Standard name
Human Ortholog
Description Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0.05 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.05 0.23 0.12 0.18 0.11 0.13 0.18
Bud 0.06 0 0.06 0 0.05 0.06 0.06 0.05 0 0 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.09 0.06 0.06 0.05 0.06
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.06 0.06 0.05 0.09 0 0 0 0 0 0
Cytoplasm 0.82 0.9 0.89 0.85 0.92 0.74 0.64 0.65 0.61 0.61 0.46 0.38 0.99 0.99 0.99 0.82 0.89 0.86 0.55 0.62 0.45 0.62 0.65 0.57
Endoplasmic Reticulum 0 0.09 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0.06 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.19 0 0 0.2 0.05 0.34 0.48 0.34 0.55 0.51 0.68 0.75 0 0 0 0 0 0 0.05 0 0.07 0.08 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 7 5 5 0 2 2 0 1 0 0 1 1 1 1 0 14 10 6 46 15 18 17 31 55
Bud 11 4 4 1 5 4 7 8 1 5 5 4 0 0 0 7 4 2 4 4 1 2 5 9
Bud Neck 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 1 0 11 11 6 9 11 17
Bud Site 0 0 1 0 0 1 0 1 1 2 0 2 0 0 0 0 0 0 – – – – – –
Cell Periphery 3 4 0 1 2 0 0 0 0 3 1 2 13 11 19 17 9 10 2 3 1 1 4 11
Cytoplasm 155 89 64 34 88 48 73 106 59 73 32 42 237 290 302 253 155 101 114 79 46 97 156 176
Endoplasmic Reticulum 4 9 2 1 2 0 2 1 1 1 0 3 1 0 2 21 6 6 1 1 2 3 7 7
Endosome 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 17 3 2 7 1 6 5 4 7
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 0 1 1 0 0 0
Mitochondria 36 0 2 8 5 22 55 55 53 61 47 83 0 0 0 12 0 2 10 4 7 12 10 11
Nucleus 0 1 1 0 1 0 0 1 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0
Nuclear Periphery 4 0 0 0 0 0 1 1 0 0 0 1 1 1 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 1 0 1 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0
SpindlePole 1 0 2 1 0 0 4 4 1 2 1 0 0 0 0 6 3 3 2 0 3 0 0 2
Vac/Vac Membrane 2 0 0 0 0 0 1 3 0 2 0 1 0 0 0 10 4 4 1 3 0 1 3 7
Unique Cell Count 188 99 72 40 96 65 114 162 97 119 69 111 240 293 304 307 175 117 206 128 102 156 240 312
Labelled Cell Count 223 112 81 47 105 77 143 183 116 151 88 139 254 304 323 368 197 138 206 128 102 156 240 312


Ambiguous, Bud, Bud Neck, Cell Periphery, Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.6 4.6 4.2 4.9 4.6 3.3 3.7 3.7 3.6 3.3 3.0 6.6 7.2 7.9 6.7 7.7 7.7 4.9 5.5 6.4
Std Deviation (1e-4) 0.4 0.6 1.1 1.0 2.0 2.5 1.0 1.3 1.6 2.0 0.9 0.8 1.1 1.1 1.5 1.6 1.6 1.9 1.2 1.2 1.1
Intensity Change (Log2) – – – -0.11 0.1 0.02 -0.45 -0.31 -0.31 -0.35 -0.48 -0.6 0.53 0.66 0.8 0.55 0.75 0.75 0.11 0.28 0.5


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.6 0.6 -2.3 -3.7 -3.7 -4.1 -4.1 -5.4 -6.8 4.0 4.5 5.0 -1.3 -0.1 -0.5
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.5639 2.6717 2.5412 2.2237 2.6625 2.8525 2.5018 2.6734 2.8231 3.2577 2.7889 2.9888 3.4521 3.9243 3.7916 4.4989 3.7276 3.8383
Actin 0.1151 0.0632 0.1553 0.0351 0.0723 0.0426 0.0558 0.0393 0.085 0.0141 0.0378 0.0392 0.0529 0.0286 0.1087 0.0396 0.0827 0.0551
Bud 0.0039 0.0024 0.0175 0.0059 0.0017 0.0007 0.0017 0.0013 0.0134 0.0058 0.0024 0.0009 0.0026 0.0029 0.0074 0.013 0.002 0.0012
Bud Neck 0.0163 0.0035 0.0067 0.0556 0.0199 0.1511 0.0045 0.0018 0.0078 0.0586 0.005 0.062 0.0026 0.0061 0.024 0.002 0.0049 0.0759
Bud Periphery 0.0079 0.0032 0.0214 0.0377 0.0034 0.0012 0.0034 0.0016 0.0423 0.0166 0.0024 0.0022 0.0108 0.0034 0.0148 0.0509 0.0045 0.0038
Bud Site 0.0168 0.0556 0.031 0.0124 0.0102 0.0018 0.0294 0.0442 0.0228 0.0152 0.0032 0.0008 0.0279 0.1184 0.0338 0.0039 0.0095 0.0014
Cell Periphery 0.0019 0.0037 0.0019 0.0028 0.0013 0.0009 0.0045 0.0021 0.0021 0.0018 0.0006 0.0015 0.0064 0.0034 0.0033 0.0046 0.001 0.0024
Cytoplasm 0.5776 0.681 0.5779 0.7584 0.6546 0.6504 0.626 0.6446 0.5277 0.6698 0.5388 0.6391 0.6086 0.5693 0.5485 0.548 0.5477 0.6609
Cytoplasmic Foci 0.0462 0.0279 0.0235 0.0185 0.0429 0.0304 0.0311 0.0117 0.0194 0.0089 0.0635 0.0214 0.0203 0.0183 0.0228 0.0364 0.0314 0.0231
Eisosomes 0.0008 0.0005 0.0004 0.0003 0.0009 0.0001 0.0021 0.0004 0.0005 0.0003 0.0008 0.0004 0.0008 0.0004 0.0007 0.0009 0.0008 0.0007
Endoplasmic Reticulum 0.0083 0.0046 0.0045 0.0051 0.0107 0.0038 0.0065 0.0026 0.0027 0.0044 0.0024 0.0029 0.008 0.0047 0.0072 0.0065 0.0069 0.0032
Endosome 0.0304 0.0079 0.0176 0.0166 0.0242 0.0099 0.0134 0.0079 0.0061 0.0116 0.0171 0.0061 0.0119 0.0054 0.0065 0.0076 0.0254 0.0062
Golgi 0.013 0.0048 0.0075 0.0032 0.0181 0.0065 0.0077 0.0016 0.0062 0.0056 0.0081 0.0049 0.0074 0.002 0.0057 0.003 0.013 0.0021
Lipid Particles 0.0113 0.001 0.0033 0.0004 0.0174 0.0008 0.0026 0.0002 0.0009 0.0011 0.0125 0.0014 0.0043 0.0009 0.0082 0.0012 0.0421 0.0018
Mitochondria 0.0078 0.0013 0.0096 0.0023 0.0172 0.0013 0.002 0.0004 0.0015 0.0544 0.0278 0.0039 0.0022 0.0004 0.0023 0.0027 0.0506 0.0027
None 0.1076 0.1311 0.1027 0.0364 0.0686 0.0906 0.1972 0.2368 0.2537 0.119 0.2595 0.206 0.2206 0.227 0.1874 0.2657 0.1375 0.1476
Nuclear Periphery 0.0087 0.0007 0.0033 0.001 0.0018 0.0006 0.0015 0.0003 0.0006 0.0006 0.0011 0.0012 0.0011 0.0009 0.0029 0.0036 0.004 0.0012
Nucleolus 0.0008 0.0002 0.0003 0.0005 0.0016 0.0002 0.0003 0.0001 0.0005 0.0005 0.0007 0.0001 0.0004 0.0002 0.0004 0.0003 0.001 0.001
Nucleus 0.0027 0.001 0.0015 0.0018 0.0017 0.0015 0.0024 0.0007 0.0012 0.001 0.0012 0.0006 0.0014 0.0017 0.0032 0.0013 0.0027 0.0011
Peroxisomes 0.0099 0.0036 0.0078 0.0018 0.0215 0.0027 0.0027 0.0006 0.0026 0.0014 0.0104 0.0034 0.004 0.0017 0.0088 0.0023 0.0252 0.0057
Punctate Nuclear 0.0092 0.0008 0.0034 0.0006 0.0058 0.0011 0.0035 0.0003 0.0016 0.0003 0.0015 0.0009 0.0012 0.0011 0.0012 0.0042 0.0039 0.0019
Vacuole 0.0025 0.0019 0.0021 0.003 0.0033 0.0014 0.0013 0.0014 0.0013 0.0076 0.0023 0.0009 0.0042 0.0029 0.0019 0.0016 0.0023 0.001
Vacuole Periphery 0.0014 0.0003 0.0008 0.0006 0.0008 0.0002 0.0002 0.0002 0.0003 0.0013 0.0011 0.0002 0.0004 0.0002 0.0004 0.0007 0.0009 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 7.8494 6.0145 4.9589 9.134 7.2694 15.6902 9.1219 13.9095 12.6168 12.7182
Translational Efficiency 0.3365 0.515 0.6749 0.4858 0.3553 0.3648 0.4329 0.3701 0.3288 0.3504

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2206 1256 991 928 746 1876 228 2979 2952 3132 1219 3907

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 750.12 706.25 943.43 876.53 851.92 779.60 1059.37 935.51 775.85 750.19 965.12 921.50
Standard Deviation 79.89 114.20 160.62 111.64 118.20 103.09 115.50 115.66 101.28 113.53 159.73 117.43
Intensity Change Log 2 — -0.086942 0.330794 0.224682 — -0.127984 0.314417 0.135035 — -0.108622 0.322108 0.177705

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.024618 0.011573 0.048570 0.054386 0.029147 0.006628 0.052694 0.036716 0.025763 0.008611 0.049341 0.040913
Bud Neck 0.083143 0.035492 0.017363 0.015383 0.027117 0.053067 0.016977 0.046933 0.068985 0.046019 0.017290 0.039439
Bud Site 0.077099 0.060375 0.227496* 0.132747* 0.104999* 0.064011 0.164835* 0.103266* 0.084150 0.062553 0.215776* 0.110268*
Cell Periphery 0.001674 0.000417 0.000810 0.001192 0.001259 0.000596 0.001411 0.000787 0.001569 0.000524 0.000923 0.000883
Cytoplasm 0.423068* 0.322193* 0.376678* 0.360452* 0.432250* 0.388897* 0.260669* 0.543490* 0.425388* 0.362147* 0.354980* 0.500015*
Cytoplasmic Foci 0.197488* 0.320853* 0.153200 0.086566 0.265998* 0.271368* 0.127267 0.026076 0.214801* 0.291213* 0.148349 0.040443
Eisosomes 0.008437 0.001185 0.000440 0.001001 0.001797 0.001260 0.000717 0.000744 0.006759 0.001230 0.000492 0.000805
Endoplasmic Reticulum 0.001882 0.002245 0.003251 0.003220 0.003771 0.000782 0.003552 0.000644 0.002359 0.001369 0.003307 0.001256
Endosome 0.016793 0.056645 0.016512 0.007151 0.019243 0.031017 0.013567 0.004311 0.017412 0.041294 0.015961 0.004986
Golgi 0.019743 0.026536 0.006942 0.003964 0.021742 0.023823 0.001177 0.000866 0.020248 0.024911 0.005864 0.001602
Lipid Particles 0.009220 0.017404 0.004546 0.003282 0.006926 0.005448 0.005892 0.001595 0.008640 0.010242 0.004798 0.001995
Mitochondria 0.009511 0.010222 0.000467 0.001876 0.004746 0.014062 0.000115 0.003597 0.008307 0.012522 0.000401 0.003188
Mitotic Spindle 0.001000 0.002835 0.004524 0.006100 0.000531 0.007322 0.000864 0.014239 0.000881 0.005523 0.003839 0.012306
None 0.001234 0.003562 0.000609 0.000871 0.001137 0.001019 0.000248 0.001057 0.001209 0.002039 0.000542 0.001013
Nuclear Periphery 0.000058 0.000342 0.000090 0.000226 0.000051 0.000077 0.000223 0.000215 0.000057 0.000183 0.000114 0.000218
Nuclear Periphery Foci 0.000180 0.000745 0.003145 0.002336 0.000818 0.000198 0.005213 0.000139 0.000341 0.000418 0.003532 0.000661
Nucleolus 0.000301 0.000956 0.000124 0.000099 0.000202 0.000507 0.000115 0.000228 0.000276 0.000687 0.000122 0.000197
Nucleus 0.036727 0.018804 0.017917 0.050561 0.017195 0.021956 0.029743 0.057704 0.031791 0.020692 0.020129 0.056007
Peroxisomes 0.033185 0.034001 0.024647 0.030733 0.021728 0.031534 0.028004 0.023896 0.030290 0.032523 0.025274 0.025520
Vacuole 0.053600 0.070094 0.092125 0.236791* 0.037838 0.074042 0.286486* 0.132750 0.049617 0.072459 0.128478 0.157462
Vacuole Periphery 0.001039 0.003522 0.000547 0.001063 0.001505 0.002385 0.000232 0.000748 0.001157 0.002841 0.000488 0.000823

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 5.99 -4.87 -2.93 -6.46 1.68 6.69 -1.38 0.69 -10.59 1.77 10.54 -4.89 -1.38 -11.67 4.04
Bud Neck 12.88 20.38 21.98 10.01 2.55 -7.03 3.26 -3.04 5.61 -6.87 7.85 19.87 13.79 7.13 -9.26
Bud Site 3.99 -15.28 -2.90 -5.51 11.54 5.85 -1.74 3.90 -3.43 3.78 6.41 -14.39 0.70 -5.89 14.84
Cell Periphery 7.24 5.02 4.46 -4.82 -0.80 4.11 0.40 4.33 -0.02 1.88 7.59 4.85 6.74 -2.53 2.10
Cytoplasm 11.25 3.68 7.92 -1.71 3.33 3.67 9.12 -8.03 -16.45 -15.67 9.55 6.84 -8.28 -17.51 -12.57
Cytoplasmic Foci -16.78 7.29 25.51 35.59 12.54 -0.54 13.71 31.96 48.48 10.56 -14.61 12.40 48.42 62.31 21.89
Eisosomes 14.61 16.89 16.10 2.71 -3.10 2.35 5.28 5.64 5.50 0.39 14.91 17.36 16.82 5.94 -1.98
Endoplasmic Reticulum -0.75 -3.31 -3.60 -1.99 0.67 4.05 0.33 4.22 1.03 6.22 3.10 -2.52 3.94 0.67 6.94
Endosome -13.19 0.78 10.25 17.55 6.22 -5.18 3.26 8.43 20.05 6.12 -14.48 1.76 15.01 25.82 8.30
Golgi -3.68 11.31 15.78 14.06 3.44 -1.01 12.71 12.93 18.68 1.42 -3.67 14.66 24.66 24.14 5.70
Lipid Particles -5.40 7.67 11.87 9.62 3.28 1.66 0.83 6.30 9.53 2.28 -2.24 6.55 16.09 12.60 5.93
Mitochondria -0.44 12.37 8.81 6.74 -1.26 -5.33 3.31 1.33 10.21 -8.66 -4.05 12.15 8.31 11.98 -7.27
Mitotic Spindle -2.09 -2.97 -3.21 -1.49 -0.51 -5.46 -1.36 -8.53 -2.38 -7.82 -5.31 -3.15 -8.44 -3.43 -4.94
None -2.36 2.69 1.33 2.71 -0.74 0.23 2.79 -0.02 -0.31 -6.72 -1.81 3.33 0.88 2.17 -2.98
Nuclear Periphery -1.94 -4.67 -6.70 -0.26 -5.61 -2.26 -7.56 -17.71 -15.31 -2.44 -2.15 -8.20 -17.62 -3.42 -12.22
Nuclear Periphery Foci -4.37 -9.18 -5.48 -3.31 2.78 5.64 -4.83 6.11 0.79 5.57 -1.75 -10.22 -3.35 -1.67 9.09
Nucleolus -4.96 4.21 4.72 6.42 0.75 -1.76 3.06 -2.43 1.29 -7.69 -3.64 4.74 0.98 3.99 -5.82
Nucleus 8.95 8.54 -7.20 -12.37 -12.05 -3.27 -4.30 -25.27 -23.33 -8.76 8.00 4.96 -19.52 -26.73 -22.72
Peroxisomes -0.31 4.37 4.65 4.69 0.94 -4.31 -0.09 1.50 6.31 0.82 -1.24 3.72 6.71 8.22 1.78
Vacuole -5.12 -11.63 -30.12 -27.43 -21.23 -10.27 -16.18 -32.56 -24.22 8.12 -9.64 -17.70 -42.20 -34.92 -9.41
Vacuole Periphery -7.24 3.72 1.69 7.04 -0.48 -3.03 6.61 4.34 7.72 -3.07 -8.47 5.64 5.00 10.81 -0.78
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck
Localization
Cell Percentages cytoplasm (46%), actin (15%), mixed (27%)
Cell Cycle Regulation Yes
cytoplasm - T/G1 (2.4e-06)
actin - S/G2 (6.5e-07)
Subcompartmental Group N/A

Ldb17

Ldb17


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ldb17-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available