.0001 0 0.0001 0 0.0001 0 0 0
Endoplasmic Reticulum 0.0067 0.0015 0.0025 0.0017 0.0066 0.0015 0.0088 0.0005 0.0029 0.0017 0.0076 0.0028 0.0055 0.0005 0.0015 0.0015 0.0012 0.0018
Endosome 0.0502 0.0017 0.0238 0.0378 0.0487 0.0029 0.0452 0.0003 0.0061 0.0121 0.044 0.0118 0.0169 0.0003 0.0126 0.0222 0.0014 0.0134
Golgi 0.009 0.0003 0.0101 0.0193 0.0212 0.0037 0.0134 0 0.0043 0.0025 0.0064 0.0034 0.005 0 0.0047 0.011 0.0001 0.0027
Lipid Particles 0.0195 0.0006 0.0108 0.0286 0.0192 0.0001 0.0157 0 0.0065 0.0058 0.0177 0.0028 0.0033 0 0.0052 0.0127 0 0.0018
Mitochondria 0.0139 0.0002 0.006 0.0123 0.0072 0.0007 0.0069 0.0001 0.0209 0.0033 0.0044 0.0046 0.0099 0.0002 0.0065 0.0025 0.0001 0.0012
None 0.0102 0.0019 0.0094 0.0251 0.0033 0.0011 0.0058 0.0026 0.0064 0.0167 0.002 0.0017 0.0034 0.0012 0.0019 0.0013 0.0008 0.0006
Nuclear Periphery 0.0071 0.0031 0.0035 0.0075 0.0154 0.0108 0.0122 0.001 0.0031 0.0015 0.005 0.0049 0.01 0.0012 0.0026 0.0089 0.0034 0.0042
Nucleolus 0.0008 0.0001 0.0002 0.0004 0.0007 0.0001 0.0021 0 0.0002 0.0001 0.0002 0.0003 0.001 0.0001 0.0013 0.0001 0 0
Nucleus 0.0234 0.0215 0.0279 0.0486 0.0314 0.0397 0.0271 0.0082 0.0224 0.0125 0.0193 0.023 0.0386 0.0091 0.0253 0.017 0.0273 0.0365
Peroxisomes 0.0108 0.0003 0.0087 0.0125 0.0056 0.0007 0.0123 0.0001 0.0022 0.009 0.029 0.0011 0.0026 0.0001 0.0021 0.0023 0.0001 0.0014
Punctate Nuclear 0.011 0.001 0.0022 0.0043 0.0059 0.0012 0.011 0.0005 0.004 0.0037 0.0043 0.0017 0.0024 0.0011 0.0021 0.0006 0.0012 0.0009
Vacuole 0.0076 0.0021 0.0028 0.0011 0.0079 0.0009 0.0076 0.0002 0.0011 0.0009 0.0014 0.0031 0.0034 0.0004 0.0023 0.0038 0.0009 0.0012
Vacuole Periphery 0.0021 0.0002 0.0006 0.0007 0.0023 0.0006 0.0023 0 0.0006 0.0004 0.0007 0.0011 0.0025 0.0001 0.0005 0.0018 0.0002 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 192.1263 140.7608 188.6347 260.1797 141.69 240.759 197.2875 249.107 293.1796 183.2344
Translational Efficiency 1.5889 1.3673 1.2482 1.3489 1.045 1.5283 1.2821 1.1769 1.3375 1.193

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
200 464 1859 1750 1645 1130 117 1505 1845 1594 1976 3255

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1021.68 1167.73 1965.15 2210.47 1022.64 1093.33 2233.17 2417.90 1022.54 1114.99 1981.02 2306.38
Standard Deviation 166.63 191.65 458.12 672.77 270.36 215.50 512.04 605.37 261.12 211.56 465.80 650.75
Intensity Change Log 2 — 0.192763 0.943696 1.113410 — 0.096431 1.126795 1.241456 — 0.145378 1.038191 1.178883

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000261 0.000335 0.000126 0.001695 0.000227 0.000343 0.001434 0.000247 0.000230 0.000341 0.000203 0.001025
Bud Neck 0.001818 0.000953 0.000694 0.003510 0.000905 0.001814 0.007448 0.002193 0.001004 0.001563 0.001094 0.002901
Bud Site 0.008518 0.007723 0.001287 0.018878 0.004938 0.012104 0.009936 0.008754 0.005326 0.010829 0.001799 0.014197
Cell Periphery 0.000135 0.000100 0.000109 0.000245 0.000105 0.000085 0.000711 0.000221 0.000108 0.000089 0.000145 0.000234
Cytoplasm 0.741344 0.815955 0.628889 0.665543 0.829972 0.802999 0.376331 0.709987 0.820365 0.806771 0.613935 0.686093
Cytoplasmic Foci 0.119866 0.054679 0.003543 0.008632 0.046392 0.057776 0.021887 0.009305 0.054357 0.056875 0.004629 0.008943
Eisosomes 0.000034 0.000013 0.000003 0.000004 0.000010 0.000014 0.000030 0.000003 0.000013 0.000014 0.000005 0.000004
Endoplasmic Reticulum 0.000860 0.000684 0.000058 0.001315 0.001014 0.000602 0.002204 0.000135 0.000998 0.000626 0.000186 0.000770
Endosome 0.007782 0.003096 0.000051 0.004923 0.001709 0.004650 0.005131 0.003166 0.002367 0.004198 0.000352 0.004111
Golgi 0.000658 0.000384 0.000121 0.005218 0.001199 0.002095 0.000818 0.006690 0.001141 0.001597 0.000162 0.005898
Lipid Particles 0.000865 0.000432 0.000195 0.001379 0.000525 0.000852 0.004785 0.000670 0.000562 0.000730 0.000466 0.001051
Mitochondria 0.000434 0.000240 0.000173 0.000484 0.000614 0.002723 0.000314 0.002241 0.000594 0.002000 0.000181 0.001296
Mitotic Spindle 0.000529 0.000686 0.001228 0.065691 0.003344 0.011759 0.003601 0.030301 0.003039 0.008536 0.001369 0.049328
None 0.001293 0.004300 0.012590 0.008857 0.006845 0.003532 0.004432 0.014336 0.006243 0.003755 0.012107 0.011390
Nuclear Periphery 0.000104 0.000095 0.000127 0.000319 0.000133 0.000120 0.001385 0.000270 0.000130 0.000113 0.000202 0.000296
Nuclear Periphery Foci 0.004086 0.004104 0.000470 0.002062 0.002864 0.002587 0.015384 0.001609 0.002997 0.003029 0.001353 0.001853
Nucleolus 0.000149 0.000105 0.000078 0.000259 0.000147 0.000141 0.000275 0.000212 0.000147 0.000130 0.000090 0.000237
Nucleus 0.037898 0.060135 0.345868 0.180829 0.074376 0.051000 0.270176 0.180138 0.070422 0.053659 0.341386 0.180509
Peroxisomes 0.000796 0.000416 0.000021 0.000247 0.000186 0.002022 0.000280 0.000098 0.000252 0.001554 0.000036 0.000178
Vacuole 0.071954 0.045244 0.004333 0.026580 0.023877 0.041586 0.273127 0.024714 0.029089 0.042651 0.020248 0.025717
Vacuole Periphery 0.000615 0.000323 0.000033 0.003330 0.000617 0.001195 0.000312 0.004708 0.000617 0.000941 0.000049 0.003967

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.74 0.72 -1.76 -1.19 -2.03 -1.65 -7.56 -0.33 1.90 7.95 -1.75 -1.18 -1.82 -0.65 -1.29
Bud Neck 2.03 1.10 -2.66 -6.67 -5.30 -3.35 -8.35 -9.08 -3.53 6.63 -2.80 -5.06 -10.30 -5.53 -4.28
Bud Site 0.63 6.72 0.55 -0.16 -6.42 -4.29 -6.52 -1.33 3.45 5.68 -4.21 4.21 -2.18 2.70 -7.05
Cell Periphery 1.64 -2.76 -4.79 -7.11 -2.62 1.80 -6.29 -8.94 -9.92 4.71 1.87 -7.67 -10.94 -12.70 -2.13
Cytoplasm -3.56 7.66 4.16 13.38 -8.53 5.44 26.50 22.96 13.42 -18.10 4.05 36.57 26.71 18.91 -13.42
Cytoplasmic Foci 5.68 11.30 10.99 11.57 -3.83 -3.06 3.38 15.15 14.99 3.96 -0.87 20.92 19.46 19.42 -5.17
Eisosomes 4.35 7.09 7.03 6.53 -1.10 -3.30 -8.63 8.11 10.47 11.63 -1.26 5.96 10.41 12.29 0.45
Endoplasmic Reticulum 0.71 4.80 2.35 1.97 -1.05 2.40 -0.98 6.19 6.58 6.60 2.39 6.02 4.80 3.77 -0.21
Endosome 1.70 2.95 2.56 3.55 -3.95 -3.39 -2.50 3.78 4.71 4.43 -2.44 6.80 4.13 5.47 -4.09
Golgi 1.39 2.64 -1.02 -1.82 -2.42 -0.90 0.70 -0.22 0.64 -0.96 -0.44 2.16 -0.11 0.40 -3.21
Lipid Particles 2.95 1.74 -5.14 -9.14 -7.53 -1.29 -8.22 -8.66 -3.56 6.17 -0.94 -3.30 -11.36 -5.62 -6.64
Mitochondria 0.53 0.60 0.55 -0.09 -0.72 -1.42 0.81 0.24 1.55 -0.78 -1.27 1.13 0.67 1.65 -1.23
Mitotic Spindle -0.38 -4.24 -8.35 -8.26 -7.66 -3.13 -1.41 -4.67 -0.80 -2.57 -2.74 0.85 -8.16 -4.28 -9.27
None -3.87 -26.62 -14.68 -4.05 9.70 4.83 3.91 -2.07 -7.23 -5.86 4.22 -7.11 -2.29 -8.93 6.61
Nuclear Periphery 0.02 -8.03 -17.02 -18.25 -12.11 -0.69 -11.57 -13.24 -14.69 8.94 -0.22 -9.20 -17.68 -22.37 -8.33
Nuclear Periphery Foci -0.08 5.43 4.06 5.32 -5.16 0.47 -5.43 2.53 1.91 6.16 -0.41 6.44 4.46 5.03 -3.27
Nucleolus 1.76 1.65 -1.45 -2.92 -2.79 0.33 -4.42 -2.14 -2.03 2.47 1.00 1.70 -2.47 -2.96 -3.39
Nucleus -4.97 -59.21 -29.76 -22.51 30.13 5.59 -8.77 -25.55 -29.62 2.88 4.42 -57.58 -33.53 -38.03 32.49
Peroxisomes 1.31 3.15 2.84 2.79 -4.18 -2.78 -1.22 7.19 3.04 3.57 -2.77 6.77 5.63 3.24 -2.99
Vacuole 2.38 7.33 -1.78 -6.84 -22.38 -9.05 -12.72 -15.30 -6.24 10.10 -7.95 -0.29 -19.67 -9.87 -17.02
Vacuole Periphery 0.96 1.94 -0.15 -1.39 -2.67 -0.70 1.36 -0.68 0.19 -1.94 -0.45 2.39 -0.49 0.10 -3.65
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
ORF
Human Ortholog
Description NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

YDL124W

YDL124W


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ydl124w-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available