Standard name | |
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Human Ortholog | |
Description | Cullin; structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation; human homolog CUL1 can complement yeast cdc53 null mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Bud | 0 | 0 | 0 | 2 | 0 | 0 | 4 | – | 3 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 6 | 15 | 3 | 24 | 18 | 27 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 4 | 9 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 2 | – | 2 | 2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 1 | 0 | 0 | – | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 29 | 46 | 25 | 15 | 61 | 69 | 101 | – | 75 | 75 | 74 | 56 | 42 | 73 | 84 | 100 | 83 | 64 | 16 | 31 | 20 | 18 | 35 | 38 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 1 | 1 | 1 | – | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 17 | 11 | 11 | 0 | 1 | 1 | 1 | 8 | 13 |
Endosome | 3 | 2 | 0 | 0 | 0 | 4 | 1 | – | 1 | 0 | 0 | 0 | 0 | 2 | 13 | 6 | 4 | 9 | 6 | 4 | 2 | 3 | 9 | 15 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 2 | 2 | 2 | 0 | 0 | 3 | 2 |
Mitochondria | 3 | 5 | 4 | 10 | 4 | 28 | 48 | – | 54 | 49 | 67 | 53 | 18 | 4 | 5 | 4 | 1 | 1 | 2 | 2 | 5 | 1 | 10 | 13 |
Nucleus | 115 | 192 | 131 | 39 | 52 | 24 | 31 | – | 18 | 13 | 14 | 11 | 73 | 78 | 54 | 86 | 57 | 35 | 165 | 290 | 137 | 142 | 116 | 141 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 0 | 4 | 4 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 4 | 1 | 3 | 4 | 8 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 8 | 4 | 4 | 8 | 17 |
Vac/Vac Membrane | 109 | 194 | 27 | 25 | 26 | 35 | 26 | – | 16 | 10 | 3 | 7 | 87 | 145 | 134 | 167 | 154 | 105 | 28 | 61 | 28 | 74 | 127 | 134 |
Unique Cell Count | 219 | 375 | 169 | 79 | 132 | 145 | 188 | 135 | 123 | 133 | 113 | 198 | 275 | 260 | 317 | 265 | 182 | 244 | 428 | 210 | 279 | 365 | 447 | |
Labelled Cell Count | 259 | 439 | 188 | 91 | 145 | 161 | 214 | 170 | 150 | 165 | 133 | 222 | 303 | 293 | 382 | 313 | 228 | 244 | 428 | 210 | 279 | 365 | 447 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.3 | 7.9 | 6.6 | 6.2 | 6.8 | 6.0 | 5.3 | – | 4.7 | 4.5 | 4.0 | 4.0 | 6.5 | 7.6 | 7.8 | 10.6 | 10.8 | 10.1 | 6.1 | 6.4 | 7.0 |
Std Deviation (1e-4) | 1.1 | 1.4 | 0.9 | 1.2 | 1.6 | 1.9 | 1.3 | – | 1.3 | 1.5 | 1.5 | 1.0 | 1.1 | 1.4 | 1.6 | 2.4 | 2.2 | 2.1 | 1.2 | 1.5 | 1.6 |
Intensity Change (Log2) | – | – | – | -0.09 | 0.06 | -0.14 | -0.3 | – | -0.49 | -0.55 | -0.71 | -0.73 | -0.01 | 0.21 | 0.25 | 0.7 | 0.72 | 0.62 | -0.1 | -0.05 | 0.09 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0.8 | 6.0 | 6.3 | 7.7 | – | 7.5 | 8.2 | 7.5 | 6.3 | 1.6 | 2.9 | 4.1 | 4.0 | 3.9 | 4.4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.1 | 0 | 3.2 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3.0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.9 | 6.2 | – | 0 | 0 | 0 | 0 | 2.7 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -4.4 | -6.7 | -10.8 | -11.6 | – | -11.1 | -11.3 | -11.6 | -11.2 | -7.8 | -10.1 | -11.6 | -10.6 | -11.5 | -10.9 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 2.8 | 0.8 | 1.8 | -0.6 | – | -1.0 | -2.0 | -4.0 | -2.5 | 5.8 | 7.7 | 7.4 | 7.9 | 8.7 | 8.1 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 4.3815 | 5.1832 | 4.6097 | 4.0205 | 4.4241 | 4.9496 | 3.1037 | 4.0521 | 3.2731 | 2.8378 | 3.0084 | 3.3988 | 3.131 | 3.6324 | 3.0818 | 2.9081 | 3.2741 | 3.1912 |
Actin | 0.0766 | 0.0002 | 0.0107 | 0.0005 | 0.004 | 0.0041 | 0.0384 | 0.0001 | 0.0081 | 0.0304 | 0.0008 | 0.0037 | 0.0177 | 0.0001 | 0.01 | 0.0002 | 0.0469 | 0.0073 |
Bud | 0.0008 | 0.0001 | 0.0007 | 0.0005 | 0.0002 | 0.0003 | 0.001 | 0.0001 | 0.0003 | 0.0003 | 0.0003 | 0.0002 | 0.0004 | 0.0001 | 0.0002 | 0.0001 | 0.0005 | 0.0001 |
Bud Neck | 0.0068 | 0.0006 | 0.0025 | 0.0008 | 0.0029 | 0.0048 | 0.005 | 0.0002 | 0.0008 | 0.0016 | 0.0026 | 0.0041 | 0.0072 | 0.0004 | 0.0006 | 0.001 | 0.0017 | 0.0021 |
Bud Periphery | 0.0011 | 0.0001 | 0.0008 | 0.0011 | 0.0003 | 0.0003 | 0.0017 | 0 | 0.0002 | 0.0004 | 0.0012 | 0.0003 | 0.0005 | 0 | 0.0004 | 0 | 0.0009 | 0.0002 |
Bud Site | 0.0124 | 0.0009 | 0.0039 | 0.0011 | 0.0006 | 0.0016 | 0.0056 | 0.0003 | 0.0016 | 0.0009 | 0.0004 | 0.0003 | 0.003 | 0.0003 | 0.0003 | 0.0003 | 0.0013 | 0.0003 |
Cell Periphery | 0.0005 | 0.0001 | 0.0004 | 0.0002 | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Cytoplasm | 0.0716 | 0.089 | 0.0803 | 0.0629 | 0.0388 | 0.0542 | 0.0405 | 0.0771 | 0.0567 | 0.0762 | 0.0959 | 0.0347 | 0.0322 | 0.0342 | 0.0329 | 0.0899 | 0.1174 | 0.0374 |
Cytoplasmic Foci | 0.0261 | 0.0005 | 0.0057 | 0.0024 | 0.0213 | 0.0072 | 0.0189 | 0.0002 | 0.007 | 0.0071 | 0.0006 | 0.0025 | 0.0154 | 0.0002 | 0.0004 | 0.0289 | 0.0061 | 0.0022 |
Eisosomes | 0.0006 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0.0006 | 0 | 0.001 | 0.0001 |
Endoplasmic Reticulum | 0.0048 | 0.0039 | 0.0063 | 0.0016 | 0.0045 | 0.0051 | 0.016 | 0.0009 | 0.0067 | 0.0041 | 0.0026 | 0.0019 | 0.0064 | 0.001 | 0.0012 | 0.0013 | 0.0048 | 0.0008 |
Endosome | 0.0243 | 0.0017 | 0.0089 | 0.0292 | 0.0397 | 0.0132 | 0.0436 | 0.0005 | 0.0218 | 0.0126 | 0.0055 | 0.0052 | 0.02 | 0.0006 | 0.0018 | 0.0069 | 0.0158 | 0.0024 |
Golgi | 0.0086 | 0 | 0.0021 | 0.0045 | 0.008 | 0.0049 | 0.0094 | 0 | 0.0079 | 0.0064 | 0.0002 | 0.0027 | 0.0035 | 0 | 0.0008 | 0.0008 | 0.0063 | 0.0009 |
Lipid Particles | 0.0139 | 0.0001 | 0.0019 | 0.0023 | 0.0613 | 0.0042 | 0.0096 | 0 | 0.0025 | 0.001 | 0.0003 | 0.0034 | 0.0041 | 0 | 0.0012 | 0.0034 | 0.0045 | 0.0006 |
Mitochondria | 0.0142 | 0.0003 | 0.0094 | 0.0257 | 0.0041 | 0.0144 | 0.0078 | 0.0002 | 0.0032 | 0.0022 | 0.0015 | 0.0013 | 0.0012 | 0.0002 | 0.0107 | 0.0003 | 0.0028 | 0.0039 |
None | 0.0444 | 0.014 | 0.0326 | 0.0621 | 0.0316 | 0.0169 | 0.0169 | 0.0004 | 0.0015 | 0.0081 | 0.0011 | 0.0004 | 0.0087 | 0.0012 | 0.0123 | 0.0028 | 0.0037 | 0.0013 |
Nuclear Periphery | 0.022 | 0.0232 | 0.0165 | 0.0089 | 0.0282 | 0.0118 | 0.0496 | 0.0183 | 0.0262 | 0.0296 | 0.0474 | 0.017 | 0.0214 | 0.0095 | 0.0114 | 0.0143 | 0.035 | 0.0078 |
Nucleolus | 0.0058 | 0.0024 | 0.0034 | 0.0024 | 0.006 | 0.0072 | 0.0027 | 0.0019 | 0.0019 | 0.0024 | 0.0062 | 0.0028 | 0.0026 | 0.0012 | 0.002 | 0.0017 | 0.0025 | 0.0022 |
Nucleus | 0.61 | 0.853 | 0.7878 | 0.7757 | 0.6946 | 0.828 | 0.7012 | 0.8902 | 0.8416 | 0.8016 | 0.8218 | 0.9067 | 0.8349 | 0.945 | 0.9085 | 0.7952 | 0.731 | 0.9188 |
Peroxisomes | 0.0265 | 0 | 0.0035 | 0.0005 | 0.0134 | 0.002 | 0.0085 | 0 | 0.0008 | 0.0005 | 0.0003 | 0.0031 | 0.0043 | 0 | 0.0008 | 0.0048 | 0.003 | 0.0012 |
Punctate Nuclear | 0.0227 | 0.0046 | 0.0121 | 0.0073 | 0.0328 | 0.0166 | 0.0106 | 0.0083 | 0.0074 | 0.0106 | 0.0067 | 0.0078 | 0.0135 | 0.0052 | 0.0024 | 0.047 | 0.0117 | 0.0095 |
Vacuole | 0.0053 | 0.0048 | 0.0085 | 0.0078 | 0.0064 | 0.0026 | 0.008 | 0.001 | 0.0032 | 0.0031 | 0.0035 | 0.0014 | 0.0024 | 0.0006 | 0.001 | 0.001 | 0.0018 | 0.0007 |
Vacuole Periphery | 0.001 | 0.0004 | 0.0019 | 0.0026 | 0.0012 | 0.0005 | 0.0043 | 0.0002 | 0.0006 | 0.0007 | 0.001 | 0.0004 | 0.0006 | 0.0001 | 0.0006 | 0.0002 | 0.0009 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 36.7351 | 37.4726 | 38.271 | 54.6072 | 38.5704 | 39.1924 | 42.7774 | 51.5569 | 48.0832 | 46.8725 |
Translational Efficiency | 0.9422 | 0.9982 | 1.0553 | 0.6714 | 0.7977 | 1.0044 | 0.988 | 0.7207 | 0.8591 | 0.8456 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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