Standard name
Human Ortholog
Description Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.07 0 0.08 0.06 0.05 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0.07 0.05 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.05 0 0 0 0 0 0 0.06 0.1 0.08 – 0.09 0.18 0 0 0 0 0 0
Cytoplasm 0.49 0.43 0.27 0.35 0.38 0.53 0.62 0.58 0.7 0.74 0.75 0.68 0.23 0.26 0.36 – 0.81 0.76 0.17 0.12 0 0.05 0 0.05
Endoplasmic Reticulum 0.44 0.52 0.69 0.56 0.55 0.36 0.22 0.2 0.15 0.09 0.08 0.12 0.73 0.7 0.6 – 0 0 0.63 0.67 0.8 0.8 0.78 0.79
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0.07 0 0 0 0 0 0 0 0.06 0.08 0.07 0 0 0 – 0.09 0 0 0.06 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0.06 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0.05 0.08 0.11 0.12 0.16 0.17 0.07 0.1 0.08 0.12 0 0 0 – 0.06 0.12 0.09 0.1 0.07 0 0 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 15 28 33 25 19 23 13 17 10 24 4 7 5 – 0 0 0 1 11 5 14 13
Bud 1 0 1 5 5 9 14 21 22 20 30 35 1 0 0 – 1 0 2 0 14 8 13 12
Bud Neck 0 0 0 0 0 0 0 1 0 0 0 0 1 0 2 – 0 0 1 0 2 2 2 4
Bud Site 1 0 0 0 0 0 0 0 0 3 0 0 0 0 0 – 0 0 – – – – – –
Cell Periphery 1 0 7 4 16 23 25 12 16 13 11 24 18 26 19 – 3 3 0 0 1 3 9 6
Cytoplasm 46 19 112 129 215 243 403 478 345 501 331 469 71 70 90 – 26 13 19 11 13 19 19 26
Endoplasmic Reticulum 41 23 289 208 318 165 142 168 74 64 35 79 224 185 150 – 0 0 70 66 389 307 390 430
Endosome 2 0 5 10 6 6 15 26 7 11 11 12 0 0 0 – 0 0 0 0 1 1 2 0
Golgi 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 2 1 2 0
Mitochondria 3 3 5 5 1 5 9 26 22 44 34 50 0 0 0 – 3 0 4 5 8 12 16 10
Nucleus 0 0 0 0 0 1 0 4 1 2 0 3 1 3 1 – 0 1 0 0 0 0 0 0
Nuclear Periphery 0 0 11 3 4 3 3 20 3 4 2 6 1 1 0 – 0 0 1 0 2 2 2 1
Nucleolus 0 0 0 0 1 1 1 4 0 0 2 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 1 1 0 0 1 1 0 0 0 – 0 0 0 0 0 0 0 1
Vac/Vac Membrane 6 1 21 28 63 55 103 137 37 68 36 83 9 3 6 – 2 2 10 9 34 16 19 34
Unique Cell Count 94 44 418 372 573 459 647 828 496 681 444 686 306 265 251 32 17 113 99 485 383 498 547
Labelled Cell Count 102 49 467 423 662 536 735 921 540 747 503 787 330 295 273 35 19 113 99 485 383 498 547


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 7.1 7.5 8.3 8.8 9.1 7.7 7.4 7.1 6.8 6.3 6.4 6.5 10.5 10.0 9.4 – 8.4 10.4 11.0 10.6 10.5
Std Deviation (1e-4) 2.3 2.2 2.4 2.6 2.2 1.7 1.6 1.5 1.4 1.4 1.3 1.4 2.4 2.3 2.1 – 1.3 1.5 2.9 2.5 2.5
Intensity Change (Log2) – – – 0.08 0.13 -0.11 -0.16 -0.23 -0.29 -0.4 -0.38 -0.36 0.33 0.27 0.18 – 0.02 0.33 0.41 0.36 0.34

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 2.4 1.6 1.3 -0.6 -0.8 -0.8 -1.0 -1.2 -0.1 -1.9 -0.7 -1.2 – 0 0
Bud 0 0 0 2.6 2.9 4.0 3.2 5.1 4.4 0 0 0 – 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Cell Periphery -0.7 1.2 2.7 2.0 -0.3 1.5 0.3 0.8 1.8 3.1 4.8 3.8 – 0 0
Cytoplasm 2.4 3.5 7.9 11.3 10.3 12.9 15.2 14.0 13.4 -1.1 -0.1 2.5 – 6.4 0
Endoplasmic Reticulum -3.8 -4.4 -9.8 -15.3 -16.9 -16.7 -20.6 -18.6 -19.7 1.2 0.2 -2.5 – -7.9 -5.9
Endosome 1.5 0 0.1 1.3 2.1 0.3 0.6 1.4 0.7 0 0 0 – 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Mitochondria 0 0 0 0.3 2.1 2.9 4.1 4.6 4.5 0 0 0 – 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Nuclear Periphery -1.9 -2.5 -2.3 -3.0 -0.2 -2.5 -2.8 -2.6 -2.3 -2.4 0 0 – 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0
Vacuole 1.5 3.3 3.7 5.4 5.8 1.5 2.9 1.8 3.9 -1.4 -2.7 -1.7 – 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.4273 9.4404 9.0753 9.1634 6.7997 10.3259 8.1086 9.4565 8.5161 7.5906 6.9139 9.3219 7.2849 8.6475 9.0235 7.5528 5.7594 8.2571
Actin 0.0245 0.0021 0.0017 0.0013 0.0622 0.0017 0.0109 0.0025 0.0002 0.0097 0.0006 0.0013 0.0534 0.0045 0.0002 0.0148 0.0029 0.0007
Bud 0.0001 0.0002 0.0001 0 0.0003 0.0001 0.0002 0.0026 0 0 0 0 0.0003 0 0 0.0002 0.0002 0
Bud Neck 0.0003 0.0006 0.0004 0.0003 0.0024 0.0006 0.0006 0.0003 0.0001 0.0004 0.0002 0.0003 0.0011 0.0001 0.0001 0.0003 0.0014 0.0007
Bud Periphery 0.0001 0.0009 0.0001 0.0001 0.0007 0.0001 0.0002 0.0061 0.0001 0 0 0.0001 0.0004 0 0.0001 0.0002 0.0005 0
Bud Site 0.0003 0.0048 0.0007 0.0001 0.0008 0.0001 0.0016 0.0477 0.0001 0 0.0001 0.0001 0.0019 0 0 0.0005 0.0003 0
Cell Periphery 0.0004 0.0068 0.0008 0.0007 0.0006 0.0004 0.001 0.001 0.001 0.001 0.0003 0.0006 0.0005 0.0005 0.0027 0.0007 0.0079 0.0008
Cytoplasm 0.0476 0.1237 0.0796 0.0547 0.0328 0.0483 0.0494 0.0287 0.034 0.0166 0.0101 0.0123 0.0088 0.0242 0.0336 0.0281 0.1567 0.0486
Cytoplasmic Foci 0.0046 0.0026 0.006 0.0037 0.0044 0.0015 0.0148 0.0008 0.0019 0.0057 0.0261 0.0013 0.0391 0.0017 0.0004 0.0043 0.0091 0.0037
Eisosomes 0.0002 0.0002 0 0.0001 0.001 0 0.0001 0 0 0.0001 0 0.0001 0.0004 0 0 0.0001 0 0
Endoplasmic Reticulum 0.8225 0.7734 0.8347 0.8328 0.6906 0.8722 0.7598 0.8848 0.9225 0.9122 0.9041 0.9243 0.7936 0.8874 0.9377 0.8987 0.7097 0.9074
Endosome 0.02 0.0084 0.0223 0.0459 0.0517 0.0157 0.0325 0.0016 0.0108 0.009 0.0096 0.0106 0.0143 0.0095 0.0037 0.0125 0.043 0.0058
Golgi 0.0031 0.0007 0.0013 0.001 0.0161 0.0011 0.0104 0.0001 0.0004 0.0253 0.0017 0.0016 0.0088 0.0071 0.0003 0.0021 0.0036 0.0006
Lipid Particles 0.0066 0.0126 0.0084 0.0036 0.0311 0.0018 0.0186 0.0003 0.0051 0.0044 0.0334 0.0016 0.0129 0.0037 0.0042 0.006 0.016 0.0049
Mitochondria 0.0011 0.0002 0.0005 0.0004 0.0149 0.0006 0.0032 0.0001 0 0.0004 0.0002 0.0124 0.0016 0.0001 0.0001 0.0008 0.0008 0.0001
None 0.0044 0.0061 0.0016 0.001 0.0036 0.0025 0.0064 0.0119 0.0003 0.0002 0.0005 0.0004 0.0046 0.0002 0.0001 0.013 0.0021 0.002
Nuclear Periphery 0.04 0.0176 0.0204 0.0384 0.0483 0.0307 0.0572 0.0057 0.0137 0.0085 0.0081 0.0219 0.0126 0.042 0.0086 0.0097 0.0142 0.0069
Nucleolus 0.0003 0.0003 0.0003 0 0.0015 0.0001 0.0002 0.0001 0 0 0 0 0.0003 0 0 0.0001 0.0001 0.0001
Nucleus 0.0068 0.004 0.0057 0.0039 0.0066 0.0042 0.0047 0.001 0.0012 0.0004 0.0003 0.0011 0.0009 0.0049 0.0006 0.0014 0.0024 0.0007
Peroxisomes 0.0052 0 0.0003 0 0.0014 0.0002 0.009 0.0001 0 0.0001 0.0023 0.0001 0.0279 0 0 0.0004 0.0002 0.0011
Punctate Nuclear 0.0054 0.0005 0.0026 0.0006 0.0096 0.0019 0.0034 0.0003 0.0006 0.0001 0.0004 0.0002 0.0138 0.0002 0.0001 0.0017 0.0007 0.0057
Vacuole 0.0051 0.033 0.0113 0.0101 0.0157 0.0148 0.0134 0.0039 0.0073 0.0048 0.0017 0.0084 0.0022 0.0127 0.0072 0.0037 0.0265 0.0099
Vacuole Periphery 0.0013 0.0012 0.0011 0.0013 0.0038 0.0014 0.0023 0.0002 0.0004 0.0008 0.0002 0.0012 0.0004 0.001 0.0004 0.0006 0.0018 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 41.0652 36.7098 51.5196 71.3006 48.0343 43.7192 39.7396 43.0235 65.0995 60.2287
Translational Efficiency 0.9799 1.0818 1.1056 0.9351 0.9154 1.3397 1.2794 1.0144 1.1405 0.9948

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
78 342 388 1007 150 797 341 1088 228 1139 729 2095

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1204.23 866.43 1240.86 1483.81 851.19 866.18 1484.51 1523.41 971.97 866.26 1354.83 1504.38
Standard Deviation 224.55 168.77 257.31 424.20 152.53 164.20 360.71 423.82 246.19 165.59 332.98 424.46
Intensity Change Log 2 — -0.474956 0.043229 0.301195 — 0.025186 0.802434 0.839751 — -0.246486 0.407019 0.548997

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002018 0.001224 0.001528 0.004671 0.000673 0.000978 0.004663 0.003128 0.001133 0.001052 0.002994 0.003870
Bud Neck 0.001652 0.004839 0.002589 0.006227 0.009172 0.013670 0.003331 0.004513 0.006599 0.011018 0.002936 0.005337
Bud Site 0.008769 0.011529 0.006769 0.041779 0.007706 0.011367 0.010920 0.037969 0.008070 0.011415 0.008711 0.039800
Cell Periphery 0.002928 0.000728 0.001913 0.025748 0.014687 0.000909 0.004964 0.024145 0.010664 0.000855 0.003340 0.024916
Cytoplasm 0.085696 0.276417 0.059052 0.050841 0.179514 0.244459 0.028445 0.058174 0.147418 0.254055 0.044736 0.054649
Cytoplasmic Foci 0.037793 0.092424 0.011740 0.012482 0.039199 0.100465 0.002956 0.009067 0.038718 0.098050 0.007631 0.010708
Eisosomes 0.000359 0.000222 0.000094 0.000474 0.000832 0.000405 0.000200 0.000301 0.000670 0.000350 0.000144 0.000384
Endoplasmic Reticulum 0.553959 0.369170 0.761305 0.685248 0.563847 0.351298 0.868735 0.756054 0.560464 0.356664 0.811557 0.722020
Endosome 0.025361 0.017663 0.010925 0.016593 0.019590 0.027687 0.007025 0.011805 0.021564 0.024677 0.009101 0.014106
Golgi 0.024876 0.002927 0.000601 0.009733 0.007849 0.006443 0.001322 0.006090 0.013674 0.005387 0.000938 0.007841
Lipid Particles 0.015438 0.028426 0.007447 0.043751 0.016558 0.034933 0.007723 0.029088 0.016175 0.032979 0.007576 0.036136
Mitochondria 0.009168 0.002724 0.000404 0.004740 0.002181 0.006226 0.000493 0.001690 0.004571 0.005174 0.000446 0.003156
Mitotic Spindle 0.012060 0.000245 0.000552 0.004082 0.001727 0.000857 0.000741 0.001624 0.005262 0.000673 0.000640 0.002805
None 0.000060 0.001755 0.000368 0.000495 0.000234 0.003169 0.000126 0.000915 0.000174 0.002745 0.000255 0.000713
Nuclear Periphery 0.002582 0.008297 0.016683 0.001643 0.000399 0.007766 0.001382 0.001250 0.001146 0.007925 0.009526 0.001439
Nuclear Periphery Foci 0.015329 0.024205 0.045341 0.016028 0.001728 0.007430 0.016855 0.008602 0.006381 0.012467 0.032016 0.012171
Nucleolus 0.000098 0.000803 0.000158 0.000058 0.000299 0.000706 0.000017 0.000050 0.000230 0.000735 0.000092 0.000054
Nucleus 0.007735 0.069433 0.041406 0.007108 0.007037 0.045722 0.010288 0.007328 0.007276 0.052842 0.026850 0.007222
Peroxisomes 0.000529 0.002427 0.000236 0.000408 0.003317 0.004905 0.000384 0.000347 0.002363 0.004161 0.000305 0.000376
Vacuole 0.190415 0.082971 0.030595 0.064471 0.116467 0.126626 0.029186 0.035150 0.141765 0.113518 0.029936 0.049244
Vacuole Periphery 0.003175 0.001571 0.000293 0.003422 0.006986 0.003980 0.000244 0.002710 0.005682 0.003257 0.000270 0.003052

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.75 0.20 -3.03 -4.59 -3.40 -0.85 -2.21 -4.38 -3.76 0.97 0.16 -2.10 -5.69 -6.23 -0.62
Bud Neck -2.99 -2.07 -7.13 -1.94 -5.24 -1.23 1.60 1.28 4.62 -1.03 -1.79 1.51 0.22 3.60 -4.01
Bud Site -0.75 0.37 -7.47 -6.90 -8.54 -1.43 -1.49 -7.89 -7.03 -5.01 -1.58 -0.93 -11.12 -10.08 -9.51
Cell Periphery 2.68 1.00 -9.79 -11.46 -10.65 3.53 2.42 -2.01 -10.29 -7.95 3.75 2.74 -4.42 -15.25 -13.07
Cytoplasm -7.16 1.33 1.08 13.08 -0.73 -3.34 7.46 6.32 17.52 -2.99 -6.65 6.68 5.82 22.02 -2.49
Cytoplasmic Foci -4.96 3.26 3.26 10.06 -0.23 -7.35 5.35 4.29 16.69 -4.28 -8.93 5.84 5.27 19.32 -1.97
Eisosomes 1.00 1.95 -0.87 -4.06 -6.20 1.60 2.33 1.99 1.29 -1.31 1.75 2.88 1.55 -0.68 -5.10
Endoplasmic Reticulum 2.86 -4.17 -2.10 -10.72 5.26 6.41 -7.55 -5.19 -21.48 4.70 6.76 -7.99 -4.82 -22.82 6.67
Endosome 1.22 2.47 1.53 0.58 -3.25 -2.33 3.82 2.38 8.11 -3.43 -1.14 4.27 2.58 6.87 -4.56
Golgi 2.04 2.27 1.41 -3.74 -5.32 0.85 4.18 1.05 0.29 -3.70 2.15 3.42 1.55 -1.80 -6.54
Lipid Particles -2.77 2.00 -5.59 -3.12 -9.50 -4.91 2.83 -3.40 1.56 -7.29 -5.69 3.55 -6.49 -1.02 -11.99
Mitochondria 1.24 1.75 0.83 -1.08 -2.93 -3.11 1.77 0.40 3.51 -1.24 -0.42 2.27 0.70 1.94 -3.13
Mitotic Spindle 1.10 1.06 0.53 -4.48 -4.15 0.54 0.45 -0.23 -1.98 -1.49 1.20 1.17 0.28 -4.63 -4.36
None -3.62 -3.64 -3.44 2.55 -0.90 -2.79 0.57 -2.11 2.06 -2.46 -3.43 -1.17 -2.96 2.63 -2.53
Nuclear Periphery -2.13 -4.07 0.51 3.13 4.85 -5.18 -5.35 -3.63 4.48 0.62 -5.20 -4.84 -0.60 5.36 4.84
Nuclear Periphery Foci -1.93 -5.40 -0.50 1.90 5.74 -4.84 -5.07 -7.60 -1.36 2.46 -3.48 -8.22 -4.41 -0.44 6.29
Nucleolus -3.12 -0.98 0.83 3.38 2.10 -2.17 1.80 1.57 5.65 -3.28 -3.49 1.22 1.68 6.51 1.50
Nucleus -8.29 -4.73 -0.38 8.87 4.94 -10.39 -2.53 -0.82 10.67 2.17 -13.17 -5.55 -1.06 13.88 5.37
Peroxisomes -4.13 2.04 0.97 4.56 -1.55 -1.79 4.20 4.45 7.50 0.33 -2.88 4.45 4.43 8.49 -0.42
Vacuole 3.70 5.16 3.57 -0.62 -7.79 -0.65 4.07 4.43 11.09 0.29 2.12 6.62 5.09 7.78 -5.16
Vacuole Periphery 1.09 2.09 -0.16 -2.52 -4.83 1.80 4.13 2.50 1.72 -4.14 1.98 4.59 2.18 0.56 -6.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity; involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter
Localization
Cell Percentages ER (71%)
Cell Cycle Regulation No
Subcompartmental Group ER-3

Vcx1

Vcx1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vcx1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available