Standard name | |
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Human Ortholog | |
Description | Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function and for correct integration of membrane-multispanning proteins into the mitochondrial outer membrane; required to maintain tubular mitochondrial morphology and functions in mitochondrial fusion; also required for normal vacuolar ion homeostasis |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4 | 3 | 13 | 1 | 3 | 1 |
Bud | 1 | 3 | 9 | 4 | 5 | 28 | 15 | 32 | 30 | 27 | 38 | 29 | 1 | 0 | 0 | 2 | 3 | 4 | 0 | 0 | 6 | 0 | 2 | 2 |
Bud Neck | 0 | 0 | 2 | 0 | 4 | 0 | 4 | 2 | 3 | 3 | 2 | 4 | 2 | 0 | 0 | 3 | 5 | 0 | 1 | 2 | 2 | 2 | 4 | 4 |
Bud Site | 0 | 0 | 0 | 0 | 1 | 6 | 4 | 7 | 5 | 10 | 3 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 2 | 0 | 4 | 4 | 3 | 3 | 5 | 1 | 1 | 3 | 2 | 0 | 4 | 2 | 1 | 1 | 4 | 2 | 1 | 2 | 3 | 1 | 2 | 1 |
Cytoplasm | 129 | 142 | 256 | 155 | 231 | 261 | 222 | 238 | 180 | 169 | 162 | 131 | 98 | 98 | 116 | 130 | 139 | 107 | 86 | 75 | 56 | 31 | 45 | 39 |
Endoplasmic Reticulum | 2 | 3 | 0 | 0 | 0 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 3 | 0 | 12 | 12 | 5 | 1 | 1 | 9 | 1 | 0 | 5 |
Endosome | 1 | 2 | 18 | 6 | 34 | 19 | 17 | 17 | 3 | 16 | 6 | 14 | 1 | 0 | 0 | 4 | 5 | 4 | 7 | 2 | 21 | 5 | 1 | 2 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 2 | 3 | 1 | 0 | 0 | 1 |
Mitochondria | 27 | 27 | 53 | 53 | 78 | 329 | 347 | 472 | 418 | 374 | 382 | 363 | 0 | 0 | 0 | 16 | 16 | 6 | 61 | 76 | 232 | 56 | 70 | 46 |
Nucleus | 0 | 0 | 0 | 1 | 1 | 2 | 7 | 8 | 2 | 7 | 2 | 7 | 1 | 0 | 0 | 1 | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 |
Nucleolus | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 6 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 1 | 32 | 10 | 16 | 9 | 8 | 13 | 3 | 9 | 11 | 17 | 0 | 0 | 2 | 3 | 4 | 1 | 0 | 0 | 2 | 0 | 0 | 0 |
SpindlePole | 1 | 1 | 8 | 6 | 26 | 38 | 42 | 63 | 38 | 45 | 45 | 46 | 0 | 0 | 0 | 0 | 5 | 5 | 3 | 3 | 11 | 2 | 6 | 1 |
Vac/Vac Membrane | 5 | 3 | 7 | 3 | 29 | 17 | 17 | 18 | 6 | 15 | 19 | 15 | 0 | 2 | 1 | 6 | 8 | 5 | 9 | 8 | 5 | 4 | 17 | 12 |
Unique Cell Count | 161 | 168 | 331 | 199 | 355 | 558 | 555 | 716 | 541 | 551 | 545 | 507 | 102 | 102 | 117 | 157 | 179 | 131 | 185 | 190 | 381 | 117 | 159 | 125 |
Labelled Cell Count | 168 | 182 | 391 | 242 | 429 | 715 | 689 | 880 | 691 | 680 | 675 | 632 | 108 | 105 | 120 | 182 | 205 | 142 | 185 | 190 | 381 | 117 | 159 | 125 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.7 | 3.8 | 3.9 | 3.6 | 4.3 | 3.3 | 3.4 | 3.5 | 3.1 | 3.1 | 3.1 | 3.1 | 4.4 | 4.7 | 4.8 | 4.9 | 5.0 | 5.0 | 4.5 | 4.5 | 4.8 |
Std Deviation (1e-4) | 0.5 | 1.1 | 1.6 | 1.7 | 2.6 | 1.8 | 3.1 | 1.4 | 1.4 | 0.6 | 1.0 | 0.7 | 0.8 | 0.7 | 1.0 | 1.5 | 1.3 | 1.1 | 1.5 | 0.9 | 2.0 |
Intensity Change (Log2) | – | – | – | -0.14 | 0.13 | -0.27 | -0.2 | -0.19 | -0.33 | -0.33 | -0.33 | -0.34 | 0.15 | 0.25 | 0.29 | 0.33 | 0.34 | 0.34 | 0.2 | 0.17 | 0.28 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | 0 | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | 1.5 | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | -1.2141 | -0.8864 | -1.0036 | -1.2049 | -1.4268 | -1.1998 | 0.5352 | 1.1006 | 0.8403 | 0.4557 | 0.4928 | 1.0371 | -0.257 | 0.6134 | -0.451 | -0.0504 | 0.3049 | -0.37 |
Actin | 0.0038 | 0.0016 | 0.0025 | 0.0054 | 0.0052 | 0.0014 | 0.023 | 0.0019 | 0.0039 | 0.0012 | 0.0041 | 0.012 | 0.0468 | 0.0011 | 0.0085 | 0.0003 | 0.0102 | 0.001 |
Bud | 0.0003 | 0.0003 | 0.0009 | 0.0003 | 0.0009 | 0.0006 | 0.0011 | 0.0061 | 0.003 | 0.0005 | 0.0022 | 0.0011 | 0.0045 | 0.0008 | 0.0011 | 0.0004 | 0.0005 | 0.0002 |
Bud Neck | 0.0011 | 0.0005 | 0.0009 | 0.0007 | 0.0004 | 0.0013 | 0.0068 | 0.0013 | 0.0029 | 0.0046 | 0.0009 | 0.0114 | 0.0043 | 0.0019 | 0.0003 | 0.0007 | 0.0003 | 0.004 |
Bud Periphery | 0.0007 | 0.0007 | 0.002 | 0.0011 | 0.0025 | 0.0009 | 0.003 | 0.0061 | 0.0084 | 0.0011 | 0.0104 | 0.0027 | 0.0107 | 0.0009 | 0.0021 | 0.0005 | 0.0009 | 0.0005 |
Bud Site | 0.0015 | 0.0102 | 0.0048 | 0.0003 | 0.0023 | 0.0017 | 0.0063 | 0.0318 | 0.0078 | 0.0005 | 0.001 | 0.0007 | 0.0206 | 0.0309 | 0.0015 | 0.0013 | 0.0017 | 0.0001 |
Cell Periphery | 0.0005 | 0.0006 | 0.0006 | 0.0002 | 0.0002 | 0.0003 | 0.0008 | 0.0012 | 0.0008 | 0.0002 | 0.0005 | 0.0005 | 0.0022 | 0.0011 | 0.0009 | 0.0002 | 0.0002 | 0.0004 |
Cytoplasm | 0.1006 | 0.0966 | 0.1169 | 0.0906 | 0.1005 | 0.1495 | 0.1709 | 0.3546 | 0.2278 | 0.2236 | 0.2562 | 0.2671 | 0.0879 | 0.197 | 0.2296 | 0.1324 | 0.1098 | 0.2745 |
Cytoplasmic Foci | 0.0579 | 0.0653 | 0.0837 | 0.0207 | 0.0415 | 0.065 | 0.0622 | 0.0689 | 0.0632 | 0.0702 | 0.0788 | 0.0795 | 0.0614 | 0.0571 | 0.0411 | 0.1698 | 0.036 | 0.03 |
Eisosomes | 0.0008 | 0.0008 | 0.0006 | 0.0009 | 0.0004 | 0.0003 | 0.0005 | 0.0002 | 0.0004 | 0.0001 | 0.0003 | 0.0003 | 0.0023 | 0.0003 | 0.0005 | 0.0004 | 0.0004 | 0.0001 |
Endoplasmic Reticulum | 0.0044 | 0.0025 | 0.0036 | 0.0033 | 0.0015 | 0.0021 | 0.0042 | 0.0024 | 0.0026 | 0.0022 | 0.0051 | 0.0025 | 0.0172 | 0.0021 | 0.0111 | 0.0019 | 0.0051 | 0.0114 |
Endosome | 0.0249 | 0.0212 | 0.0386 | 0.0205 | 0.0303 | 0.0145 | 0.039 | 0.0248 | 0.0246 | 0.0428 | 0.0411 | 0.0298 | 0.052 | 0.0292 | 0.0397 | 0.0186 | 0.0699 | 0.0136 |
Golgi | 0.0037 | 0.003 | 0.0047 | 0.0012 | 0.002 | 0.0027 | 0.006 | 0.0032 | 0.0046 | 0.0072 | 0.0047 | 0.0044 | 0.0157 | 0.0073 | 0.0056 | 0.0044 | 0.0381 | 0.0218 |
Lipid Particles | 0.0107 | 0.0064 | 0.0062 | 0.0013 | 0.0025 | 0.0073 | 0.0077 | 0.0035 | 0.0039 | 0.0026 | 0.0027 | 0.0053 | 0.0314 | 0.0065 | 0.0089 | 0.0007 | 0.0312 | 0.0009 |
Mitochondria | 0.0113 | 0.0066 | 0.0223 | 0.0047 | 0.0308 | 0.0162 | 0.0139 | 0.009 | 0.0216 | 0.0152 | 0.0225 | 0.02 | 0.0121 | 0.0085 | 0.0213 | 0.0022 | 0.0182 | 0.0038 |
None | 0.7561 | 0.7694 | 0.6866 | 0.8336 | 0.7668 | 0.7214 | 0.6216 | 0.4634 | 0.6022 | 0.6107 | 0.4913 | 0.5394 | 0.5993 | 0.6413 | 0.5967 | 0.6453 | 0.6396 | 0.633 |
Nuclear Periphery | 0.0031 | 0.0008 | 0.0015 | 0.0023 | 0.0009 | 0.0008 | 0.004 | 0.0009 | 0.0023 | 0.0009 | 0.0109 | 0.0039 | 0.0025 | 0.0035 | 0.002 | 0.0008 | 0.005 | 0.0005 |
Nucleolus | 0.0011 | 0.0008 | 0.0008 | 0.0012 | 0.0004 | 0.0006 | 0.0011 | 0.0018 | 0.0011 | 0.0005 | 0.0013 | 0.0005 | 0.0027 | 0.0006 | 0.0003 | 0.0008 | 0.0006 | 0.0001 |
Nucleus | 0.0023 | 0.0022 | 0.0016 | 0.0022 | 0.0012 | 0.0015 | 0.0028 | 0.005 | 0.0029 | 0.002 | 0.0054 | 0.0015 | 0.0016 | 0.0025 | 0.0012 | 0.0015 | 0.0013 | 0.0005 |
Peroxisomes | 0.0036 | 0.0054 | 0.0144 | 0.001 | 0.0032 | 0.0075 | 0.0113 | 0.0038 | 0.0076 | 0.0073 | 0.0449 | 0.0105 | 0.0093 | 0.0032 | 0.0148 | 0.0113 | 0.0201 | 0.0006 |
Punctate Nuclear | 0.0073 | 0.0018 | 0.0024 | 0.0037 | 0.0017 | 0.0023 | 0.0067 | 0.0025 | 0.0034 | 0.0017 | 0.0082 | 0.003 | 0.0042 | 0.001 | 0.0005 | 0.0014 | 0.0046 | 0.0005 |
Vacuole | 0.0036 | 0.0026 | 0.0038 | 0.0042 | 0.0034 | 0.0017 | 0.006 | 0.0067 | 0.0038 | 0.0035 | 0.0058 | 0.003 | 0.0099 | 0.0027 | 0.0099 | 0.0047 | 0.003 | 0.0019 |
Vacuole Periphery | 0.0007 | 0.0006 | 0.0009 | 0.0005 | 0.001 | 0.0005 | 0.0014 | 0.0009 | 0.0011 | 0.0011 | 0.0018 | 0.0011 | 0.0014 | 0.0005 | 0.0025 | 0.0005 | 0.0033 | 0.0005 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 8.418 | 5.7886 | 10.3089 | 10.1225 | 7.556 | 16.8267 | 9.3645 | 11.8508 | 11.1349 | 12.3246 |
Translational Efficiency | 1.0553 | 1.6474 | 0.6564 | 0.8682 | 0.9267 | 0.4828 | 1.2495 | 0.8732 | 0.9562 | 0.7269 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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