Standard name
Human Ortholog
Description Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.97 0.94 0.89 0.56 0.64 0.69 0.66 0.55 0.63 0.59 0.6 0.63 0.79 0.86 0.92 0.49 0.44 0.48 0.85 0.82 0.8 0.79 0.63 0.52
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.06 0 0 0 0 0.08 0.13
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.11 0.2 0.14 0.27 0.19 0.29 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0.08 0.05 0 0.05 0.06 0 0 0 0 0 0 0 0.09 0.06 0.1 0.06 0.05
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.09
Vac/Vac Membrane 0 0.08 0.12 0.52 0.41 0.24 0.23 0.31 0.19 0.29 0.17 0.27 0.31 0.29 0.16 0.56 0.6 0.46 0 0 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 1 0 1 0 1 0 0 0 1 0 0 1 1 0 0 1 3
Bud 0 0 0 0 0 1 5 4 3 3 5 2 1 0 0 0 0 0 0 0 1 1 6 10
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 1 4 0 2 1 3 6 3 5 0 0 0 2 5 0 0 0 0 0 0 0
Cytoplasm 123 160 102 97 172 167 202 185 139 152 132 155 229 297 335 148 100 105 114 150 134 185 190 157
Endoplasmic Reticulum 1 2 1 0 2 0 1 3 3 3 0 3 1 0 0 9 4 4 1 1 2 0 2 3
Endosome 0 0 2 2 5 2 0 2 0 1 1 1 3 1 2 15 14 13 1 2 4 2 25 39
Golgi 1 0 0 0 0 0 1 1 0 0 0 0 2 1 0 7 5 6 2 0 0 1 12 5
Mitochondria 4 1 0 4 7 26 60 46 59 48 65 30 0 0 0 1 3 9 1 1 3 3 6 4
Nucleus 0 1 2 3 9 9 7 27 12 9 12 15 10 5 4 10 5 9 4 15 9 24 17 14
Nuclear Periphery 0 0 1 0 0 0 1 1 0 3 0 0 0 0 0 0 1 0 0 0 0 1 1 1
Nucleolus 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 12 8 9 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 4
SpindlePole 0 0 0 2 1 0 0 1 0 0 0 0 0 0 0 7 5 4 0 0 2 1 24 27
Vac/Vac Membrane 2 13 14 90 110 59 71 106 42 74 38 66 89 101 59 170 136 101 3 8 6 9 6 15
Unique Cell Count 127 170 115 173 269 243 306 339 222 259 221 247 289 346 365 301 226 218 134 184 169 236 303 300
Labelled Cell Count 131 177 122 200 311 264 350 378 261 300 256 279 335 405 400 382 286 260 134 184 169 236 303 300


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 9.8 7.6 8.4 8.4 7.3 7.0 7.4 6.8 7.2 6.8 7.6 9.0 9.5 9.6 10.9 11.9 11.5 8.7 8.6 9.2
Std Deviation (1e-4) 0.9 2.0 1.2 1.9 1.9 1.8 1.7 1.3 1.6 1.5 1.6 1.6 1.4 1.3 1.3 2.6 2.6 2.8 1.5 1.4 1.9
Intensity Change (Log2) – – – 0.14 0.14 -0.07 -0.12 -0.05 -0.15 -0.07 -0.17 -0.01 0.24 0.32 0.34 0.52 0.64 0.59 0.19 0.17 0.28


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -5.9 -4.9 -4.1 -4.6 -6.6 -5.0 -5.7 -5.5 -5.1 -2.2 -0.8 1.0 -7.4 -7.9 -7.3
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 1.8 1.8
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.6 5.1 4.2 6.1 4.9 6.5 3.9 0 0 0 0 0 0
Nucleus 0 0 0 0 2.4 0 0 0 1.8 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 6.9 5.5 2.7 2.5 4.0 1.6 3.4 1.2 3.1 3.9 3.7 1.0 8.1 8.4 6.2

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 5.528 6.9575 6.066 5.9281 4.5333 6.0194 4.2038 5.5641 5.0511 4.4233 4.2625 5.0375 3.6237 4.9197 3.8897 3.6869 3.3094 4.1266
Actin 0.0102 0.0012 0.0013 0.0004 0.0314 0.0008 0.0311 0.0004 0.0079 0.003 0.0029 0.0034 0.0538 0.0002 0.0167 0.1251 0.0242 0.0006
Bud 0.0005 0.0002 0.0002 0.0001 0.0067 0.0001 0.0092 0.0004 0.0051 0.001 0.0003 0.0002 0.001 0.0001 0.0008 0.0009 0.0002 0.0014
Bud Neck 0.0023 0.0006 0.0011 0.0007 0.0043 0.0021 0.0015 0.0008 0.0028 0.0017 0.0012 0.0024 0.0041 0.0003 0.001 0.0031 0.0009 0.0025
Bud Periphery 0.0003 0.0001 0.0001 0 0.0032 0.0001 0.0034 0.0001 0.0019 0.0003 0.0003 0.0001 0.002 0 0.0009 0.0006 0.0002 0.001
Bud Site 0.0049 0.0016 0.0006 0.0001 0.0039 0.0002 0.0037 0.001 0.0023 0.0008 0.0008 0.0002 0.0058 0.0005 0.0145 0.002 0.0006 0.0005
Cell Periphery 0.0004 0 0 0 0.0003 0 0.0003 0 0.0002 0.0001 0.0001 0 0.0006 0 0.0003 0.0002 0 0.0001
Cytoplasm 0.4974 0.5262 0.4337 0.3189 0.4728 0.497 0.5131 0.5882 0.5442 0.3688 0.5397 0.518 0.6127 0.7442 0.559 0.4914 0.3438 0.6643
Cytoplasmic Foci 0.0186 0.0025 0.0105 0.0019 0.0356 0.0066 0.0185 0.0036 0.0127 0.0394 0.0376 0.0057 0.0099 0.0013 0.0235 0.0048 0.0282 0.0055
Eisosomes 0.0001 0 0 0 0.0003 0 0.0002 0 0 0 0 0 0.0004 0 0.0002 0.0004 0.0001 0
Endoplasmic Reticulum 0.0094 0.0015 0.0031 0.001 0.0049 0.0027 0.0095 0.0025 0.005 0.0042 0.0027 0.0031 0.0034 0.0019 0.0036 0.0015 0.0013 0.0053
Endosome 0.0337 0.0013 0.0068 0.001 0.0236 0.0069 0.032 0.0031 0.0124 0.0405 0.0264 0.0088 0.0126 0.0008 0.0264 0.0026 0.0066 0.0135
Golgi 0.0068 0.0001 0.0012 0 0.0067 0.0007 0.0086 0.0001 0.0021 0.0039 0.0247 0.0013 0.0116 0 0.0265 0.0066 0.02 0.0009
Lipid Particles 0.011 0 0.0022 0 0.011 0.0004 0.0103 0 0.0028 0.0082 0.0315 0.0034 0.038 0 0.0278 0.0016 0.0509 0
Mitochondria 0.0063 0.0003 0.0124 0.0002 0.0149 0.0043 0.012 0.0009 0.0053 0.0014 0.0056 0.0011 0.0287 0.0002 0.0293 0.0015 0.0046 0.0015
None 0.0264 0.0137 0.0118 0.0664 0.0345 0.0089 0.0067 0.0072 0.0043 0.0043 0.0054 0.0029 0.0023 0.0022 0.0021 0.0026 0.0006 0.0026
Nuclear Periphery 0.0169 0.0104 0.0144 0.0087 0.0193 0.0126 0.023 0.0106 0.0137 0.0163 0.0123 0.0171 0.0193 0.0091 0.0185 0.0107 0.0173 0.0219
Nucleolus 0.0008 0.0004 0.0005 0.0002 0.003 0.0004 0.0006 0.0003 0.0024 0.0015 0.0006 0.0004 0.0004 0.0001 0.0009 0.0014 0.0002 0.0002
Nucleus 0.3296 0.4344 0.4801 0.5956 0.2881 0.4414 0.298 0.3737 0.359 0.4622 0.2362 0.4203 0.1679 0.2368 0.2087 0.2777 0.4316 0.2665
Peroxisomes 0.005 0.0003 0.0081 0.0002 0.0094 0.0021 0.0046 0.0003 0.0014 0.0086 0.0267 0.0016 0.0132 0 0.0215 0.0014 0.0644 0.0002
Punctate Nuclear 0.0158 0.0038 0.0102 0.0041 0.0224 0.0107 0.0092 0.0051 0.0108 0.0307 0.0426 0.0078 0.0028 0.0016 0.0066 0.0631 0.0034 0.0046
Vacuole 0.0025 0.001 0.0013 0.0003 0.0029 0.0015 0.003 0.0014 0.0027 0.0023 0.0017 0.0016 0.0063 0.0005 0.0086 0.0008 0.0007 0.0055
Vacuole Periphery 0.0009 0.0002 0.0003 0.0001 0.0009 0.0003 0.0015 0.0002 0.0009 0.0007 0.0007 0.0006 0.0031 0.0001 0.0025 0.0003 0.0003 0.0016

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 67.0989 61.3153 52.0926 75.1968 62.5087 67.5585 76.147 77.925 85.4675 66.537
Translational Efficiency 1.079 1.1616 1.3931 0.944 0.9433 1.1988 0.963 0.9871 0.8812 0.9703

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
16 490 2125 1840 1504 1925 292 1418 1520 2415 2417 3258

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1209.19 995.99 1152.37 1340.77 831.06 990.49 1204.25 1335.03 835.04 991.61 1158.64 1338.27
Standard Deviation 166.44 135.82 146.72 215.84 133.25 133.51 180.66 209.19 139.10 134.00 152.17 212.99
Intensity Change Log 2 — -0.279838 -0.069437 0.149021 — 0.253190 0.535110 0.683848 — -0.038532 0.207973 0.391224

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002492 0.000938 0.000400 0.003002 0.000240 0.000123 0.000929 0.000727 0.000264 0.000288 0.000464 0.002012
Bud Neck 0.024067 0.004124 0.004529 0.019304 0.001666 0.003068 0.003477 0.016736 0.001902 0.003282 0.004402 0.018186
Bud Site 0.101341* 0.010795 0.003352 0.033086 0.003282 0.004233 0.005488 0.037980 0.004314 0.005565 0.003610 0.035216
Cell Periphery 0.000463 0.000157 0.000104 0.000220 0.000130 0.000049 0.000306 0.000118 0.000134 0.000071 0.000128 0.000176
Cytoplasm 0.247879* 0.579385* 0.298892* 0.094375 0.596252* 0.581961* 0.261854* 0.130949* 0.592585* 0.581438* 0.294417* 0.110293*
Cytoplasmic Foci 0.040041 0.030637 0.002324 0.037057 0.038395 0.014208 0.009933 0.040007 0.038413 0.017541 0.003244 0.038341
Eisosomes 0.000072 0.000026 0.000013 0.000017 0.000025 0.000011 0.000092 0.000012 0.000025 0.000014 0.000023 0.000015
Endoplasmic Reticulum 0.024585 0.004017 0.003039 0.001497 0.002658 0.001445 0.007869 0.000686 0.002888 0.001967 0.003623 0.001144
Endosome 0.013872 0.002170 0.001155 0.003981 0.001848 0.002298 0.003772 0.009249 0.001974 0.002272 0.001471 0.006274
Golgi 0.002229 0.001997 0.000419 0.006349 0.000384 0.000397 0.000178 0.013853 0.000403 0.000722 0.000390 0.009615
Lipid Particles 0.004314 0.000902 0.000413 0.001268 0.001152 0.000509 0.002719 0.001055 0.001185 0.000588 0.000692 0.001175
Mitochondria 0.001076 0.001357 0.001055 0.002030 0.001257 0.001872 0.000640 0.002691 0.001255 0.001768 0.001005 0.002318
Mitotic Spindle 0.012379 0.005535 0.014932 0.560282* 0.002496 0.016112 0.016227 0.583879* 0.002600 0.013966 0.015088 0.570552*
None 0.001252 0.005007 0.008585 0.005278 0.007766 0.005338 0.011045 0.004961 0.007698 0.005271 0.008882 0.005140
Nuclear Periphery 0.003429 0.000647 0.002031 0.003416 0.000649 0.001152 0.001889 0.001311 0.000678 0.001049 0.002014 0.002500
Nuclear Periphery Foci 0.043012 0.003335 0.001153 0.005218 0.002312 0.000938 0.003964 0.002756 0.002740 0.001425 0.001492 0.004146
Nucleolus 0.004696 0.000388 0.000811 0.004517 0.000542 0.000382 0.000883 0.002507 0.000586 0.000384 0.000819 0.003642
Nucleus 0.304564* 0.305906* 0.631433* 0.187810* 0.312111* 0.335234* 0.550837* 0.112495 0.312031* 0.329283* 0.621696* 0.155030*
Peroxisomes 0.001379 0.000885 0.000301 0.005581 0.000430 0.000379 0.000368 0.006493 0.000440 0.000482 0.000309 0.005978
Vacuole 0.154979 0.041278 0.024901 0.019220 0.026105 0.029059 0.117310 0.027809 0.027461 0.031538 0.036065 0.022958
Vacuole Periphery 0.011878 0.000514 0.000157 0.006491 0.000302 0.001232 0.000219 0.003725 0.000424 0.001086 0.000165 0.005287

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.95 3.89 2.54 -0.97 -2.92 3.71 -9.83 -6.54 -9.57 5.69 0.01 -4.90 -5.53 -5.07 -2.27
Bud Neck 1.63 1.49 -0.58 -17.29 -17.58 -4.84 -7.95 -17.42 -15.98 -12.33 -4.18 -10.63 -26.23 -24.52 -21.52
Bud Site 1.95 2.08 1.27 -10.26 -17.99 -1.37 -3.13 -15.06 -14.49 -11.02 -1.27 -0.65 -21.71 -21.18 -22.20
Cell Periphery 3.78 4.31 3.04 -4.05 -10.19 11.50 -7.88 -2.21 -13.18 6.74 8.41 0.23 -6.21 -16.26 -7.38
Cytoplasm -5.08 0.18 2.58 37.53 25.54 2.51 31.97 60.02* 60.98* 4.80 2.47 45.07 67.75 77.41* 25.11
Cytoplasmic Foci 0.99 3.87 0.64 -1.02 -13.65 11.27 15.68 2.56 -6.10 -9.57 9.76 19.12 2.14 -7.64 -17.61
Eisosomes 3.56 4.23 4.05 2.81 -2.31 9.26 -10.44 2.28 -9.50 11.14 7.31 -1.38 2.83 -7.72 5.28
Endoplasmic Reticulum 3.47 3.51 3.93 5.57 11.37 5.15 -10.03 5.72 -0.02 11.95 3.57 -6.86 6.01 2.35 16.28
Endosome 2.92 3.22 2.75 -2.16 -8.04 -0.97 -5.02 -6.25 -4.04 -1.96 -0.70 3.82 -6.03 -3.60 -9.81
Golgi 0.30 1.58 0.21 -0.19 -3.47 0.00 1.08 -3.33 -3.36 -3.58 -0.90 0.95 -4.43 -3.54 -4.88
Lipid Particles 3.12 3.37 2.11 -8.68 -12.70 5.97 -6.44 -6.68 -13.26 2.36 5.69 3.36 -8.19 -16.44 -14.11
Mitochondria -0.32 -0.91 -3.54 -2.21 -8.98 -0.96 0.66 -0.99 0.16 -4.48 -0.80 -0.12 -1.78 -1.36 -7.64
Mitotic Spindle 0.67 -0.47 -33.92* -47.29* -46.21* -5.54 -3.25 -43.71* -41.52* -33.15* -5.52 -7.32 -64.98 -61.44* -61.13*
None -4.60 -8.72 -9.41 -5.92 -1.03 2.41 -0.13 1.06 -2.29 0.98 2.56 -0.16 -0.02 -5.04 0.28
Nuclear Periphery 1.12 0.05 -0.94 -18.65 -8.84 -3.74 -13.48 -17.82 -11.78 -3.93 -3.40 -25.31 -24.62 -18.17 -9.81
Nuclear Periphery Foci 1.62 1.73 1.31 -6.60 -9.61 3.66 -2.38 -6.33 -8.74 -1.83 2.81 3.19 -8.40 -11.15 -11.54
Nucleolus 1.87 1.72 -4.47 -13.95 -13.51 0.18 -1.95 -10.47 -10.44 -9.90 0.78 -0.75 -17.00 -17.08 -16.49
Nucleus -0.42 -5.15 0.73 6.60 48.94 -3.24 -12.56 14.07 17.69 19.74 -2.74 -40.91 13.24 18.00 60.45
Peroxisomes 1.56 4.26 -3.54 -4.95 -7.97 -0.01 1.09 -6.18 -6.27 -6.56 -0.63 1.82 -9.26 -9.18 -10.29
Vacuole 2.54 2.76 2.63 0.64 -1.75 -2.01 -12.22 -12.32 -11.06 7.35 -3.01 -9.70 -11.69 -9.27 -1.37
Vacuole Periphery 1.18 1.22 1.08 -1.60 -2.37 -2.26 1.44 -2.31 0.64 -2.71 -1.90 2.51 -2.22 -0.25 -3.25
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Catalytic subunit of protein phosphatase 2A, PP2A; functionally redundant with Pph22p; C-terminally methylated; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; forms nuclear foci upon DNA replication stress; PPH21 has a paralog, PPH22, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (89%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Pph21

Pph21


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pph21-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available